21061

Species: Tetrahymena
Alias: 621, PreTt21061, 3687.m00164, 31.m00363, TTHERM_00318600, 21061
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C6

Sequence

Name Sequence Type Origin Length Description Download
21061.AA Protein None 827 None Fasta, JSON
21061.kin_dom Protein Kinase Domain None 270 None Fasta, JSON
21061.NA RNA None 2484 None Fasta, JSON

Protein domain

Protein domains of 21061.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21061.AA Ciliate-C6 497-770 43 8.99999999999e-177 593.55 In-house 1-306 (306) Show / Hide
Range on Protein: 497-770
Range on HMM: 1-306/306
Sequence Identity: 43% (132 aa)

ILEDKSLGRGTFGSVFECIEKPSKIALMKDIAQEQ------------------------LQEVYLLDRLQVYPNVIRLINYFYLPDKQLFIILELAQSSL
|....|||.|.||.|..|..|...|....||.|..                        ..|...|..|..|.|||...|||..|..|..|.|.||.|.|
INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL

EQEIQERIKEVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIAND--TYKLSDFGAARQLSLEDFYRQN-THV
...||.....||||||||||||||||.|..|....||..||||||....|..|...|.|||.||.||||..|  .|.|||||.|.||....|.|.| .|.
QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM

GSLKWMSPEMREGVEQNNIIQ----KYKLNYYQCDVFSLGLILMRMVTLEHIDGVNTDEEMKNFKVKRMMEKRKDLG-AEFLKVIEDMLIFDLKTRIDMS
|.|||||||.||...|.|..|    .....|..||.||||.||..|.||..|..||.||.|||.|...|....||.. .|..|....||......|.|||
GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS

AFKVRI
...  |
ILIQTI

Kinase 21061.AA Pkinase 497-777 19 1.2e-24 88.2 Pfam 1-293 (293) Show / Hide
Range on Protein: 497-777
Range on HMM: 1-293/293
Sequence Identity: 19% (66 aa)

ILEDKSLGRGTFGSVFECIEKPS------KIALMKDIAQEQLQ------EVYLLDRLQVYPNVIRLINYFYLPDKQLFIILELAQS-----SLE----QE
.   . .|.|.||.|..|..| .      ||   ...  ...|      |.... ||.  ||..||. .|.  .. . ...|...      .|       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-

IQERIKEVNNFYFKQEINIFSFNVKKKHY--TKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIA-NDTY----KLSDFGAARQLSLEDFYRQNTH
                        ... .  . .|. ....||   .  .|. . | ||||||.||||  |..     |..||| |.|.. .  .. .| 
-----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTF

VGSLKWMSPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILMRMVTLEHI-DGV----NTDEEMKNFKVKRMMEKRKDLG---------------------
.|.. .|.||          |....   . .|..|.|.||  |.. . . .|     | ...|. .. ... . . |                       
CGTPWYMAPEV---------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHN

--AEFLKVIEDMLIFDLKTRIDMSAFKVRIEAIIKD--M
   |....|...| .| | |.        .| | ..  .
WSEECKDFIKWCLCKDPKKRPT-------AEQILQHPWF

Kinase 21061.AA Ciliate-E2 497-716 20 2.5e-22 73.45 In-house 1-294 (365) Show / Hide
Range on Protein: 497-716
Range on HMM: 1-294/365
Sequence Identity: 20% (65 aa)

ILEDKSLGRGTFGSVFEC--IEKPSKIA--------------------------LMKDIAQEQLQEVYLLDRLQV---------------YPNVIRLINY
.   | .|.|.||||..|  .... ..|                          ..|.  ....|| ... ...                 ||.|... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYL-PDKQLFIILELAQS-SLEQEIQER-IKEVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGF---------------LIRDLHNKQAITHRDLK
|.   |. .....|..|  .|.. |... .|. ...             . | .|  ||... |||                  .. ||.|  | |||.|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE----------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK

PQNILIANDTYKLSDFGAARQLSLE------------------------------DFYRQNTHVGSLKWMSPEMREGVEQNNIIQKYKLNYYQCDVFSLG
|.|||.     |..||| ..... .                               .  .|| .|..  |.||. .| . .|  || |   |.||..|||
PENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-QKQKGYDYKCDIWSLG

LILMRMVTLEH
 || .|.. ..
VILYEMLFGKP

Kinase 21061.AA ULK 497-708 24 5.4e-21 70.08 In-house 1-246 (329) Show / Hide
Range on Protein: 497-708
Range on HMM: 1-246/329
Sequence Identity: 24% (66 aa)

ILEDKSLGRGTFGSVFECIEKPS----------KIAL---MKDIAQE---------QLQEVYLLDRL-----QVY--PNVIRLINYFYLPD-KQLFIILE
.  .. || |.|| |.. . | .          |. .   |. . .|           .|. .. .|       .  ||...|. .|. .. . ..||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LAQS-SLEQEIQERIK-----EVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIAND-------------TYK
. .   ||| |... |     |                 .||. . .|.. |.|||    ..|| .. | |||.||||||| |.             ..|
YCNGGDLEQYIKKNKKLPEDTE-----------------EKKRLSEQEAIQFFKQILNGFKELHKHN-IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLK

LSDFGAARQLSLE--DFYRQNTHV------GSLKWMSPEMREGVEQNNIIQKY--KLNYY-Q-CDVFSLGLIL
..||| |.... .  .     | |      |.   |.|.         |.|.   . .||   ||..||| |.
IADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQ---------ILQGQGEQKPYYDYKCDIWSLGCIF

Kinase 21061.AA CAMK 502-708 18 3.4e-20 61.12 In-house 1-324 (425) Show / Hide
Range on Protein: 502-708
Range on HMM: 1-324/425
Sequence Identity: 18% (60 aa)

SLGRGTFGSVFECIEKPS-------------KIALMKDIA---------------------------------QEQ--LQEVYLLDRLQV------YPNV
 ||||.|| |..||.| .             .   .| |                                   ..  ..|. .. .||        ||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLINYFY------------LPDK-------QLFIIL---ELAQSS-LEQEIQERIKEVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLH
|.|. ..               .|       ......   |...   | ... ..|.|  .....  .  | .  .....| .|   . .||   .. .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-D-QFDIV-ERGRFTEREARRYFRQICSAVHYCH

NKQAITHRDLKPQNILIAND------------------TYKLSDFGAARQLSLEDFYR----------------------QNTHVGSLKWMS-PEMREGV
..  | |||||| |||. ..                  . |..||| |...   . ..                       .| .|..  |. ||. .| 
SHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK

EQNNIIQKY-----KLNY-YQCDVFSLGLIL
 . |    .     |  | ..||. |.| ||
GHCNMQ--NATDEEKPYYGPKCDMWSCGVIL

Kinase 21061.AA Ciliate-E2-Unclassified 497-713 20 1.5e-19 64.47 In-house 1-265 (352) Show / Hide
Range on Protein: 497-713
Range on HMM: 1-265/352
Sequence Identity: 20% (58 aa)

ILEDKSLGRGTFGSVFECIEKPSK-------IALMKDIAQEQL----------QEVYLLD-------------RLQVYPNVIRLINYFYL-PDKQLFIIL
    | .|.| ||.|..|..|  |       .  .....| |           .|.  .               |.  |. ...  ...   .. ..|..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELA-QSSLEQEIQERIK--EVNNFYFKQEINIFSFNVKKKHYTKDEIL-----DFCKQIGFLIRDLHNKQAITHRDLKPQNILIAND----TYKLSDFGA
|.. . .|.| |..| |  ..          .|  . ..|. |  ...     ....||   .  || |. | |||.||.|||. |.      |..||| 
EYCEGGDLWQYIKKRKKQKQK-------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGI

AR--------------QLSLEDFYRQNTHVGSLKWM----SPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILMRMVT
..              ...  .. ...| .|..  |    .||. .| ....         |.||..||| ||  |..
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEMLF

Kinase 21061.AA ULK 497-708 24 1e-18 63.08 In-house 1-242 (324) Show / Hide
Range on Protein: 497-708
Range on HMM: 1-242/324
Sequence Identity: 24% (66 aa)

ILEDKSLGRGTFG-SVFECIEKPS-----KIAL-------MKDIAQE---------QLQEVYLLDRLQ--VYPN--VIRLINYFYLPD-KQLFIILELAQ
.  .. || |.||  |.. . | .     ..|        |... .|         . .|. ..  |     ||  ...|. .|. .. . ..||.|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

S-SLEQEIQERIK----EVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIANDT-------------YKLSDF
   ||| |... |    |                 .||  . .|.. |.|||    ..||... | |||.||||||| |..             .|..||
GGDLEQYIKKNKKLPETE-----------------EKKRLSEQEAIQFFKQICNGFKELHKHN-IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF

GAARQLSL--EDFYRQNTHV------GSLKWMSPEMREGVEQNNIIQKY--KLNYY-Q-CDVFSLGLIL
| |...    ..     | |      |.   |.|.         |.|.   . .||   ||..||| |.
GFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQ---------ILQGQGEQKPYYDYKCDIWSLGCIF

Kinase 21061.AA STE 623-716 30 3.5e-17 57.32 In-house 168-266 (359) Show / Hide
Range on Protein: 623-716
Range on HMM: 168-266/359
Sequence Identity: 30% (35 aa)

LHNKQAITHRDLKPQNILIANDTYKLSDFGAARQLSL---------------EDFYRQNTHVGSLKWMSPEM--REGVEQNNIIQKYKLNYY--QCDVFS
||... | |||.||.|||.     ||.||| . ||.                    . || ||.  ||.||.  ..|   .        . |  .||. |
LHSHH-IIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-------DKGYDTKCDIWS

LGLILMRMVTLEH
||. .. |.| ..
LGCTIIEMATGKP

Kinase 21061.AA TKL 623-708 22 8.4e-17 57.04 In-house 148-279 (364) Show / Hide
Range on Protein: 623-708
Range on HMM: 148-279/364
Sequence Identity: 22% (30 aa)

LHN-------KQAITHRDLKPQNILIANDT---------------YKLSDFGAARQLSLEDFYRQNTH------------------VGSLKWMSPEMREG
||.       | .| |||||..|||. ..                 |..||| .| .| .     . .                  .|.. ||.||. .|
LHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRG

VEQNNI-------IQKYKLNYYQCDVFSLGLIL
 ....        ..... .  .|||.| |..|
QMNYTEKVGIDEFCKGFEYS-EKCDVYSFGIVL

Kinase 21061.AA Ciliate-A1 593-709 31 2.3e-16 52.15 In-house 87-219 (301) Show / Hide
Range on Protein: 593-709
Range on HMM: 87-219/301
Sequence Identity: 31% (43 aa)

NIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIA-NDTYKLSDFGAARQLSLED-----------------FYRQNTHVGSLKW
| | .   ...  |.|| ..| ||   . |.| .. | |||||||||||   | .|. |.|  .||                      |      |.|  
NLFNYCYQNDYMKKEEIYEICYQIIEGYADIH-DHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYY

MSPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILM
||||          . . |. | | |..|||.|..
MSPEQYQMHYRDQMFIENKI-YKQSDMYSLGCIIC

Kinase 21061.AA S_TKc 497-774 21 4.2e-16 59.3 SMART 1-231 (231) Show / Hide
Range on Protein: 497-774
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

ILEDKSLGRGTFGSVFECIEKP-SKIALMKDIAQEQLQEVYLLDRLQVYPNVIRLINYFYLPDKQLFIILELAQS---SLEQEIQERIKEVNNFYFKQEI
    . .|.|.||.|. |..|   .|  .| | .  ..|. .| .    ||...|. .|.   . |....|..     .| . |..| .. ..|.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP-----

NIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIANDTYKLSDFGAARQLSLEDFYRQNTHVGSLKWMSPEMREGVEQNNIIQKY
           ..  ..  ...||   .  .|..  | ||||||.|||. . . |..||| ||||        .| .|.. .|.||.             
-----------FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------------

KLNYYQCDVFSLGLILMRMVTLEHIDGVNTDEEMKNFKVKRMMEKRKDLGAEFLKVIEDMLIFDLKTRIDMSAFKV-----RIEAII
. ..  ||. |.| ||  |.. .     . .. .|. .             |..  |. .| .| . |.            ..   .
GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 21061.AA TyrKc 497-770 18 2.4e-11 -39.34 SMART 1-280 (280) Show / Hide
Range on Protein: 497-770
Range on HMM: 1-280/280
Sequence Identity: 18% (59 aa)

ILEDKSLGRGTFGSVFECIEKPSKIALMKDIA----QEQLQEVYLLDRL-QVYPNVIRLINYFYLP------DKQLFIILELAQS-SLEQEIQERIKEVN
|  .| ||.| || |.... |       | .     .. ..|  .. .|    ||..||. .   .      ...|.|..|..   .| . .... ..  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

NFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIANDT-YKLSDFGAARQLSLE-------DFYRQ----NTH-VGS
                    . .. |.|| ||    . || |  . ||||   |.|....   | |||| .| .  .       | ||.    ... .  
-------------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

LKWMSPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILMRMVTLEHIDGVN------TDEEMKNFKVKR-MMEKRKD--------LGAEFLKVIEDMLIFD
..||.||            .|.    . ||.| |  .  . |.      .      ...|. ..  .. .|.. ..          .|  .....   .|
IRWMAPECI----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

LKTRIDMSAFKVRI
 . |  .|. . ..
PEDRPTFSEIHECF

Kinase 21061.AA CMGC 623-658 31 8.4e-11 30.77 In-house 198-255 (513) Show / Hide
Range on Protein: 623-658
Range on HMM: 198-255/513
Sequence Identity: 31% (18 aa)

LHNKQ-AITHRDLKPQNILIANDTY---------------------KLSDFGAARQLS
.| .   | ||||||.|||| ...                      |. ||| ||...
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYH

Kinase 21061.AA CMGC 497-577 17 1.2e-07 20.2 In-house 1-146 (513) Show / Hide
Range on Protein: 497-577
Range on HMM: 1-146/513
Sequence Identity: 17% (25 aa)

ILEDKSLGRGTFGSVFECIEKPS---------------KIALMKDIA------QEQ------------LQEVYLLDRLQ---------------VYPN-V
   .| .|.||.| |..|. | .               .|  .| |       |..            | |. .| .|.                 .| .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IRLINYFYLPD----------------KQLFIILELAQSSLEQEIQ
..|...|| ..                ..|... |. . .| | |.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIK

Kinase 21061.AA STE 498-567 14 1e-06 19.83 In-house 1-118 (359) Show / Hide
Range on Protein: 498-567
Range on HMM: 1-118/359
Sequence Identity: 14% (17 aa)

LED-KSLGRGTFGSVFECIEK-------------------PSKIALMK---------------------DIAQEQLQEVYLLDRLQV-YPNVIRLINYFY
.|. . .|.|.||.|. .. .                      |  |.                     .. |. |.|. .. ...   ||... . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LP------DKQLFIILEL
        | .|.|..|.
KEGHNHKNDDELWICMEY

Kinase 21061.AA Pkinase_Tyr 497-520 37 0.004598 11.0 Pfam 1-24 (270) Show / Hide
Range on Protein: 497-520
Range on HMM: 1-24/270
Sequence Identity: 37% (9 aa)

ILEDKSLGRGTFGSVFECIEKPSK
|  .| ||.| ||.|.... |...
ITFGKKLGEGAFGEVYKGTWKGDP

Kinase 21061.AA Pkinase_Tyr 623-678 38 0.013013 9.47 Pfam 127-184 (270) Show / Hide
Range on Protein: 623-678
Range on HMM: 127-184/270
Sequence Identity: 38% (23 aa)

LHNKQAITHRDLKPQNILIA-NDTYKLSDFGAARQLSLEDFY-RQNT-HVGSLKWMSPE
|..|. . ||||   |.|.. | . | .||| || .  .| | |. .      |||.||
LESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPE

Kinase 21061.AA TKL 503-512 50 0.062623 2.75 In-house 1-10 (364) Show / Hide
Range on Protein: 503-512
Range on HMM: 1-10/364
Sequence Identity: 50% (5 aa)

LGRGTFGSVF
.|.|.|| |.
IGSGGFGEVY