24183

Species: Tetrahymena
Alias: TTHERM_01689280, 24183, 41, 562.m00002, PreTt24183
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
24183.AA Protein None 483 None Fasta, JSON
24183.kin_dom Protein Kinase Domain None 154 None Fasta, JSON
24183.NA RNA None 1452 None Fasta, JSON

Protein domain

Protein domains of 24183.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24183.AA Ciliate-C7 22-177 56 7.3e-79 252.55 In-house 14-142 (164) Show / Hide
Range on Protein: 22-177
Range on HMM: 14-142/164
Sequence Identity: 56% (88 aa)

LAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIHLLMHKLNGISRQKIGT
|||...|| ||||||. ..|...|.|| |..||||||..|.|||.|||| .|||..||...|.|||.||.|                           ||
LAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG---------------------------GT

LSDIIKNTQNQRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAV
|..||...||.||||.||||| ||||.|||.||||.|.||||||||||||||||||
LNQIIERNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAV

Kinase 24183.AA Ciliate-E2-Unclassified 120-178 25 1.8e-10 32.58 In-house 106-187 (352) Show / Hide
Range on Protein: 120-178
Range on HMM: 106-187/352
Sequence Identity: 25% (21 aa)

GTLSDIIKNTQN---------------QRLNELSAI-----KYTKDIAEGLYFIHSKK-CLVNDLKMDNILIDYNGN--AVK
|.|...||.  .               ... |  |.     .|.. | .|| ..|.|. ..  |.| .|||.| ||.   .|
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIK

Kinase 24183.AA STE-Unique 120-177 31 6.2e-10 30.88 In-house 379-450 (616) Show / Hide
Range on Protein: 120-177
Range on HMM: 379-450/616
Sequence Identity: 31% (23 aa)

GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKK--CLVNDLKMDNILIDYNG-----NAV
|||..|||..         | . |  .|.||. |.||| ..||..   .  ||| .||...  |     ...
GTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVK

Kinase 24183.AA Ciliate-E2 120-178 22 1.4e-08 25.59 In-house 119-196 (365) Show / Hide
Range on Protein: 120-178
Range on HMM: 119-196/365
Sequence Identity: 22% (19 aa)

GTLSDIIKNT----------QNQRLNELSAIKYTKDIAE---------------GLYFIHSKK-CLVNDLKMDNILIDYNGNAVK
|.| |.|||           . ....|  .....| |..               .| ..|||. ..  |.| .|||.      .|
GDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IK

Kinase 24183.AA urchA 145-170 61 1.4e-08 23.92 In-house 116-141 (208) Show / Hide
Range on Protein: 145-170
Range on HMM: 116-141/208
Sequence Identity: 61% (16 aa)

DIAEGLYFIHSKKCLVNDLKMDNILI
||||||  .|.|  |.|||| ||.|.
DIAEGLKVMHEKGFLCNDLKEDNCLV

S_TKc 24183.AA S_TKc 11-303 17 2.8e-08 -55.42 SMART 1-231 (231) Show / Hide
Range on Protein: 11-303
Range on HMM: 1-231/231
Sequence Identity: 17% (56 aa)

HEMVKELKD-----XXLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIH
 |.....         ....|.|....||| |.              ....|||.| .  . |.. .|.  ..  |....|.  | |             
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDG-------------

LLMHKLNGISRQKIGTLSDIIKNTQNQR----LNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVK--------------GNVIFQAPE
              |.| |.||. . ..    ..|  | .|.. |...| ..||.. .  ||| .|||.|     .|              |   . |||
------------DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQLTTFCGTPWYMAPE

CYDPSKFDIYSQEYMNLGVPVQQNPSQRVFYRQNLINIQKIYYINL-KSEACSLGYLLYTMISGFQANLVFSKHQPLQYNADFQNLAYEKQLRYIIDGLT
                                            .  |.   |.| .|| |..|             |... |...   .... .|... 
VL----------------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-SPEAKDFIRKCL

KFIPRERLKVKEALI---------VL
.. |..|. . |||           .
QKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 24183.AA ULK 120-173 30 5.4e-08 24.1 In-house 105-166 (329) Show / Hide
Range on Protein: 120-173
Range on HMM: 105-166/329
Sequence Identity: 30% (19 aa)

GTLSDIIKNTQN--------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYN
|.|...||. ..        .||.|  ||.. |.|..|. ..|....   |.| .||||. .
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG

Kinase 24183.AA Pkinase 120-178 33 7.1e-08 28.92 Pfam 85-152 (293) Show / Hide
Range on Protein: 120-178
Range on HMM: 85-152/293
Sequence Identity: 33% (23 aa)

G----TLSDIIKNTQNQRL--NELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNA---VK
|     |.|.|.  .. ..   |  ...| . |..||...||....  ||| .||||| ||.    ||
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK

Kinase 24183.AA CAMK 22-89 14 3.5e-07 18.42 In-house 12-140 (425) Show / Hide
Range on Protein: 22-89
Range on HMM: 12-140/425
Sequence Identity: 14% (19 aa)

LAKEKSTN------------KRYAIKGIPIKDSKDNV----------------------DQVILGQVQQEIQMLNQCKG------SPYVANLLHKIEG--
|...|.|.            ...||| |. |  ||..                      ... . .|..||.......|       | . .|.. .|   
LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPH

-----------------NDYIFLVL--TE
                 ......|.  .|
YFKNTNDYETSKQVFTKDKHMYMVMEIME

Kinase 24183.AA STE 120-178 29 8.6e-07 20.14 In-house 122-187 (359) Show / Hide
Range on Protein: 120-178
Range on HMM: 122-187/359
Sequence Identity: 29% (21 aa)

GTLSDIIK---NTQN---------QRLNELSAIKYTKDIAEG-LYFIHSKKCLVNDLKMDNILIDYNGNAVK
|.|.||||    ...         .|..|   ......| .| ||..||..    |.| .|||.      ||
GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VK

Kinase 24183.AA ULK 120-173 31 2e-06 19.26 In-house 102-162 (324) Show / Hide
Range on Protein: 120-173
Range on HMM: 102-162/324
Sequence Identity: 31% (19 aa)

GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYN
|.|...||. ..       .||.|  ||.. |.|..|. ..|....   |.| .||||  .
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNG

Kinase 24183.AA CAMKL 120-178 32 2e-06 16.73 In-house 106-169 (297) Show / Hide
Range on Protein: 120-178
Range on HMM: 106-169/297
Sequence Identity: 32% (21 aa)

GT--LSDIIKNTQN--QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGN-AVK
|   | | |..  .  .|. |  | .| . | ......||..    |.| .|||.|.|||  .|
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIK

Kinase 24183.AA ULK 28-87 21 9e-06 16.57 In-house 26-96 (324) Show / Hide
Range on Protein: 28-87
Range on HMM: 26-96/324
Sequence Identity: 21% (15 aa)

T-NKRYAIKGIP---IKDSKDNVD-QVILGQVQQEIQMLNQCK--GSPY--VANLLHKIEGN--DYIFLVL
| |. .|.| |.   ....| . . |... . ..||| . . |   .|.  .  |..  |    ..|....
TQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM

Kinase 24183.AA ULK 24-87 16 2.3e-05 14.81 In-house 20-99 (329) Show / Hide
Range on Protein: 24-87
Range on HMM: 20-99/329
Sequence Identity: 16% (13 aa)

KEKST---NKRYAIKGIPIK-DSKDNVD---QVILGQVQQEIQMLNQCK---GSPY----VANLLHKIEGN--DYIFLVL
..|.    |. .|.| |...  ...| .   |... ....||. . . |   ....    .  |..  |    ..|....
NKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

Kinase 24183.AA STE 25-74 16 2.5e-05 14.92 In-house 35-96 (359) Show / Hide
Range on Protein: 25-74
Range on HMM: 35-96/359
Sequence Identity: 16% (10 aa)

EKSTNKRYAIKGIPIKDSK-----------DNVDQVILGQVQQEIQMLNQCKG-SPYVANLL
...|....||| .......           .|... .. |...||.....|.  .|.. . .
NGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY

Kinase 24183.AA CAMK 125-178 21 0.000685 7.63 In-house 155-236 (425) Show / Hide
Range on Protein: 125-178
Range on HMM: 155-236/425
Sequence Identity: 21% (18 aa)

IIKNTQN------------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNG----------------NAVK
|......             |..|  | .| . |.... ..||..    ||| .|||.|.|.                | .|
IVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK

Kinase 24183.AA Pkinase 22-87 27 0.002812 12.67 Pfam 17-79 (293) Show / Hide
Range on Protein: 22-87
Range on HMM: 17-79/293
Sequence Identity: 27% (19 aa)

LAKEKSTNKRYAIKGIPIKDSKDNVDQVI--LGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVL
....|.|.|..|.| |. .. |...||    |    .|||... . ..|..  |..  | .|.| .|.
KCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVM

Kinase 24183.AA CAMKL 22-87 21 0.002884 6.11 In-house 17-100 (297) Show / Hide
Range on Protein: 22-87
Range on HMM: 17-100/297
Sequence Identity: 21% (18 aa)

LAKE-KSTNKRYAIKGIP--IKDSKDNVDQVILG-------QVQQEIQMLNQCK--GSPYVANLLHKIEGNDY------IFLVL
||.  . |....||| |    .  ......  .|        ...||| . . .  . | .  |.. ||  ..      |.||.
LATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

Kinase 24183.AA STE-Unique 22-74 20 0.016936 4.01 In-house 16-67 (616) Show / Hide
Range on Protein: 22-74
Range on HMM: 16-67/616
Sequence Identity: 20% (11 aa)

LAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLL
... |....|.||| |..|  ||        . . ||. .  .. ........
NCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH-HQNIVKYY