Gene 22632 (Tetrahymena)
22632
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 22632.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22632.AA | Ciliate-C7 | 106-246 | 64 | 3.6e-92 | 295.8 | In-house | 1-142 (164) | Show / Hide |
Range on Protein: 106-246 Range on HMM: 1-142/164 Sequence Identity: 64% (91 aa) FKYLGSGKQGWVLLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKCKGSSYVVNLLKVIEGKEFKYLILSECQ-GTLLELIDKCPNKRLN |..|| |.||.|||||. .||.|.||||..|.|.||.|.|....|.|||||.|..||.|.|||.||. .||..| ||.|.||| ||| ..|.. .||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN ELSAIKYAKDIAEGLLYMHSQKCISNDLKMDNILIDYNGNAV |.||||||||||.||.|.||..|. ||||||||||||||||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAV |
|||||||||
| Pkinase | 22632.AA | Pkinase | 103-244 | 25 | 2.3e-18 | 66.02 | Pfam | 1-146 (293) | Show / Hide |
Range on Protein: 103-244
Range on HMM: 1-146/293
Sequence Identity: 25% (39 aa)
FSDFKYLGSGKQGWVLLAKELSTNRRFAIKGLHVKDSQGKIFQE---TFDQAQQEINMLEKCKGSSYVVNLLKVIEGKEFKYLILSECQGTLLELIDKC-
. . .||| | | .... .|....|.| . ... . |. . .|| .. .. .. ..| |. . | | |... |.|.| ..| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFD
-----PNKRL--NELSAIKYAKDIAEGLLYMHSQKCISNDLKMDNILIDYNGN
.... | ...|.. |..|| |.||...| ||| .||||| ||.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH
|
|||||||||
| Kinase | 22632.AA | AGC | 103-244 | 23 | 4.1e-17 | 39.34 | In-house | 1-193 (395) | Show / Hide |
Range on Protein: 103-244 Range on HMM: 1-193/395 Sequence Identity: 23% (46 aa) FSDFKYLGSGKQGWVLLAKEL------STNRRFAIKGLHVKD--------SQGKIFQE-TFDQ----AQQEINMLEKCKG---------SSYVVN-LLKV | | .| | | | |... .|.. .|.| | |. . .. | . .| ..| |.||||.. . ..|. | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS IEGKEF--KYLILSECQ---------GT-LLELIDKC--PNKRLNELSAIKYAKD-------IAEGLLYMHS-QKCISND-LKMDNILIDYNGN . |. |... .. | | |. . ..|..| | || |. .| |.|| .. | | || .|||.| .|. FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH |
|||||||||
| Kinase | 22632.AA | Ciliate-E1 | 109-296 | 17 | 7.8e-17 | 51.66 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 109-296 Range on HMM: 1-202/202 Sequence Identity: 17% (37 aa) LGSGKQGWVLLAKELSTN-RRFAIKGLHVKDSQGKIFQETFDQAQQEIN-MLEKCKGSSYVVNLLKVIEGKE--FKYLILSECQGTLLELID-------- .|.| .. |. || ..| . |.| . .... |..|.. ..|.. ... |. |.......|. .. ....|. .|. .|.. .. IGNGSFSIVFKAKQQNNNYNQVAQK---IINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---KCPNKRLNELSAIKYAKDIAEGLLYMHSQKCISNDLKMDNILIDYNGNAVQG---NLLFQAPECYDPQGFKDYQDKYQ-ELGLKISTKPTIKLVSLI . .. .... .. .... .|| ..|... | |.|..||||. .|| | .|. . .. . .| |...|. . ... . . . | QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKI DQLIDLY .. |.| NYKSDIY |
|||||||||
| Kinase | 22632.AA | Ciliate-E2-Unclassified | 103-244 | 19 | 1.4e-16 | 54.02 | In-house | 1-185 (352) | Show / Hide |
Range on Protein: 103-244 Range on HMM: 1-185/352 Sequence Identity: 19% (36 aa) FSDFKYLGSGKQGWVLLAKELSTNRRFAIKGLHVKDSQG-KIFQETFDQAQQEINMLEKCK------------------GSSYVVNLLKVIEGKEFKYLI . | .|.| .| | .... ... .|.| .... .. |. .. . .|.. ... | . ..|... . . |. |.. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LSEC-QGTLLELIDKCPN---------------KRLNELSAI-----KYAKDIAEGLLYMHSQK-CISNDLKMDNILIDYNG---N . | .|.|.. | |... |.. | |. .|.. | .|| |.|... .| |.| .|||.| || . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYY |
|||||||||
| Kinase | 22632.AA | CAMKL | 107-244 | 28 | 9.2e-16 | 46.64 | In-house | 5-165 (297) | Show / Hide |
Range on Protein: 107-244 Range on HMM: 5-165/297 Sequence Identity: 28% (46 aa) KYLGSGKQGWVLLAKE-LSTNRRFAIKGLHVK----DSQGKIF------QETFDQAQQEINMLEKCK--GSSYVVNLLKVIEGKEF------KYLILSEC | || | | | ||. . |... ||| .. | | . | . ..||. ... . . .. |. ||| .|. ||.. | KTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYC QGT---LLELIDKCPNKR--LNELSAIKYAKDIAEGLLYMHSQKCISNDLKMDNILIDYNGN .| |.. |.| ...| . | | .| . | ... |.||.. . |.| .|||.|.||| SGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGN |
|||||||||
| Kinase | 22632.AA | CAMK | 108-243 | 18 | 1.1e-15 | 46.36 | In-house | 1-216 (425) | Show / Hide |
Range on Protein: 108-243 Range on HMM: 1-216/425 Sequence Identity: 18% (40 aa) YLGSGKQGWVLLAKELSTN------------RRFAIKGLHVKDSQGKI----------------------FQETFDQAQQEINMLEKCKG------SSYV ||.| | | |... .|. ...||| . | ..| ... .. ..||... |..| . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNLLKVIEG-------------------KEFKYLIL---SECQGT-----LLELIDKCPN-------------KRLNELSAIKYAKDIAEGLLYMHSQKC ..|. |.| ... |... |.| |.. | . .. .|..| | .| . |.... |.||.. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI ISNDLKMDNILIDYNG . ||| .|||.|.|. VHRDLKPENILLDDNN |
|||||||||
| Kinase | 22632.AA | STE | 103-228 | 16 | 2.1e-14 | 47.38 | In-house | 1-174 (359) | Show / Hide |
Range on Protein: 103-228 Range on HMM: 1-174/359 Sequence Identity: 16% (29 aa) FSDFKYLGSGKQGWVLLAKEL------STNRR---------FAIKGLHVKDSQ-----------GKIFQETFDQAQQEINMLEKCKG-SSYVVNLLKVIE . . . .|.| | | .|. .|.. .||| ....... ....| ..| ..||... ||. . ..|. . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------EFKYLILSECQ-GTLLELID---KCPN---------KRLNELSAIKYAKDIAEG-LLYMHSQKCI . . .... . |.| ..|. .|.. .|..| ......| .| | | ||.. | KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHII |
|||||||||
| Kinase | 22632.AA | Ciliate-E2 | 103-239 | 18 | 4.3e-14 | 44.74 | In-house | 1-194 (365) | Show / Hide |
Range on Protein: 103-239 Range on HMM: 1-194/365 Sequence Identity: 18% (36 aa) FSDFKYLGSGKQGWVLLAKELSTNRRFA--------------------IKGLHVKDSQGKIFQETFDQAQQEIN----------MLEKCKGSSYVVNLLK . | .|.| .| | ..| .....|| |. . .. ....... .. .||| .||. . . ..... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE VIE--GKEFKYLILSECQG-TLLELIDKCPNKR---------LNELSAIKYAKDIAE---------------GLLYMHSQK-CISNDLKMDNILI . . .. ||.. ||| .|...| ... || ..| .... | |.. .| |.||.. .| |.| .|||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF |
|||||||||
| Kinase | 22632.AA | S_TKc | 103-375 | 16 | 3.4e-13 | 16.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 103-375
Range on HMM: 1-231/231
Sequence Identity: 16% (52 aa)
FSDFKYLGSGKQGWVLLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKCKGSSYVVNLLKVIEGKEFKYLILSECQG---TLLELIDKCP
. . .|.| | | .... .|.|..||| .. .....||..|.| . ..|.|. |.. .. |... | | .|...|.|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNELSAIKYAKDIAEGLLYMHSQKCISNDLKMDNILID-------------YNGNAVQGNLLFQAPECYDPQGFKDYQDKYQE----------
.. ..| | .|.. |...| |.||.. | ||| .|||.| . . . | . . ||| .|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGC
-LGLKISTKPTIKLVSLIDQLIDLYIQQTLSMLGTGGSYLIYLMVQDFKNELIFKKYQPLNYSIEFQQFTYKNQLKFIIDGLTQFKPEDRLSIKDVLI--
| .. .| ... ... . ..| .|... |. ||.|... ..|
ILYEMLCGYPPFP-------QMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE
---ILKGII
. .
WDIKCHPWF
|
|||||||||
| Kinase | 22632.AA | CMGC | 103-243 | 18 | 1.6e-12 | 36.52 | In-house | 1-221 (513) | Show / Hide |
Range on Protein: 103-243 Range on HMM: 1-221/513 Sequence Identity: 18% (42 aa) FSDFKYLGSGKQGWVLLAKE--------------LSTNRRFAIK---GLHVKDSQGK--IFQETFD-QAQQEINMLEKCK----------------GSSY . |..|.| | | .. ||.. ||| . .. |.| | . | |. || .|.. . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVNLLKVIEGKEFK-----------------YLILSECQGTLLELIDKCP-------NKRLNELS------------AIKYA------KDIAEGLL--YM .|.|. .. |. . ||. .. .|...|.... .. |.| .. . | .|| |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSQK--CISNDLKMDNILIDYNG ||.. | ||| ||||. |. HSHWGNIIHRDLKPENILINHNC |
|||||||||
| Kinase | 22632.AA | Aur | 188-244 | 44 | 7.1e-10 | 21.71 | In-house | 83-140 (257) | Show / Hide |
Range on Protein: 188-244 Range on HMM: 83-140/257 Sequence Identity: 44% (26 aa) QGTLLELIDKCPNKRLNELSAIKYAKDIAEGLLYMHSQKCISNDLKMDNILID-YNGN .|.| ... | ||||..| | || ..|...| |.||.. | |.| |||.| ||| GGELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGN |
|||||||||
| Kinase | 22632.AA | Aur | 103-132 | 46 | 5e-07 | 14.05 | In-house | 1-30 (257) | Show / Hide |
Range on Protein: 103-132 Range on HMM: 1-30/257 Sequence Identity: 46% (14 aa) FSDFKYLGSGKQGWVLLAKELSTNRRFAIK | | || || | | ||.. .|. .||.| FEIGKPLGKGKFGNVYLARHKKTHFIFALK |
|||||||||
| Kinase | 22632.AA | TyrKc | 103-301 | 15 | 0.000101 | -146.28 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 103-301
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)
FSDFKYLGSGKQGWVLLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKC-KGSSYVVNLLKVIEGKE------FKYLILSE--CQGTLLE
. | ||.| | | ... . |.| |. .| | .|.... | . .|.|. |. .. ..|. | . | |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
LIDKCPNKRLNELSAIKYAKDIAEGLLYMHSQKCISNDLKMDNILIDYNG-----------NAVQG-------NLLFQ---------------APECYDP
. |. .| |. .... .||.| | ||..|| || |.|.. |. . . . |||| .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
Q---------------------GFKDYQD------------KYQELG--LKISTK--------PTIKLVSLIDQLIDL---------YIQQTL
| . | . .| . | ... . .. ... | . | . .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
|
|||||||||