Gene 13816 (Tetrahymena)
13816
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 13816.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13816.AA | Ciliate-C7 | 29-169 | 63 | 9.4e-90 | 287.94 | In-house | 1-142 (164) | Show / Hide |
Range on Protein: 29-169 Range on HMM: 1-142/164 Sequence Identity: 63% (90 aa) FKFLGKGQQGNVLLAKEQKTNRRYAIKGFLIKHDNGEIIEDHLKSANKEIEMLQQCKGSPFVVNIFRQIDGQYFKYLILNECQ-GSLNQILDKQSNKLLN |.|||.|||| |||||.||||.||||||. .....|.| .|.......||..|.|||.||.||....|..||.| ||.||||| |.||||.....||.|| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EITAIKYSKDIAEGLLHIHSKKCVANDLKMDNILIDYNGNAK ||.||||.||||.||..||||.||.||||||||||||||||. EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAV |
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| Pkinase | 13816.AA | Pkinase | 26-169 | 21 | 6.9e-16 | 57.25 | Pfam | 1-152 (293) | Show / Hide |
Range on Protein: 26-169 Range on HMM: 1-152/293 Sequence Identity: 21% (34 aa) FDDFKFLGKGQQGNVLLAKEQKTNRRYAIKGFLIKHDNGEIIEDHLKSANKEIEMLQQCKGSPFVVNIFRQIDGQYFKYLILNECQG-----SLNQILDK . . .|.| | | ......|....|.| . |... . . .. . ||.... . ..|..| ... |... |.| .| .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST QSNKLL--NEITAIKYSKDIAEGLLHIHSKKCVANDLKMDNILIDYNGNA----K .... . | ....| . |..|| ..||.... ||| .||||| ||. | WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK |
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| Kinase | 13816.AA | S_TKc | 26-266 | 18 | 6.5e-13 | 12.44 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-266
Range on HMM: 1-231/231
Sequence Identity: 18% (54 aa)
FDDFKFLGKGQQGNVLLAKEQKTNRRYAIKGFLIKHDNGEIIEDHLKSANKEIEMLQQCKGSPFVVNIFRQIDGQYFKYLILNECQG---SLNQILDKQS
.. . .||| | | .... ||.|..||| ... .||..|.. . |..|... .. . |... | | .| ....|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
N----KLLNEITAIKYSKDIAEGLLHIHSKKCVANDLKMDNILIDYNGNAK--------------GNYQYCAPECCLDSEIYEYPKEYQK----------
. ..| .| .| . |...| ..||.. . ||| .|||.| . | | |.||| . | |
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL----------GYGKCKCDWWSCGC
--QQILIETNPTPKTMVDDDQGVTQQYIRQIKKDIEFIQCSENTFYPIIFNSQNEKEFVQALDSYVPM-------LQ-------KQIK
| | | |. ...|. |. |.|.. . . | || .
ILYEMLCGYPPFP---------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | 13816.AA | Ciliate-E2 | 26-181 | 16 | 1.2e-12 | 39.68 | In-house | 1-197 (365) | Show / Hide |
Range on Protein: 26-181
Range on HMM: 1-197/365
Sequence Identity: 16% (36 aa)
FDDFKFLGKGQQGNVLLAKEQKTNRRYA--------------------IKGFLIKHDNGEIIEDHLKSANKEIE----------MLQQCKGSPFVVNIFR
.. | .|.|..| | ..| |.....| |. |.. |. .. .. ..||. .|.| . .|......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE
QID--GQYFKYLILNECQG-SLNQIL---DKQSNKLLN------EITAIKYSKDIAE---------------GLLHIHSKK-CVANDLKMDNILIDYNGN
. ||.. ||| .| ... .|..|. .. | .....| |.. .| ..|||. .. |.| .|||.
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----
AKGNYQYCAPECCL
...
-----------IKI
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| Kinase | 13816.AA | Ciliate-E1 | 32-167 | 21 | 1.5e-12 | 37.6 | In-house | 1-147 (202) | Show / Hide |
Range on Protein: 32-167 Range on HMM: 1-147/202 Sequence Identity: 21% (33 aa) LGKGQQGNVLLAKEQKTN-RRYAIKGFLIKHDNGEIIEDHLKSANKEIE-MLQQCKGSPFVVNIFRQID-GQY-FKYLILNECQGSLNQILD-------- .|.| .. |. || |..| . .|.| ... .. . ..|. . .||. ... |. ...|. .|. |. ....|...|. ||.. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINC---CFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---KQSNKLLNEITAIKYSKDIAEGLLHIHSKKCVANDLKMDNILIDYNGN .| .. ... .. ... .|| .|... |.|..||||. .|| QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN |
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| Kinase | 13816.AA | ASK | 32-162 | 28 | 3.5e-12 | 36.63 | In-house | 2-127 (254) | Show / Hide |
Range on Protein: 32-162 Range on HMM: 2-127/254 Sequence Identity: 28% (38 aa) LGKGQQGNVLLAKEQKTNRRYAIKGFLIKHDNGEIIEDHLKSANKEIEMLQQCKGSPFVVNIFRQIDGQYFKYLILNECQGSLNQILDKQSNKLL-NEIT |||| | | .....| .| ||| .... . . ||.. .| . | . . ...||| . . ||| ..| . . || | LGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR------YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENT AIKYSKDIAEGLLHIHSKKCVANDLKMDNILI |.| | ||| .| .. | |.| ||.|. MNFYTKQILEGLKYLHENQIVHRDIKGDNVLV |
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| Kinase | 13816.AA | Delta | 26-169 | 29 | 2.6e-11 | 37.16 | In-house | 1-140 (259) | Show / Hide |
Range on Protein: 26-169 Range on HMM: 1-140/259 Sequence Identity: 29% (42 aa) FDDFKFLGKGQQGNVLLAKEQKTNRRYAIKGFLIKHDNGEIIEDHLKSANKEIEMLQQCKGSPFVVNIFRQIDGQYFKYLILNECQGSLNQILDKQSNKL | | |||| | |.|| ...|. |||| .| | ...| . . | .| .||. .| . . . .. | . |. . FHFHKVLGKGSFGKVMLAELKGKNKYYAIK--CLKKDV-VLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGG-DLMYHIQQCHR LNEITAIKYSKDIAEGLLHIHSKKCVANDLKMDNILIDYNGNAK .| | |. .| || .|.| . |||.||.|.|..| | FDEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIK |
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| Kinase | 13816.AA | IRE | 74-171 | 29 | 3e-11 | 34.84 | In-house | 37-160 (292) | Show / Hide |
Range on Protein: 74-171 Range on HMM: 37-160/292 Sequence Identity: 29% (36 aa) ANKEIEMLQ--QCKGSPFVVNIFRQIDGQYFKYLILNECQGSLNQILDK-----------------QSNK-----LLNEITAIKYSKDIAEGLLHIHSKK ...||.||. . | |. . | .. | || | |||||. .. ..|. ....|. .. |....|| | || . ISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQN CVANDLKMDNILIDYN-GNAKG-N | .||| ||||..| |..| | IVHRDLKPHNILIHMNRPNQHGEN |
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| Kinase | 13816.AA | Ciliate-E2-Unclassified | 26-169 | 21 | 4.3e-11 | 34.73 | In-house | 1-187 (352) | Show / Hide |
Range on Protein: 26-169 Range on HMM: 1-187/352 Sequence Identity: 21% (40 aa) FDDFKFLGKGQQGNVLLAKEQKTNRRYAIKGFLIKHDNG-EIIEDHLKSANKEIEMLQQCK------------------GSPFVVNIFRQIDGQYFKYLI . | .|.|..| | .... |.. ||.| .... .|. . |.. ... | .||.|. | . . |.. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LNEC-QGSLNQILDKQSN---------------KLLNEITAI-----KYSKDIAEGLLHIHSKK-CVANDLKMDNILIDYNG---NAK . | .|.| |.. |... | . | |. .| . | .|| ..|.|. .. |.| .|||.| || . | MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIK |
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| Kinase | 13816.AA | CAMK | 31-169 | 16 | 6.3e-11 | 30.71 | In-house | 1-236 (425) | Show / Hide |
Range on Protein: 31-169 Range on HMM: 1-236/425 Sequence Identity: 16% (39 aa) FLGKGQQGNVLLAKEQKTN------------RRYAIKGFLIK----------------------HDNGEIIEDHLKSANKEIEMLQQCKG------SPFV ||.|. | | |... .|. ...||| | |.. .. . .|. .|||......| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNIFRQIDG-------------------QYFKYLIL---NECQGS------LNQILDKQSN------------KLLNEITAIKYSKDIAEGLLHIHSKKC .... .. . . |... |.| .. | .. .. . ..| | .| . |.... ..||.. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VANDLKMDNILIDYN-----------------GNAK | ||| .|||.|.| .| | VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK |
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| Kinase | 13816.AA | Aur | 26-55 | 50 | 1.7e-10 | 23.35 | In-house | 1-30 (257) | Show / Hide |
Range on Protein: 26-55 Range on HMM: 1-30/257 Sequence Identity: 50% (15 aa) FDDFKFLGKGQQGNVLLAKEQKTNRRYAIK |. | |||| ||| ||.. ||. ..|.| FEIGKPLGKGKFGNVYLARHKKTHFIFALK |
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| Kinase | 13816.AA | STE-Unique | 112-169 | 29 | 4.7e-10 | 31.32 | In-house | 379-450 (616) | Show / Hide |
Range on Protein: 112-169 Range on HMM: 379-450/616 Sequence Identity: 29% (21 aa) GSLNQILDKQSN-------KLLNEITAIKYSKDIAEGLLHIHSKK--CVANDLKMDNILIDYNG-----NAK |.| ||.. .. .|. | .|.| . |.|||...||.. . ||| .||... | ..| GTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVK |
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| Kinase | 13816.AA | Aur | 111-169 | 43 | 2.4e-05 | 9.52 | In-house | 83-142 (257) | Show / Hide |
Range on Protein: 111-169 Range on HMM: 83-142/257 Sequence Identity: 43% (26 aa) QGSLNQILDKQSNKLLNEITAIKYSKDIAEGLLHIHSKKCVANDLKMDNILID-YNGNAK .|.| . | || || ..|..| || ..|...| . |||. . |.| |||.| ||| | GGELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIK |
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| Kinase | 13816.AA | TyrKc | 26-227 | 14 | 3.6e-05 | -139.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 26-227
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)
FDDFKFLGKGQQGNVLLAKEQKTNRRYAIKGFLIKHDNGEIIEDHLKSANKEIEMLQQC-KGSPFVVNIF--RQID-------GQYFKYLILNECQGSLN
| || |. | | ... . |.| . .. .|.... . . | .|... . .... . . . |.|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLK
QILDKQSNKLLNEITAIKYSKDIAEGLLHIHSKKCVANDLKMDNILIDYNG--------------------------------NAK--GNYQYCAPECCL
. | | .| |. . .... .||.| ..|||.|. || |.|.. |. ..| . .||||
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN
DS----------------EIYEYPKEYQKQQIL-----------IETN---PTPKT--------MVDDDQGVTQQYIRQ----------IKKDI
.. ||. | .. .|. ... | |. . |. . .| . |....
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 13816.AA | STE-Unique | 27-55 | 34 | 0.000952 | 8.53 | In-house | 1-29 (616) | Show / Hide |
Range on Protein: 27-55 Range on HMM: 1-29/616 Sequence Identity: 34% (10 aa) DDFKFLGKGQQGNVLLAKEQKTNRRYAIK . ..|.| ||| ... |...|.||| NCQQMIGRGSFGNVHNCQNKKDCFRCAIK |
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