Gene 13125 (Tetrahymena)

13125

Species: Tetrahymena
Alias: 451, 13125, PreTt13125, 3707.m00169, 4.m00524, TTHERM_00059410
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A9

Sequence

Name Sequence Type Origin Length Description Download
13125.AA Protein None 842 None Fasta, JSON
13125.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
13125.NA RNA None 2529 None Fasta, JSON

Protein domain

Protein domains of 13125.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13125.AA Ciliate-A9 75-330 35 8.10000000001e-237 573.89 In-house 1-392 (392) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-392/392
Sequence Identity: 35% (140 aa)

IELIEKIDEGSFGVVFKGRDIQ--DGSLCAVKVTQNNKEKYTS-----IETSILRGLDHPNIVKFK---------------------KFIELDSNKYIVM
.|.|..|.||.||.|...||||  |....||||.|.||.|...     .|..||...|||||||||                     ||.|.|.|..|||
FEPIKIIGEGAFGCVIQCRDIQQEDKQEYAVKVIQKNKMKMDCIEFQDQEAKILQQHDHPNIVKFKNIKNINTQKETKQLNYIFQISKFCESDQNIHIVM

EYIGCGTLQQLIEERKAKNNPFNQQEISVIMSHLMSALKCMHENNVLHRDIKPE----------------------------------------------
||..|||||||..|||..|..||.||||.||...|||...||..|..|||.||.                                              
EYMKCGTLQQLMKERKKNNQWFNEQEISQIMKCIMSAVMYMHQKNICHRDLKPDRQINKCIQLFISSFIHLFINHHNYCKQQNKQTNKQTNEKINQVKIF

----NILLGSKEDLSKLKLSDFGLS--------VKYQDGVPFKSYSQKCGTVIFMAPEILAEKQYSKPID------------------------------
    |||.|.|.||...|..|||||        |.|.......|..|.|||.|.||||....||||.|.|                              
ILTENILIGDKNDLTQVKIADFGLSKSFVKSQRVQYFTQWTYHSMYQQCGTLIYMAPEFFINKQYSQPVDHAVSMKSRKRLIYLFLQLIILFLNSLKSQN

-------------IWSCGIILYMLYTMGKHPFKS--SSISREEYIKKIINLDVSKEVLD-----EDDFPSEMLNKEPSNRYTASQVLKHPFI
             .||||||.|||..||||||..  .....|.|.|..|......|..|     ...|...|.|..|||||.|.|.||||.|
QFILYRQFKQQVDMWSCGIIMYMLLCMGKHPFWCPYEKNDDEDYFKMKIQCNPQWEFWDNCSNNAKNFIQKMTNINPSNRYNAFQCLKHPWI
Kinase 13125.AA S_TKc 75-330 32 1.6e-78 268.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-231/231
Sequence Identity: 32% (86 aa)

IELIEKIDEGSFGVVFKGRDIQDGSLCAVKVTQNNKEKYTSIETSILRGLDHPNIVKFKKFIELDSNKYIVMEYIGC--GTLQQLIEERKA--KNNPFNQ
 |...|| .|.||.|.|.|.. .| ..|.|.      . .  | .||.  .||||||.. ...  .. |.||||..   |.| ..|..|.   .. ||. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

QEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSKEDLSKLKLSDFGLSVKYQDGVPFKSYSQKCGTVIFMAPEILAEKQYSK-PIDIWSCGIILYML
 ..  .|  . .||. .|.....|||.||||||| .      .|..||||. ..         .  |||  .||||.|   .|.| ..|.||||.||| .
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

YTMGKHPFKSSSISREEYIKKIINLDVSKEVLDEDDFPSEMLNKEPSNRYTASQVLK-------HPFI
.. |. ||       .. .|||          .  || . .|.|.|..|.|| ..|.       ||..
LC-GYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13125.AA Ciliate-E2 75-330 25 2.2e-73 250.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

IELIEKIDEGSFGVVFKGRDIQDG-----------------------SLCAVKVTQNNKEKYTSIETSILR----------------GLDHPNIVKFKKF
...|.|| .|.||.|.|.......                       .. |.|. ..|. .... | .|.|                 |.||||.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--LDSNKYIVMEYIGCGTLQQLIEERKAKN-------NPFNQQEISVIMSHLMS---------------ALKCMHENN-VLHRDIKPENILLGSKEDL
 .   |.| |.||||.  |.|...|...| |        ..|. .||. || .. .               ||. .|..| ..||||||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SKLKLSDFGLSVKYQD-------GVPFKSYSQK----------------------CGTVIFMAPEILAEKQ---------YSKPIDIWSCGIILYMLYTM
  .|..||||| ||.|       ..  | | .|                      |||  .||||||  |.         |.. .||||.|.|||.. . 
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-

GKHPFKSSSISREEYIKKIINLDVS-------------------KEVLDED--DFPSE----MLNKEPSNRYT-ASQVLKHPFI
||.||          ...|.. ...                   .. ....  |. .     ||.|.|..|.| ..|.|.||..
GKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 13125.AA CAMK 80-330 20 2.2e-71 229.08 In-house 1-425 (425) Show / Hide 
Range on Protein: 80-330
Range on HMM: 1-425/425
Sequence Identity: 20% (88 aa)

KIDEGSFGVVFKGRDIQDG------------SLCAVKV-------------------------------TQNNKEKYTSIETSILRG-------LDHPNI
.. .||||.|.........              .|.|.                               .. ...|    | .|..        ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFKKFIEL-------------------DSNKYIVM---EYIGCG----TLQQLIEER------------KAKNNPFNQQEISVIMSHLMSALKCMHENN
.|.  ..|                    |.. |.||   ||.  |     | . | |.              ..  |. .| . ..  . ||.. .|..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

VLHRDIKPENILLGSKEDLS--------------KLKLSDFGLSVKYQDGV---------------------PFKSYSQKCGTVIFMA-PEILAEKQ---
. |||.||||||| ...| |              ..|..|||.. |...|                      . . ..  |||  .|| ||.|  |.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YSKPIDIWSCGIILYMLYTMGKHPFKSS--------------------SISREEY--IKKII-----------NLDVSKE---VLDED-
           |....|.||||.|||..   |. || ..                     | . .|  . . .             |.|.|    .... 
MQNATDEEKPYYGPKCDMWSCGVILYIM-LCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

-DFPSEMLNKEPSNRYTASQVLKHPFI
 |. . ||...|..|.|..|.|.||..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 13125.AA Pkinase 75-330 27 1e-66 232.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

IELIEKIDEGSFGVVFKGRDIQDGSLCAVKVTQNNKEKYTSI-------ETSILRGLDHPNIVKFKKFIELDSNKYIVMEYIGCG----TLQQLIEERKA
.....|| .||||.|.|.... .| . |||.    .||           | .|.. |.|||||... . | ... |.|||| ..|     |  .|.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KNNPF--NQQEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSKEDL-SKLKLSDFGLSVKYQDGVPFKSYSQKCGTVIFMAPEILA-EKQYSKPIDI
....|    .|.  .|  . ..|. .|.....|||.||||||. .. .. ...|..||||. ...   .   ..  |||  .||||..   . |....|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSCGIILYMLYTMGKHPFKSS----SISREEYIKKIINLDVSKEVLDEDDFP------------------------SEMLNKEPSNRYTASQVLKHPFI
||||.||| ... |. ||...    ...  . |..|   ... .   ... .                        . .|.| |. |.|| |.|.||..
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 13125.AA Ciliate-E2-Unclassified 75-330 22 2.4e-64 220.11 In-house 1-352 (352) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-352/352
Sequence Identity: 22% (81 aa)

IELIEKIDEGSFGVVFKGRDIQDGSLC-----AVKVTQNNKEKYTS----------IETS--------------ILRGLDHPNIVKFKKFIELDSNKYIV
 ..|..| .|.||.|.| ...... .      . |. .... .. .          ..                ||. ..||.|||.    . . | |||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYIGCGTLQQLIE-------------ERKAKNNPFNQQEIS-----VIMSHLMSALKCMHENN-VLHRDIKPENILLGSKEDLS--KLKLSDFGLSVKY
|||.  |.|.| |.             ... ... |  |...      .. .. ..|. .|..| ..||||||||||.  ... .  ..|..|||.| ||
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF--DNNGKNYYIKIIDFGISKKY

QDGV-------------PFKSYSQKCGTVIFM----APEILAEKQYS----KPIDIWSCGIILYMLYTMGKHPFKS-SSIS-------------REEYIK
|. .             ... ....||| ..|    |||.| ...|.    . .||||.|.||| . . |..||.. ....             |.....
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF-GYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

KIINLDVSKEVLDE----DDFP-------S----EMLNKEPSNRYTASQVLKHPFI
.|.. ....   ..    .. .       .     ||.| |..|.|..|.|.||..
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 13125.AA CAMK-Unique 75-330 22 3.9e-64 210.55 In-house 1-363 (363) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-363/363
Sequence Identity: 22% (82 aa)

IELIEKIDEGSFGVVFKGRDIQDGSLCAVKVTQN-----NKEKY------------------TSIETSILRGLDHPNIVKFKKF---IELDSNK------
..... | .|.||.|... |.  | ..|.|. ..     .| |                   .  | .|.. .|||||.|.  .   | .|...      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

----------YIVMEYIGCGTLQQLIEER-KAK---------------NNPFNQ--QEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSKED-----
          ||||||. .|.|...| .. . .               . .|.    ... ||  | ||.. ||.... |||.|.|||.. . ..     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------LSKLKLSDFGLSVKYQDGVPFKSYS---QKCGTVIFMAP--------------EILAEKQYSKPI----DIWSCGIILYMLYTMGKHPFKSS
         ...||.||||...|.     |...     ||| ..|||              |....  |. .     ||||.| |.|.. . |..|| ..
RDFPYDWSNWHIKLCDFGLCCHYNH---NKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLC-GCPPFDCE

SISR------EEYIKKII--NL-DVSKEVLDE--------DDFPSEMLNKEPSNRYTASQVLKHPFI
.. |       | ...|   .. ...... .          ||    .. .|. | .|.. |.|..|
CEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 13125.AA CAMKL 76-330 27 4.6e-62 196.8 In-house 2-297 (297) Show / Hide 
Range on Protein: 76-330
Range on HMM: 2-297/297
Sequence Identity: 27% (83 aa)

ELIEKIDEGSFGVVFKGRDIQD-GSLCAVKVTQNNKEKY------------------TSIETSILRGLD---HPNIVKFKKFIELDSN------KYIVME
.... . .||||.|  ...|.  |   |.|.   .| .                      | .|.. |.   ||||.|.   || ...       |.|||
RIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVME

YIGCGT--LQQLIEERKAKNNPFNQQEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSKEDLSKLKLSDFGLSVKYQD--GVPFKSYSQKCGTVIFM
|.. |   |.. |.... .. ..   |   .   ..||.. .|.... ||||||||||| .. .  ..|..|||.| .|..    | .  .  ||.  .|
YCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILAE--KQYS-KPIDIWSCGIILYMLYTMGKHPFKSSSIS-------REEYIKKI-----INLDVSKEVLDEDDFPSEMLNKEPSNRYTASQVLKHP
||||..   |.|  ...||||||.|||..   |. ||.  ...       ... ....     | ..|| ..    |. . ||.. |. |.|. |...||
APEIFQGNNKPYDGPKVDIWSCGVILYAM-VCGYLPFDDDTYNKQGKDNIYLYWKIMCGYYPPIWYHVS-DCR---DLIRKMLQVNPEKRPTIHQIMNHP

FI
. 
WM
Kinase 13125.AA ULK 75-330 25 1.9e-60 207.12 In-house 1-329 (329) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-329/329
Sequence Identity: 25% (86 aa)

IELIEKIDEGSFGVVFKGRDIQD----GSLCAVKVTQNNKEKYTS-------------IETSILRGLD--------HPNIVKFKKFIELD--SNKYIVME
..|.... .||||.|.|||....    . ..|.|. . .|..  .              |  |.. |.        ||||||.... | .   | ||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YIGCGTLQQLIEERKA------KNNPFNQQEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSK----EDLSK------LKLSDFGLSVKYQDG--VP
|   |.|.|.|...|       ... ...||.  .. ......|..|..|. ||||||.|||.  .    ..  |      ||..|||.. . ...    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK-KVHPNGVLKIADFGFAKHVDNDNMEQ

FKSYSQK-----CGTVIFMAPEILA----EKQYS-KPIDIWSCGIILYMLYTMGKHPFKSSSISREE---YIKKIIN------------LD---------
.  ....     ||| ..|||.||     .|.|. .  |||| |.|.| . . || ||... .. .    ..| | |            |.         
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY-GKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

VSKEVLDEDDFPSEMLNKEPSNRYTASQVLKHPFI
.|.|.    |. . || .... | .  ....||..
ISPECK---DLIRRMLQYDEKDRISWEELFNHPWF
Kinase 13125.AA ULK 75-330 25 7.7e-59 201.8 In-house 1-324 (324) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-324/324
Sequence Identity: 25% (86 aa)

IELIEKIDEGSFG-VVFKGRDIQD---GSLCAVKVTQ-----NNKEK--------YTSIETSILRGLD---HPN--IVKFKKFIELD--SNKYIVMEYIG
..|.... .|||| .|.|||....   . . |.|. .     ..| .            | .|.. |.   |||  |||.... | .   | ||.|||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

CGTLQQLIEERKA-----KNNPFNQQEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSKEDLSK-----------LKLSDFGLSVKYQDG-VPFKSY
.|.|.|.|...|      ... ...||.  .. ......|..|..|. ||||||.|||.  ...  |           ||..|||.. . ...      .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI--HNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

SQKC------GTVIFMAPEILA----EKQYS-KPIDIWSCGIILYMLYTMGKHPFKSSSISREE---------------YIK-KIINLD-------VSKE
 . .      || ..|||.||     .|.|. .  |||| |.|.| . . || ||.|. .. ..               ||| . |. .       .|.|
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY-GKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPE

VLDEDDFPSEMLNKEPSNRYTASQVLKHPFI
.    |. . || .... | .  ....||..
CK---DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 13125.AA Ciliate-E2a 76-278 37 7.4e-57 165.9 In-house 2-217 (275) Show / Hide 
Range on Protein: 76-278
Range on HMM: 2-217/275
Sequence Identity: 37% (84 aa)

ELIEKIDEGSFGVVFKGRDIQDGSLCAVKVTQNNKEKYTS-------IETSILRGLDHPNIVKFKKFIELDSNKYIVMEYIGCGTLQQLIEERK-AKNNP
..| || .|.||.|.. . .|.|   |.|.  . |   .         | .|.| |||||| |.  . | ..| |.||||.  |.| . | . |  . . 
KFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE-

FNQQEISVIMSHLMS-ALKCMHENNVLHRDIKPENILLG--SKED--LSKLKLSDFGLSVKYQDGVPFKSYSQKCGTVIFMAPEILAEKQ------YSKP
   |||. ||  | . .|  || .|..|||.||||||.   ||..  .|..|..||||. ....  . . . |||||  ..|||.|. |.      |.. 
--IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMF-QKCGTPGYVAPEVLNNKEVLKHKQYDTK

IDIWSCGIILYMLYTMGKHPFK
 |.||||.|.| |  .|| |||
CDMWSCGVIFYIL-LCGKPPFK
Kinase 13125.AA STE 75-266 23 3e-51 176.58 In-house 1-258 (359) Show / Hide 
Range on Protein: 75-266
Range on HMM: 1-258/359
Sequence Identity: 23% (63 aa)

IELIEKIDEGSFGVVFKGRDIQ---------------DGSLCAVKVTQ--------------------NNKEKYTSIETSILRGLD--HPNIVKFKKFIE
 |.|||| .|.||.|.|....                 | ..|.|.                      .....    | .|.. ..  ||||||.    .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LD-------SNKYIVMEYIGCGTLQQLIEERKAKNNPFN----------QQEISVIMSHLMSA-LKCMHENNVLHRDIKPENILLGSKEDLSKLKLSDFG
 .       .. .|.|||.. |.| ..|.... ...|.|           ..|..|   .  . |.  |.... |||||| ||||         ||.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

LSVKYQDGVP--------------FKSYSQKCGTVIFMAPEILAE------KQYSKPIDIWSCGIIL
.. . .| ..               .     .||  .||||..        |.|.   |||| |. .
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 13125.AA TyrKc 75-330 23 2.9e-16 40.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 75-330
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

IELIEKIDEGSFGVVFKGRDIQDGSLCAVKVTQNNKEKYTSI--ETSILRGL--DHPNIVKFKKFIELD-------SNKYIVMEYIGCGTLQQLIEERKA
|.|..|. || ||.|.||. .     .|||. ....     .  | .|.. |  .|||||..   .  .          .|||||   | |.. . ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KNNPFNQQEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSKEDLSKLKLSDFGLSVKYQDG----VPFKSYSQK---CGT--VIF--MAPEILAEKQ
|   .. ..   ..    .     |..|. |||.   |.|.|..      | |||||| .  |.    .  . |..|   .|   .    |||| . .. 
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSKPIDIWSCGIILYMLYTMGKHPFKS------SSISREEYIKKIINLDVSKEVL------DEDDFPSEML---NKEPSNRYTASQVLKHPFI
..   |.|| |. .. ..| |. |         | .   ||.|.   ..  ....        |.  . |.   . .|..| | |..  | ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 13125.AA Pkinase_Tyr 75-221 25 5.4e-14 48.02 Pfam 1-158 (270) Show / Hide 
Range on Protein: 75-221
Range on HMM: 1-158/270
Sequence Identity: 25% (42 aa)

IELIEKIDEGSFGVVFKGRDI----QDGSLCAVKVTQNNKEKYTSI---------ETSILRGL-DHPNIVKFKKFIE-LDSN--KYIVMEYIGCGTLQQL
|....|. ||.||.|.||.      ...  .|||.    ||....          | .|.. | .|||||..   .   .     ||||||  .| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IEERKAKNNPFNQQEISVIMSHLMSALKCMHENNVLHRDIKPENILLGSKEDLSKLKLSDFGLS
  ...  ..|.. ...  .     ...   ...|  |||.   |.|...  .. . | .||||.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NN-VVKICDFGLA
Kinase 13125.AA Ciliate-E2a 310-330 52 8e-09 22.13 In-house 255-275 (275) Show / Hide 
Range on Protein: 310-330
Range on HMM: 255-275/275
Sequence Identity: 52% (11 aa)

MLNKEPSNRYTASQVLKHPFI
||.| |..|.|| | |.||. 
MLEKDPKKRITAQQALNHPWF
Kinase 13125.AA STE 311-330 63 2e-06 18.57 In-house 338-359 (359) Show / Hide 
Range on Protein: 311-330
Range on HMM: 338-359/359
Sequence Identity: 63% (14 aa)

LNKEPSNRYTASQVLK--HPFI
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LQKDPNKRPTASQLLKSEHPFI