24609

Species: Tetrahymena
Alias: 9, PreTt24609, TTHERM_02013450, 24609, 936.m00002
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
24609.AA Protein None 315 None Fasta, JSON
24609.kin_dom Protein Kinase Domain None 174 None Fasta, JSON
24609.NA RNA None 947 None Fasta, JSON

Protein domain

Protein domains of 24609.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24609.AA Ciliate-C7 13-175 81 1.1e-123 398.2 In-house 1-164 (164) Show / Hide
Range on Protein: 13-175
Range on HMM: 1-164/164
Sequence Identity: 81% (133 aa)

FRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN
||||||| |||||||||.||||| |||||||||.|||.|.|.||.|.||..|||.|.||||||.|..|||||||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYM
||||||||.||||||||||||.|.|||||||||||||.|||||.||||||||..||.|..||||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM

Pkinase 24609.AA Pkinase 10-184 28 2e-27 98.08 Pfam 1-181 (293) Show / Hide
Range on Protein: 10-184
Range on HMM: 1-181/293
Sequence Identity: 28% (54 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLTQILER
|   | .|.|  | | .... .|. .||.| . .|.   . |. . ..  .|..|.|.. ..|..| |.| ||  .  |.|.  |.|      |  ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLADNL-INKSGYAMNQYMGNFLYQAPE
 .....   |  ...|.  |..||.|.||....  ||| .||||| .|.      ..|||||  . . ...  |. . |   | |||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPE

Kinase 24609.AA CAMK 15-184 18 1.3e-24 75.65 In-house 1-290 (425) Show / Hide
Range on Protein: 15-184
Range on HMM: 1-290/425
Sequence Identity: 18% (55 aa)

FLGQGVQGLVLLAKDSKTN------------MRVAIKGVQV----------------RDPQGNLD------EDLNNRVKQEVEILKKCR------DSPYV
 ||.|  | | |... .|.             .|||| .                  .| ... .      .    .|..|.||.||..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLIDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNLINKS----------------------GYAMNQYMGNFLYQA-PE
   ||| .|||.|..                 .|  ..|||.|  .. ..                      |  |. . |   | | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

Kinase 24609.AA Ciliate-E1 16-185 21 5e-24 75.32 In-house 1-181 (202) Show / Hide
Range on Protein: 16-185
Range on HMM: 1-181/202
Sequence Identity: 21% (39 aa)

LGQGVQGLVLLAKDSKTN-MRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLTQILE---------
.|.| ...|. ||  ..|   ||.| ..... .   ......  |.. .|.|  .   |.. .||... .|  ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPEC
  ..... ...   .. . .. .|| ..|..  .  |.|..||||.  || | .|||....|.|.. . ...      |. ||.
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ

Kinase 24609.AA CAMKL 10-186 26 5.4e-24 73.32 In-house 1-205 (297) Show / Hide
Range on Protein: 10-186
Range on HMM: 1-205/297
Sequence Identity: 26% (55 aa)

YSDFRFLGQGVQGLVLLAKD-SKTNMRVAIKGVQVR----DPQGNLD------EDLNNRVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV
|   . ||.|  | | ||.. . |. .|||| .  .    ||. .        |.   |...|..|.|. .    | ...| . .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLADNLI---NKSGYAMNQYMGNFLY
.  |.|    | . .... ..|  . |  | .|   |  ...|.||.     |.| .|||.|..|  |. ..|||..   .   ...|  ..   |   |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

QAPECF
.||| |
MAPEIF

Kinase 24609.AA Ciliate-E2-Unclassified 10-187 20 4.9e-23 76.77 In-house 1-239 (352) Show / Hide
Range on Protein: 10-187
Range on HMM: 1-239/352
Sequence Identity: 20% (49 aa)

YSDFRFLGQGVQGLVLLAKDSKTN-------MRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFS
|   . .||| .| | .....|..       | ....  |    . . ..   .. ..|....|               .  ..|..| ....|. .|  
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EI---MNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI

YLVLTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLADN
|.|.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|  ..  |.| .|||.|  |   .  ..|||.. .
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

LINKSGYA--------------MNQYMGNFLYQ----APECFD
... ...               |.. .|.  |.    |||...
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ

S_TKc 24609.AA S_TKc 10-273 21 2.2e-22 81.6 SMART 1-231 (231) Show / Hide
Range on Protein: 10-273
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLTQILERNQ
|   | .|.|  | | .... ||. .|||| .              .....|..||||  . |..| |.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPECFDPADP-----------
 ..    ..|  | .|.  |...| |.||.  .  ||| .|||.|   .  ..|||||  |        . . |   | ||| . . ..           
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI

----FIGKV-YHDEYQKLGFSVRQQPSNRGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFVPKNRMPIKEALI-----ILKGII
    . |.  .. ..|..   ..                                ...| .|... .. |..|. . |||       .   .
LYEMLCGYPPFP-QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 24609.AA Ciliate-E2 10-186 18 1e-21 71.29 In-house 1-259 (365) Show / Hide
Range on Protein: 10-186
Range on HMM: 1-259/365
Sequence Identity: 18% (50 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIK-------------GVQ-VRDPQGNLDEDLNNRVKQEVEILKKCR---------------DSPYVVSLIDQ
|   . .||| .| | ..|. |.. ..|||             .|.       .. ..  . .|||  |... .               ..|... ... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHGN
|.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||  ..  |.| .|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVVSDFGLADNLINK---------SGYAMNQY----------------------MGNFLYQAPECF
  ..||||. .. ..         ..  |.                         |.  |.||| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL

Kinase 24609.AA ULK 10-184 24 2.6e-20 67.7 In-house 1-221 (329) Show / Hide
Range on Protein: 10-184
Range on HMM: 1-221/329
Sequence Identity: 24% (55 aa)

YSDFRFLGQGVQGLVLLAKDSKT----NMRVAIKGVQ----VRDPQ---GNLDEDLNNRVKQEVEILKKCRD---SPY----VVSLIDQFEGQQF--SYL
|.  . ||.|  | |  ... ||    |  ||.| ..     ....   |   . . . .|.|..|.||  .   ...    .| |.| || ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLADNLINK--
..  |.| .| |....|..        |||.|  ||..  .|..|. ..|.. .   |.| .||||. .                ..|||.|  . |   
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

SGYAMNQYM------GNFLYQAPE
.   |  .       |  || ||.
EQQMMMTCVNEKRLCGTPLYMAPQ

Kinase 24609.AA ULK 10-160 25 6.3e-20 67.44 In-house 1-185 (324) Show / Hide
Range on Protein: 10-160
Range on HMM: 1-185/324
Sequence Identity: 25% (49 aa)

YSDFRFLGQGVQG-LVLLAKDSKT---NMRVAIKGVQ--------VRDPQGNLDEDLNNRVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL
|.  . ||.|  |  |  ... ||   |  ||.| ..         ... |   . . .  |.|..|.||     .|.  .| |.| || .   . |...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM

TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA
  |.| .| |....|..       |||.|  ||..  .|..|. ..|.. .   |.| .||||  .                ..|||.|
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

Kinase 24609.AA STE 10-184 18 4.1e-19 64.24 In-house 1-232 (359) Show / Hide
Range on Protein: 10-184
Range on HMM: 1-232/359
Sequence Identity: 18% (45 aa)

YSDFRFLGQGVQGLVLLAKDSK---------------TNMRVAIKGVQVRDPQGNLDE------------DLNNRVKQEVEILKKCRD-SPYVVSLIDQF
. . ...|.|  | | .|.. |               |. ..||| . ... . .  |            .  .....|..|.|||.. .|..|  .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EGQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLA
.         .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||.     |.| .|||.     .  .|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

DNLIN---------------KSGYAMNQYMGNFLYQAPE
 .|..                ..   |   |   . |||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE

Kinase 24609.AA SAK 10-163 30 3.6e-17 54.76 In-house 1-150 (254) Show / Hide
Range on Protein: 10-163
Range on HMM: 1-150/254
Sequence Identity: 30% (47 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNK
|     ||.|    |  ||  .| . |||| .  .  |.     . .||..||||  . .  | .. |   || . . ||||  |. | .   . ... .
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKT---GMVQRVRNEVEIHCQLKH-PSILELYNYFEDNNYVYLVLEMCHNGEMHRYM-KHRMR

RLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNL
   |  | .. ..|  |. |.||   .  || . |||.    .  . |||||  |
PFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQL

Kinase 24609.AA TyrKc 10-269 17 2.1e-07 -102.91 SMART 1-280 (280) Show / Hide
Range on Protein: 10-269
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE--CQGTLTQ
 .  . || |  | | ... .   . ||.| ..                 .| .|..|   . | .| |.     |.        .....|  . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILERNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINK------SGYAMNQY--MGNFL----YQAPECF--
 | ....| |.    .... .||.|  |.||| |   ||   |.|..  . . .|||||. .. ..      . | . .    |...      ||||.  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

---------------------DPADPFIG-----KVYHDEYQKLGFS-VRQQPSN----RGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFV
                     . . |  |     .   . ....     . || |                        |     .. .  |.    .. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F--VCCPDEMYQIMKQCWHED

PKNRMPIKEALIIL
|..|   .|   ..
PEDRPTFSEIHECF