Gene 5517 (Tetrahymena)

5517

Species: Tetrahymena
Alias: 3708.m00137, PreTt05517, TTHERM_00440630, 49.m00289, 5517, 431
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: CAMKK
Subfamily: CAMKK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
5517.AA Protein None 1141 None Fasta, JSON
5517.kin_dom Protein Kinase Domain None 301 None Fasta, JSON
5517.NA RNA None 3426 None Fasta, JSON

Protein domain

Protein domains of 5517.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5517.AA CAMKK-Unclassified 739-1039 41 4e-190 625.02 In-house 1-392 (392) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-392/392
Sequence Identity: 41% (164 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKVNAFTLLER--------EVAIMKKIDHPYLVKLYEVIDDPDDDKIYM--
|..|...|||.||||||||....||.| ..|||||||..|||||.|.|....||||....        |.|||||..||...||||||||||.|||||  
YEFLDKLGRGSFGKVKLATRRYTTDDG-VQKQFAIKVFKKQKLKKKKFIYNDNAFTMKMKNRLHLVQQEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQ

VMEFVQKGSIMSNTFWKKDLQQND--------------PDQYEKIFGGDDDIAHNKKKQE----------MLPKKLSEEKCKKYFQQFALAIDYMHNFAQ
|||..|.|.|||...||.|.|.||              |||............||...|.          |.|.|..|...||||.|......|||||.|
VMEYCQMGQIMSWDYWKQDYQPNDGEIEYFFQTQTEYKPDQFCCQYYNQNGKLHNRQNQKICLFSNQILEMKPYKMHEQYLKKYFRQCCKGLQYMHNFNQ

--------------------IIHRDIKPENILIDEEDN-----LKIADFGVSHIMETSEDSKINDNAGTKTFTAPEGWSRN-FKGKPLD-----------
                    ||||||||.|||||.|||     .||||||.|.|||.....|...||||..|.|||.||.. ||....|           
ACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPL

----------------MWAAGATLYYMATGELPFFSKDPNKLKN-AILNDEVKFP----DDLNHELIDLLKKLLDKNPDTRITASDMLVHPWL
                .|..|.|.|.|....|||..|....|.. .|...|..||    ....||..||..|..||||..|||...||||||.
RKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCSHEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase 5517.AA CAMKK 739-1039 35 1.8e-178 571.5 In-house 1-396 (396) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-396/396
Sequence Identity: 35% (144 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNK----QKLKRKLFSM-----------------KVNAFTLLEREVAIMKKIDHPYLVKLYEV
|.|..|||.| |||||||..|. |     .|..|||..||    .|||.|....                 ..|.|.....|.|||||..||. ||||||
YELMKEIGQGQFGKVKLAYNEYDT-----QKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEV

IDDPDDDKIYMV-MEFVQKGSIMSNTFWKKDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKLSEEK---------------------CKKYFQQFALA
||||..|||||| ||....|.||.. .||.|.|.|.|.||.....       |...|.......||..                     ..|||......
IDDPQNDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYS-------NRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKG

IDYMHNFAQ-------------------IIHRDIKPENILIDEED---NLKIADFGVSHIMETSEDSKIND----------NAGTKTFTAPEGWSR-N--
..|.||...                   ||||||||.|||||||.   ..||||||||||.|.......|.          .|||..|.||| .|. |  
LEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQK

-------------FKGKPLDMWAAGATLYYMATGELPFFSKDPNKLKN---AILNDEVKFPD-------------DLNHELIDLLKKLLDKNPDTRITAS
             ..||..|.||.|.|||.. .|..||.... ..|..   .|.||..|||.             .....|.||.|..|.|||..|||..
ENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIP

DMLVHPWL
...||||.
QIKVHPWV
Kinase 5517.AA CAMKL 739-1039 28 3.1e-85 271.96 In-house 1-297 (297) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-297/297
Sequence Identity: 28% (98 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMK-------VNAFTLLEREVAIMKKID---HPYLVKLYEVIDDPDD----D
|......|.|.|||||||| .. |     ... |||. .|.|.. . ...|             ..||..|||...   ||  .||||||..|.     .
YRIGKTLGKGSFGKVKLATHIRTT-----GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETK

KIYMVMEFVQKGS------IMSNTFWKKDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKLSEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILID
|||.||| .. |.      | ..   .                                ....|. ...||.|   |..|.|.   |.||||||||||.|
KIYLVMEYCSGGEMDLFDYIVKHGHRR--------------------------------GRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLD

EED--NLKIADFGVSHIME---TSEDSKINDNAGTKTFTAPEGWSR--N-FKGKPLDMWAAGATLYYMATGELPFFSKDPN-------KLKNAILNDEVK
| .  |.||.||| | ...     .. | .   |.  . |||  ..    . |.. |.|..| .|| | .|.|||   . |       .|.. |  .  .
ENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YY

FP--DDLNHELIDLLKKLLDKNPDTRITASDMLVHPWL
.|   ..  ...||..|.| .||. |.|. . . |||.
PPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 5517.AA CAMK 744-1039 21 6.9e-82 263.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 744-1039
Range on HMM: 1-425/425
Sequence Identity: 21% (100 aa)

EIGRGGFGKVKLATSEIPTDKGVI------KKQFAIKVSNKQKLKR-----------KLFSMKVN--------AFTLLEREVAIMKK-------IDHPYL
..|||.||||||..    | |         ....|||. .|.|||            . .| . .            ..||..||||       .||| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYEVIDDPD-----------------DDKIYMVM---EFVQKG---------------------SIMSNTFWKKDLQQNDPDQYEKIFGGDDDIAHNK
.|||||..||.                 |...||||   |... |                                                       
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ---------------------------------

KKQEMLPKK--LSEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILIDEED-----------------NLKIADFGVSHIMETSE-------------
   . . ..  ..|. ...||.| . |..|.|.   |.|||.||||||.|. .                 |.||.||| . ... .|             
--FDIV-ERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEM

---------DSKINDNAGTKTFTA-PEGWSR--------------NFKGKPLDMWAAGATLYYMATGELPFFSK-------------DPNKLKNAILNDE
         . | ..  ||  . | ||  ..                 |.. |||..|  || | .|..|| ..             ....|.  |.. .
HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGK

VKFPDDLNH------------------------ELIDLLKKLLDKNPDTRITASDMLVHPWL
  ||..                           | .||..|.| ..|. |.|... | |||.
YDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5517.AA Pkinase 739-1039 26 4.5e-73 253.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-293/293
Sequence Identity: 26% (90 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKVNAFTLLEREVAIMKKIDHPYLVKLYEVIDDPDDDKIYMVMEFVQKG--
|.... ||.|.||.|.... .. | |     ..|.|. .|.. | .    ....     .|..|||...||. |.||..  |  .|.||||||....|  
YHIGRKIGSGSFGCVYKCH-HKGTGK-----IVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY

--SIM----SNTFWKKDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKL--SEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILIDEEDNL----K
  . .                                       .  ...  ||. ||.|. | . ...|.|.   |||||.||||||||.....    |
VMDLFDYIST----------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVK

IADFGVSHIMETSEDSKINDNAGTKTFTAPEGWS-RNFKGKPLDMWAAGATLYYMATGELPFFSK------DPNKLKNAILNDEVKFPDDLN--------
|.|||..  ...  .|  .. .||  . |||    ..  |.. |||..| .||.|..|..|| ..      |.... . |.  ...|. .          
ICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFF

-------------HELIDLLKKLLDKNPDTRITASDMLVHPWL
              |..|..|..|.|.|  |.|| . | |||.
RHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5517.AA AGC 739-1039 21 1.7e-70 180.55 In-house 1-395 (395) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-395/395
Sequence Identity: 21% (94 aa)

YTLLQEIGRGGFGKVKLATS----EIPTDKGVI-KKQFAIKVSNKQK---LKR--KLFSMKVN-------AFTLLEREVAIMKKID----------HPYL
. .|  ||.|.|||| |.      .     ..  .|..|.|| .|..   .|.  ..   ..            . .|  |..|..          ||..
FEFLKVIGKGSFGKVYLVRKKDGCH-----KKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGY---VWEERNILEKCNHTHNHPIKSHHPFI

VK-LYEVIDDPDDDKIYMVME----FVQKGSIMSNTFWKKDLQQNDPDQYEKIFGGD-DDIAHNKKKQEMLPK---KLSEEKCKKYFQQ-------FALA
|| |.    |.| ...|.|||    .|   .                    .  ||. .   |....     .   ...|| .. |. .        .||
VKILHYSFQDKDHTYLYFVMEYMPRYVN--D--------------------LYCGGGCELFLHLQGR-----RKEGRFDEERARFYAAEMQKICGCIVLA

IDYMHNFAQIIHRD-IKPENILIDEEDNLKIADFGVSHIMETSEDS-------------------------------------------------KINDN
..|.|.   ||||| .||||||.||. ..|..||| . .. ....                                                  . .  
LEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTF

AG--TKTFTAPEGWSRNFKGKPLDMWA--AGATLYYMATGELPFFSKDPN----------KLKNAIL------NDEVKFP----------DDLNHELIDL
 |  |  . |||       ||. | |.   |. .| | ||  ||....|.          .. . |.      |..||||          . .  |. ||
CGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDL

LKKLLDKNPDTRIT----------ASDMLVHPWL
.|||| |.|. |..          |..   ||| 
IKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 5517.AA S_TKc 739-1039 27 7.3e-70 239.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKVNAFTLLEREVAIMKKIDHPYLVKLYEVIDDPDDDKIYMVMEFVQK--G
|..|..||.|.||||....          ....|||. .                  ..||..|.|| .||..||||.|..|   |..|||||..    |
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLG

SIMSNTFWKKDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKLSEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILIDEEDNLKIADFGVSHIMET
. ..                             |.. . |.....|  ...|..| ..|..|.|.  .|||||.||||||.||  ..||.|||.. ..  
DLFD--------------------------YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--

SEDSKINDNAGTKTFTAPEGWSRNFKGKPLDMWAAGATLYYMATGELPFFSKDPNKLKNAILNDEVKFPDDLNHELIDLLKKLLDKNPDTRITASDMLV-
      .   ||  . |||     . ... |.|. | .|| |..|. ||   ..... . |.           .|..|...|.|.|.|. |.|| . |  
------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HPWL
      |||.
EWDIKCHPWF
Kinase 5517.AA Ciliate-E2 739-1039 21 1.9e-63 216.62 In-house 1-365 (365) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-365/365
Sequence Identity: 21% (87 aa)

YTLLQEIGRGGFGKVKLA----------TSEIPTDK--------GVIKKQFAIKVSNKQKLKRKLFSMKVNAFTLLE------REVAIMKKIDHPYLVKL
| ... ||.|.||.|...             |  .|        .| .|..|.|. .|.... ..  .. . .  ..       |  |.....||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIK--QEIHIMREINCFYKKINEKNILEQLNHPNIIKM

YEVIDDPDDDKIYMVMEFVQKGSIMS-----NTFWKKDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKLSEEKCKKYFQQFAL---------------
||.  . ||..||.|||..| |. ..     ... .. ..                        .   |...|...|....| .                
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIIL

AIDYMHNFAQIIHRDIKPENILIDEEDNLKIADFGVSHIMETSED---------SKINDN----------------------AGTKTFTAPEGWSRNF--
|. |.|.   ||||||||||||.     .||.||| | .  ....          ... .                      .||  . |||  ..    
ALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYD

-------KGKPLDMWAAGATLYYMATGELPFFSKDPNKLKNAILNDEVKFP------------------DDLNHELIDLLKK----LLDKNPDTRIT-AS
        ..  |.|..| .||.| .|..||         . |.. ...||                  ...  | .||.||    .|.|.|. ||| ..
NQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE

DMLVHPWL
. | |||.
QILNHPWF
Kinase 5517.AA Ciliate-E2-Unclassified 739-1039 23 5.2e-62 212.32 In-house 1-352 (352) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-352/352
Sequence Identity: 23% (89 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKVNAFTLLERE---VA--------IMKKIDHPYLVKLYEVIDDPDDDKIY
|.... ||.||||||...  .    . ..|    |.. .... ..|   .. .. .. ...   .         |.. ..||..||....    |...||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQ--DKQNIY

MVMEFVQKG--SIMSNTFWK---KDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKLSEEKCK-----KYFQQFALAIDYMHNFAQIIHRDIKPENILI
.|||... |  . . . ..|   |                 .|. ||.|..    |...|...|     .|| |  ....|.|    ||||||||||||.
IVMEYCEGGDLWQYIKKRKKQKQK----------------GNDLFHNMKQR----KIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF

DEED---NLKIADFGVSHIMETS--------------EDSKINDNAGTKTFT----APEGWSRNFKG----KPLDMWAAGATLYYMATGELPFFSKDPNK
|..    ..||.||| |   ...               . ......||  .     |||   ..  .    .  |.|. |  ||.| .|..||.... ..
DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQ

----------------LKNAILNDEVKFP--------DDLNHELIDLLK----KLLDKNPDTRITASDMLVHPWL
                |.. |.. ...||        .... | .|...    |.|.|||. |||... | |||.
HQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5517.AA AMPK 739-935 31 3.6e-49 144.16 In-house 1-151 (254) Show / Hide 
Range on Protein: 739-935
Range on HMM: 1-151/254
Sequence Identity: 31% (64 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKVNAFTLLEREVAIMKKIDHPYLVKLYEVI-DDPDDDKIYMVMEFVQKGS
| . . ||.| |||||..| ..       ... |||. ||||.| .  . ..      .||. |.|.. || ...||||| . |.|  |.||||.|. | 
YIIGKTIGEGTFGKVKMGTHILT------GEKVAIKILNKQKIKDQDMVERI------QREIHILKLFRHPHIIQLYEVIIETPTD--IFMVMEYVSGGE

----IMSNTFWKKDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKLSEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILIDEEDNLKIADFGVSHI
    | ..                                    ..|.|.  ...|||   ...|.|.   | ||| ||||.|.|.. |.||.||| | .
LFDYIVKH------------------------------------GRLQEREACRFFQQIISGVEYCHRH-MIVHRDLKPENLLLDHNKNIKIVDFGLSNM

ME
|.
MK
Kinase 5517.AA Meta 878-1039 37 4.2e-48 136.99 In-house 118-287 (287) Show / Hide 
Range on Protein: 878-1039
Range on HMM: 118-287/287
Sequence Identity: 37% (65 aa)

KKLSEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILIDEEDNLKIADFGVSHIMETSEDSKIND--NAGTKTFTAPEGW---SRN-FKGKPLDMWAA
. |||..  .||.   . . | |    ||||||||.| |....   ||||||||.. | . |  . .   |||  | |||     .   . |. || || 
NPLSEDQAWSYFRDIVCGLEYLH-YQKIIHRDIKPSNLLLNDDGHVKIADFGVSNEFEGD-DAFLCNGSTAGTPAFMAPEACSEEQNHFYCGRALDVWAM

GATLYYMATGELPFFS--KDPNKLKNAILNDEVKFPD--DLNHELIDLLKKLLDKNPDTRITASDMLVHPWL
|.||| .  |  || .       | . | |..|.||.  ..  .| |. |..||||| .||. ..  .||| 
GVTLYCFVFGQCPFIDKTNYIMCLHDKIKNHPVMFPEQPEISEDLKDCIKRMLDKNPEHRIMIPEIKTHPWV
Kinase 5517.AA MARK 879-1039 37 5.2e-44 141.86 In-house 100-262 (262) Show / Hide 
Range on Protein: 879-1039
Range on HMM: 100-262/262
Sequence Identity: 37% (62 aa)

KLSEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILIDEED--NLKIADFGVSHIMETSEDSKINDNAGTKTFTAPE-GWSRNFKGKPLDMWAAGATL
.|.|| ....|.|   |. |.|.   |.|||||||||||||.   | ||.||| |   .  ...| |   ||. . |||   ..   |.. |.|. |  |
RLHEEEARRIFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFS--ICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL

YYMATGELPFF--SKDPNKLKNAILNDEVKFPDDLNHELIDLLKKLLDKNPDTRITASDMLVHPWL
|.| .| .||   ..| ..|.  ||. . ..|. . .|. .|...||  ||. |.|... . |||.
YFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 5517.AA Meta 739-840 36 1.8e-39 111.61 In-house 1-113 (287) Show / Hide 
Range on Protein: 739-840
Range on HMM: 1-113/287
Sequence Identity: 36% (44 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKV-----------------NAFTLLEREVAIMKKIDHPYLVKLYEVIDDP
|.|  |||.| .|.|||| .|        ..  |.|. .| ||...   |.                  |.. .  .|.||.|| |||  |||.||.|||
YRLMEEIGKGSYGVVKLAYNE------EDHHHYAMKILSKKKLLKQYGFMRRPPPRGNKPNQGGCIQPRNPLDRVYQEIAILKKLDHPNVVKLVEVLDDP

DDDKIYMVMEFVQKGSIMS
 .| .|||.|.|.||..|.
NEDYLYMVFEYVEKGPVME
Kinase 5517.AA MARK 739-837 34 2.1e-25 80.14 In-house 1-88 (262) Show / Hide 
Range on Protein: 739-837
Range on HMM: 1-88/262
Sequence Identity: 34% (35 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKR-KLFSMKVNAFTLLEREVAIMKKIDHPYLVKLYEVIDDPDDDK-IYMVMEFVQKG
| .|..|| |...|||||.. ..|.     ...|||. .|.|| . .       ..  ..||..||||.|||. .||..||. ..  . ||..|| . .|
YKMLKTIGHGSYAKVKLACH-KHTG-----RKVAIKIYEKFKLNDPQ-------WMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGG

S
.
E
Kinase 5517.AA AMPK 958-1039 36 6.2e-16 43.86 In-house 173-254 (254) Show / Hide 
Range on Protein: 958-1039
Range on HMM: 173-254/254
Sequence Identity: 36% (30 aa)

SRNFKGKPLDMWAAGATLYYMATGELPFFSKDPNKLKNAILNDEVKFPDDLNHELIDLLKKLLDKNPDTRITASDMLVHPWL
..   |   | |  |  || |  | |||   .  .|   |.|.|.. |..|. |  ||.|..| ..|  ||| .|   |||.
GKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 5517.AA TyrKc 739-1039 19 1.5e-13 -3.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 739-1039
Range on HMM: 1-280/280
Sequence Identity: 19% (65 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKVNAFTLLEREVAIMKKI--DHPYLVKLYEVIDDP-----DDDKIYMVME
 ||....|.| ||.| ..|            | |.|. .. .               . ||  ||.|.  .|| .|.|| |. ..      .. ...|||
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

FVQKGSIMSNTFWKKDLQQNDPDQYEKIFGGDDDIAHNKKKQEMLPKKLSEEKCKKYFQQFALAIDYMHNFAQIIHRDIKPENILIDEEDNLKIADFGVS
.. .|.       |. |. . |.                         |. ..  ..  | |   .| |   ..||||.   |.|..|.   ||.||| |
YMPHGDL------KDYLRKHRPK-------------------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLS

HIMETS------EDSKI-----NDNA-GTKTFTAPEGWSRNFKGKPLDMWAAGATLYYMAT-GELPFFS-----KDPNKLKNAILND-EVKFPDD-----
   .        .| .      . ..      .||| .  .      | |. | ... . | |. |        ...  . . . .    . |..     
RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS

---LNHELIDLLKKLLDKNPDTRITASDMLVHPWL
      |. .. |.  . .|. | | |.   |  .
FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 5517.AA Pkinase_Tyr 739-837 30 4.2e-11 38.24 Pfam 1-93 (270) Show / Hide 
Range on Protein: 739-837
Range on HMM: 1-93/270
Sequence Identity: 30% (31 aa)

YTLLQEIGRGGFGKVKLATSEIPTDKGVIKKQFAIKVSNKQKLKRKLFSMKVN-AFTLLEREVAIMKKI-DHPYLVKLYEVIDDPDDD-KIYMVMEFVQK
 |.....|.| ||.|...|     |..  | . |.|.  |.       .|. .     . ||..|||.. .|| .|.|| |. | ..  .||.|||....
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKML-KE------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH

GS
|.
GD
Kinase 5517.AA Pkinase_Tyr 914-931 44 0.057287 7.29 Pfam 141-158 (270) Show / Hide 
Range on Protein: 914-931
Range on HMM: 141-158/270
Sequence Identity: 44% (8 aa)

NILIDEEDNLKIADFGVS
|.|..|.   ||.||| .
NCLVTENNVVKICDFGLA