Gene 13276 (Tetrahymena)
13276
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 13276.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13276.AA | Ciliate-E2 | 675-829 | 20 | 2.5e-17 | 56.02 | In-house | 120-344 (365) | Show / Hide |
Range on Protein: 675-829
Range on HMM: 120-344/365
Sequence Identity: 20% (48 aa)
NLYQYVKDR-----------NSINTPQCLKIAKDIL---------------ITLTYFQRNL-IIHAGLKPSNILFMDFEYKNPLISDLGIAK--------
.|..| |.. .... ....| | || | | . ||| .||.|||| . |.|.|..|
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFGLSKKYDDDNQN
-----LAKWLTIEGESTSVHGF----------------APKYSGPEIFDGQTN----------KFTDTWSFGCILLHLFTGEVPWSGLSEYQQVKHYKQH
..||.. . ||.. | | |||. |. . . | ||.|.|| . .|. |. .|| | |
RTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKID
INEEN-------------KTNKLPVQIEALIEK----C
..... ...|.. . || | .
FPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM
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| Kinase | 13276.AA | TKL | 591-831 | 15 | 9e-17 | 56.93 | In-house | 1-348 (364) | Show / Hide |
Range on Protein: 591-831
Range on HMM: 1-348/364
Sequence Identity: 15% (56 aa)
LGVGSFGPVYQV-YAG---------GRVMAFKQIEL--DLVKTK-----------------NAMQDLQTLYLQVNTLVGSM-DHKGIMPLVGMSFDINE-
.| |.|| ||. . | |...| |.. | .|| . .. . . ... |. .| | ...| .....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-------SHIMKTNIFMPIA-QTNLYQYVKDRNSINTPQCLKIAKDILITLTYFQRNL--------IIHAGLKPSNILFMDF------------EYKNPL
.. .. | | . .|. |. .| ...|.|| . | . ||| ||..||| . . ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
ISDLGIAKLAKWLTIEGES----------------TSVHGFAPKYSGPEIFDGQTN--------------KFT---DTWSFGCILLHLFTGEVPWSGLSE
|.|.|... .. . . |. . | . ||...||.| ... | .||| .| ..|...|.... .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
YQQV--------------KHYKQHINEENKT-------NKLPVQIEALIEKCCK
.... | .. | .. .. . | .. |...|..
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWD
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| Kinase | 13276.AA | STE | 585-797 | 18 | 7.9e-16 | 52.47 | In-house | 1-272 (359) | Show / Hide |
Range on Protein: 585-797 Range on HMM: 1-272/359 Sequence Identity: 18% (51 aa) YQIQKQLGVGSFGPVYQVYAG-----------------GRVMAFKQIELDLVKTKNAM------------QDLQTLYLQVNTLVGSMD-HKGIMPLVGMS .......| |.|| ||. . |..|| ||..|. ..|. ...| . .... . . |. | |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY FDIN--ESHIMKTNIFMPIAQ-TNLYQYVK------DRNS--------INTPQCLKIAKDILIT-LTYFQRNLIIHAGLKPSNILFMDFEYKNPLISDLG |. . .. . .|.| | . .| .... .. .| .|...|| | | .. ||| .||.|||. ..| | FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------VKLCDFG IAKLAKW--------------LTIEGESTSVHGFAPKYSGPEIFDGQTNK-------FTDTWSFGCILLHLFTGEVPWSGLS ... .|. ...... | . ||. ...... | ||.|| .... ||..||. .. VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMH |
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| Kinase | 13276.AA | S_TKc | 585-846 | 21 | 5e-15 | 43.51 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 585-846 Range on HMM: 1-231/231 Sequence Identity: 21% (61 aa) YQIQKQLGVGSFGPVYQVYAGG--RVMAFKQIELDLVKTKNAMQDLQTLYLQVNTLVGSMDHKGIMPLVGMSFDINESHIMKTNIFMPIAQT---NLYQY |.| ...| |.|| ||... . |..| |.| ..... .| | .|. | | .. | . ..| . . .|..| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDY VKDRNS------INTPQCLKIAKDILITLTYFQRNLIIHAGLKPSNILFMDFEYKNPLISDLGIAKLAKWLTIEGESTSVHGFAPKYSGPEIFDGQTNK- |.|.. .. .. .... |. | | .. ||| |||.|||. . . |.| |.|.. |.. | | | ||.. . .| IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL---------TTFCG-TPWYMAPEVL--GYGKC FTDTWSFGCILLHLFTGEVPWSGLSEYQQVKHYKQHINEENKTNKLPVQIEALIEKCCK-DKK----YIQLKY-----QQQQYK | ||.|||| ...|. |.. |.. ..| . . .|.||.. | . .. . .. KCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 13276.AA | Pkinase | 585-801 | 24 | 2.8e-10 | 37.42 | Pfam | 1-223 (293) | Show / Hide |
Range on Protein: 585-801 Range on HMM: 1-223/293 Sequence Identity: 24% (59 aa) YQIQKQLGVGSFGPVYQVY--AGGRVMAFKQIELDLVKTKNAMQDLQTLYLQVNTLVGSMDHKGIMPLVGMSFDINESHIMKTNIFMPIAQT-----NLY |.| ...| |||| ||. . |.. | |.|... | . .... . . . ...|. | | .. | ..|| . |. .. |. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFED--KDHIY---MVMEYCEGGLYVMDLF QYVK--DRNSI--NTPQCLKIAKDILITLTYFQRNLIIHAGLKPSNILFM-DFEY----KNPLISDLGIAKLAKWLTIEGESTSVHGFA--PKYSGPEI- |.. ..... .| .... || | | .. ||| |||.|||. . . | |.| |.||... . .. ..|. | | ||. DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK---ICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVI -FDGQTNKFTDTWSFGCILLHLFTGEVPWSGL----SEYQQ .. . | ||.|||| ...|. |..| . . | RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQ |
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| Kinase | 13276.AA | Ciliate-E2b | 676-793 | 25 | 2.6e-08 | 21.52 | In-house | 87-210 (272) | Show / Hide |
Range on Protein: 676-793 Range on HMM: 87-210/272 Sequence Identity: 25% (33 aa) LYQYVKDRN--SINTPQCLKIAKDILITLTYFQRNLIIHAGLKPSNILFMDFEYKNPLISDLGIAKLAKWLTIEGE----STSVHGFAPKYSGPEIFD-- | .. . . ..| . . . . |. .| | . . ||. .||.||. | . . |.|.||. . . | ... | | | ||| LFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGY--MKLIDMGTAKH---MYKKNEQMTRTFTIIG-TPHYMAPEIIQSL ---GQTNKFT-DTWSFGCILLHLFTGEVPW |. . | ||.| .| . | ||| QPGGKGYTYKVDIWSVGICLYEFMCGYVPW |
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| Kinase | 13276.AA | DYRK2 | 673-721 | 37 | 7.1e-08 | 21.33 | In-house | 84-134 (318) | Show / Hide |
Range on Protein: 673-721 Range on HMM: 84-134/318 Sequence Identity: 37% (19 aa) QTNLYQYVKDRNS--INTPQCLKIAKDILITLTYFQRNLIIHAGLKPSNIL ..||| | | .. .. . |. || | ..| |||. ||| ||| SMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL |
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| Kinase | 13276.AA | Ciliate-E2-Unclassified | 675-859 | 20 | 8e-08 | 23.25 | In-house | 107-332 (352) | Show / Hide |
Range on Protein: 675-859
Range on HMM: 107-332/352
Sequence Identity: 20% (49 aa)
NLYQYVKDRNS-----------------INTPQCL-----KIAKDILITLTYFQRNL-IIHAGLKPSNILFMDFEY-KNPLISDLGIAK-----------
.| || |.|.. . |.. .... || | | ... ||| .||.|||| . . .. |.|.||.|
DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTN
----LAKWLTIEGESTS-VHGFAPKYSGPEIFDGQTNK---F--TDTWSFGCILLHLFTGEVPWSGLSEYQQVKHYKQHINEENKTNKLPVQIEALIEKC
.. | . ... .. |.| ||...|| . . | ||.|.|| . .|. | .. ...|. . .| | | .. |....
QQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N-NA------YRKQLYQNI
CKDKKYIQLKYQQQQYKQIQAQSKKLNK----QM
.. . ... .|| |... . | . . .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKM
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| Kinase | 13276.AA | Ciliate-E3 | 710-787 | 32 | 1.7e-07 | 19.76 | In-house | 124-202 (202) | Show / Hide |
Range on Protein: 710-787 Range on HMM: 124-202/202 Sequence Identity: 32% (28 aa) IIHAGLKPSNILFMDFEY-----KNPLISDLGIAKLAKWLTIEG--ESTSVHGFAPKYSGPEIFD-GQTNKFTDTWSFGCILLHLF ||| .||.||| | .. | |.|.| ..| | . .| |. | |. ||. | .| | | | | ... | IIHSDIKPDNIL-VDKNNNQLIIK---ICDFG---ESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC |
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| Kinase | 13276.AA | TyrKc | 585-840 | 17 | 2.8e-07 | -104.95 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 585-840 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) YQIQKQLGVGSFGPVYQVYAGGRVMAFKQIELDLVKTKNAMQDLQTLYLQVNTLVGSM--DHKGIMPLVGMSFDINE-----SHIMKTNIFMPIAQTNLY . |.|| | || ||. . . ||. .. . .. . . .|. | |.| . . .| .|| .| ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLK QYVKDRNS-INTPQCLKIAKDILITLTYFQRNLIIHAGLKPSNILFMDFEYKNPLISDLGIAKLAKWL---TIEGESTSV----HG---FAPKYSGPEIF .| ... ..... |... .| | .. .|| | |.| . ||| | .. . ... .. .| . . || . DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI -DGQTNKFTDTWSFGCILLHLFT-GEVPWSGL----SEYQQVKHYKQHINEENKTNK--------LPVQIEALIEKCCKD-------KKYIQLKY .| . .| |||| . .|| |. |..| . |.| .| .. . . | . ....|.. . | . NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 13276.AA | Ciliate-E3 | 585-603 | 47 | 4e-06 | 15.39 | In-house | 1-19 (202) | Show / Hide |
Range on Protein: 585-603 Range on HMM: 1-19/202 Sequence Identity: 47% (9 aa) YQIQKQLGVGSFGPVYQVY | .|..|| |.|| ||... YTVQQILGCGQFGRVYKAF |
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| Kinase | 13276.AA | Ciliate-E2b | 585-615 | 35 | 7.8e-05 | 10.81 | In-house | 1-34 (272) | Show / Hide |
Range on Protein: 585-615 Range on HMM: 1-34/272 Sequence Identity: 35% (12 aa) YQIQKQLGVGSFGPVYQVYA---GGRVMAFKQIE . |.|| | ||.||.| . . | |.|. MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCIS |
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| Kinase | 13276.AA | DYRK | 775-803 | 51 | 0.000122 | 13.58 | In-house | 186-214 (320) | Show / Hide |
Range on Protein: 775-803 Range on HMM: 186-214/320 Sequence Identity: 51% (15 aa) DTWSFGCILLHLFTGEVPWSGLSEYQQVK | ||.|||| ||||.. .| .|| | . DMWSLGCILAELFTGWPLFPGENEYDQLA |
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| Kinase | 13276.AA | ULK | 675-739 | 24 | 0.000604 | 9.76 | In-house | 106-190 (329) | Show / Hide |
Range on Protein: 675-739 Range on HMM: 106-190/329 Sequence Identity: 24% (21 aa) NLYQYVKDR----------NSINTPQCLKIAKDILITLTYFQRNLIIHAGLKPSNILFMDFEYKN----------PLISDLGIAK .| || | . . .. ...... |.|| . . . . ||| .||.||| . |. |.| | || DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK |
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| Kinase | 13276.AA | ULK | 675-739 | 23 | 0.000726 | 9.67 | In-house | 103-186 (324) | Show / Hide |
Range on Protein: 675-739 Range on HMM: 103-186/324 Sequence Identity: 23% (20 aa) NLYQYVKDRNS---------INTPQCLKIAKDILITLTYFQRNLIIHAGLKPSNILFMDFEYKN----------PLISDLGIAK .| || | .. .. ...... |.|. . . . . ||| .||.||| . |. |.| | || DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK |
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| Kinase | 13276.AA | DYRK2 | 760-789 | 45 | 0.001031 | 7.58 | In-house | 168-198 (318) | Show / Hide |
Range on Protein: 760-789 Range on HMM: 168-198/318 Sequence Identity: 45% (14 aa) YSGPEIF-DGQTNKFTDTWSFGCILLHLFTG | ||.. |. .. .| ||||||. |.|| YRAPEVILGGKYGMAIDMWSFGCIMAELYTG |
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| Kinase | 13276.AA | DYRK | 673-721 | 33 | 0.001657 | 9.3 | In-house | 84-136 (320) | Show / Hide |
Range on Protein: 673-721 Range on HMM: 84-136/320 Sequence Identity: 33% (18 aa) QTNLYQYVKDRNS---INTPQCLKIAKDILITLTYFQRN-LIIHAGLKPSNIL ..|||.. | .. .. |.|. || | . ..| |||. ||| ||. SMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM |
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| Kinase | 13276.AA | DYRK2 | 585-603 | 47 | 0.001916 | 6.69 | In-house | 1-19 (318) | Show / Hide |
Range on Protein: 585-603 Range on HMM: 1-19/318 Sequence Identity: 47% (9 aa) YQIQKQLGVGSFGPVYQVY | | . .| |||| | .| YEILEVIGKGSFGQVVKCY |
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| Kinase | 13276.AA | Ciliate-E2-Unclassified | 585-603 | 52 | 0.002417 | 7.48 | In-house | 1-19 (352) | Show / Hide |
Range on Protein: 585-603 Range on HMM: 1-19/352 Sequence Identity: 52% (10 aa) YQIQKQLGVGSFGPVYQVY | |.||.| |.|| ||... YKIIKQIGQGGFGKVYKCQ |
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| Kinase | 13276.AA | ULK | 585-605 | 47 | 0.002734 | 7.44 | In-house | 1-18 (329) | Show / Hide |
Range on Protein: 585-605 Range on HMM: 1-18/329 Sequence Identity: 47% (10 aa) YQIQKQLGVGSFGPVYQVYAG |.. ..|| |||| .|| | YCLNHCLGKGSFG---KVYKG |
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| Kinase | 13276.AA | ULK | 763-832 | 25 | 0.002825 | 7.39 | In-house | 220-304 (329) | Show / Hide |
Range on Protein: 763-832 Range on HMM: 220-304/329 Sequence Identity: 25% (22 aa) PEIFDGQ--TNKFTDT----WSFGCILLHLFTGEVPWSGLSEYQQV-KHYKQHINEENKTN----KLPVQIEAL-----IEKCCKD |.|. || ...| ||.|||. . .|..|... ..|. ..... || ... . | | |.. | . ||| PQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKD |
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| Kinase | 13276.AA | ULK | 763-812 | 21 | 0.003228 | 7.34 | In-house | 216-296 (324) | Show / Hide |
Range on Protein: 763-812 Range on HMM: 216-296/324 Sequence Identity: 21% (18 aa) PEIFDGQ-----TNKF-TDTWSFGCILLHLFTGEVP---WSGLSEY-------------------QQVKHYK----QHINEE |.|. || . . .| ||.|||. . .|..| | ..| |.....| ..| .| PQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPE |
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| Kinase | 13276.AA | ULK | 585-601 | 50 | 0.003509 | 7.21 | In-house | 1-18 (324) | Show / Hide |
Range on Protein: 585-601 Range on HMM: 1-18/324 Sequence Identity: 50% (9 aa) YQIQKQLGVGSFG-PVYQ |.. ..|| |||| ||. YCLNHCLGKGSFGVKVYK |
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| Kinase | 13276.AA | Ciliate-E2 | 585-602 | 44 | 0.004568 | 6.35 | In-house | 1-18 (365) | Show / Hide |
Range on Protein: 585-602 Range on HMM: 1-18/365 Sequence Identity: 44% (8 aa) YQIQKQLGVGSFGPVYQV | ..|..| |.|| ||.. YKFIKKIGQGNFGSVYKC |
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| Kinase | 13276.AA | DYRK | 585-603 | 42 | 0.081379 | 2.91 | In-house | 1-19 (320) | Show / Hide |
Range on Protein: 585-603 Range on HMM: 1-19/320 Sequence Identity: 42% (8 aa) YQIQKQLGVGSFGPVYQVY |.| . .| |||| | ... YEILEYIGKGSFGQVVKCW |
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