Gene 21728 (Tetrahymena)

21728

Species: Tetrahymena
Alias: 854, 21728, 182.m00038, TTHERM_00976420, PreTt21728
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
21728.AA Protein None 655 None Fasta, JSON
21728.kin_dom Protein Kinase Domain None 165 None Fasta, JSON
21728.NA RNA None 1968 None Fasta, JSON

Protein domain

Protein domains of 21728.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21728.AA Ciliate-C7 59-220 74 2.4e-112 361.37 In-house 1-164 (164) Show / Hide 
Range on Protein: 59-220
Range on HMM: 1-164/164
Sequence Identity: 74% (122 aa)

FRFLAHGAQGLVLLAKDSKTNMRYAIKGVQVRDFLGNLDEDLNNQVKQEVEILKKCRDSPYVVSLIDQFEGNEFSYLVLTECQ-GTLTQILEF-QNKRLN
|||| .|.|||||||||.|||||||||||||||  ||.|.|.||||.||..|||.|.||||||.|..||||..|.||||.||| |||.||.|  ||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

ELSAIKYAKDIAQGLYYIHSKGYLVNDLKTDSILIDYNGNAVVCGFDVADNFEKNSGYSINKYM
|.|||||||||||||||||||...||||| | |||||||||||| |..|||....|.|.||.||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Kinase 21728.AA Ciliate-E1 62-231 18 5.6e-20 62.02 In-house 1-182 (202) Show / Hide 
Range on Protein: 62-231
Range on HMM: 1-182/202
Sequence Identity: 18% (35 aa)

LAHGAQGLVLLAKDSKTN-MRYAIKGVQVRDFLGNLDEDLNNQVKQEVEILKKCRDSPYVVSLIDQFE--GNEFSYLVLTECQGTLTQILE---------
...| ...|. ||  ..|   .|.| ......    ....... |.. .|.|  .   |.. .||...   | ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

---FQNKRLNELSAIKYAKDIAQGLYYIHSKGYLVNDLKTDSILIDYNGNAVVCGFDVADNFEKNSGYSINKYMGNFLYQAPECY
    ... ....  .. .... .|| ..|... .  |.| . |||. .|| | | | ..... .|. .....      |. ||.|
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQY
Kinase 21728.AA CAMK 61-229 16 1.2e-19 59.3 In-house 1-290 (425) Show / Hide 
Range on Protein: 61-229
Range on HMM: 1-290/425
Sequence Identity: 16% (49 aa)

FLAHGAQGLVLLAKDSKTN------------MRYAIKGVQVRDFLGNL----------------------DEDLNNQVKQEVEILKKCR------DSPYV
 | .|. | | |... .|.             ..||| .  .   ..                       ..    .|..|.||.||..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLIDQFEG-------------------NEFSYLVL---TECQGT------LTQILEFQN-------------KRLNELSAIKYAKDIAQGLYYIHSKGY
..|.. .|                    ... |.|.     |.|       .  | |  .             .|..|  | .| . |.... |.||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKTDSILIDYN-----------------GNAVVCGFDVADNFEKNSGYS----------------------INKYMGNFLYQA-PE
   ||| . ||.|.|                 .|  .. |  |  |......                        . . |   | | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
Kinase 21728.AA STE 56-229 18 3.2e-19 64.63 In-house 1-232 (359) Show / Hide 
Range on Protein: 56-229
Range on HMM: 1-232/359
Sequence Identity: 18% (44 aa)

YSDFRFLAHGAQGLVLLAKDSK---------------TNMRYAIKGVQVRDF-----------LGNLDEDLNNQVKQEVEILKKCRD-SPYVVSLIDQFE
. . ... .|| | | .|.. |               |. ..||| . ...            | | ...  .|...|..|.|||.. .|..|  .. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GN-------EFSYLVLTECQ-GTLTQILE------FQNK-------RLNELSAIKYAKDIAQG-LYYIHSKGYLVNDLKTDSILIDYNGNAVVCGFDVAD
 .       .  ....  .  |.|..|..      ....       |..|   ......| .| |||.||...   |.| . ||.     .  | | |. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

NFEK---------------NSGYSINKYMGNFLYQAPE
....               ...   |   |   . |||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 21728.AA S_TKc 56-333 19 9.1e-17 62.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 56-333
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

YSDFRFLAHGAQGLVLLAKDSKTNMRYAIKGVQVRDFLGNLDEDLNNQVKQEVEILKKCRDSPYVVSLIDQFEGNEFSYLVLTECQG---TLTQILEFQN
|   | . .|| | | .... ||. ..||| .              .....|..||||  . |..| |.| |.  .. |.|.  | |   .| .... ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

KR-----LNELSAIKYAKDIAQGLYYIHSKGYLVNDLKTDSILIDYNGNAVVCGFDVADNFEKNSGYSINKYMGNFLYQAPECYDPADP-----------
..     ..|  | .|.. |...| |.||.| .  ||| . ||.|   .  .| | .|  .        . . |   | |||   . ..           
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI

----YIGITVRLEPSVRVNILDKLFLKAKQYYSFNINRAKHVLQGVGYLVSNKHEQLNYDDEFKNFVYHKQLKYIIEGLTNFVPMNRISINEALI-----
    . | .           ....| | .                                        ...| .|... .. | .|... |||      
LYEMLCGYPPFP-------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

ILKGII
 .   .
KCHPWF
Kinase 21728.AA Pkinase 56-178 25 3e-16 58.52 Pfam 1-128 (293) Show / Hide 
Range on Protein: 56-178
Range on HMM: 1-128/293
Sequence Identity: 25% (34 aa)

YSDFRFLAHGAQGLVLLAKDSKTNMRYAIKGVQVRDFLGNLDED---LNNQVKQEVEILKKCRDSPYVVSLIDQFEGNEFSYLVLTECQGTLTQILEFQ-
|   | .  |. | | .... .|. ..|.| . .|.   . |.    |     .|..|.|.. ..|..| |.| || .   |.|.  |.|.|.  ..   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFD

------NKRL--NELSAIKYAKDIAQGLYYIHSKG
      ....   |  ...|.. |..||.|.||.|
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMG
Kinase 21728.AA ULK 56-194 24 6.7e-16 52.07 In-house 1-166 (329) Show / Hide 
Range on Protein: 56-194
Range on HMM: 1-166/329
Sequence Identity: 24% (40 aa)

YSDFRFLAHGAQGLVLLAKDSKT----NMRYAIKGVQVRDFLGNLD----EDLNNQVKQEVEILKKCRD---SPY----VVSLIDQFEGNEF--SYLVLT
|.  . | .|. | |  ... ||    |  .|.| ..   .  ...    . . ...|.|..|.||  .   ...    .| |.| ||   .   |... 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

ECQG-TLTQILEFQ---------NKRLNELSAIKYAKDIAQGLYYIHSKGYLVNDLKTDSILIDYN
 |.| .| |... .         .|||.|  ||.. |.|..|. ..|....   |.| . |||. .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG
Kinase 21728.AA ULK 56-194 25 9.5e-16 52.41 In-house 1-162 (324) Show / Hide 
Range on Protein: 56-194
Range on HMM: 1-162/324
Sequence Identity: 25% (41 aa)

YSDFRFLAHGAQG-LVLLAKDSKT---NMRYAIKGVQ---VRDFLGNLD-EDLNNQVKQEVEILKKCR--DSPY--VVSLIDQFEGN--EFSYLVLTECQ
|.  . | .|. |  |  ... ||   |  .|.| ..    ...  . . . . .. |.|..|.||     .|.  .| |.| ||     . |...  |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-TLTQILEFQNK--------RLNELSAIKYAKDIAQGLYYIHSKGYLVNDLKTDSILIDYN
| .| |... ..|        ||.|  ||.. |.|..|. ..|....   |.| . |||  .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNG
Kinase 21728.AA Ciliate-E2-Unclassified 56-232 18 5.5e-15 48.44 In-house 1-239 (352) Show / Hide 
Range on Protein: 56-232
Range on HMM: 1-239/352
Sequence Identity: 18% (45 aa)

YSDFRFLAHGAQGLVLLAKDSKTNMRY------AIKGVQVRDFLGNLDEDLNNQVKQEVEILK---------------KCRDSPYVVSLIDQFEGNEFSY
|   . . .|..| | .....|..  |        . .. .    | | ...|. ..|....|               .  ..|..| ....|.  .  |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNE-MKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LVLTEC-QGTLTQILEFQNK----------------RLNELSAI-----KYAKDIAQGLYYIHSKG-YLVNDLKTDSILIDYNG---NAVVCGFDVADNF
.|.  | .|.| |... ..|                .. |  |.     .|.. | ||| |.|.|.  .  |.| . ||.| ||   .  ...|  . . 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

EKNSGY-----------SINKY---MGNFLYQ----APECYD
..|...           . ...   .|.  |.    |||...
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
Kinase 21728.AA CMGC 56-195 17 3.9e-14 41.93 In-house 1-221 (513) Show / Hide 
Range on Protein: 56-195
Range on HMM: 1-221/513
Sequence Identity: 17% (39 aa)

YSDFRFLAHGAQGLVLLAKDSKTNMR--------------YAIKGVQVRDFLGN------LDEDLNNQVKQEVEILKKCR----------------DSPY
|   . . .|. | |  ..| .|| .              .||| .  .    .      . . ..     |..|||. .                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVSLIDQFEGNEFS-----------------YLVLTECQGTLTQILEFQNK-----RLNELSAIK---------------YA------KDIAQGLY--YI
.|.|.| |  ..                   |||   .. .| |... ...     | ..||  .               .       . | .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSKG--YLVNDLKTDSILIDYNG
||..   .  |||   |||. |.
HSHWGNIIHRDLKPENILINHNC
Kinase 21728.AA Ciliate-E2 56-229 17 1.6e-13 42.76 In-house 1-257 (365) Show / Hide 
Range on Protein: 56-229
Range on HMM: 1-257/365
Sequence Identity: 17% (45 aa)

YSDFRFLAHGAQGLVLLAKDSKTNMRYAIK-------------GVQVRDF-LGNLDEDLNNQVKQEVEILKKCR---------------DSPYVVSLIDQ
|   . .  |..| | ..|. |.. ..|||             .|..  . . .. ..  .|.|||  |... .               ..|... ... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GNEFSYLVLTECQG-TLTQILEFQNK----------RLNELSAIKYAKDIAQ---------------GLYYIHSKG-YLVNDLKTDSILIDYNGNA
|.   ..  |||.  ||| .| .... ..|          ...|  .... | |.|               .| |.|||.  .  |.| . ||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

VVCGFDVADNFEKNSGYSI-----NKYMGNF--------------------------LYQAPE
 .. |  . .. ... . .     ..||  .                           |.|||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE
Kinase 21728.AA AGC 59-196 21 2.8e-12 26.54 In-house 1-193 (395) Show / Hide 
Range on Protein: 59-196
Range on HMM: 1-193/395
Sequence Identity: 21% (43 aa)

FRFL---AHGAQGLVLLAKDS------KTNMRYAIKGVQVRD---------FLGNLDE-------DLNNQVKQEVEILKKCRD---------SPYVVS-L
|.||     |. | | |...        |.  ||.| .. ..            .. |       .    |..| .||.||.          .|..|. |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGY----VWEERNILEKCNHTHNHPIKSHHPFIVKIL

IDQFEGNEF--SYLVLTECQ----------G--TLTQILEF-QNKRLNELSAIKYAKD-------IAQGLYYIHS-KGYLVND-LKTDSILIDYNGN
   |. ..    |.|.  ..          |  ..... .  ...|..|  |  ||         |. .| |.|| .|.   | || . ||.| .|.
HYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH
Kinase 21728.AA TyrKc 56-329 14 0.000255 -152.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 56-329
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)

YSDFRFLAHGAQGLVLLAKDSKTNMRYAIKGVQVRDFLGNLDEDLNNQVKQEVEILKKC-RDSPYVVSLIDQFEGNE------FSYLVLTE--CQGTLTQ
 .  . | .|| | | ... .   .  |.| ..                 .| .|..|   . | .| |.      .        .....|  . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILEFQNKRLNELSAIKYAKDIAQGLYYIHSKGYLVNDLKTDSILIDYNGNAVVCGFDVADNFEKN-------SGYSI-----NKYMGNFLYQAPECY---
 |    ..|.    .... .||.|  |.|||..   || .  .|.. |. . .. |  . . .         . |.       |.|      ||||    
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

--------------------DPADPYIG-----ITVRLEPSVRVNILDKLFLKAKQYY---SFNINRAKHVLQGVGYLVSNKHEQLNYDDEFKNFVYHKQ
                    . . || |     .. .    |. .. .   ..  ...   |                             |     .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE---VIEYVKQGYRMPQPPNDYPMS-----------------------------F--VCCPDE

LKYIIEGLTNFVPMNRISINEALIIL
.  |..   .. | .| . .|   ..
MYQIMKQCWHEDPEDRPTFSEIHECF