15976

Species: Tetrahymena
Alias: 15976, 738, PreTt15976, 32.m00220, TTHERM_00321580
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C3

Sequence

Name Sequence Type Origin Length Description Download
15976.AA Protein None 1143 None Fasta, JSON
15976.kin_dom Protein Kinase Domain None 139 None Fasta, JSON
15976.NA RNA None 3432 None Fasta, JSON

Protein domain

Protein domains of 15976.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15976.AA Ciliate-C3 700-838 81 1.8e-93 316.85 In-house 1-140 (140) Show / Hide
Range on Protein: 700-838
Range on HMM: 1-140/140
Sequence Identity: 81% (114 aa)

FVVKIVELKGNEG-SIVLKQPQEEQNDYSQQQMREISILSNLPKNNLIIEYKGHSKNKKYFQIFLEYYEGKTLLSFINEINDNKKYKDQNHKDLKLRKLQ
|.||.|.||.|.. ...||||||||||||.|||||||||||||||||||.|.||.||.|.|||||||.||.||..|||||.|||||.|||||||||.|||
FIVKKVKLKENKDRKVALKQPQEEQNDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFEGQTLEKFINEIYDNKKYQDQNHKDLKLQKLQ

ISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKIKIIDF
|||||||||||||||||||||||.|||||||.|.||||||
ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF

Kinase 15976.AA Ciliate-E2 728-875 20 1.8e-21 70.43 In-house 61-286 (365) Show / Hide
Range on Protein: 728-875
Range on HMM: 61-286/365
Sequence Identity: 20% (48 aa)

QQQMREISILSNLP---------------KNNLIIEYKGHSK--NKKYFQIFLEYYEGKTLLSFIN--EINDNKKYKDQNHKDLKLRKLQ-ISKQILQ--
.|...||.|.  .                ... ||... . .  ..... . .||..|..|...|.   .. |.. .    | ..... . |.|||||  
EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGF

-------------AIDYLHEHN-IVHGDIKLSNILINSQDKIKIIDFSESGFLAEE----------------------------------------TIGY
             |. |||. | |.| |||..|||.     ||||||  | .. ..                                        | ||
KTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGY

TIG--YDAKDNL-------KTRYIDYYSLGILL
     .  |..         .  .|..|||..|
MAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

Kinase 15976.AA CAMKL 755-838 28 2.8e-17 51.56 In-house 93-173 (297) Show / Hide
Range on Protein: 755-838
Range on HMM: 93-173/297
Sequence Identity: 28% (27 aa)

NKKYFQIFLEYYEGKT--LLSFINEINDNKKYKDQNHKDLKLRKLQIS------KQILQAIDYLHEHNIVHGDIKLSNILINSQD--KIKIIDF
. |......|| .|    |. .| .  . .            .... .      .||. |..|.|.|.||| |||. |||. ...  .||||||
T-KKIYLVMEYCSGGEMDLFDYIVKHGHRR------------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDF

Kinase 15976.AA AGC 802-838 41 1.3e-16 37.99 In-house 161-199 (395) Show / Hide
Range on Protein: 802-838
Range on HMM: 161-199/395
Sequence Identity: 41% (16 aa)

QILQAIDYLHE-HNIVHGD-IKLSNILINSQDKIKIIDF
.|. |..|||. ..|.| | .|. |||....  ||. ||
CIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

Kinase 15976.AA MARK 801-838 55 3.5e-16 49.57 In-house 111-150 (262) Show / Hide
Range on Protein: 801-838
Range on HMM: 111-150/262
Sequence Identity: 55% (22 aa)

KQILQAIDYLHEHNIVHGDIKLSNILINSQD--KIKIIDF
.||. |. |.|..|||| |||. |||| ..   .||||||
RQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF

Kinase 15976.AA Ciliate-E2-Unclassified 688-841 22 8.9e-16 51.23 In-house 1-194 (352) Show / Hide
Range on Protein: 688-841
Range on HMM: 1-194/352
Sequence Identity: 22% (43 aa)

YDEKETINSISQFVVKIVELKGNEGSIVLKQPQEEQNDYSQQQM-------REISILSNLP------------------KNNLIIEYKGHSKNKKYFQIF
|   ..|.. .. .|. .. | .   .  ..    ...|.|.|.       .|. .. |.                   .. .|. .  . ..|... | 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYYEGKTLLSFINEIND-----NKKYKDQNH-KDLKLRKLQ------ISKQILQAIDYLHEHN-IVHGDIKLSNILINSQD---KIKIIDFSES
.|| ||..|. .|.. .      | ....... | .  .. .      . .||||...|||. | |.| |||..|||....    .||||||. |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

Kinase 15976.AA CAMK 801-838 38 1.3e-15 46.05 In-house 186-240 (425) Show / Hide
Range on Protein: 801-838
Range on HMM: 186-240/425
Sequence Identity: 38% (21 aa)

KQILQAIDYLHEHNIVHGDIKLSNILINSQD-----------------KIKIIDF
.||..|..|.|.||||| |.|. |||... .                 .||||||
RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF

Kinase 15976.AA Ciliate-E8 802-841 54 2.8e-15 44.19 In-house 97-138 (138) Show / Hide
Range on Protein: 802-841
Range on HMM: 97-138/138
Sequence Identity: 54% (23 aa)

QILQAIDYLHEHNIVHGDIKLSNILINS--QDKIKIIDFSES
||. |. |||  ||.| |.|| |||.      |||||||  |
QIMDAFCYLHNNNIIHCDFKLNNILVQRNDDTKIKIIDFGFS

Kinase 15976.AA TKL 746-838 18 4.4e-15 50.77 In-house 87-198 (364) Show / Hide
Range on Protein: 746-838
Range on HMM: 87-198/364
Sequence Identity: 18% (24 aa)

IIEYKG---HSKN----------KKYFQIFLEYYEGKTLLSFINEINDNKKYKDQNHKDLKLRKLQISKQILQAIDYLHEHN--------IVHGDIKLSN
|. ..|    ...          .... |  ||..| .||....                  ........| ....||| .|        |.| |.| .|
IVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

ILINSQDK--------------IKIIDF
||...  .              .|| ||
ILVDENWTNVSNYMYNPNADWCCKICDF

Kinase 15976.AA Pkinase 701-838 23 8.3e-15 53.43 Pfam 14-156 (293) Show / Hide
Range on Protein: 701-838
Range on HMM: 14-156/293
Sequence Identity: 23% (36 aa)

VVKIVELKGNEGSIVLKQPQEEQNDYSQQQM----REISILSNLPKNNLIIEYKGHSKNKKYFQIFLEYYEGK----TLLSFINEINDNKKYKDQNHKDL
.|..   ||..   ..|.   . .. ...|     .||.|. .| .   |.....   .|..  . .|| ||      | ..|           ..|. .
CVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---------WRHGCF

--KLRKLQ-ISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKI----KIIDF
    . .. . .|||....|.|...|.| |.|..||||.... |    ||.||
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF

Kinase 15976.AA CMGC 714-838 16 7.1e-14 41.06 In-house 41-248 (513) Show / Hide
Range on Protein: 714-838
Range on HMM: 41-248/513
Sequence Identity: 16% (36 aa)

IVLKQPQEEQNDYSQQQ------------MREISILSNLP-----------------KNNLI--IEYKGHSKNK--------------KYFQIFLEYYEG
. .|   ... .  |..             |||.|| .|                  .||..  ...  |....              ... .  || . 
VAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-

KTLLSFINEIND-----NKKYKDQNH-------------KDLKLRKLQISKQILQAID--YLHEHN--IVHGDIKLSNILINSQ----------------
..|. .| . ..     .... .. |             | . .   ....|||....  |.| |.  |.| |.| .|||||..                
HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNP

----DKIKIIDF
    ...||.||
CQKNGRLKICDF

Kinase 15976.AA S_TKc 688-951 18 7.8e-14 25.97 SMART 1-231 (231) Show / Hide
Range on Protein: 688-951
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

YDEKETINSISQFVVKIVELKGNEGSIVLKQPQEEQNDYSQQQMREISILSNLPKNNLIIEYKGHSKNKKYFQIFLEYYEG--KTLLSFINEINDNKKYK
|.  ..| . .  .|. .  |.      .|.         .. .|||.||..  .   |. ....  . ... ...|| .|   .|...| . . .....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

DQNHKDLKLRKLQISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKIKIIDFSESGFLAEETIGYTIGY---DAKDNLKTR-YIDYYSLGILLIIIFY-
  .  . .     . .||..|..|.|.|.|.| |.| .|||...   |||.||  . .|   |.  |  |          ..  .| .|.|..|.. .. 
PFPE-HARF----YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCG

--SFQIEILCNCGEKKKCKMQNHEEFILQAISKMDEQRKNQYSQIFFDQIKSLLNDQPYLRQTQRQKCE-------QKYF
   |.                 ... ... |           |. . | |. .|.  |  | |  .  .         .|
YPPFP-----------------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 15976.AA TyrKc 694-951 16 2.3e-07 -103.61 SMART 1-280 (280) Show / Hide
Range on Protein: 694-951
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

INSISQF------VVKIVELKGNEGSIVLKQPQEEQNDYSQQQMREISILSNL-PKNNLIIEYKGHSKNK-------KYFQIFLEYYEGKTLLSFINEIN
|  . .       .|   ..|        |  .|.     .  |||..|...| ...  |.   |    .       .   | .|| ..  |.... .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

DNKKYKDQNHKDLKLRKLQISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKIKIIDFSESGFLAEETIGY------TIGYDAKD--NLKT-RYIDYYS
..              .|... || .  .|||..|..| |.   |.|....  .|| ||     |. .   .      .  |..|   . ||   |  ..
PK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

LGILLIIIF------YSFQIEI--LCNCGEKKKCK-----MQNHEEFILQAISKMDEQRKNQY---------SQIFFDQIKSLLNDQPYLRQTQRQKCEQ
.  .   .|      .|| . .  ..  |..         | | |  ... . . .  .. ..         ..  .. .|.  . .|  | | ..    
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE--VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

KYF
..|
ECF