Gene 3630 (Tetrahymena)

3630

Species: Tetrahymena
Alias: PreTt03630, TTHERM_00655320, 96.m00099, 3630, 7
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C6

Sequence

Name Sequence Type Origin Length Description Download
3630.AA Protein None 488 None Fasta, JSON
3630.kin_dom Protein Kinase Domain None 281 None Fasta, JSON
3630.NA RNA None 1467 None Fasta, JSON

Protein domain

Protein domains of 3630.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3630.AA Ciliate-C6 206-477 62 1.5e-198 665.86 In-house 1-306 (306) Show / Hide 
Range on Protein: 206-477
Range on HMM: 1-306/306
Sequence Identity: 62% (192 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQDILSNMPDYYACKQICVSEQM--DNISSSAFHEIEVLEKLKKYDYVKKLQNYIVS-NRSTYLILDLAESNL
|..||||||||.|.|||.|||||.||||.|||..||||||||||....||  .|..|. |||||||||||||..|.|.|||... ||.||..||||||.|
INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL

QEQINQKQAD------------------LEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREE--NYYLSDFGCAQELYQSEQFQNN-IAF
|..|..|||.                  .|.|...|||.|..|||||||.||....|.|||.|||||||...  |||||||||||.|.|||...|| |..
QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM

GTLKWMSPELREMKR----------DKTINFFKSDIFSLGMILLYMLTLADISQVNCDEIFKQAKIRLMKNMYKDTKYSQIILLVIKMLETNPDHRPDSS
||||||||||||||.          ...|..||.|||||||||||||||.|||||||||..|..|||.||||.||..|..||.||.||||||||||||.|
GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS

ILIQTI
||||||
ILIQTI
Kinase 3630.AA S_TKc 206-475 22 1.3e-28 102.35 SMART 1-220 (231) Show / Hide 
Range on Protein: 206-475
Range on HMM: 1-220/231
Sequence Identity: 22% (62 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQDILSNMPDYYACKQICVSEQMDNISSSAFHEIEVLEKLKKYDYVKKLQNYIVSNRSTYLILDLAES---NL
 .. . .|.|..| |||...|.               ..|.|.|           ..  ||..|.|  . ... ||  ....  . |.......    .|
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

QEQINQKQADL--EQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREENYYLSDFGCAQELYQSEQFQNNIAFGTLKWMSPELREMKRDKTI
 . | ...      .|.  .. ... || . |. . |  ||.||||||.|||. | .  ..||| | .|        .   ||. .|.||.         
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GY

NFFKSDIFSLGMILLYMLT---LADISQVNCDEIFKQAKIRLMKNMYKDTKYSQIILLVIKMLETNPDHRPDSSILIQ
...|.|. |.| ||  ||.   . .    . ...||. .             .. . .. |.|. .|..||    . |
GKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase 3630.AA Pkinase 206-477 20 6.3e-28 99.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 206-477
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQDILSNMPDYYACKQICVSEQMDNISSSAFH--EIEVLEKLKKYDYVKKLQNYIVSNRSTYLILDLAES---
. .   .||||.| ||| ..|  ..             .|.|.|..... ..   ....  ||... .| . ... .|  .  .... |......|    
YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

--NLQEQIN-QKQADLEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIR-EENY----YLSDFGCAQEL-YQSEQFQNNIAFGTLKWMSPEL
   | . |  ...  .  |  .|. ... || . |. ..| .||.||||||.||||  . .      ..|||.|  . | . .  ..   ||. .|.||.
VMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEV

REMKRDKTIN-----FFKSDIFSLGMILLYMLTLADISQVNC------DEIFKQAKIRLMKNMYKDTKY---------------------SQIILLVIKM
        |.       |.|..|.| || .||.   . . ..      |.... ..|.  ....   .                      .  . .. ..
--------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LETNPDHRPDSSILIQT--I
|. .|  ||    . |   .
LCKDPKKRPTAEQILQHPWF
Kinase 3630.AA Ciliate-E2 206-419 19 5.2e-22 72.34 In-house 1-291 (365) Show / Hide 
Range on Protein: 206-419
Range on HMM: 1-291/365
Sequence Identity: 19% (57 aa)

IDFRDSLGSGSYGDVYKV---KNKHKEIIKNQDILSNMPD----YYACKQICVSEQMDNISSSAFHEIEVLEKLK---------------KYDYVKKLQN
..|   .|.|..|.|||.   |......|| .| ..  .     ... |.. .  .. |   . . || .. ...               . ... |.  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

YIV--SNRSTYLILDLAES-NLQEQINQK---------QADLEQFNQEEIVKFLVQIGK---------------TLALIYSDEGIVHRDLKPSNILIREE
.    .. . ||......  .|.. |...         . | ..|. .|| ..  || .                |  . |   |.|||.||.|||.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

NYYLSDFGCAQ---------------ELYQSEQFQNNIAFG----------------TLKWMSPELREMKR-----DKTINFFKSDIFSLGMILLYMLT
   ..||| ..               ..|.  . .... .|                |.  |.||  ..|      ...   .|.||.|||.|| .||.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
Kinase 3630.AA Ciliate-E1 212-408 20 3.1e-21 66.14 In-house 1-202 (202) Show / Hide 
Range on Protein: 212-408
Range on HMM: 1-202/202
Sequence Identity: 20% (44 aa)

LGSGSYGDVYKVKNKHKEIIKNQDILSNMPDYYACKQICVSEQMDNISSSAFHEIEVLEKLKKYDYVKKLQNYIVSNRS--TYLILDLAESNLQEQIN--
.|.||...|.| |...  ... ....          ..|  . .... .    ...... .||..|. ....|| .  .  ...|... . .|.....  
IGNGSFSIVFKAKQQNNNYNQVAQKI---------INCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH

-------QKQADLEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILI-REENYYLSDFGCAQ-------ELYQSEQFQNNIAFGTLKWMSPELR
       |.| .  ||.......  .|. . |. ...  .| |||.||.|||| ...|| ..|||...       . .| ...... .    . .  |. 
NRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQ-YNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP-EQ-

EMKRDKTINFFKSDIF
|......|| .||||.
EHNKNQKIN-YKSDIY
Kinase 3630.AA STE 206-419 21 6e-21 70.78 In-house 1-263 (359) Show / Hide 
Range on Protein: 206-419
Range on HMM: 1-263/359
Sequence Identity: 21% (58 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQDILSN---MPDYYACKQICVSEQM---------------DNISSSAFHEIEVLEKLKK-YDYVKKLQNYIV
 .. . .|.|..| ||| .|... .|   . ..|   . ...| ||. ....                ...  .  .||... |...  ... |   . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SNR-------STYLILDLAE-SNLQEQINQKQADLEQFN----------QEEIVKFLVQIGKT-LALIYSDEGIVHRDLKPSNILIREENYYLSDFGCAQ
 .        . .... . .   | . |..|   ....|           ..| ....|| |  |... |   |.|||.||.|||.      |.|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL----VKLCDFGVCG

ELYQ---------------SEQFQNNIAFGTLKWMSPEL--REMKR-DKTINFFKSDIFSLGMILLYMLT
 | .               . | ..|   ||  ||.||   .. .  ||  . .|.|| |||  .. |.|
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMAT
Kinase 3630.AA ULK 206-419 24 5.8e-20 67.57 In-house 1-247 (324) Show / Hide 
Range on Protein: 206-419
Range on HMM: 1-247/324
Sequence Identity: 24% (62 aa)

IDFRDSLGSGSYG-DVYKVKNKHKEIIKNQDILSNMPDYYACKQICVSEQMDNISS--------SAFHEIEVLEKLK--KYDY--VKKLQNYIVSN--RS
.  .. ||.||.|  ||| .|| ..             |.|||.|  ... .. .         .   ||... |||  |  .  . ||  .  .     
YCLNHCLGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNN

TYLILDLAES-NLQEQINQKQADLEQ-----FNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREENYY-------------LSDFGCAQELYQ
.|.|... .  .|.. |....   |.     ....|...|. ||   .  ... ..|.|||.||.|||| . . .             ..||| |. .  
IYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

--SEQFQNNIAF------GTLKWMSPELREMK-RDKTINFFKSDIFSLGMILLYMLT
   ||...  .       ||   |.|.. . .   |  . .|.||.|||.|. .||.
NNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 3630.AA ULK 206-419 22 9.8e-19 62.1 In-house 1-251 (329) Show / Hide 
Range on Protein: 206-419
Range on HMM: 1-251/329
Sequence Identity: 22% (59 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQDILSNMPDYYACKQIC-----VSEQMDN---ISSSAFHEIEVLEKLK---KYDY----VKKLQNYIVSN--
.  .. ||.||.| ||| .|| ..    ...      ..|||.|.      ......   .  .   ||... |||   .  .    . ||  .  .   
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNE------KVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH

RSTYLILDLAES-NLQEQINQKQA-DLEQ-----FNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREENYY-------------LSDFGCAQE
  .|.|... .  .|.. |....   ...     ....|...|. ||   .  ... ..|.|||.||.|||| . . .             ..||| |. 
NNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

LYQS--EQFQNNIAF------GTLKWMSPELREMK-RDKTINFFKSDIFSLGMILLYMLT
.  .  ||...  .       ||   |.|.. . .   |  . .|.||.|||.|. .||.
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 3630.AA CMGC 206-364 18 2e-18 56.3 In-house 1-249 (513) Show / Hide 
Range on Protein: 206-364
Range on HMM: 1-249/513
Sequence Identity: 18% (47 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIK---NQDILSNMPDYYACKQICVSEQMDN----------ISSSAFHEIEVLEKLK---------------KYDY
 .  . .|.|.|| ||| ..|. .  |       . .   ..| | |   . ...          ....|. ||. |..|.               | . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQ-AHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

-VKKLQNYIVSNR-----------------STYLILDLAESNLQEQINQKQAD-----LEQFNQEE------------IVKFL------VQIGKTLA--L
 . ||.......                  . ||. .. . .| . | ..| |        ... .            | .|.       || . |.   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IYSDEG-IVHRDLKPSNILIREENY---------------------YLSDFG
. |  | |.||||||.|||| ...                       . |||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
Kinase 3630.AA Ciliate-E2-Unclassified 206-419 19 1.1e-17 57.94 In-house 1-265 (352) Show / Hide 
Range on Protein: 206-419
Range on HMM: 1-265/352
Sequence Identity: 19% (54 aa)

IDFRDSLGSGSYGDVYKVKN-KHK------EIIKNQDILSNMPDYYACKQICVSEQMDNISSSAFHE------------IEVLEKLKKYDYVKKLQNYIV
  .   .|.|..|.|||... |.|      ...|.|.. ..   .     .   ..| |...  ...            .  . ..|.... .. ||   
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI--

SNRSTYLILDLAESNLQEQINQKQADL--------------EQFNQEEIV-----KFLVQIGKTL-ALIYSDEGIVHRDLKPSNILIREE----NYYLSD
     |......| .  .|. .|.  .              ..|  ....     ... || . |  |...  .|.|||.||.|||. ..    .  ..|
-----YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIID

FGCAQELYQSEQ-------------FQNNIAF-GTLKWM----SPELREMKRDKTINFFKSDIFSLGMILLYMLT
|| . .. |...             .|.   | ||.  |    .||. . .   .  ..|.||.|||.|| .||.
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase 3630.AA TKL 340-414 22 6.1e-16 53.89 In-house 160-279 (364) Show / Hide 
Range on Protein: 340-414
Range on HMM: 160-279/364
Sequence Identity: 22% (27 aa)

GIVHRDLKPSNILIREEN---------------YYLSDFGCAQELYQSEQ------------------FQNNIAFGTLKWMSPELREMKRDKT-------
.|.|||||..|||. | .                 ..||| .... ||..                   ...   ||. ||.||. ... . |       
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----INFFKSDIFSLGMIL
       . |.|..| |..|
FCKGFEYSEKCDVYSFGIVL
Kinase 3630.AA TyrKc 206-477 15 4.4e-11 -43.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 206-477
Range on HMM: 1-280/280
Sequence Identity: 15% (50 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQDILSNMPDYYACKQICVSEQMDNISSSAFHEIEVLEKL-KKYDYVKKLQNYIVSN-------RSTYLILDL
| . . ||.| .| ||| . |                  | | .  .           .|.... || .. . . .|  ....           .... .
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

AES-NLQEQINQKQADLEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREEN-YYLSDFGCAQELYQS-------EQFQ-----NNIAFGT
..  .|.. .  .. .   .. .. ..| .|| .  . . |  ...||||   |.|. |..    |||| . ..|         .        .  .   
MPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

LKWMSPELREMKRDKTINFF----KSDIFSLGMILLY-MLTLADISQ-------VNCDEIFKQAKIRLMKNMYKD-------TKYSQIILLVIKMLETNP
..||.||        .||.     |||..| | .... ..|. .          .. .|.... | . .    ..       .  . .  .  .  . .|
IRWMAPE--------CINYGKFTTKSDVWSFG-VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

DHRPDSSILIQTI
. ||  | ... .
EDRPTFSEIHECF
Kinase 3630.AA STE20 339-391 39 4.2e-10 33.42 In-house 136-193 (288) Show / Hide 
Range on Protein: 339-391
Range on HMM: 136-193/288
Sequence Identity: 39% (23 aa)

EGIVHRDLKPSNILIREE-NYYLSDFGCAQELYQ----SEQFQNNIAFGTLKWMSPEL
..|.|||.|  |||. |. .  |.||| .. | .    ..||. |   ||  ||.||.
NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEV
Kinase 3630.AA STE20 206-278 20 2e-06 20.21 In-house 1-66 (288) Show / Hide 
Range on Protein: 206-278
Range on HMM: 1-66/288
Sequence Identity: 20% (15 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQDILSNMPDYYACKQICVSEQMD--NISSSAFHEIEVLEKLKKYDYV
 .. . .|.||||.|||. .|.   . |        . .| |.. ......  .   . . || .. ..|   ..
YELLEKIGQGSYGKVYKAYHKPTGEYCN--------QRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNI
Kinase 3630.AA TKL 212-224 61 0.001177 9.05 In-house 1-13 (364) Show / Hide 
Range on Protein: 212-224
Range on HMM: 1-13/364
Sequence Identity: 61% (8 aa)

LGSGSYGDVYKVK
.|||..| ||| |
IGSGGFGEVYKGK