Gene 16356 (Tetrahymena)
16356
Group:
Other
Family:
Ciliate-A8
Sequence
Protein domains of 16356.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 16356.AA | Ciliate-A8 | 32-173 | 52 | 1.8e-78 | 267.02 | In-house | 1-151 (151) | Show / Hide |
Range on Protein: 32-173 Range on HMM: 1-151/151 Sequence Identity: 52% (80 aa) YDFQKVLEKGDFSLAMIAYSQKLKCQVAIKVFKQFEKFNQENEKELDKKIEVLQNITNEIYFLKTIEKIYDKQQGLIAIVTEPYDC--------NLNKIL |..||||||||||....|||....||||||..|.....|..|.||..|.|...|.|.||.|.|..||.|.||.||.||||||..|| ||..|| YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL E--LNKLNIEQIVAIAYQLLKGLDVLKKNGISFQNYILSENILYSQSKNKFL | |||...|||||..|||||.|.|....|| . | ..|||||.|||.|. ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCD-IKPQNILYSWSKNQFI |
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| Kinase | 16356.AA | Ciliate-E1 | 38-175 | 22 | 1.9e-23 | 73.46 | In-house | 1-151 (202) | Show / Hide |
Range on Protein: 38-175
Range on HMM: 1-151/202
Sequence Identity: 22% (34 aa)
LEKGDFSLAMIAYSQKLK-CQVAIKVFKQFEKFNQENEKELDKKIE-VLQNITNEIYFLKTIEKIYDKQQGLIAIVTEPYDCNLNKILE-----------
...|.||. .|..|. . .|||.|... ..||... .. |.. ... . .|.| .. |. |...| ...|..| ..|.|.. |.
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC
---LNKLNIEQIVAIAYQLLKGLDVLKKNGISFQNYILSENILYSQSKNKFLIA
|.....|...|..||..|| |. ..| ..... .|||.... ......
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIK-PQNILINNQ-GNYVYC
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| Kinase | 16356.AA | S_TKc | 32-270 | 15 | 2.5e-10 | -25.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 32-270
Range on HMM: 1-231/231
Sequence Identity: 15% (43 aa)
YDFQKVLEKGDFSLAMIAYSQKLKCQVAIKVFKQFEKFNQENEKELDKKIEVLQNITNEIYFLKTIEKIYDKQQGLIAIVTEPYDC---NLNKILELNK-
|.. ... || |. . .. | . .||||. | . . . |..|.. . . | .. ..| . . .|.| | .| .... ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR
------LNIEQIVAIAYQLLKGLDVLKKNGISFQNYIL-----SENILYSQSKNKFLIAYYGLQNTMANS------------LPMKTH-EIDIFSLGLIV
.. .. ..||....|. . ..| |. |||| .. |. || . .. | .. ..|. |.| |.
HGLRFPFPE-HARFYMYQICCALEYCHSHG------IIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCIL
AETFIQRRLTQKEILNLKQKKFLEVFPYQERSKDVDFINQIISKMTDPNKDKRLQLIPILL-----QSLDSF
.| . . . . .. . .| . .... .|.|. . . .||. .| . |
YEMLCGYPPFP-QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 16356.AA | CMGC | 32-152 | 12 | 3.8e-07 | 18.55 | In-house | 1-205 (513) | Show / Hide |
Range on Protein: 32-152 Range on HMM: 1-205/513 Sequence Identity: 12% (27 aa) YDFQKVLEKGDFSLAMIAYS--------------QKLKCQVAIKVFKQFEKFNQENE-------------KELDKKIEVLQNI----------------T |. |.. .| .. .. . . .|||| .|. . . . | |. |... YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALRE----IKILKHLNKNHDPNWQRRDDPDNK NEIYFLKTIEKIYDKQ---------------QGLIAIVTEPYDCNLNKILELNK-----------------------------LNIEQIVAIAYQLLKGL .. . .| .. .|.|. . .|.| |..| .... |. . | .| ..||.|.|| HHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGL D--VLKKNG--I . . ... | KLKYCHSHWGNI |
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| Kinase | 16356.AA | MOK | 32-164 | 28 | 2e-05 | 12.43 | In-house | 1-132 (283) | Show / Hide |
Range on Protein: 32-164 Range on HMM: 1-132/283 Sequence Identity: 28% (39 aa) YDFQKVLEKGDFSLAMIAYSQKLKCQVAIKVFKQ-FEKFNQENEKELDKKIEVLQNITNEIYFLKTIEKIYDKQQGLIAIVTEPYDCNLNKILELNK--L | . .| || | | . | | || || .| |. . | .. . |. | ..|.. | .|.. | | |. .. . | YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNL---REIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYL NIEQIVAIAYQLLKGLDVLKKNGISFQNYILSENIL ..| |||.| || . .||| | . |||| PQKKIMHYMYQLCKSLDHMHRNGI-FHRDVKPENIL |
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| Kinase | 16356.AA | DYRK2 | 110-152 | 26 | 0.000194 | 9.98 | In-house | 78-123 (318) | Show / Hide |
Range on Protein: 110-152 Range on HMM: 78-123/318 Sequence Identity: 26% (12 aa) IVTEPYDCNLNKILELNKL---NIEQIVAIAYQLLKGLDVLKKNGI |..| .. || . . |. . . . . |...|..|. |.|| | ITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNI |
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| Kinase | 16356.AA | Ciliate-F2 | 110-179 | 28 | 0.000214 | 12.15 | In-house | 74-142 (200) | Show / Hide |
Range on Protein: 110-179 Range on HMM: 74-142/200 Sequence Identity: 28% (20 aa) IVTEPYDCNLNKILELNKLNIEQIVAIAYQLLKGLDVLKKNGISFQNYILSENILYSQSKNKFLIAYYGL .| | || . ..|. || |. |.. || | |. | ||..| |..|.. ..| FVQETEDCCIKQQLQSCKLTDNQQYEEIQQFINGLAELENLGL-IHGDIKIENMIYNRPKQRFMFDDFQL |
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| Kinase | 16356.AA | TSSK | 32-62 | 27 | 0.000444 | 9.26 | In-house | 1-47 (289) | Show / Hide |
Range on Protein: 32-62 Range on HMM: 1-47/289 Sequence Identity: 27% (13 aa) YDFQKVLEKGDFSLAMIAYSQKLKCQ----------------VAIKV |...|.. .| .. .||| | || ||||. YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKI |
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| Kinase | 16356.AA | DYRK1 | 32-69 | 31 | 0.000629 | 9.12 | In-house | 1-38 (321) | Show / Hide |
Range on Protein: 32-69 Range on HMM: 1-38/321 Sequence Identity: 31% (12 aa) YDFQKVLEKGDFSLAMIAYSQKLKCQVAIKVFKQFEKF |. . . || | . || .. ...||||. | | YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPF |
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| Kinase | 16356.AA | DYRK2 | 32-66 | 36 | 0.077885 | 1.37 | In-house | 1-38 (318) | Show / Hide |
Range on Protein: 32-66 Range on HMM: 1-38/318 Sequence Identity: 36% (14 aa) YDFQKVLEKGDFSLAMIAYSQKLKCQVAIKVF---KQF | .|. || | . .| |.| ||||. | | YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRF |
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