Gene 22398 (Tetrahymena)

22398

Species: Tetrahymena
Alias: 1146, TTHERM_00220700, PreTt22398, n.22398, 22398, 18.m00424
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A8

Sequence

Name Sequence Type Origin Length Description Download
22398.AA Protein None 771 None Fasta, JSON
22398.kin_dom Protein Kinase Domain None 149 None Fasta, JSON
22398.NA RNA None 2808 None Fasta, JSON

Protein domain

Protein domains of 22398.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22398.AA Ciliate-A8 29-177 58 6.1e-94 318.39 In-house 1-151 (151) Show / Hide 
Range on Protein: 29-177
Range on HMM: 1-151/151
Sequence Identity: 58% (89 aa)

YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKKGNLASIF
|...|.|.|||||.||.|.|.|....|||||.|....|||||..||.|.|.|....|.|||||..||.|||......|.||||||.|||||||.|||||.
YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL

K--LNKLDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFI
.  |||....||.|||||||..|.....||||...||..|||||.||||||
ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI
Kinase 22398.AA Ciliate-E1 35-219 23 1.9e-30 96.43 In-house 1-202 (202) Show / Hide 
Range on Protein: 35-219
Range on HMM: 1-202/202
Sequence Identity: 23% (48 aa)

LQKGDFSEVVLAHSENLN-KKVAIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKKGN--LASIF---
. .|.|| |. | ..| | ..||.|| .  . .|...|.. .||.  ....|.|.||. .|..|..|...... ..|.|.  .. . ...  |  ..   
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRL-EYWQQC

--KLNKLDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFIIA--NPSH--YKNDQYNENQQGTNQKSKSQEDS-------DKQNQKNIL
  . |... .|......||. ||  |....||...|| .|||.... ......    |.   .|.... .. |  .. ...|         .|... |. 
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

VDIY
.|||
SDIY
Kinase 22398.AA S_TKc 29-291 16 9.8e-13 9.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-291
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)

YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKK--GNLAS
| . ... || |..| ...  . ...|||||.|          | ...||.  ..  . ..|  ... .||   . . .|.|.||          |.| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCD-------GDLGDLFD

IFKLNK-------LDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFI------------------------IANPSHYKNDQYNENQQG
. | ..       ..  ..  ..||....|  . ..|||   .| .||| ..     |                        .                 
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQLTTFCGTPWYMAPEVL----------------

TNQKSKSQEDSDKQNQKNI-LVDIYSIGLLVIEALLQRPLENEEQLNLNDQDLMKVLPSLQTSEHYEFIHNFVCKMVNKDISQRLQPEDLIN------NL
               . .   .|..|.| ...| |  .|.        ..| ..|..         |... |..|. .|| ..|.   .. .      . 
---------------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCH

EQF
. |
PWF
Kinase 22398.AA Ciliate-E3 29-178 27 5.7e-12 33.9 In-house 1-145 (202) Show / Hide 
Range on Protein: 29-178
Range on HMM: 1-145/202
Sequence Identity: 27% (42 aa)

YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQN---KINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKKGNLA
|   .|| .| |. |  |.. ..|..|||| .  ...||     .| .  .|.  .  ..  ....   .|. |... .  .| |.| |       |.| 
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQIN-SQNVVKCHDQYYDQQNKMIFIVQEYCSN-------GDLY

SIFKLNKLDLKQ--ILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFII
   |  .. . |  |. .  |...|.  .  | || . || |||| . ..|| ||
HYIK--QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLII
Kinase 22398.AA Pkinase 29-149 19 1e-09 35.44 Pfam 1-121 (293) Show / Hide 
Range on Protein: 29-149
Range on HMM: 1-121/293
Sequence Identity: 19% (26 aa)

YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKK--EIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNF----DFY----
| ..... .| |..| ..|  . .|.||.||.|   ....   ..  .  ||.   .|. .  |. ...  .|..     .|.|.|..     | .    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYIS

KKKGNLASIFKLNKL--DLKQILALTYQLLRGL
          . ...  . ...    ||.||||
T--------WRHGCFYFSEWECKFYMYQILRGL
Kinase 22398.AA Ciliate-E2a 29-78 35 4.3e-09 22.94 In-house 1-50 (275) Show / Hide 
Range on Protein: 29-78
Range on HMM: 1-50/275
Sequence Identity: 35% (18 aa)

YIFEKILQKGDFSEVVLAHSENLNKK-VAIKILKNTDEQNKINFEEFKKEI
| |.|.. || |  |.||   . .|. ...|. |  ..|.|.. |.|..||
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEI
Kinase 22398.AA CK2 29-117 28 2.4e-08 20.25 In-house 1-85 (288) Show / Hide 
Range on Protein: 29-117
Range on HMM: 1-85/288
Sequence Identity: 28% (26 aa)

YIFEKILQKGDFSEVVLAHSENLNKKV--AIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDF
|  .. . .| .|||  .   . |.|.   |||||       .  .  | ||.  | |.| . |  ... ..| .    |.| |. .| ||
YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKP------VKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDF
Kinase 22398.AA CAMK 34-123 16 6.4e-08 20.85 In-house 1-160 (425) Show / Hide 
Range on Protein: 34-123
Range on HMM: 1-160/425
Sequence Identity: 16% (26 aa)

ILQKGDFSEVVLAHSENLN------------KKVAIKILKNTDEQNKI-------------------------NFEEFKKEIRAFEMLKG------EKYI
.| .| |..| |.   | .            .||||||.. .  ..|                          . .....||.   .|.|       . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LPFIEQIQDDK-----------------LNLFAVVT---EFCDN-------FDFYKKKGN
. ..| ..|..                  . .  |.   |.|..       ||. ...|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGC
Kinase 22398.AA PDK1 29-60 38 7.1e-08 19.65 In-house 1-36 (307) Show / Hide 
Range on Protein: 29-60
Range on HMM: 1-36/307
Sequence Identity: 38% (14 aa)

YIFEKILQKGDFSEVVLAHSENL----NKKVAIKIL
.||.|.. .| .|.|.|| .       ||..||||.
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKIC
Kinase 22398.AA CAMK1 29-78 28 1.1e-07 18.3 In-house 1-41 (276) Show / Hide 
Range on Protein: 29-78
Range on HMM: 1-41/276
Sequence Identity: 28% (15 aa)

YIFEKILQKGDFSEVVLAHSENL---NKKVAIKILKNTDEQNKINFEEFKKEI
|.| |.. .| ||||.|.   .    .|..|||....            || .
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK------------KKFM
Kinase 22398.AA MARK 29-79 27 1.5e-07 20.94 In-house 1-51 (262) Show / Hide 
Range on Protein: 29-79
Range on HMM: 1-51/262
Sequence Identity: 27% (14 aa)

YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIR
| . | . .| ...| ||.. . ..||||||..... .   ...... ||.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIE
Kinase 22398.AA Ciliate-F2 132-178 40 5.2e-07 21.73 In-house 91-137 (200) Show / Hide 
Range on Protein: 132-178
Range on HMM: 91-137/200
Sequence Identity: 40% (19 aa)

KLDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFII
||  .|.   . |.. ||  ||| |.| | || .|..| | |..|..
KLTDNQQYEEIQQFINGLAELENLGLIHGDIKIENMIYNRPKQRFMF
Kinase 22398.AA TyrKc 29-288 14 6.2e-07 -110.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-288
Range on HMM: 1-280/280
Sequence Identity: 14% (46 aa)

YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIRAFEML-KGEKYILPFIEQIQDD-----KLNLFAVVTEFCDNFDFYKKKG
  ..|.|  | | ||....      .||.| ||.         |.| .|.|   .| .  . |. ..  . ..           .|.|..       ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM-------PHG

NLASIFKLNK--LDLKQILALTYQLLRGLVLLENKGIIIGH--IKSDNILYSRSKNQFIIANPSHYK-------NDQYNE-----NQQGTNQKSKSQED-
.| .  . ..  | .|. |   .|  .|   |. |..|  |  .   |.|... .         . |        | |..     ...   .|...... 
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCI--HRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

----------SDKQNQKNILVDIYSIGLLV--IEALLQRPLENEEQLNLNDQDLMKVLPSL--QTSEHY----------EFIHNFVCKMVNKDISQRLQP
          . . .  ..  |..| | .   |  . | | ....|  ...|.... . .       ..          . ...   .  . | ..|   
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

EDLINNL
....  .
SEIHECF
Kinase 22398.AA Ciliate-F2 29-60 43 0.067343 3.0 In-house 1-31 (200) Show / Hide 
Range on Protein: 29-60
Range on HMM: 1-31/200
Sequence Identity: 43% (14 aa)

YIFEKILQKGDFSEVVLAHSENLNKKVAIKIL
| .  ||  | |   . | |||  . |||||.
YQYVGILGNGLFGQQIQAYSENY-QSVAIKII
Kinase 22398.AA Pkinase 216-288 15 2.656211 2.15 Pfam 193-293 (293) Show / Hide 
Range on Protein: 216-288
Range on HMM: 193-293/293
Sequence Identity: 15% (16 aa)

VDIYSIGLLVIEALLQRPLENEE-------QLNLNDQDLMKVLPSLQTSEHY-------------------EFIHNFVCKMVNKDISQRLQPEDLINN--
||..|.|....| |. ||.  ..       |. . ...... |..    ..                    |    |.... .|| ..|. .|.. .   
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

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