Gene 7706 (Tetrahymena)
7706
Group:
Other
Family:
Ciliate-C5
Sequence
Protein domains of 7706.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 7706.AA | Ciliate-C5 | 69-346 | 82 | 3.8e-189 | 628.11 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 69-346 Range on HMM: 1-260/260 Sequence Identity: 82% (228 aa) IYLTSYISQGGFGCVFEAKYNEEIVAIKCSKTNFEKIEEEEKILKLLKDTPYVFKSIKGFTNQKKSRYYQISKRYSCNLKEIMKSFFEQRKTLPLNQIIG ||||||||||||||||||||||||||.||||.|||||.|||||.|||||||||||||..|.|.|||.|||||||||||||.||.|||.|.|||||||||| IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG FAIQMSTVFEKIEQNKLIHSDVKPENILYDSEEKCFYLCNYGESKQFKDGSKTYDMLFRFEFILFYILYVQKLKGFAPKYAAPEITDTKNGTFNIKYDIY ||||||||||||.||.|||||||||||||||.||||.||.|||||.||||||||| ||||..|||||||||. ||.|||||||| FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYD-----------------LKGFTRKYAAPEITDD-NGFFNIKYDIY GLGVILLELTLGKFLEDSDCSFIRNGQLPNYISKNALYQDINQIIVKMLEKMPQNRINSFELTKKLNDLRLKLENQFI |||.|||||||||||||.||.|||||.||||||||||||||||||.|||||||||||.||||||.||.||||||.||| GLGIILLELTLGKFLEDEDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI |
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| Kinase | 7706.AA | Ciliate-E1 | 75-268 | 21 | 3.4e-20 | 62.74 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 75-268 Range on HMM: 1-202/202 Sequence Identity: 21% (49 aa) ISQGGFGCVFEA---KYNEEIVAIKCSKTNFE--------KIEEEEKILKLLKDTPYVFKSIKGFTNQKKSRYYQISKRYSCNLKEIMK---------SF |..|.|. ||.| ..|.. ||.| ...| .|.|. ||.| .| |... |. . .. ...| ..|.||. .. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC FEQRKTLPLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSEEKCFYLCNYGESKQFKDGSKTYDMLFRFEFILFYI---LYVQKLKGFAPKYAAP .. . . |.. ..|. .. ..|...||.| ||.|||....... | | .|.. .. .. ||. .|. | QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC--------------------DFGISKFLKNNQNQQCQYKGYTHYYYPP EITD------TKNGTFNIKYDIY | || . |.|.||| EQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 7706.AA | CMGC | 69-200 | 15 | 5.6e-16 | 48.09 | In-house | 1-220 (513) | Show / Hide |
Range on Protein: 69-200
Range on HMM: 1-220/513
Sequence Identity: 15% (35 aa)
IYLTSYISQGGFGCVFEAKY----------------NEEIVAIKCSKTNFEKIE---------------EEEKILKLLK----------------DTPYV
..| .| .| |.... ..|||||| | .|.... | |||| |. . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI
FKSIKGFTNQK---------------KSRYYQISKRYSCNLKEIMKSFF------------------------EQRKTLPLNQIIGFAIQMSTVFE--KI
| . |. . | . ..|....|. .. | ... .| .. |. . . .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC
EQNK--LIHSDVKPENILYDSE
... || | |||||| ...
HSHWGNIIHRDLKPENILINHN
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| Kinase | 7706.AA | S_TKc | 69-339 | 20 | 1.5e-14 | 36.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 69-339 Range on HMM: 1-231/231 Sequence Identity: 20% (58 aa) IYLTSYISQGGFGCVFEAKYNE--EIVAIKCSKTNFEKIEEEEKILKLLKDTPYVFKSIKGFTNQKKSRYYQISKRYSC---NLKEIMKSFFEQR--KTL . | .|.||.|. .. .. .|||||. | |.|. | .||| . |.. | . | . ...| . . .|....|. .. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSEEKCFYLCNYGESKQFKDGSKTYDMLFRFEFILFYILYVQKLKGFAPKYAAPEITDTKNGTF | .. .. |. | . ... || |.|||||| |. . .| | ..|. . | | |||. . PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------------------------TTFCGTPWYMAPEVL-----GY NI-KYDIYGLGVILLELTLGKFLEDSDCSFIRNGQLPNYISKNALYQDINQIIVKMLEKMPQNRINSFELTK----KLNDLRL . | |.. .|.|| |. |. . . . . . . .. ..| |.|.| |..|. |. . .. . GKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 7706.AA | Ciliate-E2 | 69-337 | 17 | 1.9e-11 | 35.57 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 69-337 Range on HMM: 1-365/365 Sequence Identity: 17% (69 aa) IYLTSYISQGGFGCVFEA-------------------------KYNEEIVAIKCSKTN-FEKIEEEEKILKLLK---------------DTPYVFKSIKG . . | ||.||.|... |.. |.|.|. | | | |. |..|.. .. . |.. | . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FTNQKKSRYYQISKRYSC-NLKEIMKSFFEQRKTLPL-------NQIIGFAIQMSTVF---------------EKIEQNK-LIHSDVKPENILYDSEEKC | ..... .| . .. .|....|.. .|. . ..|. . | .| | . ... || | ||||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ FYLCNYGESKQFKDGSKTYDMLFRFEFILFYIL--------YVQKLKGF------------APKYAAPEITDTKN------GT-FNIKYDIYGLGVILLE .. | ||...| .. . . .. .. . | . . | | |||| |. .. . | ||. ||||| | IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD----QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE LTLGKFLEDSDCSFIRNGQLPNYISKNA--------------------------LYQDINQIIVK----MLEKMPQNRINSFELTKKLNDL . ||. .. . . |. ..| | ||.| |..||...| .. . MLFGKPPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 7706.AA | Ciliate-E3 | 182-214 | 45 | 1.4e-08 | 23.22 | In-house | 121-155 (202) | Show / Hide |
Range on Protein: 182-214 Range on HMM: 121-155/202 Sequence Identity: 45% (16 aa) QNKLIHSDVKPENILYDSEEK--CFYLCNYGESKQ . ..|||| ||.||| |... | ||||| EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQ |
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| Kinase | 7706.AA | TKL | 75-116 | 18 | 2.5e-08 | 26.1 | In-house | 1-83 (364) | Show / Hide |
Range on Protein: 75-116 Range on HMM: 1-83/364 Sequence Identity: 18% (15 aa) ISQGGFGCVFEAKYNE----------EIVAIKCSKT-------------------------------NFEKIEEEEKILKLLK | .||||.|. .|.. . ||.| |. .....||| .... |. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR |
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| Kinase | 7706.AA | Ciliate-B2 | 70-212 | 24 | 3.5e-07 | 12.84 | In-house | 2-151 (197) | Show / Hide |
Range on Protein: 70-212 Range on HMM: 2-151/197 Sequence Identity: 24% (37 aa) YLTSYISQGGFGCVFEAKYNEEI------VAIKCSKT----NFEKIEEEEKILKLLKDTPYVFKSIKGFTNQKKSRYYQISKRYSCNLKEIMKSFFEQRK ||. || .||.| ..| | .. .|.| . | |..| ||.|.. .| | | . ... | . | ||. .. |.| YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK TLPLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSEEKCFYLCNYGES . . .. |. .. . .| |.||.||| .... . .|..| | CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGN-YVYCDFGIS |
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| Kinase | 7706.AA | Pkinase | 77-207 | 24 | 5.9e-07 | 25.68 | Pfam | 9-154 (293) | Show / Hide |
Range on Protein: 77-207 Range on HMM: 9-154/293 Sequence Identity: 24% (36 aa) QGGFGCVFEAKYNEE--IVAIKCSKTNFEKIEE--------EEKILKLLKDTPYVFKSIKGFTNQKKSRYYQISKRYSCNLKEIMKSF----FEQRKTL- .|.||||.... . |||.|. | || .. | .|.| | . |.. . . |.. |...| . . |. | | ...... SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY -PLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSEEKC---FYLC . .... .. |. | . ... || |.||||||.|.. . . .| FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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| Kinase | 7706.AA | TyrKc | 69-334 | 16 | 1e-06 | -114.94 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 69-334
Range on HMM: 1-280/280
Sequence Identity: 16% (54 aa)
IYLTSYISQGGFGCVFEAKYNEEIVAIKCSK--TNFEKIEEEEKILKLL-KDTPYVFKSIKGFTNQ--------------------------KKSRYYQI
| | . | || |...... . ||.|. | . | . .| .|.. | .. | . . . | | .|.|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--
SKRYSCNLKEIMKSFFEQRKTLPLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSEEKCFYLCNYGESKQFKDG------SKTYDMLFRFEFILF
|.. . . |..| . | ......|| | |.|.... . . | |. .|. ...|.. .
---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEH------
YILYVQKLKG-FAPKYAAPEITDTKNGTFNIKYDIYGLGVILLEL-TLGKFLEDSD--CSFIRNGQLPNYISKN-ALYQDIN--------------QIIV
. |. . . ||| . |.|..| |.. || . |. |.|. . .. | .. .|. . . | | ||.
-----KGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK
KMLEKMPQNRINSFELTKKL
. . | .| . |. ...
QCWHEDPEDRPTFSEIHECF
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| Kinase | 7706.AA | ULK | 246-326 | 20 | 3e-06 | 18.05 | In-house | 211-314 (324) | Show / Hide |
Range on Protein: 246-326 Range on HMM: 211-314/324 Sequence Identity: 20% (22 aa) PKYAAPEITDTK--NGTFN-IKYDIYGLGVILLELTLGK--FLEDSDCS-F----------------IRNGQLPNYI--SKNALYQDINQIIVKMLEKMP | | ||.| . . .. .| ||. ||.|. |. || | .. .. . |.| ... .. . . . ... ..| .||.. . PLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDE QNRIN ||. KDRIS |
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| Kinase | 7706.AA | MSK | 248-277 | 33 | 1.8e-05 | 14.46 | In-house | 171-203 (277) | Show / Hide |
Range on Protein: 248-277 Range on HMM: 171-203/277 Sequence Identity: 33% (11 aa) YAAPEITDT---KNGTFNIKYDIYGLGVILLEL |.|||. .. ..|... |...||||| .. YMAPEMLRRGYAQDGGYDEACDWWSLGVILYTM |
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| Kinase | 7706.AA | ULK | 246-326 | 20 | 2.6e-05 | 14.62 | In-house | 215-319 (329) | Show / Hide |
Range on Protein: 246-326 Range on HMM: 215-319/329 Sequence Identity: 20% (22 aa) PKYAAPEITDTK--NGTFN-IKYDIYGLGVILLELTLGKFL----EDSDC-----SFIRNG---------QLPNYI---SKNALYQDINQIIVKMLEKMP | | ||.| . . .. | ||. ||.|. |. || .. . |.|. | ... ... . ... ..| .||.. . PLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDE QNRIN ||. KDRIS |
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| Kinase | 7706.AA | TKL | 184-281 | 18 | 4.8e-05 | 14.13 | In-house | 160-286 (364) | Show / Hide |
Range on Protein: 184-281
Range on HMM: 160-286/364
Sequence Identity: 18% (24 aa)
KLIHSDVKPENILYDS-------------EEKCFYLCNYGESKQFKDGSKTYDMLF-----RFEFILFYILYVQKLKGFA--PKYAAPEITDTK------
..|| | |..||| |. .. | .| .| |. .. .. |. . | .. ... | . |||. . .
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESA-E---HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEK
--------NGTFNIKYDIYGLGVILLELTLGK
..... | |.| |..| |. ..
VGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC
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| Kinase | 7706.AA | MSK | 182-201 | 65 | 5.5e-05 | 12.78 | In-house | 119-138 (277) | Show / Hide |
Range on Protein: 182-201 Range on HMM: 119-138/277 Sequence Identity: 65% (13 aa) QNKLIHSDVKPENILYDSEE | . || | ||||||.|.|| QKGIIHRDLKPENILFDDEE |
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| Kinase | 7706.AA | Ciliate-E3 | 243-278 | 33 | 0.000142 | 10.52 | In-house | 169-202 (202) | Show / Hide |
Range on Protein: 243-278 Range on HMM: 169-202/202 Sequence Identity: 33% (12 aa) GFAPKYAAPEITDTKNGTFNIKYDIYGLGVILLELT |. | |||||. | .. . |.| .|.....| GWTPFYAAPEQND--QQQISKESDYYSVGAVFCQLC |
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| Kinase | 7706.AA | ULK | 69-116 | 26 | 0.000251 | 11.11 | In-house | 1-68 (329) | Show / Hide |
Range on Protein: 69-116 Range on HMM: 1-68/329 Sequence Identity: 26% (18 aa) IYLTSYISQGGFGCVFEA--KYNE----EIVAIKC------SKTNFE--------KIEEEEKILKLLK ..| . .| || |... | .. |.||.| .. | | .. | ||.| || YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLK |
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| Kinase | 7706.AA | Ciliate-B2 | 239-271 | 34 | 0.00049 | 5.27 | In-house | 160-197 (197) | Show / Hide |
Range on Protein: 239-271 Range on HMM: 160-197/197 Sequence Identity: 34% (13 aa) QKLKGFAPKYAAPEITDTK-----NGTFNIKYDIYGLG .| ||| ||| || . . . ||| .| IKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 7706.AA | ULK | 152-196 | 27 | 0.001058 | 8.9 | In-house | 108-162 (329) | Show / Hide |
Range on Protein: 152-196 Range on HMM: 108-162/329 Sequence Identity: 27% (15 aa) KSFFEQRKTLPLNQ----------IIGFAIQMSTVFEKIEQNKLIHSDVKPENIL ... ...|.||... .| | .| | . ... || | ||.||| EQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL |
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| Kinase | 7706.AA | ULK | 152-196 | 25 | 0.002157 | 7.97 | In-house | 105-158 (324) | Show / Hide |
Range on Protein: 152-196 Range on HMM: 105-158/324 Sequence Identity: 25% (14 aa) KSFFEQRKT---------LPLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENIL ... ...|. |. ...|.| .| | . ... || | ||.||| EQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNIL |
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| Kinase | 7706.AA | ULK | 69-116 | 22 | 0.008065 | 5.91 | In-house | 1-68 (324) | Show / Hide |
Range on Protein: 69-116 Range on HMM: 1-68/324 Sequence Identity: 22% (15 aa) IYLTSYISQGGFG-CVFEA--KYNE---EIVAIKCSK------TNFE--------KIEEEEKILKLLK ..| . .| || |... | .. ..||.|. . | ... | .|.| || YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLK |
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| Kinase | 7706.AA | Pkinase | 266-334 | 13 | 0.029901 | 9.04 | Pfam | 194-293 (293) | Show / Hide |
Range on Protein: 266-334 Range on HMM: 194-293/293 Sequence Identity: 13% (13 aa) DIYGLGVILLELTLGKFLEDSD--------CSFIRNGQLPNYISKNALY---------------------QDINQIIVKMLEKMPQNRINSFELTKK--L |....|.|| |. .|... ... |.. | . . .. ..| ..|.| |. |.. .. . . DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 7706.AA | Ciliate-E3 | 69-96 | 33 | 0.046222 | 2.57 | In-house | 1-30 (202) | Show / Hide |
Range on Protein: 69-96 Range on HMM: 1-30/202 Sequence Identity: 33% (10 aa) IYLTSYISQGGFGCVFEA--KYNEEIVAIK . . .|.|| |. | | .|||| YTVQQILGCGQFGRVYKAFDFQNNQDVAIK |
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