Gene 28806 (Tetrahymena)
28806
Group:
Other
Family:
Ciliate-A7
Sequence
Protein domains of 28806.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 28806.AA | Ciliate-A7 | 394-700 | 36 | 4.8e-145 | 488.17 | In-house | 1-360 (360) | Show / Hide |
Range on Protein: 394-700
Range on HMM: 1-360/360
Sequence Identity: 36% (132 aa)
ALKLQLHPK------LKQTNQINQIGQDQ--NSSIISHNHKCDQFVQKC-MCEMLKDEWNVLQKMDHPHILKAFQ---LYENIEIEPNSFCCAIEMELAE
..|. . .| . ||.. . .. .. .| .. | |.|||.|.|.|.|||||||...|. .|...|......||.|.||.||
RMKQIFESSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAE
CNLHQLLAKVSQHKQFCLS------------FAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCD-DTTGQYFTKLADLGTAREYSNENHNSSTL--
|.|.|.......||..... ...... ....||.||||..|..|||||..|.||||. ....||..||||.|.|..|....|..|||
CDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQ
------FQNWKIRNPDYQPPEIITFLNE------AKNKE----QIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFSCRGATQNDPL-YKLIFEKRYQEFW
..|||.|...|..||||..||. ||||. ||||. .|||||.|.|..|. ||..|||..||.|....||||. ||..|.|.|..||
QIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFW
SQEKFQRMLNHWA---------TEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQNPWF
.....|.|.||.. |.|..||...|..|...|....||||..|...||.|||
QWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF
|
|||||||||
| Kinase | 28806.AA | Ciliate-E2 | 444-700 | 18 | 1.1e-26 | 88.68 | In-house | 84-365 (365) | Show / Hide |
Range on Protein: 444-700
Range on HMM: 84-365/365
Sequence Identity: 18% (58 aa)
NVLQKMDHPHILKAFQLYENIEIEPNSFCCAIEMELAEC-NLHQLLAKVSQHKQFC--------LSFAKRILLEVTS---------------ALNYLHNN
|.|....||.|.| . .... . .. . ||... .| ... . .. .... . .|.| .... ||.|||..
NILEQLNHPNIIKMYECFQEK----DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK
SNYTHNDIKADNVFIFCDDTTGQYFTKLADLGTAREYSNENHNSS-----TLFQNWK----------------------IRNPDYQPPEIITFLNEAKNK
| | ||| .|... |..|.|....|...| | . .... | . .| |..|||. .. ..
NNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-
EQIDNVLGF-DEKKADIFNLGTLFFAVLFQLRPFSCRGATQNDPLYKLIFEKRYQEF---WSQEKFQRMLNHWATE-QNEQDMYLMIQLITN----MIQQ
.. .|.||. || ... || .|| .. | .. .. . | . .| . . ... ...|| . |.|
-----QKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQK
DPSQRPT-IQEVLQNPWF
||..|.| ....|..|||
DPEKRITGWEQILNHPWF
|
|||||||||
| S_TKc | 28806.AA | S_TKc | 366-700 | 17 | 2.8e-23 | 84.56 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 366-700
Range on HMM: 1-231/231
Sequence Identity: 17% (62 aa)
FEKSKMIGRTNSSYVYSLHDENNQVLHRALKLQLHPKLKQTNQINQIGQDQNSSIISHNHKCDQFVQKCMCEMLKDEWNVLQKMDHPHILKAFQLYENIE
.|. . ||. . || .. . . |.| |... | ..|.| .||.| | . ...
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD--
IEPNSFCCAIEMELAEC---NLHQLLAKVSQH---KQFCLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQYFTKLADLGTAREYSNE
. . ||... .|.... | | ..| |.... .. .||.|.|.. . | |.| .|... |..| | ||..
-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-------HIKICDFGLARQL---
NHNSSTLFQNWKIRNPDYQPPEIITFLNEAKNKEQIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFSCRGATQNDPLYKLIFEKRYQEFWSQEKFQRMLN
. . |.| .||.. |.. .|.|. .| ... | ||. | . ..|.|
---------TTFCGTPWYMAPEVL----------------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------
HWATEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQ-------NPWF
....| .. | ||..|||. |.|| |||
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 28806.AA | Ciliate-E2-Unclassified | 366-700 | 20 | 3.4e-17 | 56.2 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 366-700 Range on HMM: 1-352/352 Sequence Identity: 20% (81 aa) FEKSKMIGRTNSSYVYSLHDENNQVLHRALKLQLHPKLKQTNQINQ-IGQDQNSSIISHNHKCDQFVQKCMCEMLKDEWNVLQKMDHPHILKAFQLYENI ... | ||. . . || . ..... . |.| . . .||.. . . |. .. |.| .. | ... |. ..||.|.| . YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKY-NKIMQQ---ILLNHPHPFIVK------MF EIEPNSFCCAIEMELAE-CNLHQLLAKVSQ--------------HKQFCLSFAK-----RILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQ-Y ... . ... | ||..| .|.| . | .. |.| || ... .. ..|.||| . | | ||| .|... | |. | YCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF---DNNGKNY FTKLADLGTAREYSNENHNSSTLFQ-----------NWKIR-NPDYQ----PPEIITFLNEAKNKEQIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFSC |..|.| ...| ..| |. .| | . .| |. .||.. | . | .|.||. || .... ||. .||.. YIKIIDFGISKKY-QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----------YKCDIWSLGVILYEMLFGYYPFYD RGATQND-------------PLYKLIFEKRYQEFW---------SQEKFQRMLNHWATEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQNPWF . .|.. ||. |..| .| .. .... . ..| .|. |.. .|..|.|....|. ||| NNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN---------------DLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| Kinase | 28806.AA | TKL | 484-696 | 18 | 3.7e-16 | 54.67 | In-house | 126-362 (364) | Show / Hide |
Range on Protein: 484-696 Range on HMM: 126-362/364 Sequence Identity: 18% (46 aa) LHQLLAKVSQHKQFCLSFAKRILLEVTSALNYLHNNS-------NYTHNDIKADNVFIFCDDTT---------GQYFTKLADLGTAREYS---NENHNSS ||.|. .. |. |.. ...||||.. . | |.| .|.... . |. ... |..|.|..|. | | |.... LHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMT TLF----------QNWKIR-NPDYQPPEIITFLNEAKNK----EQIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFS---CRGATQNDPLYKLIFEKRYQ | .. ... .| . .||.. .. ..| | ... . ..| |.|.. | ... .| ||.. .. .|| ....|..... TMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSE-KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCD EFWSQEKFQR---MLNHWATEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQ .. . . .. . .... . |..|.. ..||..||. ||.|. KGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK |
|||||||||
| Kinase | 28806.AA | CAMK | 431-583 | 14 | 4e-14 | 41.2 | In-house | 70-292 (425) | Show / Hide |
Range on Protein: 431-583
Range on HMM: 70-292/425
Sequence Identity: 14% (32 aa)
VQKCMCEMLKDEWNVLQK-------MDHPHILKAFQLYEN---------------IEIEPNSFCCAIE--MELAECN--LHQLLAKVSQHKQ--------
.. ....... | ....| .|||.|.| .. ||. . ....... . ||... . |. .. .|..
RRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQF
-------FCLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQ------------YFTKLADLGTAREYSNEN-------HNSSTLFQNW
|. . |.|. . ||..|.|.. | |.| .|. . ... . . |..| | |... . ... . . .
DIVERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN
-------------KIRNPDYQP-PEII
| | . ||..
QWTTPTEGQKMKTFCGTPEYMAAPEVL
|
|||||||||
| Kinase | 28806.AA | CAMKL | 446-551 | 21 | 4e-12 | 34.85 | In-house | 66-174 (297) | Show / Hide |
Range on Protein: 446-551 Range on HMM: 66-174/297 Sequence Identity: 21% (25 aa) LQKMD---HPHILKAFQLYENIEI-EPNSFCCAIEMELAECN---LHQLLAKVSQHK-QFCLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCD ..... ||.| | .. .|. | . . .. . ||... |.. . | .. . . |.|. . ||.||.|.. | |||..|. . .. MKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDEN DTTGQYFTKLADLG . |..| | GNN---NIKIIDFG |
|||||||||
| Kinase | 28806.AA | CAMK | 674-700 | 44 | 1.5e-11 | 32.76 | In-house | 399-425 (425) | Show / Hide |
Range on Protein: 674-700 Range on HMM: 399-425/425 Sequence Identity: 44% (12 aa) IQLITNMIQQDPSQRPTIQEVLQNPWF ..|| .| | ||..|.||...|. ||. KDLIRKMLQVDPEKRMTIEQCLNHPWM |
|||||||||
| Kinase | 28806.AA | CAMKL | 674-700 | 40 | 4.1e-11 | 31.57 | In-house | 271-297 (297) | Show / Hide |
Range on Protein: 674-700 Range on HMM: 271-297/297 Sequence Identity: 40% (11 aa) IQLITNMIQQDPSQRPTIQEVLQNPWF ..|| | | .|..||||..... ||. RDLIRKMLQVNPEKRPTIHQIMNHPWM |
|||||||||
| Kinase | 28806.AA | Ciliate-E2a | 674-700 | 40 | 1.2e-09 | 24.63 | In-house | 249-275 (275) | Show / Hide |
Range on Protein: 674-700 Range on HMM: 249-275/275 Sequence Identity: 40% (11 aa) IQLITNMIQQDPSQRPTIQEVLQNPWF ..|. | . ||..|.|.|. |..||| KDLMKKMLEKDPKKRITAQQALNHPWF |
|||||||||
| Kinase | 28806.AA | CMGC | 664-700 | 32 | 2.2e-08 | 22.67 | In-house | 477-513 (513) | Show / Hide |
Range on Protein: 664-700 Range on HMM: 477-513/513 Sequence Identity: 32% (12 aa) EQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQNPWF ...... . | |. .| | ||..|.|... || |.| FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
|||||||||
| Kinase | 28806.AA | NEK | 673-700 | 39 | 2.9e-08 | 25.6 | In-house | 259-286 (286) | Show / Hide |
Range on Protein: 673-700 Range on HMM: 259-286/286 Sequence Identity: 39% (11 aa) MIQLITNMIQQDPSQRPTIQEVLQNPWF . .||..|.| ||.|||.....|..| LQNLISQMLQKDPEQRPSCNQILEMPFI |
|||||||||
| Kinase | 28806.AA | Pkinase | 673-700 | 39 | 3.1e-08 | 30.21 | Pfam | 266-293 (293) | Show / Hide |
Range on Protein: 673-700 Range on HMM: 266-293/293 Sequence Identity: 39% (11 aa) MIQLITNMIQQDPSQRPTIQEVLQNPWF ....|......||..|||....|| ||| CKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 28806.AA | Pkinase | 442-565 | 20 | 3.2e-08 | 30.13 | Pfam | 50-168 (293) | Show / Hide |
Range on Protein: 442-565 Range on HMM: 50-168/293 Sequence Identity: 20% (27 aa) EWNVLQKMDHPHILKAFQLYENIEIEPNSFCCAIEMELAECN--LHQLLAKVS--QHKQF--CLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIF | ......||.|.. . .|. .. .. . ||..|. . | . .| .|. | .|...... ..|.|.|.. . | |.| .|..| EIQIMKRLNHPNIVRLYDWFED-----KDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILID CDDTTGQYFTKLADLGTAREYSNENHNSST ..... . |..| | |. .. . .|| . NNGHIDA-CVKICDFGLAKQFD-Y-NNS-M |
|||||||||
| Kinase | 28806.AA | WEE | 503-563 | 23 | 4.1e-08 | 23.39 | In-house | 114-189 (297) | Show / Hide |
Range on Protein: 503-563 Range on HMM: 114-189/297 Sequence Identity: 23% (18 aa) KRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQY---------------FTKLADLGTAREYSNENHNS . ||... .|...|.| . |.||| .|.|| .. | |..|.| . . . .|.|. WQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNP |
|||||||||
| Kinase | 28806.AA | CMGC | 446-559 | 13 | 4.5e-08 | 21.63 | In-house | 75-257 (513) | Show / Hide |
Range on Protein: 446-559 Range on HMM: 75-257/513 Sequence Identity: 13% (25 aa) LQKM-----------------DHPHILKAFQLYENIEIEPNSF-----------CCAIEMELAECNLHQLLAKVSQ------------------------ |... .|..|.| . . . ..| . . . .|. ...|.|.. . .. LKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPH -HKQFCLSFAKRILLEVTSALN--YLHNNS-NYTHNDIKADNVFIFCDDTT---------------GQYFTKLADLGTAREYSNE | | . . . . .|. |.| . | | |.| |. | . . .. |..| | || |... NIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH |
|||||||||
| Kinase | 28806.AA | WEE | 675-700 | 53 | 4.5e-07 | 19.86 | In-house | 272-297 (297) | Show / Hide |
Range on Protein: 675-700 Range on HMM: 272-297/297 Sequence Identity: 53% (14 aa) QLITNMIQQDPSQRPTIQEVLQNPWF ||| .|.. ||.||||.|. ||.| QLIKWMMHPDPEQRPTCQQLLQHPVL |
|||||||||
| Kinase | 28806.AA | NEK | 437-566 | 23 | 1.5e-05 | 15.98 | In-house | 48-184 (286) | Show / Hide |
Range on Protein: 437-566 Range on HMM: 48-184/286 Sequence Identity: 23% (34 aa) EMLK-DEWNVLQKMDHPHILKAFQLYENIEIEP-NSFCCAIEMELAE--CNLHQL---LAKVS-QHKQFCLSFAKRILLEVTSALNYLHNNS----NYTH ... | ..|....||.| | |. .. | |..| |.|| .| .|.|. . | ..| | . ... .||.|.|... . | QNAQNNEVRILKQLKHPNIVK---YYDSFIEEQNNCLC--IVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILH NDIKADNVFIFCDDTTGQY-FTKLADLGTAREYSNENHNSST-L ||| |.|. ... .| . |. |.| ... .... .| . RDIKPQNIFLTKNNN--DYHNVKIGDFGISKVLNHTTDMAYTTQ |
|||||||||
| Kinase | 28806.AA | Ciliate-E2a | 486-560 | 24 | 0.000808 | 7.15 | In-house | 85-164 (275) | Show / Hide |
Range on Protein: 486-560 Range on HMM: 85-164/275 Sequence Identity: 24% (20 aa) QLLAKVSQHKQFCLS--FAKRILLEVTS-ALNYLHNNSNYTHNDIKADNVFIF-CDDTT-GQYFTKLADLGTAREYS-NEN .|. | .|.|.| ...|. .. .|.|.|.. |. | |.| .|... |. . . |..| |.|. .. .|. ELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQR-NIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEK |
|||||||||
| Kinase | 28806.AA | Ciliate-E2a | 439-463 | 36 | 0.00343 | 5.27 | In-house | 46-70 (275) | Show / Hide |
Range on Protein: 439-463 Range on HMM: 46-70/275 Sequence Identity: 36% (9 aa) LKDEWNVLQKMDHPHILKAFQLYEN ...| | ....|||.|.| . ||. FMNEINIMRQLDHPNIIKLYEVYED |
|||||||||