29587

Species: Tetrahymena
Alias: TTHERM_01246670, PreTt29587, 29587, 761, 289.m00014
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
29587.AA Protein None 544 None Fasta, JSON
29587.kin_dom Protein Kinase Domain None 174 None Fasta, JSON
29587.NA RNA None 1635 None Fasta, JSON

Protein domain

Protein domains of 29587.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29587.AA Ciliate-C7 78-240 81 1.3e-125 404.47 In-house 1-164 (164) Show / Hide
Range on Protein: 78-240
Range on HMM: 1-164/164
Sequence Identity: 81% (134 aa)

FRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN
||||||| |||||||||.|||||||||||||||.|||.|.|.||.|.||..|||.|.||||||.|..|||||||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYM
||||||||.||||||||||||.|.|||||||||||||.|||||.||||||||..||.|..||||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM

Pkinase 29587.AA Pkinase 75-249 28 2.7e-27 97.6 Pfam 1-181 (293) Show / Hide
Range on Protein: 75-249
Range on HMM: 1-181/293
Sequence Identity: 28% (53 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLTQILER
|   | .|.|  | | .... .|. ..|.| . .|.   . |. . ..  .|..|.|.. ..|..| |.| ||  .  |.|.  |.|      |  ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLADNL-INKSGYAMNQYMGNFLYQAPE
 .....   |  ...|.  |..||.|.||....  ||| .||||| .|.      ..|||||  . . ...  |. . |   | |||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPE

Kinase 29587.AA CAMK 80-249 18 2.1e-24 74.92 In-house 1-290 (425) Show / Hide
Range on Protein: 80-249
Range on HMM: 1-290/425
Sequence Identity: 18% (54 aa)

FLGQGVQGLVLLAKDSKTN------------MRYAIKGVQV----------------RDPQGNLD------EDLNNRVKQEVEILKKCR------DSPYV
 ||.|  | | |... .|.             ..||| .                  .| ... .      .    .|..|.||.||..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLIDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNLINKS----------------------GYAMNQYMGNFLYQA-PE
   ||| .|||.|..                 .|  ..|||.|  .. ..                      |  |. . |   | | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

Kinase 29587.AA Ciliate-E1 81-250 20 1.5e-23 73.8 In-house 1-181 (202) Show / Hide
Range on Protein: 81-250
Range on HMM: 1-181/202
Sequence Identity: 20% (38 aa)

LGQGVQGLVLLAKDSKTN-MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLTQILE---------
.|.| ...|. ||  ..|   .|.| ..... .   ......  |.. .|.|  .   |.. .||... .|  ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPEC
  ..... ...   .. . .. .|| ..|..  .  |.|..||||.  || | .|||....|.|.. . ...      |. ||.
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ

Kinase 29587.AA CAMKL 75-251 26 5.1e-23 70.17 In-house 1-205 (297) Show / Hide
Range on Protein: 75-251
Range on HMM: 1-205/297
Sequence Identity: 26% (54 aa)

YSDFRFLGQGVQGLVLLAKD-SKTNMRYAIKGVQVR----DPQGNLD------EDLNNRVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV
|   . ||.|  | | ||.. . |. ..||| .  .    ||. .        |.   |...|..|.|. .    | ...| . .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLADNLI---NKSGYAMNQYMGNFLY
.  |.|    | . .... ..|  . |  | .|   |  ...|.||.     |.| .|||.|..|  |. ..|||..   .   ...|  ..   |   |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

QAPECF
.||| |
MAPEIF

Kinase 29587.AA Ciliate-E2-Unclassified 75-252 21 9.7e-23 75.72 In-house 1-239 (352) Show / Hide
Range on Protein: 75-252
Range on HMM: 1-239/352
Sequence Identity: 21% (51 aa)

YSDFRFLGQGVQGLVLLAKDSKTN----MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFSYLV
|   . .||| .| | .....|..    | |..|  .. . | .  .   .. ..|....|               .  ..|..| ....|. .|  |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLADNLIN
.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|  ..  |.| .|||.|  |   .  ..|||.. ....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

KSGYA--------------MNQYMGNFLYQ----APECFD
 ...               |.. .|.  |.    |||...
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ

S_TKc 29587.AA S_TKc 75-338 21 2.8e-22 81.25 SMART 1-231 (231) Show / Hide
Range on Protein: 75-338
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLTQILERNQ
|   | .|.|  | | .... ||. ..||| .              .....|..||||  . |..| |.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPECFDPADP-----------
 ..    ..|  | .|.  |...| |.||.  .  ||| .|||.|   .  ..|||||  |        . . |   | ||| . . ..           
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI

----FIGKV----YHDEYQKLGVSVRQQPSNRGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFVPKDRMPIKEALI-----ILKGII
    . |.     ..  ..|.|                                    ...| .|... .. |..|. . |||       .   .
LYEMLCGYPPFPQMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 29587.AA Ciliate-E2 75-251 18 6.3e-22 72.04 In-house 1-259 (365) Show / Hide
Range on Protein: 75-251
Range on HMM: 1-259/365
Sequence Identity: 18% (50 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIK-------------GVQ-VRDPQGNLDEDLNNRVKQEVEILKKCR---------------DSPYVVSLIDQ
|   . .||| .| | ..|. |.. ..|||             .|.       .. ..  . .|||  |... .               ..|... ... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHGN
|.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||  ..  |.| .|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVVSDFGLADNLINK---------SGYAMNQY----------------------MGNFLYQAPECF
  ..||||. .. ..         ..  |.                         |.  |.||| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL

Kinase 29587.AA ULK 75-249 24 1.4e-19 65.09 In-house 1-221 (329) Show / Hide
Range on Protein: 75-249
Range on HMM: 1-221/329
Sequence Identity: 24% (54 aa)

YSDFRFLGQGVQGLVLLAKDSKT----NMRYAIKGVQ----VRDPQ---GNLDEDLNNRVKQEVEILKKCRD---SPY----VVSLIDQFEGQQF--SYL
|.  . ||.|  | |  ... ||    |  .|.| ..     ....   |   . . . .|.|..|.||  .   ...    .| |.| || ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLADNLINK--
..  |.| .| |....|..        |||.|  ||..  .|..|. ..|.. .   |.| .||||. .                ..|||.|  . |   
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

SGYAMNQYM------GNFLYQAPE
.   |  .       |  || ||.
EQQMMMTCVNEKRLCGTPLYMAPQ

Kinase 29587.AA ULK 75-225 25 2.7e-19 65.18 In-house 1-185 (324) Show / Hide
Range on Protein: 75-225
Range on HMM: 1-185/324
Sequence Identity: 25% (48 aa)

YSDFRFLGQGVQG-LVLLAKDSKT---NMRYAIKGVQ--------VRDPQGNLDEDLNNRVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL
|.  . ||.|  |  |  ... ||   |  .|.| ..         ... |   . . .  |.|..|.||     .|.  .| |.| || .   . |...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM

TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA
  |.| .| |....|..       |||.|  ||..  .|..|. ..|.. .   |.| .||||  .                ..|||.|
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

Kinase 29587.AA STE 75-249 18 1.4e-18 62.27 In-house 1-232 (359) Show / Hide
Range on Protein: 75-249
Range on HMM: 1-232/359
Sequence Identity: 18% (45 aa)

YSDFRFLGQGVQGLVLLAKDSK---------------TNMRYAIKGVQVRDPQGNLDE------------DLNNRVKQEVEILKKCRD-SPYVVSLIDQF
. . ...|.|  | | .|.. |               |. ..||| . ... . .  |            .  .....|..|.|||.. .|..|  .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EGQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLA
.         .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||.     |.| .|||.     .  .|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

DNLIN---------------KSGYAMNQYMGNFLYQAPE
 .|..                ..   |   |   . |||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE

Kinase 29587.AA CMGC 75-225 18 6.4e-17 51.25 In-house 1-251 (513) Show / Hide
Range on Protein: 75-225
Range on HMM: 1-251/513
Sequence Identity: 18% (47 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMR--------------YAIKGVQVRDPQGN------LDEDLNNRVKQEVEILKKCR----------------DSPY
|   . .|.|  | |  ..| .|| .              .||| .  .    .      . . .. |   |..|||. .                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVSLIDQFEGQQFS-----------------YLVLTECQGTLTQILERNQ-------NKRLNEIS------------AIKYA------NDIAQGLY--YI
.|.|.| |   .                   |||   .. .| |....||       .. |.|                ..         | .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSKS--CLVNDLKMDNILIDYHGNA--------------------VVSDFGLA
||.    .  |||  ||||.  .                       . |||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA

Kinase 29587.AA TyrKc 75-334 17 4.1e-07 -107.61 SMART 1-280 (280) Show / Hide
Range on Protein: 75-334
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE--CQGTLTQ
 .  . || |  | | ... .   .  |.| ..                 .| .|..|   . | .| |.     |.        .....|  . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILERNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINK------SGYAMNQY--MGNFL----YQAPECF--
 | ....| |.    .... .||.|  |.||| |   ||   |.|..  . . .|||||. .. ..      . | . .    |...      ||||.  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

---------------------DPADPFIG-----KVYHDEYQKLGVS-VRQQPSN----RGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFV
                     . . |  |     .   . ....     . || |                        |     .. .  |.    .. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F--VCCPDEMYQIMKQCWHED

PKDRMPIKEALIIL
|.||   .|   ..
PEDRPTFSEIHECF