Gene 15975 (Tetrahymena)

15975

Species: Tetrahymena
Alias: PreTt15975, 739, 15975, TTHERM_00321570, 32.m00219
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C3

Sequence

Name Sequence Type Origin Length Description Download
15975.AA Protein None 1145 None Fasta, JSON
15975.kin_dom Protein Kinase Domain None 148 None Fasta, JSON
15975.NA RNA None 3438 None Fasta, JSON

Protein domain

Protein domains of 15975.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15975.AA Ciliate-C3 728-864 80 6.1e-91 308.43 In-house 1-140 (140) Show / Hide 
Range on Protein: 728-864
Range on HMM: 1-140/140
Sequence Identity: 80% (112 aa)

FIVKKVKLKENGGRKVALKQPLEEEKDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFKGETLFSFIKKLYKSQQFYDQNQK---LKKLK
|||||||||||..|||||||| ||..||||||||||||||||||||||||||||||||||||||||||.|.||..||...|......|||.|   |.||.
FIVKKVKLKENKDRKVALKQPQEEQNDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFEGQTLEKFINEIYDNKKYQDQNHKDLKLQKLQ

ISKQILQAIEYLHEHNIVHGDIKLSNILINARDEIKIIDF
|||||||||.|||||||||||||.||||||..||||||||
ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF
Kinase 15975.AA Ciliate-E2 717-901 20 2.4e-22 73.49 In-house 1-286 (365) Show / Hide 
Range on Protein: 717-901
Range on HMM: 1-286/365
Sequence Identity: 20% (59 aa)

YDEIKEISSSQF-IVKKVKLKENGGR-------------------KVALKQPLEEEKDYSKQQMREISILSNLP---------------KNNLIIQYVGH
|. || | . .| .|.|.| .... .                   |. ..     .|.  .|...||.|.  .                ... ||... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

QK--NNKQFQIFLEYFKGETLFSFIKKLYKSQQFY----DQNQKLKKLKISKQILQ---------------AIEYLHEHN-IVHGDIKLSNILINARDEI
 .  ... . . .||..| .||..||. .|....      .    . ..|.|||||               |.||||. | |.| |||..|||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIIDFS------------------------------------------------ESGFLVEEIIGFTEDY-DAKDNFKTRYIDYYSLGILL
|||||                                                   |..  ||..  ... . | .  .  .|..|||..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 15975.AA CMGC 717-864 17 2.7e-18 55.88 In-house 1-248 (513) Show / Hide 
Range on Protein: 717-864
Range on HMM: 1-248/513
Sequence Identity: 17% (45 aa)

YDEIKEISSSQF-IVKKVKLKENG-------------GRKVALKQPLEEEKDYSKQQ------------MREISILSNLP-----------------KNN
|. || | .  . .| | . |...             ...||.|   ... .   ..             |||.|| .|                  .||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LI-IQYVGHQKN---------------NKQFQIFLEYFKGETLFSFIKKLY------KSQQFYDQN----------QKLKKLK----ISKQILQAIE--Y
.. .... . ||               .... .  ||  . .|. .||.        . . . .            .  |..     ...|||....  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHEHN--IVHGDIKLSNILINAR--------------------DEIKIIDF
.| |.  |.| |.| .||||| .                    ...||.||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase 15975.AA Pkinase 736-864 24 1.6e-17 63.08 Pfam 20-156 (293) Show / Hide 
Range on Protein: 736-864
Range on HMM: 20-156/293
Sequence Identity: 24% (36 aa)

KENGGRKVALKQPLEEEKDYSKQQM----REISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFKGE----TLFSFIKKLYKSQQFYDQNQKLKKL----
. . |..||.|.   .... .|.|     .||.|. .| .   |... .   ...   . .||  |      ||..|.            .. ...    
HKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----------WRHGCFYFSE

----KISKQILQAIEYLHEHNIVHGDIKLSNILINARDEI----KIIDF
    .. .|||...||.|...|.| |.|..||||. ...|    ||.||
WECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase 15975.AA CAMKL 784-864 30 3.6e-17 51.22 In-house 93-173 (297) Show / Hide 
Range on Protein: 784-864
Range on HMM: 93-173/297
Sequence Identity: 30% (28 aa)

NNKQFQIFLEYFKGET--LFSFI--KKLYKSQQFYDQNQKLKKLKIS------KQILQAIEYLHEHNIVHGDIKLSNILINARD--EIKIIDF
. |......||  |    || .|  ..  .           .... .      .||. |..|.|.|.||| |||. |||.  ..   ||||||
T-KKIYLVMEYCSGGEMDLFDYIVKHGHRR-----------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDF
Kinase 15975.AA MARK 827-864 55 1.1e-16 51.21 In-house 111-150 (262) Show / Hide 
Range on Protein: 827-864
Range on HMM: 111-150/262
Sequence Identity: 55% (22 aa)

KQILQAIEYLHEHNIVHGDIKLSNILINARD--EIKIIDF
.||. |..|.|..|||| |||. |||| ..    ||||||
RQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF
Kinase 15975.AA STE 717-864 23 1.3e-16 55.3 In-house 1-191 (359) Show / Hide 
Range on Protein: 717-864
Range on HMM: 1-191/359
Sequence Identity: 23% (46 aa)

YDEIKEISSSQFI-VKKVKLKENG--------------GRKVALKQPLEEEK-----------------DYSKQQMREISILSNLPK-NNLIIQYVGHQK
.. |..| .  |  | | . ..|.              |. .| ||   |..                 .  .| ..||.|.... .    |..| |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NN-------KQFQIFLEYFKGETLFSFIKKLYKSQQFYDQNQK------LKKL-KISKQILQA-IEYLHEHNIVHGDIKLSNILINARDEIKIIDF
..        .  |..||  | .| ..||. |. ..  ..|..       . . .| .|||..  .|||.|.|.| ||| .|||.     .|..||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDF
Kinase 15975.AA CAMK 729-864 19 2.2e-16 48.6 In-house 9-240 (425) Show / Hide 
Range on Protein: 729-864
Range on HMM: 9-240/425
Sequence Identity: 19% (46 aa)

IVKKVKLKENGG-----------RKVALKQ----PLEEE-----------------------KDYSKQQ-MREISILSNLPK------NNLIIQYVGHQK
.||... |...|           .||| |      | .                        ....... .|||.|...| .         ||.   .  
KVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYE

N-------------------NKQFQIFL---EYFKGE----TLFSFIKKL-YKSQQF--YDQNQKLKKL------KISKQILQAIEYLHEHNIVHGDIKL
.                   .|.. ...   ||  |      ||..|..  ... .|   |   . ...      .. .||..|..|.|.||||| |.|.
DPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKP

SNILINARD-----------------EIKIIDF
 |||.. ..                  ||||||
ENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
Kinase 15975.AA TKL 723-864 17 3.2e-16 54.91 In-house 1-198 (364) Show / Hide 
Range on Protein: 723-864
Range on HMM: 1-198/364
Sequence Identity: 17% (38 aa)

ISSSQFI-VKKVKLKENG-------GRKVALKQPLE------------------------EEKDYSKQQMREISILSNLPK--NNLIIQYVG---HQKN-
| |  |  | | |.. .|       |. || |.  .                        .....|. . .|.  .  . .     |.|..|     .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------NKQFQIFLEYFKGETLFSFIKKLYKSQQFYDQNQKLKK-LKISKQILQAIEYLHEHN--------IVHGDIKLSNILINARDE--------
          .|. |  || .| .|....               . . ......| ....||| .|        |.| |.| .|||..   .        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYN

------IKIIDF
      .|| ||
PNADWCCKICDF
Kinase 15975.AA Ciliate-E8 828-867 52 7.7e-16 45.96 In-house 97-138 (138) Show / Hide 
Range on Protein: 828-867
Range on HMM: 97-138/138
Sequence Identity: 52% (22 aa)

QILQAIEYLHEHNIVHGDIKLSNILINA--RDEIKIIDFSES
||. |. |||  ||.| |.|| |||.       ||||||  |
QIMDAFCYLHNNNIIHCDFKLNNILVQRNDDTKIKIIDFGFS
Kinase 15975.AA Ciliate-E2-Unclassified 717-867 25 1.6e-14 46.83 In-house 1-194 (352) Show / Hide 
Range on Protein: 717-867
Range on HMM: 1-194/352
Sequence Identity: 25% (50 aa)

YDEIKEISSSQF-IVKKVKLKENGGRKVALKQPLEEEKDYSKQQ------MREISILSNLP------------------KNNLIIQYVGHQKNNKQFQIF
|  || | . .| .|.|.. |...  . |.|.     .. .||.      |.|. .. |.                   .. .|. .. . .. . . | 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYFKGETLFSFIKKLYK---------SQQFYDQNQKLKKLK------ISKQILQAIEYLHEHN-IVHGDIKLSNILINARD---EIKIIDFSES
.||..| .|. .|||  |          .. ...    .. |      . .||||..||||. | |.| |||..|||..      .||||||. |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS
Kinase 15975.AA S_TKc 717-977 20 2.3e-12 4.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 717-977
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

YDEIKEISSSQF-IVKKVKLKENGGRKVALKQPLEEEKDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFKG--ETLFSFIKKLYK-SQQ
|. ...| .  |  |.|.. |.  ||.||.|.         .. .|||.||..  .   |... ..  . . . ...||  |   .||..|||  .   .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

FYDQNQKLKKLKISKQILQAIEYLHEHNIVHGDIKLSNILINARDEIKIIDFSESGFLVE-----------EIIGFTEDYDAKDNFKTRYIDYYSLGILL
|.      .  .. .||..|.||.|.|.|.| |.| .|||..   .|||.||  . .|             |..           . .. .| .|.|..|
FPFPE-HAR--FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCIL

IRIFY--------SLEFKILCNCGESKKQTQRQECEYKYFQKYGKIIDYKNIVIDRTDMIQNLLY-EINN-ISTDQINQ----GINYPYN
.  ..         . ||...                                 .  |.|...|  . .. ..  .. |      . |. 
YEMLCGYPPFPQMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15975.AA TyrKc 717-972 15 5.7e-08 -93.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 717-972
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

YDEIKEISSSQF-IVKKVKLKENGGRKVALKQPLEEEKDYSKQQMREISILSNL-PKNNLIIQYVGHQKNN-------KQFQIFLEYFKGETLFSFIKKL
   .|.. . .| .| | ..|    ..|| |   |.     .  |||..|...| ...  |.. .|            ..  | .|| ..  | ....| 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

YKSQQFYDQNQKLKKLKISKQILQAIEYLHEHNIVHGDIKLSNILINARDEIKIIDFSESGFLVEE-IIGFTEDYDAK-----DN------------FKT
 .        .  ..|... || .  ||||..|..| |.   |.|....  .|| ||  | .. ..   |  .||  |      .            ...
RPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

R--------------------YIDYYSLG-----ILLIRIFYSLEFKILCNCGES----KKQTQRQECEYKYFQKYGKIIDYKNIVIDRTDMIQNLLYEI
.                    | .    |     .  ....  ..      . ..                              |.  ..| | .  . 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------FVCCPDEMYQ-IMKQC

NNI------STDQINQGI
 .       .  .| . .
WHEDPEDRPTFSEIHECF