21201

Species: Tetrahymena
Alias: 876, PreTt21201, TTHERM_00923220, 21201, 164.m00094
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
21201.AA Protein None 358 None Fasta, JSON
21201.kin_dom Protein Kinase Domain None 211 None Fasta, JSON
21201.NA RNA None 1077 None Fasta, JSON

Protein domain

Protein domains of 21201.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21201.AA Ciliate-A7 71-352 35 3.7e-125 422.1 In-house 26-360 (360) Show / Hide
Range on Protein: 71-352
Range on HMM: 26-360/360
Sequence Identity: 35% (119 aa)

LKEM-VHKQLD----------CHTKQCYLLENEYYFLSQISHPHIIKLTS--------ELKSESKSCYFTLEKGLCDMYDRTFRQDHTQLKNYDLN----
.|.  .| ...           |  .|| | |||.||.. .|||||.| .        |.. .. .| ...|.. ||  .  .   | . ||...|    
VKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQ--YFSQHYPHKNLHHNEKIE

--------EVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDKNL------FKLADFGYAKQIEKTLIYSS--------DLYNKWKYRCREYMAPELI
        ..|.|..|.| ||||||.|....|||||||||..|..|       |||||||.||..... ...|        |.|..|||||..|.|||.|
NQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEII

QIVNN----NVAINNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDE-IFQYLDNKSSYVSFWMNFKDILNEFEKEEK-----E
...|.    |.|.|.|.|...| |.|..||.|.||||||.|.|...|...|............ ...|.....|....||......|.|.||..     .
NCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNT

RQQNYGIEHLKDLLENMLCHNPSERFNTLQIITHPWL
.||...|...||||..|||.|||.|....||..|||.
DQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF

Kinase 21201.AA Ciliate-E2 89-352 19 2.4e-23 77.01 In-house 80-365 (365) Show / Hide
Range on Protein: 89-352
Range on HMM: 80-365/365
Sequence Identity: 19% (65 aa)

LENEYYFLSQISHPHIIKLTSELKS-ESKSCYFTLEKGLC-DMYD--------RTFRQDHTQLKNYDLNEVRNCAKQVAL---------------ALHYL
. ||   |.|..||.|||.    ..   ...|. .|     |..|        |.. ..  . |.....|...  ||..                ||.||
I-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYL

HTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKTLIYSS-----DLYNKWK----------------------YRCREYMAPELIQIVN--NNVAI
| . .. | |||||||..      |..|||..|.. .  .. .      .|   |                      .   .||||| ..  .  |.   
HSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---

NNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKERQQNYGIEHL---------
          ..      | |....|. .. |.|  .|.                          .. |  ....|....  | .  .            
----------QKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQ

--KDLLEN----MLCHNPSERFN-TLQIITHPWL
  |||. .    ||. .|..|..   ||. |||.
ECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 21201.AA Ciliate-E2-Unclassified 96-352 19 4.2e-22 73.48 In-house 75-352 (352) Show / Hide
Range on Protein: 96-352
Range on HMM: 75-352/352
Sequence Identity: 19% (61 aa)

LSQISHPHIIKLTSELKSESKSCYFTLEKGLCDMYDRTFRQDH------------TQLKN---YDLNEVR-----NCAKQVALALHYLHTELHVSHNDIK
|... ||.|.|.  . ... . .|. .|  .|.  |  .   .             ..|.    . ....     . ..|. ..| ||| .... | |||
LLNHPHPFIVKMFYCFQDKQN-IYIVME--YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIK

PENIIMFDKN---LFKLADFGYAKQIE-----------KTLIYSSDLYNKWKYRC--REYM----APELIQIVNNN--VAINNKKILTNILNNCYIDEVK
||||.. ...     |..||| .|...           |. |.......    .|   .||    |||..|  |..   |                   |
PENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWT---FCGTPNYMPQYTAPEVLQGQNYDHSKA------------------YK

TDVFAFGMSIFVMIFSVLPYK--TQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKERQQN-----YGIE-HLKDLLE----NMLCHNPSERF
 |....|. .. |.|  .|..  ..|  ... .... . |      .  ..  . | ..|. . . ..     ...  . ||...     ||  ||..| 
CDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N-N------A-YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI

NTLQIITHPWL
.  ||. |||.
TFEQILNHPWF

Kinase 21201.AA Pkinase 84-352 17 1e-21 77.88 Pfam 40-293 (293) Show / Hide
Range on Protein: 84-352
Range on HMM: 40-293/293
Sequence Identity: 17% (53 aa)

KQCYLLEN--EYYFLSQISHPHIIKLTSELKSESKSCYFTLEKGLC-----DMYDRTFRQDHTQLKNYDLNEVRNCAKQVALALHYLHTELHVSHNDIKP
.... . .  | . .  ..||.|..|     . ....|. .|   .     | .|.  ...|. .   . .|......|.. .| |.|    . | |.||
WKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKP

ENIIMFDKNLF----KLADFGYAKQIEKTLIYSSDLYNKWKYRCREYMAPELIQIVNNNVAINNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLP
||| . ...      |..||| |||..    | ..  ...    ..|||||.|.                    .  .  | |....|  .. |..    
ENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIR-------------------GGQYYGPKVDMWSCGCILYEMLCGR--

YKTQEGAFFEDEIFQYLDNK----SSYVSFWMNFKDILNEFEKEEKERQQNYGI---------------EHLKDLLENMLCHNPSERFNTLQIITHPWL
                 ...    . .   .| ...   ... .. .   ..                 | .||.....|| .|..| .  ||  |||.
--------------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

S_TKc 21201.AA S_TKc 61-352 16 2.1e-15 48.88 SMART 1-231 (231) Show / Hide
Range on Protein: 61-352
Range on HMM: 1-231/231
Sequence Identity: 16% (53 aa)

LQNAEQI------TCFLKEMVH-------KQLDCHTKQCYLLENEYYFLSQISHPHIIKLTSELKSESKSCYFTLEKGLC---DMYDRTFRQDHTQL-KN
 .  ..|      ....   ..       |...        ...|   |..  ||.|.||     .  .. |. .|       |..|.  .. .  | . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

YDLNEVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKTLIYSSDLYNKWKYRC--REYMAPELIQIVNNNVAINNKKILT
..  ..|  ..|...|| |.|   .. | |.||||| . .    |..||| |.|.              .  |  ..|||||..                
FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----------------

NILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKERQQNYGIEHLKDLLENMLCHNPSERF
        .  | |. ..|  .. |.    |.        ....|. .                                 . .||.....|. .|..| 
------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRP

NTLQIIT-------HPWL
   .. .       |||.
TA-EALQDEWDIKCHPWF

Kinase 21201.AA Aur 154-195 39 1.7e-12 28.79 In-house 108-149 (257) Show / Hide
Range on Protein: 154-195
Range on HMM: 108-149/257
Sequence Identity: 39% (17 aa)

KQVALALHYLHTELHVSHNDIKPENIIMFD-KNLFKLADFGYA
.|...||.|.| . .. | |||||||.. . ..  |..|||..
YQICNALDYCH-SKNIIHRDIKPENILLDQCNGNIKICDFGWS

Kinase 21201.AA CMGC 137-200 18 8e-11 30.84 In-house 161-256 (513) Show / Hide
Range on Protein: 137-200
Range on HMM: 161-256/513
Sequence Identity: 18% (18 aa)

DHTQ------------LKNYDLNEVRNCAKQVALALH--YLHTE-LHVSHNDIKPENIIMFDKNLF--------------------KLADFGYAKQIEK
.. .             |.. .  .|  ..|.  .|.  |.|   . . | |.||||| . ...                      |..||| |.....
SE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP

Kinase 21201.AA CAMKL 303-352 27 1e-10 30.31 In-house 246-297 (297) Show / Hide
Range on Protein: 303-352
Range on HMM: 246-297/297
Sequence Identity: 27% (15 aa)

KDILNEFEKEEKERQQNYGIE----HLKDLLENMLCHNPSERFNTLQIITHPWL
||   ........   .. |      ..||.  || .||..|..  ||  |||.
KDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 21201.AA DCAMKL 155-204 35 2.2e-10 27.93 In-house 123-177 (279) Show / Hide
Range on Protein: 155-204
Range on HMM: 123-177/279
Sequence Identity: 35% (20 aa)

QVALALHYLHTELHVSHNDIKPENIIMFD----KNLFKLADFGYAKQIEK--TLIY
... || ||| |. . | ||||||    .    .   ||.||| |. ...   ..|
CLCKALKYLH-EMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLY

Kinase 21201.AA CAMK 323-352 36 4.7e-10 27.84 In-house 396-425 (425) Show / Hide
Range on Protein: 323-352
Range on HMM: 396-425/425
Sequence Identity: 36% (11 aa)

EHLKDLLENMLCHNPSERFNTLQIITHPWL
.  |||. .||. .|..|..  |.  |||.
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 21201.AA STE 147-226 26 5.4e-10 31.6 In-house 151-235 (359) Show / Hide
Range on Protein: 147-226
Range on HMM: 151-235/359
Sequence Identity: 26% (24 aa)

NEVRNCAKQVALA-LHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKTLI-----------YSSDLYNKWKYRCREYMAPELIQ
....  ..|.  . |.|||    . | |||| || .      ||.||| ..|.....            ....  ..    .  .|||| ||
SQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ

Kinase 21201.AA CAMKL 154-200 32 2.1e-09 26.0 In-house 134-181 (297) Show / Hide
Range on Protein: 154-200
Range on HMM: 134-181/297
Sequence Identity: 32% (16 aa)

KQVALALHYLHTELHVSHNDIKPENIIMFDKN--LFKLADFGYAKQIEK
.|.  |..|.|    . | |||||||   ...    |..||| . ....
RQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRP

Kinase 21201.AA CAMK 84-200 19 2.8e-09 25.3 In-house 73-248 (425) Show / Hide
Range on Protein: 84-200
Range on HMM: 73-248/425
Sequence Identity: 19% (35 aa)

KQCYLLENEYYFLSQ-------ISHPHIIKLTSELK------------SESK-------SCYFTL---EKGLC-----DMYDRTFRQDHTQLKN------
| .  ...|.  ...       ..||.||||                 . ||        .|. .   |         |..|.  .. .   ..      
KDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV

----YDLNEVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDK-----------------NLFKLADFGYAKQIEK
    ..  |.| . .|.. |.||.|    . | |.||||| . |.                 |  |..||| |.....
ERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP

Kinase 21201.AA LKB 325-352 39 3.9e-09 23.33 In-house 238-265 (265) Show / Hide
Range on Protein: 325-352
Range on HMM: 238-265/265
Sequence Identity: 39% (11 aa)

LKDLLENMLCHNPSERFNTLQIITHPWL
| .|.. ||   ...||. .||  |||.
LQNLIKGMLQYDHNKRFSCHQIMHHPWF

Kinase 21201.AA LKB 159-200 40 5.7e-09 22.83 In-house 116-156 (265) Show / Hide
Range on Protein: 159-200
Range on HMM: 116-156/265
Sequence Identity: 40% (17 aa)

ALHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEK
.. |||   .|.| |||| |. .   |  |. ||| | |...
GCEYLHSQ-RVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHH

Kinase 21201.AA DCAMKL 326-352 44 3.5e-08 20.98 In-house 253-279 (279) Show / Hide
Range on Protein: 326-352
Range on HMM: 253-279/279
Sequence Identity: 44% (12 aa)

KDLLENMLCHNPSERFNTLQIITHPWL
|||  .||  .|  |.   ||  ||| 
KDLISHMLQVDPEKRYTAEQIMQHPWV

Kinase 21201.AA CMGC 327-352 38 2.6e-07 19.11 In-house 488-513 (513) Show / Hide
Range on Protein: 327-352
Range on HMM: 488-513/513
Sequence Identity: 38% (10 aa)

DLLENMLCHNPSERFNTLQIITHPWL
|||..||. .|..|    |.  ||..
DLLKKMLQYDPDKRITAEQALQHPYF

Kinase 21201.AA Aur 325-352 42 4.6e-07 14.13 In-house 230-257 (257) Show / Hide
Range on Protein: 325-352
Range on HMM: 230-257/257
Sequence Identity: 42% (12 aa)

LKDLLENMLCHNPSERFNTLQIITHPWL
.|||  . | |.|..| .  ||  ||| 
AKDLISKILQHDPKQRMTLDQIMNHPWI

Kinase 21201.AA STE 323-352 25 1.2e-05 16.02 In-house 328-359 (359) Show / Hide
Range on Protein: 323-352
Range on HMM: 328-359/359
Sequence Identity: 25% (8 aa)

EHLKDLLENMLCHNPSERFNTLQIIT--HPWL
...|| ... |  .|..| .. | .   ||..
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

TyrKc 21201.AA TyrKc 46-352 13 0.000106 -146.63 SMART 1-280 (280) Show / Hide
Range on Protein: 46-352
Range on HMM: 1-280/280
Sequence Identity: 13% (48 aa)

LQETQQIQT-----------SFQNNQLQNAEQITCFLKEMVHKQLDCHTKQCYLLENEYYFLSQI--SHPHIIKLTSELKSES------KSCYFTLEKGL
..  ...             .           |..  | . .            . .|   ....  .||.|..|     ...      .  .  .|  .
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME--Y

CDMYD-RTFRQDHTQLKNYDLNEVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKT---LIYSSDLYNKWKYRCRE----
..  | . . ..|       . .  . . |.|    |||   .. | |.   |.   ...  | .||| .. |.        |.| | | . ...     
MPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLP

--YMAPELIQIVNNNVAINNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKER
   |||| |          |... |           |.||..||  .. .        |  .   ...|.|            |. .....  .. .  .
IRWMAPECI----------NYGKFTT----------KSDVWSFGVCMWEIF-------TYGQQPYPGMIQQ-----------MMSNQEVIEYVKQGYRMP

QQNY--------GIEHLKDLLENMLCHNPSERFNTLQIITHPWL
|  .          . . .. .    ..|..| .  .|  |  .
QPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 21201.AA DCAMKL 86-107 40 0.000738 7.28 In-house 59-80 (279) Show / Hide
Range on Protein: 86-107
Range on HMM: 59-80/279
Sequence Identity: 40% (9 aa)

CYLLENEYYFLSQISHPHIIKL
. . .||   ...|.|||||.|
EHMIDNEVSIMQKIKHPHIIQL

Kinase 21201.AA CAMKL 83-107 19 0.033166 2.67 In-house 39-80 (297) Show / Hide
Range on Protein: 83-107
Range on HMM: 39-80/297
Sequence Identity: 19% (8 aa)

TKQCYLLEN--------------EYYFLSQIS---HPHIIKL
.. .. . |              |.  .....   ||.||||
WNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL