Gene 29589 (Tetrahymena)

29589

Species: Tetrahymena
Alias: 760, 29589, PreTt29589, TTHERM_01246690, 289.m00016
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
29589.AA Protein None 434 None Fasta, JSON
29589.kin_dom Protein Kinase Domain None 174 None Fasta, JSON
29589.NA RNA None 1305 None Fasta, JSON

Protein domain

Protein domains of 29589.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29589.AA Ciliate-C7 78-240 81 1.3e-125 404.47 In-house 1-164 (164) Show / Hide 
Range on Protein: 78-240
Range on HMM: 1-164/164
Sequence Identity: 81% (134 aa)

FRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN
||||||| |||||||||.|||||||||||||||.|||.|.|.||.|.||..|||.|.||||||.|..|||||||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYM
||||||||.||||||||||||.|.|||||||||||||.|||||.||||||||..||.|..||||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Pkinase 29589.AA Pkinase 75-249 28 2.7e-27 97.6 Pfam 1-181 (293) Show / Hide 
Range on Protein: 75-249
Range on HMM: 1-181/293
Sequence Identity: 28% (53 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLTQILER
|   | .|.|  | | .... .|. ..|.| . .|.   . |. . ..  .|..|.|.. ..|..| |.| ||  .  |.|.  |.|      |  ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLADNL-INKSGYAMNQYMGNFLYQAPE
 .....   |  ...|.  |..||.|.||....  ||| .||||| .|.      ..|||||  . . ...  |. . |   | |||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPE
Kinase 29589.AA CAMK 80-249 18 2.1e-24 74.92 In-house 1-290 (425) Show / Hide 
Range on Protein: 80-249
Range on HMM: 1-290/425
Sequence Identity: 18% (54 aa)

FLGQGVQGLVLLAKDSKTN------------MRYAIKGVQV----------------RDPQGNLD------EDLNNRVKQEVEILKKCR------DSPYV
 ||.|  | | |... .|.             ..||| .                  .| ... .      .    .|..|.||.||..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLIDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNLINKS----------------------GYAMNQYMGNFLYQA-PE
   ||| .|||.|..                 .|  ..|||.|  .. ..                      |  |. . |   | | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
Kinase 29589.AA Ciliate-E1 81-250 20 1.5e-23 73.8 In-house 1-181 (202) Show / Hide 
Range on Protein: 81-250
Range on HMM: 1-181/202
Sequence Identity: 20% (38 aa)

LGQGVQGLVLLAKDSKTN-MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLTQILE---------
.|.| ...|. ||  ..|   .|.| ..... .   ......  |.. .|.|  .   |.. .||... .|  ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPEC
  ..... ...   .. . .. .|| ..|..  .  |.|..||||.  || | .|||....|.|.. . ...      |. ||.
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ
Kinase 29589.AA CAMKL 75-251 26 5.1e-23 70.17 In-house 1-205 (297) Show / Hide 
Range on Protein: 75-251
Range on HMM: 1-205/297
Sequence Identity: 26% (54 aa)

YSDFRFLGQGVQGLVLLAKD-SKTNMRYAIKGVQVR----DPQGNLD------EDLNNRVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV
|   . ||.|  | | ||.. . |. ..||| .  .    ||. .        |.   |...|..|.|. .    | ...| . .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLADNLI---NKSGYAMNQYMGNFLY
.  |.|    | . .... ..|  . |  | .|   |  ...|.||.     |.| .|||.|..|  |. ..|||..   .   ...|  ..   |   |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

QAPECF
.||| |
MAPEIF
Kinase 29589.AA Ciliate-E2-Unclassified 75-252 21 9.7e-23 75.72 In-house 1-239 (352) Show / Hide 
Range on Protein: 75-252
Range on HMM: 1-239/352
Sequence Identity: 21% (51 aa)

YSDFRFLGQGVQGLVLLAKDSKTN----MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFSYLV
|   . .||| .| | .....|..    | |..|  .. . | .  .   .. ..|....|               .  ..|..| ....|. .|  |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLADNLIN
.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|  ..  |.| .|||.|  |   .  ..|||.. ....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

KSGYA--------------MNQYMGNFLYQ----APECFD
 ...               |.. .|.  |.    |||...
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
S_TKc 29589.AA S_TKc 75-338 20 6.1e-22 80.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-338
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLTQILERNQ
|   | .|.|  | | .... ||. ..||| .              .....|..||||  . |..| |.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPECFDPADP-----------
 ..    ..|  | .|.  |...| |.||.  .  ||| .|||.|   .  ..|||||  |        . . |   | ||| . . ..           
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI

----FIGKV-YHDEYLKLGVSVRQQPSNRGIDLSFTQNKHKPLNYDGEFKNFVYHKQLKYIIDGLTNFVPKNRMPIKEALI-----ILKGII
    . |.  .. .. ..   ..                                ...| .|... .. |..|. . |||       .   .
LYEMLCGYPPFP-QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29589.AA Ciliate-E2 75-251 18 6.3e-22 72.04 In-house 1-259 (365) Show / Hide 
Range on Protein: 75-251
Range on HMM: 1-259/365
Sequence Identity: 18% (50 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIK-------------GVQ-VRDPQGNLDEDLNNRVKQEVEILKKCR---------------DSPYVVSLIDQ
|   . .||| .| | ..|. |.. ..|||             .|.       .. ..  . .|||  |... .               ..|... ... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHGN
|.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||  ..  |.| .|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVVSDFGLADNLINK---------SGYAMNQY----------------------MGNFLYQAPECF
  ..||||. .. ..         ..  |.                         |.  |.||| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL
Kinase 29589.AA ULK 75-249 24 1.4e-19 65.09 In-house 1-221 (329) Show / Hide 
Range on Protein: 75-249
Range on HMM: 1-221/329
Sequence Identity: 24% (54 aa)

YSDFRFLGQGVQGLVLLAKDSKT----NMRYAIKGVQ----VRDPQ---GNLDEDLNNRVKQEVEILKKCRD---SPY----VVSLIDQFEGQQF--SYL
|.  . ||.|  | |  ... ||    |  .|.| ..     ....   |   . . . .|.|..|.||  .   ...    .| |.| || ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLADNLINK--
..  |.| .| |....|..        |||.|  ||..  .|..|. ..|.. .   |.| .||||. .                ..|||.|  . |   
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

SGYAMNQYM------GNFLYQAPE
.   |  .       |  || ||.
EQQMMMTCVNEKRLCGTPLYMAPQ
Kinase 29589.AA ULK 75-225 25 2.7e-19 65.18 In-house 1-185 (324) Show / Hide 
Range on Protein: 75-225
Range on HMM: 1-185/324
Sequence Identity: 25% (48 aa)

YSDFRFLGQGVQG-LVLLAKDSKT---NMRYAIKGVQ--------VRDPQGNLDEDLNNRVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL
|.  . ||.|  |  |  ... ||   |  .|.| ..         ... |   . . .  |.|..|.||     .|.  .| |.| || .   . |...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM

TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA
  |.| .| |....|..       |||.|  ||..  .|..|. ..|.. .   |.| .||||  .                ..|||.|
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 29589.AA STE 75-249 18 1.4e-18 62.27 In-house 1-232 (359) Show / Hide 
Range on Protein: 75-249
Range on HMM: 1-232/359
Sequence Identity: 18% (45 aa)

YSDFRFLGQGVQGLVLLAKDSK---------------TNMRYAIKGVQVRDPQGNLDE------------DLNNRVKQEVEILKKCRD-SPYVVSLIDQF
. . ...|.|  | | .|.. |               |. ..||| . ... . .  |            .  .....|..|.|||.. .|..|  .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EGQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLA
.         .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||.     |.| .|||.     .  .|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

DNLIN---------------KSGYAMNQYMGNFLYQAPE
 .|..                ..   |   |   . |||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 29589.AA CMGC 75-225 18 6.4e-17 51.25 In-house 1-251 (513) Show / Hide 
Range on Protein: 75-225
Range on HMM: 1-251/513
Sequence Identity: 18% (47 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMR--------------YAIKGVQVRDPQGN------LDEDLNNRVKQEVEILKKCR----------------DSPY
|   . .|.|  | |  ..| .|| .              .||| .  .    .      . . .. |   |..|||. .                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVSLIDQFEGQQFS-----------------YLVLTECQGTLTQILERNQ-------NKRLNEIS------------AIKYA------NDIAQGLY--YI
.|.|.| |   .                   |||   .. .| |....||       .. |.|                ..         | .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSKS--CLVNDLKMDNILIDYHGNA--------------------VVSDFGLA
||.    .  |||  ||||.  .                       . |||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 29589.AA TyrKc 75-334 16 9.2e-07 -113.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 75-334
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE--CQGTLTQ
 .  . || |  | | ... .   .  |.| ..                 .| .|..|   . | .| |.     |.        .....|  . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILERNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINK------SGYAMNQY--MGNFL----YQAPECF--
 | ....| |.    .... .||.|  |.||| |   ||   |.|..  . . .|||||. .. ..      . | . .    |...      ||||.  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

---------------------DPADPFIG-----KVYHDEYLKLGVS-VRQQPSN----RGIDLSFTQNKHKPLNYDGEFKNFVYHKQLKYIIDGLTNFV
                     . . |  |     .   . . ..     . || |                        |     .. .  |.    .. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F--VCCPDEMYQIMKQCWHED

PKNRMPIKEALIIL
|..|   .|   ..
PEDRPTFSEIHECF