Gene 4501 (Tetrahymena)
4501
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 4501.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 4501.AA | Ciliate-C7 | 109-271 | 79 | 3.1e-120 | 387.01 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 109-271 Range on HMM: 1-164/164 Sequence Identity: 79% (130 aa) FRFLGHGDYGLVLLAKDSKTNMRYAIKGVQVRDLDGNLEEDLNNQVKKEVEILKKCRESPYVVSLIDQFEGQQFSYLVLTECQ-GTLSQILERNQNKRLN |||||.| .||||||||.||||||||||||||| ||...|.||||..|..|||.|..|||||.|..|||||||.||||.||| |||.||.||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHGNAVVSDFGLADNLTSKSGYTINQYM ||||||||.||||||||||.||..|||||||||||||.|||||.||||||||| ||.|.||||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Kinase | 4501.AA | AGC | 109-256 | 24 | 7.3e-29 | 70.42 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 109-256 Range on HMM: 1-202/395 Sequence Identity: 24% (50 aa) FRFL---GHGDYGLVLLAKDS------KTNMRYAIKGVQ----VRDLDGNLEEDLNNQ--------VKKEVEILKKCRE---------SPYVVS-LIDQF |.|| | | .| | |... |. ||.| .. . ... | .| .. |..| .||.||. .|..|. | | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGQQF--SYLVLTECQ----------G-TLSQILERN-QNKRLNEISAIKYAND-------IAQGLYYIHQ-KNYLVND-LKMDNILIDYHGNAVVSDFG . .. |.|. .. | | ..| ...|..| | || |. .| |.|. ... | || .|||.| .|. .||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LA |. LC |
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| Kinase | 4501.AA | CAMK | 111-291 | 17 | 3.2e-27 | 84.17 | In-house | 1-313 (425) | Show / Hide |
Range on Protein: 111-291
Range on HMM: 1-313/425
Sequence Identity: 17% (54 aa)
FLGHGDYGLVLLAKDSKTN------------MRYAIKGVQVRDLDGNL----------------------EEDLNNQVKKEVEILKKCRE------SPYV
||.| .| | |... .|. ..||| . . |... .. .|..|.||.||... | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VSLIDQFEG-------------------QQFSYLVL---TECQGT------LSQILERNQN------------KRLNEISAIKYANDIAQGLYYIHQKNY
..|.. .| ... |.|. |.| .. | |. .. .|..| | .| |.... |.|..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNLTSKSGYT----------------------INQYMGNFLYQA-PECYDPA-----
||| .|||.|.. .| ..|||.| ........ . . | | | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
-------EPYIGK
.||.|.
QNATDEEKPYYGP
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| Kinase | 4501.AA | Ciliate-E1 | 112-297 | 21 | 1.6e-25 | 80.29 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 112-297 Range on HMM: 1-202/202 Sequence Identity: 21% (44 aa) LGHGDYGLVLLAKDSKTN-MRYAIKGVQVRDLDGNLEEDLNNQVKKEVE-ILKKCRESPYVVSLIDQFEGQQ--FSYLVLTECQGTLSQILE-------- .|.|....|. || ..| .|.| ..... | ... .....|| |.| .. |.. .||... .| ........|. .| . |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---RNQNKRLNEISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHGNAVVSDFGLADNLTSKSGYTINQYMGNFLYQAPECYD-----PAEPYIGK ..... ... .. . .. .|| ..||.| . |.|..||||. || | .|||....| ... ..... |. ||.| . .... . QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN IYHDEY . | | YKSDIY |
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| Kinase | 4501.AA | CAMKL | 106-291 | 24 | 2.1e-25 | 77.93 | In-house | 1-215 (297) | Show / Hide |
Range on Protein: 106-291 Range on HMM: 1-215/297 Sequence Identity: 24% (53 aa) YSDFRFLGHGDYGLVLLAKD-SKTNMRYAIKGVQ--VRDLDGNLE--------EDLNNQVKKEVEILKKCR--ESPYVVSLIDQFEGQQF------SYLV | . ||.| .| | ||.. . |. ..||| . .| . . |. ...|..|.|. . | ...| . .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQGT---LSQILERNQNKR--LNEISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHG--NAVVSDFGLADNLT---SKSGYTINQYMGNFLY . |.| | . .... ..| . | | .| | ...|.|... |.| .|||.|..| |. ..|||.. . ..| . . | | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY QAPECYDP-AEPYIGK .||| . .||.|. MAPEIFQGNNKPYDGP |
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| Pkinase | 4501.AA | Pkinase | 106-266 | 27 | 1.5e-24 | 87.93 | Pfam | 1-169 (293) | Show / Hide |
Range on Protein: 106-266 Range on HMM: 1-169/293 Sequence Identity: 27% (48 aa) YSDFRFLGHGDYGLVLLAKDSKTNMRYAIKGVQVRDLDGNLEED---LNNQVKKEVEILKKCRESPYVVSLIDQFEGQQFSYLVLTECQG-----TLSQI | | .| | .| | .... .|. ..|.| . .|. . . .. | |..|.|.. .|..| |.| || . |.|. |.| |. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY LERNQNKRL--NEISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHGNA----VVSDFGLADN--LTSKSGYT ... ..... | ...|. |..||.|.|... . ||| .||||| .|. ..||||| . ..| .| ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT |
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| S_TKc | 4501.AA | S_TKc | 106-377 | 21 | 1.8e-22 | 81.91 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 106-377 Range on HMM: 1-231/231 Sequence Identity: 21% (62 aa) YSDFRFLGHGDYGLVLLAKDSKTNMRYAIKGVQVRDLDGNLEEDLNNQVKKEVEILKKCRESPYVVSLIDQFEGQQFSYLVLTECQG---TLSQILERNQ | | .|.| .| | .... ||. ..||| . .....|..|||| |..| |.| |. .. |.|. | | .| ....... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG NKR----LNEISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHGNAVVSDFGLADNLTSKSGYTINQYMGNFLYQAPECYDPAEPYIGKIYHDEYL .. ..| | .|. |...| |.|... . ||| .|||.| . ..||||| | . . | | ||| | RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------------GYG K-------LGVCVKQEPSNRLFFDNYFLRINYNLVSNKHKELIYDDEFQNFVYHKQLKYIIEGLTNFVPKNRMPIKEALI-----ILKGII | .|... . . |. . .... ...| .|... .. |..|. . ||| . . KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 4501.AA | ULK | 106-280 | 23 | 4.1e-21 | 70.51 | In-house | 1-221 (329) | Show / Hide |
Range on Protein: 106-280 Range on HMM: 1-221/329 Sequence Identity: 23% (52 aa) YSDFRFLGHGDYGLVLLAKDSKT----NMRYAIKGVQVRDLDGNLE----EDLNNQVKKEVEILKKCR---ESPY----VVSLIDQFEGQQF--SYLVLT |. . ||.| .| | ... || | .|.| .. .. .. . . ...|.|..|.|| ... .| |.| || ... |... YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECQG-TLSQILERNQN--------KRLNEISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHGNAV------------VSDFGLADNLTSK--SGY |.| .|.|....|.. |||.| ||.. .|..|. ..|..|. |.| .||||. . ..|||.| ... . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ TINQYM------GNFLYQAPE . . | || ||. MMMTCVNEKRLCGTPLYMAPQ |
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| Kinase | 4501.AA | ULK | 106-256 | 26 | 4.6e-21 | 71.53 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 106-256 Range on HMM: 1-185/324 Sequence Identity: 26% (49 aa) YSDFRFLGHGDYG-LVLLAKDSKT---NMRYAIKGVQVRDLDGNLE----EDLNNQVKKEVEILKKCRE--SPY--VVSLIDQFEGQ--QFSYLVLTECQ |. . ||.| .| | ... || | .|.| .. . . . . .. |.|..|.|| | .|. .| |.| || . . |... |. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN G-TLSQILERNQN-------KRLNEISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHGNAV------------VSDFGLA | .|.|....|.. |||.| ||.. .|..|. ..|..|. |.| .|||| . ..|||.| GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 4501.AA | Ciliate-E2 | 106-280 | 18 | 2e-20 | 66.83 | In-house | 1-257 (365) | Show / Hide |
Range on Protein: 106-280 Range on HMM: 1-257/365 Sequence Identity: 18% (49 aa) YSDFRFLGHGDYGLVLLAKDSKTNMRYAIK-------------GVQVRDLDGNLE-EDLNNQVKKEVEILKKCRE---------------SPYVVSLIDQ | . .| | .| | ..|. |.. ..||| .|.. . .. .|.|.| |... .. .|... ... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GQQFSYLVLTECQG-TLSQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHQKN-YLVNDLKMDNILIDYHGN |. .. |||. ||| .| .... | . |...| .... |.| .| |.|.|| . |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVSDFGLADNLTSKSGY------------------------------TINQYMGNFLYQAPE ..||||. ... .. . ..|.. |. |.||| IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE |
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| Kinase | 4501.AA | STE | 106-280 | 19 | 3.4e-20 | 68.08 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 106-280 Range on HMM: 1-232/359 Sequence Identity: 19% (47 aa) YSDFRFLGHGDYGLVLLAKDSK---------------TNMRYAIKGVQVRD--------LDGNLE-----EDLNNQVKKEVEILKKCRE-SPYVVSLIDQ . . ...|.| .| | .|.. | |. ..||| . ... . . | .. .|..||..|.|||. .|..| .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC FEGQ-------QFSYLVLTECQ-GTLSQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHQKNYLVNDLKMDNILIDYHGNAVVSDFGL .. . .... . |.|..|.. ...| .|..| .... .| .| |||.|.... |.| .|||. . .|||. YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGV ADNLTS---------------KSGYTINQYMGNFLYQAPE . .||. .. | | . ||| CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | 4501.AA | Ciliate-E2-Unclassified | 106-283 | 20 | 3.8e-20 | 66.58 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 106-283 Range on HMM: 1-239/352 Sequence Identity: 20% (50 aa) YSDFRFLGHGDYGLVLLAKDSKTN----MRYAIKGVQVRDLDGNLEEDLNNQVKKEVEILK---------------KCRESPYVVSLIDQFEGQQFSYLV | . .|.| .| | .....|.. | |..| .. .. . .. .. .||....| . .|..| ....|. .| |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTEC-QGTLSQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHQKN-YLVNDLKMDNILIDYHG---NAVVSDFGLADNLTS . | .|.|.|... ..|.|.. | |. .|. | ||| |.|.|| . |.| .|||.| | . ..|||.. .. . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ KSGYT--------------INQYMGNFLYQ----APECYD .... ... .|. |. |||... NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | 4501.AA | TyrKc | 106-321 | 18 | 1.1e-07 | -98.2 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 106-321
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)
YSDFRFLGHGDYGLVLLAKDSKTNMRYAIKGVQVRDLDGNLEEDLNNQVKKEVEILKKC-RESPYVVSLIDQFEGQQ------FSYLVLTE--CQGTLSQ
. . ||.| .| | ... . . |.| .. .| .|..| . | .| |. |. .....| . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
ILERNQNKRLNEISAIKYANDIAQGLYYIHQKNYLVNDLKMDNILIDYHGNAVVSDFGLADNLTSK------SGYTINQY--MGNFL----YQAPECY--
| ....| |. .... .||.| |.|.||. || |.|.. . . .|||||. ..... . | . |... ||||
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
---------------------DPAEPYIG----KIYHDE---YLKLG-------V-------------------CVKQEPSNRLFFDNYFLRI
. ..|| | .. .| |.| | | . .|..| | . ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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