Gene 15448 (Tetrahymena)
15448
Group:
Other
Family:
Ciliate-C6
Sequence
Protein domains of 15448.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 15448.AA | Ciliate-C6 | 183-453 | 67 | 4.4e-204 | 684.27 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 183-453 Range on HMM: 1-306/306 Sequence Identity: 67% (208 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDG--ENQSSQIFHEIEVLEKLKKYENVIKLQNYIIE-ERATYLVLDLAESTL |||||||| ||.|||.|.|||.|.||||.||||.|||||||||||| |.. |||.|||||||||||||||||||||.|||.|| .|.||.||||||||| INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL QDEINNKQAN------------------LEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQ--NFYLSDFGCAEKLFEQEGARKN-LVM ||.|..|||| .|.|||.|||.|..|||||||.|..|..|||||||||||||.|. |.||||||||..||..|..|.| ..| QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM GTLKWMSPELKEMKK----------NQVVDYFKSDIFSFGMLLLYMLTLSDISSVNSDEFTKSQKIRIMKDYCKGIS-KEIILLTSKMLETNPDNRPDAA ||||||||||.|||| ||..||||.||||.||.|||||||||||.||.|||.|.|||||||..||.|| ||||.|.|||||||||.|||.. GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS IIINTI |.|.|| ILIQTI |
|||||||||
| Kinase | 15448.AA | S_TKc | 183-451 | 23 | 3.3e-29 | 104.27 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 183-451
Range on HMM: 1-220/231
Sequence Identity: 23% (64 aa)
INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKLKKYENVIKLQNYIIEERATYLVLDLAES---TL
. .| |..|.|.|...| ..|.|.|. .| ||..|.| . .|..|| .. . |.|..... .|
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL
QDEINNKQANL--EKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQNFYLSDFGCAEKLFEQEGARKNLVMGTLKWMSPELKEMKKNQVV
| | ... . .|.| .. ... || . |. . || |||.||.|||. . . ..||| | .| . . ||. .|.||.
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GY
DYFKSDIFSFGMLLLYMLT----LSDISSVNSDEFTKSQKIRIMKDYCKGISKEIILLTSKMLETNPDNRPDAAIIIN
...|.|. |.| .| ||. . .... .||. |.| . . .|.|. .|..|| | . .
GKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ
|
|||||||||
| Kinase | 15448.AA | Pkinase | 183-453 | 20 | 4.1e-28 | 100.49 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 183-453
Range on HMM: 1-293/293
Sequence Identity: 20% (63 aa)
INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFH--EIEVLEKLKKYENVIKLQNYIIEERATYLVLDLAES---
. .| ||.|.|.| ..| . .|.|.| . ... . .. ||... .| . .|...| . ... |.|....|
YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY
--TLQDEIN-NKQANLEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIK-DQNF----YLSDFGCAEKLFEQEGARKNLVMGTLKWMSPELK
| | | .. .. |.| |. ... || . |. . .|| |||.||.||||. . . ..|||.|... . . . . ||. .|.||.
VMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-
EMKKN-QVVDYFKSDIFSFGMLLLYMLT----LSDI----SSVNSDEFTKSQKI-RIMKDYCKGIS-------------------KEIILLTSKMLETNP
. . . |.|..|.| .| .||. .. . .. .. . . ... |. . .| .| . . ...|. .|
---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP
DNRPDAAIIINT--I
|| |. | . .
KKRPTAEQILQHPWF
|
|||||||||
| Kinase | 15448.AA | STE | 184-396 | 22 | 4.5e-25 | 85.56 | In-house | 1-263 (359) | Show / Hide |
Range on Protein: 184-396 Range on HMM: 1-263/359 Sequence Identity: 22% (60 aa) NYR-DSLGIGSYGQVFKVKNKYKDIIKNPDILQ----NMPDYYACKQIHMIQDG---------------ENQSSQIFHEIEVLEKLKK-YENVIKLQNYI . . .| |..|.|.| .|. ...| . . .. ...| ||... .. ... || .||... |... .|..| . WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY IEER-------ATYLVLDLAE-STLQDEIN---NKQANLE-------KFDESEIVKFLSQIGKT-LALIQIEEGIAHRDIKPSNILIKDQNFYLSDFGCA . | .... . . .| | |. .. .| .|.||.| ... || | |... | ||||||.|||. |.|||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL----VKLCDFGVC EKLFEQ--------------EGA-RKNLVMGTLKWMSPELKEMKKNQ-VVDY-FKSDIFSFGMLLLYMLT .| . .. . | . || ||.|| . .. . .| .|.|| |.| ... |.| GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT |
|||||||||
| Kinase | 15448.AA | ULK | 183-396 | 22 | 5.7e-23 | 77.09 | In-house | 1-251 (329) | Show / Hide |
Range on Protein: 183-396 Range on HMM: 1-251/329 Sequence Identity: 22% (58 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIH---MIQDGEN-----QSSQIFHEIEVLEKLK-------KYENVIKLQNYIIEE-- .. .. || ||.|.|. | ...... | .| ..|||.| |.|. . . .. ||... ||| . .|..|| . . YCLNHCLGKGSFGKVY----KGRNKKTK-D-YVN--EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH RATYLVLDLAES-TLQDEINNKQA------NLEKFDESEIVKFLSQIGKTLALIQI-EEGIAHRDIKPSNILIKDQNFY-------------LSDFGCAE .|..... . .|.. |.... . .. |.|...|. || .. . ...| ||||||.||||.. . . ..||| | NNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQI--LNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK KLFEQ--EGARKNLVM------GTLKWMSPELKEMK-KNQVVDYFKSDIFSFGMLLLYMLT .. . | . || |.|.. . . ... . .|.||.|.|... .||. HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY |
|||||||||
| Kinase | 15448.AA | ULK | 183-396 | 22 | 2.3e-22 | 76.23 | In-house | 1-247 (324) | Show / Hide |
Range on Protein: 183-396 Range on HMM: 1-247/324 Sequence Identity: 22% (58 aa) INYRDSLGIGSYG-QVFKVKNKYKDIIKNPDILQNMPDYYACKQIH---MIQDGEN-----QSSQIFHEIEVLEKLK--KYEN--VIKLQNYIIEE--RA .. .. || ||.| .|.| .|| .. |.|||.| |... . . .. ||... ||| | .| ..|| . . YCLNHCLGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNN TYLVLDLAES-TLQDEINNKQA-----NLEKFDESEIVKFLSQIGKTLALIQI-EEGIAHRDIKPSNILIKDQNFY-------------LSDFGCAEKLF .|..... . .|.. |.... . .. |.|...|. || .. . ...| ||||||.||||.. . . ..||| | ... IYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQI--CNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD E-QEGARKN-------LVMGTLKWMSPELKEMK-KNQVVDYFKSDIFSFGMLLLYMLT . .. . .. .. || |.|.. . . ... . .|.||.|.|... .||. NNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY |
|||||||||
| Kinase | 15448.AA | Ciliate-E2 | 183-451 | 19 | 3.1e-22 | 73.11 | In-house | 1-361 (365) | Show / Hide |
Range on Protein: 183-451
Range on HMM: 1-361/365
Sequence Identity: 19% (74 aa)
INYRDSLGIGSYGQVFKVKNKYKDI-----IKNPDILQNMP---DYYACKQIHMIQDGENQSSQIFHEIEVLEKLK---------------KYENVIKLQ
.. .| |..|.|.|.|.. .. |.. ... . .... |.. | . .|| ||. || .. ... . |.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY
NYII--EERATYLVLDLAES-TLQDEINNK---------QANLEKFDESEIVKFLSQIGK---------------TLALIQIEEGIAHRDIKPSNILIKD
. . . |||..... .|.| |.|. . ..|.| || .. || . | . . | ||||||.|||.
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--
QNFYLSDFGCAE---------------KLFEQEGARKNLVMG----------------TLKWMSPELKEMKK-----NQVVDYFKSDIFSFGMLLLYMLT
..||| . |.. . . ... | |. |.|| ..|| .| .|.||.|.|..| .||.
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
L----SDISSVNSDEFTKSQKIRIMKDYCK--------GISKEIILLTSK----MLETNPDNRPD-AAIIIN
.. . .| . ... .. |. .|.| . | .| ||. .|..|.. . |.|
GKPPFQQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
|
|||||||||
| Kinase | 15448.AA | TKL | 189-453 | 14 | 5.6e-21 | 72.28 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 189-453
Range on HMM: 1-364/364
Sequence Identity: 14% (57 aa)
LGIGSYGQVFKVKNKYKDIIKNPDILQNMP----DYYACKQIHMIQ-DGENQSSQI---------------------FHEIEVLEKLKK--YENVIKLQN
.| |..|.|.| | . . | | | |.... . | .. .|| |.|.|.. ... .|....
IGSGGFGEVYKGKWRGWGG-KC-------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG
YIIEERA-------------TYLVLDLA-ESTLQDEINNKQANLEKFDESEIVKFLSQIGKTLALIQIEE-------GIAHRDIKPSNILIKDQN-----
| .... ..| ... .| . .. . .... .| . .. .. .|.|||.|..|||... .
YCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSN
----------FYLSDFGCAEKLFEQEG------------------ARKNLVMGTLKWMSPEL--KEMKKNQVV---------DYF-KSDIFSFGMLLLYM
..||| . ... .. ... . ||. ||.||. ..|. .. | .|. |.|..|||..| .
YMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
LTLSDISSVNSDEFTKSQK------IRIMKDY--------------------CKGISKEIILLTSKMLETNPDNRPDAAIIINTI
|| . .|. ... . .|... |. . .... | . ...|..|| . |. ..
LTRCR---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | 15448.AA | CAMK | 188-396 | 19 | 1.3e-20 | 62.51 | In-house | 1-329 (425) | Show / Hide |
Range on Protein: 188-396
Range on HMM: 1-329/425
Sequence Identity: 19% (65 aa)
SLGIGSYGQVFKVKNK-YKDIIKNPDILQNMPDYYACKQIHM----------------IQDGENQS----------SQIFHEIEVLEKLKK------YEN
|| ||.|.|.....| . .. |. | . .|.| | |.. .... ....|||.. ||.. .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN
VIKLQNYIIE-------------------ERATYLVL---DLAEST-----LQDEINNKQANLEK-----------FDESEIVKFLSQIGKTLALIQIEE
.||| .. .. |.|. .... | | | . . |. |.|.| .. || .. .
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
GIAHRDIKPSNILIKDQNF---------------Y---LSDFGCAEKLFEQE----------------------GARKNLVMGTLKWMS-PELKEMKK--
|.|||.|| |||. | | . ..||| | |... | | . . ||. |. ||. . |.
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC
------NQVVDY--FKSDIFSFGMLLLYMLT
.. .| .|.|. | | .| ||.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLC
|
|||||||||
| Kinase | 15448.AA | CMGC | 183-341 | 18 | 2.8e-18 | 55.79 | In-house | 1-249 (513) | Show / Hide |
Range on Protein: 183-341
Range on HMM: 1-249/513
Sequence Identity: 18% (46 aa)
INYRDSLGIGSYGQVFKVKNKYKDIIK---NPDILQNMPDYYACKQIH---MIQD------GENQSSQIFHEIEVLEKLK---------------KYEN-
. .| |.||.|.| ..| . | . . ..| | | . . ... .. .. ||. |..|. | .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQ-AHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN
VIKLQNYIIEER-----------------ATYLVLDLAESTLQDEINNKQA-----NLEKFDESE------------IVKFL------SQIGKTLA--LI
..||.... . ||| .. . .| . | |.| . ...| . | .|. || . |. .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC
QIEEG-IAHRDIKPSNILIKDQNF---------------------YLSDFG
| | |||.||.|||| ... . |||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
|
|||||||||
| Kinase | 15448.AA | Ciliate-E1 | 189-385 | 22 | 1.4e-17 | 54.09 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 189-385
Range on HMM: 1-202/202
Sequence Identity: 22% (48 aa)
LGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKLKKYENVIKLQNYIIEERA--TYLVLDLAESTLQDEIN--
.| ||...||| |.. ... .... ... ... ... ..| ...... .||....|....||. . . ....... . .|.|...
IGNGSFSIVFKAKQQNNNYNQVAQKII---------NCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH
-------NKQANLEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQ-NFYLSDFGCAEKLFEQEGARKNLVMGTLKWMSPELKE-----M
.| | .|.. .... |. . |. ... .| ||||||.||||..| |. ..|||.. .| ... .. | . .|| . .
NRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQ-YNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEH
KKNQVVDYFKSDIF
.||| ..| ||||.
NKNQKINY-KSDIY
|
|||||||||
| Kinase | 15448.AA | NAK | 183-341 | 24 | 1.7e-14 | 44.73 | In-house | 1-171 (299) | Show / Hide |
Range on Protein: 183-341 Range on HMM: 1-171/299 Sequence Identity: 24% (42 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKLKKYENVIKLQN-YIIEER------ATYLVLDLA . . |. | ...|..|.. | ... | . .. || | . ....|.. .. .|||...||.. .|.... .| |.. . .|.. . YTVEKYLAEGGFSYVYLVQDNYINHPDN---PNSNGEKYALKRM-ICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYC ES-TLQDEINNKQ-ANLEKFDESEIVKFLSQIGKTLALI-QIEE--GIAHRDIKPSNILIK----DQNFYLSDFG . .|.|..|... .. .| | ||....... . .. . |. .|.|||||. |||.. | |. | ||| CHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFG |
|||||||||
| Kinase | 15448.AA | TyrKc | 183-453 | 15 | 1.5e-11 | -36.06 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 183-453
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)
INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKL-KKYENVIKLQNYIIEE-------RATYLVLDL
| . || | .|.|.| . | | | .. . .|.... || .. .|...| ..... ..|. .
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY
AE-----STLQDEINNKQANLEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQN-FYLSDFGCAEKLFEQ-------EGARKN---LVM
.. . |.. .. . .. ..| || . . . .. |||. |.|..... |||| . .. . . ||
MPHGDLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK
--GTLKWMSPELKEMKKNQVVDYFKSDIFSFGMLL--LYMLTLSDISS-----VNSDEFTKSQKIRIMKDYCKG--------ISKEIILLTSKMLETNPD
..||.|| | . .|||..||| .. .. . . . .. .| . | . . . . ..|. . .. . .|.
TMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE
NRPDAAIIINTI
.|| . |. .
DRPTFSEIHECF
|
|||||||||
| Kinase | 15448.AA | NAK | 425-453 | 27 | 0.000157 | 10.95 | In-house | 271-299 (299) | Show / Hide |
Range on Protein: 425-453 Range on HMM: 271-299/299 Sequence Identity: 27% (8 aa) SKEIILLTSKMLETNPDNRPDAAIIINTI |.... | ..||...|..||. . ..| . SQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
|||||||||