Gene 21673 (Tetrahymena)

21673

Species: Tetrahymena
Alias: 177.m00077, TTHERM_00958760, 857, 21673, PreTt21673
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
21673.AA Protein None 461 None Fasta, JSON
21673.kin_dom Protein Kinase Domain None 143 None Fasta, JSON
21673.NA RNA None 1386 None Fasta, JSON

Protein domain

Protein domains of 21673.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21673.AA Ciliate-C7 78-222 78 7.50000000001e-108 346.76 In-house 1-146 (164) Show / Hide 
Range on Protein: 78-222
Range on HMM: 1-146/164
Sequence Identity: 78% (115 aa)

FRFLGQGVQGLVLLAKDSKNNIRYAIKGVQIRDPNGNLDKDLSDRVSQEVEILKKCRESPYVVSLLDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN
||||||| |||||||||.|.|.||||||||.||..||.|.|. ..| ||..|||.|..|||||.||.|||||||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVCKF
||||||||.||||||||||||.|.|||||||||||||.|||||| |
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDF
Pkinase 21673.AA Pkinase 75-220 26 1.8e-21 76.98 Pfam 1-154 (293) Show / Hide 
Range on Protein: 75-220
Range on HMM: 1-154/293
Sequence Identity: 26% (43 aa)

YSDFRFLGQGVQGLVLLAKDSKNNIRYAIKGVQIRDPNGNLDKD---LSDRVSQEVEILKKCRESPYVVSLLDQFEGQQFSYLVLTECQG-----TLTQI
|   | .|.|  | | .... ......|.| .  |. . . |.    |     .|..|.|..  .|..| |.| ||  .  |.|.  |.|      |  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LERNQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVC
... .....   |  ...|.  |..||.|.||....  ||| .||||| .|.      .|
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 21673.AA ULK 75-212 25 5.2e-18 59.54 In-house 1-164 (329) Show / Hide 
Range on Protein: 75-212
Range on HMM: 1-164/329
Sequence Identity: 25% (41 aa)

YSDFRFLGQGVQGLVLLAKDSKN----NIRYAIKGVQIR--DPNGNLD--KDLSDRVSQEVEILKKCR---ESPY----VVSLLDQFEGQQF--SYLVLT
|.  . ||.|  | |  ... |.    |. .|.| ...   . . |..  . . . . .|..|.||      ...    .| |.| || ...   |... 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

ECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILID
 |.| .| |....|..        |||.|  ||..  .|..|. ..|.. .   |.| .||||.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIH
Kinase 21673.AA Ciliate-E1 81-274 19 5.8e-17 52.08 In-house 1-181 (202) Show / Hide 
Range on Protein: 81-274
Range on HMM: 1-181/202
Sequence Identity: 19% (40 aa)

LGQGVQGLVLLAKDSKNN-IRYAIKGVQIRDPNGNLDKDLSDRVSQEVE-ILKKCRESPYVVSLLDQFEGQQ--FSYLVLTECQGTLTQILE--------
.|.| ...|. ||  .|| . .|.| .....   | ...  . ...|   |.|  ..  |.. ..|... .|  ........|. .|.. |.        
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW

---RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVCKFLTNLNKLDRFDFLQNILINQIADFGLADNLINKSGYAFNQYMG
   ..... ...   .. . .. .|| ..|..  .  |.|..||||.  || | |                        |||....|.|.. .  ..   
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC------------------------DFGISKFLKNNQNQQCQYKGY

NFLYQAPEC
   |. ||.
THYYYPPEQ
Kinase 21673.AA CAMKL 75-220 24 4.6e-16 47.62 In-house 1-171 (297) Show / Hide 
Range on Protein: 75-220
Range on HMM: 1-171/297
Sequence Identity: 24% (42 aa)

YSDFRFLGQGVQGLVLLAKD-SKNNIRYAIKGVQIR----DPNGNLD------KDLSDRVSQEVEILKKCR--ESPYVVSLLDQFEGQQF------SYLV
|   . ||.|  | | ||.. . .....||| . ..    ||. .        ..   |. .|..|.|. .    | ...|.. .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVC
.  |.|    | . .... ..|  . |  | .|   |  ...|.||.     |.| .|||.|..|  |. ..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKII
Kinase 21673.AA Ciliate-E2 75-275 17 4.7e-16 51.58 In-house 1-259 (365) Show / Hide 
Range on Protein: 75-275
Range on HMM: 1-259/365
Sequence Identity: 17% (52 aa)

YSDFRFLGQGVQGLVLLAKDSKNNIRYAIK-------------GVQ-IRDPNGNLDKDLSDRVSQEVEILKKCRE---------------SPYVVSLLDQ
|   . .||| .| | ..|. |.. ..|||             .|.       .. |.    ..||  |... ..               .|... . . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHGN
|.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||  ..  |.| .|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVVCKFLTNLNKLDRFDFLQNILINQIADFGLADNLINKSGY------------------------------AFNQYMGNFLYQAPECF
                          |.||||. .. ... .                               ||.. |.  |.||| .
------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL
Kinase 21673.AA ULK 75-211 27 5.5e-16 53.27 In-house 1-159 (324) Show / Hide 
Range on Protein: 75-211
Range on HMM: 1-159/324
Sequence Identity: 27% (43 aa)

YSDFRFLGQGVQG-LVLLAKDSKN---NIRYAIKGVQIR--DPNGNLD--KDLSDRVSQEVEILKKCRE--SPY--VVSLLDQFEGQ--QFSYLVLTECQ
|.  . ||.|  |  |  ... |.   |  .|.| ...     . |..  . . .   .|..|.||  |  .|.  .| |.| || .   . |...  |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILI
| .| |....|..       |||.|  ||..  .|..|. ..|.. .   |.| .||||
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI
Kinase 21673.AA Ciliate-E2-Unclassified 75-276 19 1.1e-15 50.91 In-house 1-239 (352) Show / Hide 
Range on Protein: 75-276
Range on HMM: 1-239/352
Sequence Identity: 19% (51 aa)

YSDFRFLGQGVQGLVLLAKDSKNNIRYAIKGVQIRDPNGNLDKDLSDRVSQEVEILKKCRE-------------------SPYVVSLLDQFEGQQFSYLV
|   . .||| .| | .....|..  ||.|       .  . .  .|      ..  ....                   .|..| ....|. .|  |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHGNAVVCKFLTNLNKLDRFD
.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|  ..  |.| .|||.|  |.                 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----------------

FLQNILINQIADFGLADNLINKSGYAFNQY---------------MGNFLYQ----APECFD
   |  |  |.|||.. .... ...  ..                .|.  |.    |||...
---NYYIK-IIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
Kinase 21673.AA CAMK 80-273 17 1.2e-15 46.22 In-house 1-290 (425) Show / Hide 
Range on Protein: 80-273
Range on HMM: 1-290/425
Sequence Identity: 17% (54 aa)

FLGQGVQGLVLLAKDSKNN------------IRYAIKGVQ-----------------IRDPNGNL-----DKDLSDRVSQEVEILKKCRE------SPYV
 ||.|  | | |... ...             ..||| .                  |.. ..       .    ..| .|.||.||...       | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLLDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYHG-------NAVVCKFLTNLNKLDRFDFLQNILINQIADFGLADNLINKS----------------------GYAFNQYMGNFLYQ
   ||| .|||.|...       .             . ||  .|     |.|||.|  .. ..                      |  .. . |   | 
VHRDLKPENILLDDNNDDSDPVEHD------------EIFD--WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PE
| ||
AAPE
Kinase 21673.AA S_TKc 75-362 20 3.1e-15 46.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-362
Range on HMM: 1-231/231
Sequence Identity: 20% (64 aa)

YSDFRFLGQGVQGLVLLAKDSKNNIRYAIKGVQIRDPNGNLDKDLSDRVSQEVEILKKCRESPYVVSLLDQFEGQQFSYLVLTECQG---TLTQILERNQ
|   | .|.|  | | .... | . ..||| .              ... .|..||||    |..| |.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVCKFLTNLNKLDRFDFLQNILINQIADFGLADNLINKSGYAFNQYMGNF
 ..    ..|  | .|.  |...| |.||.  .  ||| .|||.|                              |.|||||  |        . . |  
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------------------HIKICDFGLARQL--------TTFCGTP

LYQAPECFDPSDPFIGKVYHDEYLK-------LGVT----VRQEPSNRGLDLKLASNKHKELNYDDEFKNFVYHKQLKYIIEGLTNFVPKNRMPIKEALI
 | ||| .              | |       .|..    .  .|  .  ....  .| .              ...| .|... .. |..|. . ||| 
WYMAPEVL-------------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-----ILKGII
      .   .
DEWDIKCHPWF
Kinase 21673.AA STE 75-273 17 5.2e-14 45.97 In-house 1-232 (359) Show / Hide 
Range on Protein: 75-273
Range on HMM: 1-232/359
Sequence Identity: 17% (45 aa)

YSDFRFLGQGVQGLVLLAKDSK---------------NNIRYAIKGVQIRDPN-----------GNLDKDLSDRVSQEVEILKKCRE-SPYVVSLLDQFE
. . ...|.|  | | .|.. |               .. ..||| . ... |            | ...  ... .|..|.|||.  .|..|  .. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVCKFLTNL
         .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||.     |.| .|||.               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

NKLDRFDFLQNILINQIADFGLADNLIN---------------KSGYAFNQYMGNFLYQAPE
                ..|||.. .|..                ..   |   |   . |||
--------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 21673.AA CMGC 75-212 19 3.6e-13 38.69 In-house 1-218 (513) Show / Hide 
Range on Protein: 75-212
Range on HMM: 1-218/513
Sequence Identity: 19% (42 aa)

YSDFRFLGQGVQGLVLLAKDSKNNIR--------------YAIKGVQIRDPNGNLDKD------LSDRVSQEVEILKKCR----------------ESPY
|   . .|.|  | |  ..| ..| .              .||| .  .  . .  |.      .. |   |..|||. .                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVSLLDQFEGQQFS-----------------YLVLTECQGTLTQILERNQ-------NKRLNEIS------------AIKYA------NDIAQGLY--YI
.|.|.| |   .                   |||   .. .| |....||       .. |.|                ..         | .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSKS--CLVNDLKMDNILID
||.    .  |||  ||||.
HSHWGNIIHRDLKPENILIN
Kinase 21673.AA Ciliate-C7 243-264 68 3.5e-09 26.09 In-house 143-164 (164) Show / Hide 
Range on Protein: 243-264
Range on HMM: 143-164/164
Sequence Identity: 68% (15 aa)

IADFGLADNLINKSGYAFNQYM
..||||||||..||.|..||||
VCDFGLADNLTQKSKYQINQYM
Kinase 21673.AA TyrKc 75-358 16 2.2e-05 -135.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 75-358
Range on HMM: 1-280/280
Sequence Identity: 16% (57 aa)

YSDFRFLGQGVQGLVLLAKDSKNNIRYAIKGVQIRDPNGNLDKDLSDRVSQEVEILKKC-RESPYVVSLLDQFEGQQ------FSYLVLTE--CQGTLTQ
 .  . || |  | | ... .   |  |.| ..                 .| .|..|   . | .| |.     |.        .....|  . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILERNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVCKFLTNLNKLDRFDFLQNILINQIADFGLADNLINK------SGYA
 | ....| |.    .... .||.|  |.||| |   ||   |.|..  .                        .  |.||||. .. ..      . | 
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------------TVKISDFGLSRDIYDDDQQGESKDYY

FNQY--MGNFL----YQAPECF-----------------------DPSDPFIG-----KVYHD--EYLKLGVTVRQEPS----NRGLDLKLASNKHKELN
  .    |...      ||||.                       .   |  |     .   .  ||.| |   .| |.                     
RKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------

YDDEFKNFVYHKQLKYIIEGLTNFVPKNRMPIKEALIIL
    |     .. .  |..   .. |..|   .|   ..
----F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 21673.AA ULK 235-249 34 0.008274 5.87 In-house 154-185 (324) Show / Hide 
Range on Protein: 235-249
Range on HMM: 154-185/324
Sequence Identity: 34% (11 aa)

LQNILINQ-----------------IADFGLA
.|||||.                  |||||.|
PQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 21673.AA ULK 235-249 34 0.008764 5.65 In-house 158-189 (329) Show / Hide 
Range on Protein: 235-249
Range on HMM: 158-189/329
Sequence Identity: 34% (11 aa)

LQNILINQ-----------------IADFGLA
.|||||.                  |||||.|
PQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 21673.AA CMGC 236-249 28 0.022011 2.6 In-house 213-251 (513) Show / Hide 
Range on Protein: 236-249
Range on HMM: 213-251/513
Sequence Identity: 28% (11 aa)

QNILIN-------------------------QIADFGLA
.|||||                          |.|||||
ENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA