Gene 27883 (Tetrahymena)
27883
Group:
Other
Family:
Ciliate-C4
Sequence
Protein domains of 27883.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 27883.AA | Ciliate-C4 | 32-213 | 28 | 2.4e-94 | 302.55 | In-house | 115-361 (361) | Show / Hide |
Range on Protein: 32-213
Range on HMM: 115-361/361
Sequence Identity: 28% (71 aa)
YCQGGSVLEFVAKKQNYNERQ------CAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYK------NDDNSIKLIDLGINLQSKDKKQSE----SQLP
|||...|.....||..|...| |.|..|.||.||.|.||....|..||...||.||| |.....||||.|...|...||... ....
YCQNERVYKINFKKLYYHLFQDKNNNLCKKFIQHICHALWHLHQNKWVHCDIKPENILVKYKSDFGGSNNIQQVKLIDFGSCFQFNNKKHIQSMATPEYM
QIQELPFLAPEQLE------------------GRNIEVSNSWNVGVFLYILFSGQHPFQSLDPQKSLDQ----IKKGIFTFTKQCFHNCS----------
....|.|...||.| .........|..|........|.....|........| ||.|||....|||.|..
PPEMLNFIIQEQNEDEQLQQNHQHDMFQYLQNYECPWSIDIWSMGCVMMEIITGIPHWMSYKCRVHHKQVKNFIKHGIFCHKQQCFENIIQKQKKFCKQI
-----------------VELKDLLSKLLTKNERKRISIKQCLDHEWI
..||||..|.|..|.|.|||.|||..|.||
DQYMKEHNYQFCCQVIDQQLKDLIKKMLKFNPRERISPKQCCQHPWI
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| Kinase | 27883.AA | Ciliate-E2 | 32-213 | 22 | 1.3e-37 | 126.67 | In-house | 115-365 (365) | Show / Hide |
Range on Protein: 32-213 Range on HMM: 115-365/365 Sequence Identity: 22% (60 aa) YCQGGSVLEFVAKK-----------QNYNERQCAKIVQQICS---------------ALLHSHQKA-IIHQNIKSSKILLKYKNDDNSIKLIDLGINLQS |||||. ... .. ....|.....| .||.. || . |.| ||| .|| . ||. ||.||.|. . YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKY KDKKQSESQLPQIQ------------------------------ELPFLAPEQLEGRNI----------EVSNSWNVGVFLYILFSGQHPFQSLDPQKSL .|. | ... |.. ....||| |.| .. . . | .|| ||.. .|..|| . DDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------Q DQIKKGIFTFTKQC--------------FHNCSVELKDLLSK----LLTKNERKRIS-IKQCLDHEWI .|||.. . | ... ....| | |||..| .| |.. |||. ..|.|.|.|. QQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 27883.AA | CAMK-Unique | 32-213 | 20 | 2.9e-31 | 100.32 | In-house | 116-363 (363) | Show / Hide |
Range on Protein: 32-213 Range on HMM: 116-363/363 Sequence Identity: 20% (51 aa) YCQGGSVLEFVAK--------------------KQNYNE--RQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYK-ND------------DNSIKLI ||||| ... ..| .. ..| .. . |.|.. ||. . |.. |.| ..| |...| .| .. |||. YCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLC DLGINLQSKDKKQSESQ-LPQIQ--ELPFLAP--------------EQLEGRNIEVSN-----SWNVGVFLYILFSGQHPFQSLDPQ--------KSLDQ | |. .... .... ..|. ....|| | .... . .| || .|....| .|| . . . .. DFGL---CCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFEC IKKGIF-TFTKQCFHN---CSVELKDLLSKLLTKNERKRISIKQCLDHEWI |.|| . .| .. .| |.|.||.. ...| .|.|.|. |.|.|| ICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | 27883.AA | Ciliate-E2-Unclassified | 32-213 | 23 | 6.3e-30 | 101.01 | In-house | 102-352 (352) | Show / Hide |
Range on Protein: 32-213 Range on HMM: 102-352/352 Sequence Identity: 23% (60 aa) YCQGGSVLEFVAKK-----------------QNYNERQCA-----KIVQQICSALLHSHQKA-IIHQNIKSSKILLKYKNDDNSIKLIDLGI--NLQSKD ||.||. ... |. . |.|.. .. ||...| . |.| ||| .|| . ||.. .. . ||.||.|| ..|. . YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN KK-----------QSESQLPQIQELPFL----APEQLEGRNIEVSNS-----WNVGVFLYILFSGQHPFQSLDPQK----------------SLDQIKKG .. ... . ... . .. ||| |.| | . | . | .|| || . |..||.. . . ...||.. NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK IFTFTKQCF----HNCSVELKDLLS----KLLTKNERKRISIKQCLDHEWI .. | |. . .. | | ||... |.| || |||...| | | |. NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 27883.AA | CDPK | 139-213 | 38 | 8.9e-25 | 73.11 | In-house | 197-271 (271) | Show / Hide |
Range on Protein: 139-213 Range on HMM: 197-271/271 Sequence Identity: 38% (29 aa) WNVGVFLYILFSGQHPFQSLDPQKSLDQIKKGIFTFTKQCFHNCSVELKDLLSKLLTKNERKRISIKQCLDHEWI | || |||| .| || |. ....||| ..| .......|.| ||| .|.|.... ||.| |.|.| |. WSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | 27883.AA | MSK | 32-213 | 32 | 4.5e-24 | 78.26 | In-house | 82-277 (277) | Show / Hide |
Range on Protein: 32-213 Range on HMM: 82-277/277 Sequence Identity: 32% (65 aa) YCQGGSVLEFVAKKQNYNERQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDDNSIKLIDLGINLQSKDKKQSESQLPQIQE----LPFLAPEQ ||.|| .. |... | |. |. .. .|. | |||.||| .| ||. ..|. .|||| | .. . |.|.. . . | . ||| YCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGF---ARLFPQDEEW--RMKSPCFTLHYMAPEM LEG---RNI---EVSNSWNVGVFLYILFSGQHPFQ--SLDPQ---KSLD----QIKKGIFTFTKQCFHNCSVELKDLLSKLLTKNERKRISIKQCLDHEW |.. . |. | .|| || . .|| ||| . | | .| |.|| | |. . | |.. |||...||||. || . ..||| LRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEW I . K |
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| Kinase | 27883.AA | CAMK | 139-213 | 26 | 3.8e-22 | 67.54 | In-house | 318-425 (425) | Show / Hide |
Range on Protein: 139-213 Range on HMM: 318-425/425 Sequence Identity: 26% (29 aa) WNVGVFLYILFSGQHPFQSL-------------DPQKSLDQIKKGIFTFTKQCFHN--------------------CSVELKDLLSKLLTKNERKRISIK | .|| |||. .| ||.. .... . .|.|| ..| | . .| | |||..|.|... ||..|. WSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIE QCLDHEWI |||.|.|. QCLNHPWM |
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| Kinase | 27883.AA | CAMK2 | 35-213 | 30 | 5.3e-22 | 71.2 | In-house | 82-259 (259) | Show / Hide |
Range on Protein: 35-213 Range on HMM: 82-259/259 Sequence Identity: 30% (55 aa) GGSVLEFVAKKQNYNERQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDDNSIKLIDLGINLQSKDKKQSESQLPQIQELPFLAPEQLE----G || . | . . | | . .||| .. | ||. |.| .| .|| | .|| | |. . .. .| .|.|| | | GGELFEDIVAREYYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPG--YLSPEVLRKDPYG RNIEVSNSWNVGVFLYILFSGQHPFQSLDPQKSLDQIKKGIFTFTKQCFHNCSVELKDLLSKLLTKNERKRISIKQCLDHEWI . ... | || |||| | || | . ||| | . . . | |.|. ..|| | .||| .. | | || KPVDI---WACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI |
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| Kinase | 27883.AA | DAPK | 139-213 | 40 | 2.6e-16 | 43.46 | In-house | 190-264 (264) | Show / Hide |
Range on Protein: 139-213 Range on HMM: 190-264/264 Sequence Identity: 40% (30 aa) WNVGVFLYILFSGQHPFQSLDPQKSLDQIKKGIFTFTKQCFHNCSVELKDLLSKLLTKNERKRISIKQCLDHEWI | .|| ||| || || | | | . | . | | | || .|| | .||. |..|| | || WSIGVITYILLSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
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| Kinase | 27883.AA | RSK | 139-213 | 28 | 3.8e-16 | 55.8 | In-house | 196-278 (278) | Show / Hide |
Range on Protein: 139-213 Range on HMM: 196-278/278 Sequence Identity: 28% (24 aa) WNVGVFLYILFSGQHPFQS---LDPQKSLDQIKKGIFTFTKQCFHNCSVELKDLLSKLLTKNERKRIS-----IKQCLDHEWI | || .| ...|. |||. .... ...|.|| |..| .. | | |||..|.|.... ||.. ... ..|.|. WSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 27883.AA | CAMK | 32-99 | 26 | 1.3e-14 | 42.86 | In-house | 141-241 (425) | Show / Hide |
Range on Protein: 32-99 Range on HMM: 141-241/425 Sequence Identity: 26% (27 aa) YCQGG----SVLEFVAKKQN---------------YNERQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDD--------------NSIKLIDL ||.|| ..... .. . ..||.......|||||. . |.. |.| .| ||| ..||| | ||.|| YCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF G | G |
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| Kinase | 27883.AA | Pkinase | 139-213 | 22 | 4.7e-14 | 50.77 | Pfam | 196-293 (293) | Show / Hide |
Range on Protein: 139-213 Range on HMM: 196-293/293 Sequence Identity: 22% (22 aa) WNVGVFLYILFSGQHPFQSL------DPQKSLDQIKKGIFTFTKQCFHNCS-----------------VELKDLLSKLLTKNERKRISIKQCLDHEWI | .|. ||....|. ||.. |... ...|..... | . .. | |.||.....|.|. ||....|.| |.|. WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| S_TKc | 27883.AA | S_TKc | 1-213 | 20 | 1.7e-13 | 20.94 | SMART | 16-231 (231) | Show / Hide |
Range on Protein: 1-213 Range on HMM: 16-231/231 Sequence Identity: 20% (52 aa) MKVSSSG-----------QISLVEHKISRSSKYTKGILSLRKYCQ------------G--GSVLEFVAKKQN------YNERQCAKIVQQICSALLHSHQ .|. . . . | .| .. . | | ..| | |..... |.. ..| .......|||.|| . |. YKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHS KAIIHQNIKSSKILLKYKNDDNSIKLIDLGINLQSKDKKQSESQLPQIQELPFLAPEQLEGRNIEVSNSWNV--------GVFLYILFSGQHPFQSLDPQ . ||| .| . ||| ||..| |. | .. . ..||| | ... |. ||....|. ||. ..| HGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQ KSLDQIKKGIFTFTKQCFHNCSVELKDLLSKLLTKNERKRISIKQCLD-------HEWI . ...|. | |.||...|.|.|. .||... ..| |.|. MMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 27883.AA | CDPK | 32-100 | 35 | 1.9e-11 | 31.59 | In-house | 84-156 (271) | Show / Hide |
Range on Protein: 32-100 Range on HMM: 84-156/271 Sequence Identity: 35% (26 aa) YCQGGSVLEFVAKKQNYNERQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDDN----SIKLIDLGI || || .. .. | ...|.. |.|..|| ||. . |.. |.| ..| ||...|.||. ||.|| |. YCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGT |
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| Kinase | 27883.AA | DAPK | 35-100 | 34 | 3.4e-11 | 28.43 | In-house | 87-153 (264) | Show / Hide |
Range on Protein: 35-100 Range on HMM: 87-153/264 Sequence Identity: 34% (23 aa) GGSVLEFVAKKQNYNERQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDDN-SIKLIDLGI || |.. | || .. . || ... | | | | | .| | |. .|. | ||.|| |. GGELFDFLCEKECLNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGL |
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| Kinase | 27883.AA | Pkinase | 32-100 | 25 | 6.6e-07 | 25.51 | Pfam | 81-158 (293) | Show / Hide |
Range on Protein: 32-100 Range on HMM: 81-158/293 Sequence Identity: 25% (20 aa) YCQGG----SVLEFVA--KKQNY--NERQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDDN--SIKLIDLGI ||.|| . ... .. .. |..| ... ||...| . |.. ||| .|.. ||.. .|... ..|..| |. YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGL |
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| Kinase | 27883.AA | RSK | 32-99 | 30 | 2.9e-05 | 15.62 | In-house | 82-152 (278) | Show / Hide |
Range on Protein: 32-99 Range on HMM: 82-152/278 Sequence Identity: 30% (22 aa) YCQGGSVLEFVAKKQN---YNERQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDD-NSIKLIDLG || || .. |.. |. .. . .| .|. | ||. ||| .| . ||. .. . .|||.| | YCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFG |
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| TyrKc | 27883.AA | TyrKc | 9-213 | 13 | 0.000261 | -152.95 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 9-213 Range on HMM: 1-280/280 Sequence Identity: 13% (40 aa) ISLVEH--------------------KISRSSKYTKGILS----LRKY---------------------------------CQGGSVLEFVAKKQN-YNE |.| . | .... . ... ..|. . .|. ... |... . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM RQCAKIVQQICSALLHSHQKAIIHQNIKSSKILLKYKNDDNSIKLIDLGINLQSKDKKQS-------ESQLPQ---IQE--LPF--LAPEQLEGRNIEVS .. .. ||.. . |.| .|| . .|.. .. .| | | |.| . . .. || .||| . | . KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGL---SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKF NS----WNVGVFLYILFS-GQHPFQS-----LDPQKSLDQIKKGIFTFTKQCFHN--------CSVELKDLLSKLLTKNERKRISIKQCLDHEWI .. | || .. .|. || | ...| . ..|.| . .| |. |. .. .. . .| . ... || . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| EFh | 27883.AA | EFh | 336-364 | 20 | 2e-06 | 28.82 | SMART | 1-29 (29) | Show / Hide |
Range on Protein: 336-364 Range on HMM: 1-29/29 Sequence Identity: 20% (6 aa) KLQAVFTAIDENGNGQLSLDELLTGMARF .....| .| .|.|.....|....|... EFKEMFRMFDKDGDGYIDFEEFKDMMKSL |
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| Efhand | 27883.AA | efhand | 336-364 | 24 | 2e-06 | 27.75 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 336-364 Range on HMM: 1-29/29 Sequence Identity: 24% (7 aa) KLQAVFTAIDENGNGQLSLDELLTGMARF .|...| .| .|.|.....|....|... ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
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| EFh | 27883.AA | EFh | 375-403 | 31 | 2.4e-08 | 34.97 | SMART | 1-29 (29) | Show / Hide |
Range on Protein: 375-403 Range on HMM: 1-29/29 Sequence Identity: 31% (9 aa) ELKDIFQKMDEDNSGEVSQEEFIHAFAEQ |.|..|...| |..|... |||...... EFKEMFRMFDKDGDGYIDFEEFKDMMKSL |
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| Efhand | 27883.AA | efhand | 375-403 | 34 | 1.2e-07 | 32.34 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 375-403 Range on HMM: 1-29/29 Sequence Identity: 34% (10 aa) ELKDIFQKMDEDNSGEVSQEEFIHAFAEQ |||..|...| |..|... |||....... ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
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| Efhand | 27883.AA | efhand | 411-439 | 31 | 0.000107 | 21.61 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 411-439 Range on HMM: 1-29/29 Sequence Identity: 31% (9 aa) MILQSFKQLDQDGSGIVNLEEFTYLLQNG .. . ||..|.||.| ...||| .... ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
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| EFh | 27883.AA | EFh | 411-439 | 27 | 0.002041 | 18.19 | SMART | 1-29 (29) | Show / Hide |
Range on Protein: 411-439 Range on HMM: 1-29/29 Sequence Identity: 27% (8 aa) MILQSFKQLDQDGSGIVNLEEFTYLLQNG . . |. .|.||.| ...||| .... EFKEMFRMFDKDGDGYIDFEEFKDMMKSL |
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