Gene 18020 (Tetrahymena)

18020

Species: Tetrahymena
Alias: PreTt18020, 270, 3796.m00125, 260.m00027, TTHERM_01164160, 18020
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
18020.AA Protein None 1035 None Fasta, JSON
18020.kin_dom Protein Kinase Domain None 251 None Fasta, JSON
18020.NA RNA None 3108 None Fasta, JSON

Protein domain

Protein domains of 18020.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 18020.AA S_TKc 23-303 22 1.1e-39 139.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-303
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FRHDGFLGC-SNAPVYRYVDINKSDHILAFKELKIKDDEDYKRVVSNFKTLQRIKVNKHPNIIQILGFCKSIKQKVYGEDISAYLIMEHCEG---NLDDY
..    .|  . . ||. .... ...| | |..|       ... .  . |..    .||||....... .          . |..||.|.|   .| ||
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK----HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDY

IQMMKKSGNQ--FTLTEIKKFFSQTISALEFLQSNLKIAHRDIKPENILVDKTNFKIADLDDSKIDLNKTMEKSLVLGTLSFMAPELLKAYNRMKDRLSY
|. ... |..  |.  ...... |...|||.. |. .| |||.||||||.|. . ||.|   ...        . . ||. .||||.|          .|
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL----------GY

NAYKSDVYSLGLCLLYMCT----FKKFSKDERLNGVINKTAYLKQVKQLRSQVKERYGSVLSKLIKMMLEMDAALRPDFTTLKN----IAIDKAF
.  |.|..|.| .|  |..    |             .  . .|...           . .  .|. .|..| . ||    . .    |...  |
GKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18020.AA CAMK 79-227 23 8.9e-32 99.12 In-house 96-321 (425) Show / Hide 
Range on Protein: 79-227
Range on HMM: 96-321/425
Sequence Identity: 23% (54 aa)

KHPNIIQILGFCKS-----------IKQK-VYGE-DISAYLIM---EHCEGN-----LDDYIQMMKKSGNQ-----------FTLTEIKKFFSQTISALE
.|||||... .  .             .| |. . |   |..|   |.|.|      | |||.  .. |..           ||  | ...| | .||..
DHPNIIKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH

FLQSNLKIAHRDIKPENILVDKT------------------NFKIADLDDS--KIDLNKTM---------------------EKSLVLGTLSFMA-PELL
.. |.  |.|||.||||||.|.                   | ||.|   .  ... .. .                       . . ||...|| ||.|
YCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL

KA--YNRMKDR-----LSYNAYKSDVYSLG
.      |          |  .|.|. |.|
NGKGHCNMQ-NATDEEKPYYGPKCDMWSCG
Kinase 18020.AA TKL 50-298 18 8.1e-30 104.54 In-house 30-364 (364) Show / Hide 
Range on Protein: 50-298
Range on HMM: 30-364/364
Sequence Identity: 18% (64 aa)

AFKELKIKD-----------------------DEDYKRVVSNFKTLQRIKVN-KHPNIIQILGFCKSIKQK-VYGEDI----SAYLIMEHC-EGNLDDYI
| | .|...                       |.....    ..   ... . .||||.|..|.|.....  | .. .      ...|| |  |.| .|.
AVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYL

QMMKKSGNQFTLTEIKKFFSQTISALEFLQSNLK-------IAHRDIKPENILVDKTN---------------FKIADLDDSKI-----DLNKTM-----
.          .  . ..  .. .....| |.         |.|||.|..|||||. .                ||.|.  |.      . |.||     
H----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME

---------EKSLVLGTLSFMAPELLKAYNRMKDR---------LSYNAYKSDVYSLGLCLLYMCTFKKFSKDERLNGVI-----NKTAYLKQVKQLRSQ
          .. . ||. .||||.|.  .  ..          ..|.  |.|||| |..|  ..| ..  .|.  . .|        ...  .|.||  
SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS-EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPP

VK------------ERYGSVLSKLIKMMLEMDAALRPDFTTLKNIA
..            .     ..||...  ..|.  || |.... . 
IPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 18020.AA Ciliate-E2-Unclassified 36-237 23 1.3e-29 99.84 In-house 15-267 (352) Show / Hide 
Range on Protein: 36-237
Range on HMM: 15-267/352
Sequence Identity: 23% (63 aa)

VYRYVDINKSDHILAFKELK---IKDDEDYKRVVSNFKTL-QRIKVNKHPNIIQ--------ILGFCKSIKQKVYGEDIS-----AYLIMEHCEG-NLDD
||. .....   . | |..|   |...  ....  ...   .... .|. ..          ||  ....  .|. ...       |..|| ||| .| .
VYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPF-IVKMFYCFQDKQNIYIVMEYCEGGDLWQ

YIQ-------------MMKKSGNQFTLTEIK-----KFFSQTISALEFLQSNLKIAHRDIKPENILVDKT----NFKIADLDDSK---------------
||.             . .|....||  ..|     ..| | ...||.| ....| ||||||||||.|.     . ||.|.  ||               
YIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQK

IDLNKTMEKSLVLGTLSFM----APELL--KAYNRMKDRLSYNAYKSDVYSLGLCLLYMCTFK
.. .| .. . . ||...|    |||.|  . |. .|       ||.|..||| .| .|.. .
MQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEMLFGY
Kinase 18020.AA Pkinase 51-237 27 4.1e-28 100.48 Pfam 32-209 (293) Show / Hide 
Range on Protein: 51-237
Range on HMM: 32-209/293
Sequence Identity: 27% (55 aa)

FKELKIKDDEDYKRVV-SNFKTLQRIKVNKHPNIIQILGFCKSIKQKVYGEDISAYLIMEHCEG-----NLDDYIQMMKKSGNQF--TLTEIKKFFSQTI
.|  ..|...|. ..  |  . ..|..   ||||....... .        . . |..||.|||      | |||.   .... |  .  |.|... |..
IKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQIL

SALEFLQSNLKIAHRDIKPENILVD-KTNF----KIADLDDSKI--DLNKTMEKSLVLGTLSFMAPELLKAYNRMKDRLSYNAYKSDVYSLGLCLLYMCT
..||.. |. .| |||.||||||.| . .     ||.|   .|     |..   . . ||. .||||...         .|  .|.|..|.|. | .|..
RGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR-------GGQYYGPKVDMWSCGCILYEMLC

FK
 .
GR
Kinase 18020.AA Ciliate-E2 51-296 22 1.6e-26 88.0 In-house 49-361 (365) Show / Hide 
Range on Protein: 51-296
Range on HMM: 49-361/365
Sequence Identity: 22% (78 aa)

FKELKIKDDEDYKRVVSNFKTLQRIK-------------VNKHPNIIQILGFCKSIKQKVYGEDISAYLIMEHCEG-NLDDYIQMMKKSG-------NQF
....||.   . . . .  . ...|.              ..|||||..  . ...       | . ||.|| |.| .| |||. .||.        ..|
IYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK------DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYF

TLTEIKKFFSQTIS---------------ALEFLQSNLKIAHRDIKPENILVDKTNFKIADLDDSKIDLNK-----------TMEKSL------------
|. |||... | ..               |||.| |. .| ||||||||||.     ||.|.  ||.  ..            .                
TEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQ

---------VLGTLSFMAPELLK--AYNRMKDRLSYNAYKSDVYSLGLCLLYMCTFKK-FSKDERLNGVINKTAYLKQVKQLRSQVKER-----------
         ..||. .|||| |.   |.  ...  |. ||.|..||| .| .|.. |  |               ..| ||   .  .            
IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD-YKCDIWSLGVILYEMLFGKPPF---------------QQQIKQCKIDFPCPEWQKDTQCIQC

----YGSVLSK---LIKM----MLEMDAALRPD-FTTLKN
    . ..  .   |||     ||. |   |.. .  ..|
KWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 18020.AA Ciliate-C6 100-299 25 1.5e-25 87.48 In-house 84-306 (306) Show / Hide 
Range on Protein: 100-299
Range on HMM: 84-306/306
Sequence Identity: 25% (59 aa)

E-DISAYLIMEHCEGNLDDYIQMMKKS------------------GNQFTLTEIKKFFSQTISALEFLQSNLKIAHRDIKPENILVDKT--NFKIADLDD
| . ..|.. .  | .| | |||  .                     .|.  || .| .|    |  ...  .||||||||.|||. .   |..  |   
EPNRQTYIVLDLAESTLQDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGC

SK-IDLNKTMEKS-LVLGTLSFMAPELLKAYN----RM----KDRLSYNAYKSDVYSLGLCLLYMCTFKKFSKDERLNGVINKTAYLKQ--VKQLRSQVK
.. ...   . .. ...|||. |.|||  .            .. . |  .|.|. |||. |||| | .  |        .|    .|.  .. .. . |
AQQLFQSEFTRNNDIHMGTLKWMSPELREMKKQYNQHQDDNSNQQIDY--FKCDIFSLGMILLYMLTLSDISQ-------VNCDEFMKNQKIRIMKNMCK

ERYGSVLSKLIKMMLEMDAALRPDFTTLKNIAI
.   . . ||.. |||..   |||   |.. .|
DISYKEIIKLVSKMLETNPDHRPDMSILIQ-TI
Kinase 18020.AA CAMKL 79-227 28 5.2e-22 66.89 In-house 73-223 (297) Show / Hide 
Range on Protein: 79-227
Range on HMM: 73-223/297
Sequence Identity: 28% (48 aa)

KHPNIIQILGFC--KSIKQKVYGEDIS-----AYLIMEHCEGN---LDDYIQMMKKSGNQFTLTEIKKFFSQTISALEFLQSNLKIAHRDIKPENILVDK
||||||...     ..                 ||.||.|.|    | |||.  .. .  ..  | ...| | .||.... |.  |.||||||||||.|.
KHPNIIKLYEVIETPEH---------DIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDE

TN---FKIADLDDSK--ID--LNKTMEKSLVLGTLSFMAPELLKAYNRMKDR--LSYNAYKSDVYSLG
 .    ||.|   |   ..   ..    .   |....||||...       .   .|...| |. |.|
NGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQ-------GNNKPYDGPKVDIWSCG
Kinase 18020.AA CMGC 55-175 18 3.8e-21 65.4 In-house 45-247 (513) Show / Hide 
Range on Protein: 55-175
Range on HMM: 45-247/513
Sequence Identity: 18% (37 aa)

KIKDDEDYK--------------RVVSNFKTLQRIK-------------VNKHPN-IIQILGFCKSIKQKVYGE---------DISAYLIMEHCEGNLDD
||| .. |.              |     | |....              |||.| |.... .... . . ...         . . ||..|... .| .
KIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQ

YIQMMKK-----SGNQFTLTE------------IKKFF------SQTISALE--FLQSN-LKIAHRDIKPENILVDKTNF--------------------
||.....      .. ..  .            ||.|.       | . .|.  .. |. ..| |||.||||||.....                     
YIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGR

-KIAD
 ||.|
LKICD
Kinase 18020.AA ULK 76-238 28 6.9e-21 70.9 In-house 66-249 (324) Show / Hide 
Range on Protein: 76-238
Range on HMM: 66-249/324
Sequence Identity: 28% (56 aa)

KVN--KHPN--IIQILGFCKSIKQKVYGEDI-SAYLIMEHCEG-NLDDYIQMMKK-----SGNQFTLTEIKKFFSQTISALEFLQSNLKIAHRDIKPENI
| .  ||||  |.. . ....        .    |.||| |.| .|..||.  ||      .. ..  |...|| | .... .|... .| ||||||.||
KLKELKHPNHHIVKLYDWFET-------SNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH-NIIHRDIKPQNI

LVDKTN-------------FKIADLDDSKI-D---LNKTMEKSLV-----LGTLSFMAPELLKAYNRMKD--RLSYNAYKSDVYSLGLCLLYMCTFKK
|. . .             .||||   .|. |   ....| ...|      ||  .|||..|     ..   .  |. ||.|..||| |..| . . |
LIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQIL-----QGQGEQKPYYDYKCDIWSLG-CIFYEMLYGK
Kinase 18020.AA STE 36-235 21 1.5e-20 69.35 In-house 15-263 (359) Show / Hide 
Range on Protein: 36-235
Range on HMM: 15-263/359
Sequence Identity: 21% (58 aa)

VYRYVDIN-----KSDHI---------LAFKELKIKDD-----------------EDYKRVVSNFKTLQRIK-VNKHPNIIQILGFCKSIKQKVYGEDI-
||. ....     |.. .          | |.......                 |. ...    |.... . .  ||||.. .| .     .   ..  
VYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM--HPNIVKYYGCYFKEGHN---HKND

-SAYLIMEHCE-GNLDDYIQMMKKSGNQFT----------LTEIKKFFSQTISA-LEFLQSNLKIAHRDIKPENILVDKTNFKIAD------LDDS--KI
 . ...||... | ||| |.  .. |....           ..|...  |.. . |..| |.  | |||||| |||.     |..|      |.||  .|
DELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL----VKLCDFGVCGQLTDSMANI

DLNK--------TME-KS-LVLGTLSFMAPELLKA----YNRMKDRLSYNAY--KSDVYSLGLCLLYMCT
 . .        ||  |.  . ||  .|||| ..     .         . |  |.|..|||.... |.|
-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGR--------DKGYDTKCDIWSLGCTIIEMAT
Kinase 18020.AA ULK 36-238 23 3.9e-20 67.07 In-house 15-253 (329) Show / Hide 
Range on Protein: 36-238
Range on HMM: 15-253/329
Sequence Identity: 23% (60 aa)

VYRYVDINKS---DHILAFKELKIK-DDEDYKR---------VVSNFKTLQRIKVN-----KHPNIIQILGFCKSIKQKVYGEDI-SAYLIMEHCEG-NL
||.  ....    . . | | . ..  .....          . .  |.....| .     .||||.. . ....        .    |.||| |.| .|
VYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFET-------SNHNNIYIIMEYCNGGDL

DDYIQMMKK------SGNQFTLTEIKKFFSQTISALEFLQSNLKIAHRDIKPENILVDKTN-------------FKIADLDDSKI-DLN---KTMEKSLV
..||.  ||       .. ..  |...|| | .... .|... .| ||||||.|||... .             .||||   .|  | .   . |... |
EQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCV

L-----GTLSFMAPELLKAYNRMKD--RLSYNAYKSDVYSLGLCLLYMCTFKK
      ||  .|||..|     ..   .  |. ||.|..||| |..| . . |
NEKRLCGTPLYMAPQIL-----QGQGEQKPYYDYKCDIWSLG-CIFYEMLYGK
Kinase 18020.AA TyrKc 49-298 16 2.4e-08 -87.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-298
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

LAFKEL---------------------KIKDDEDYKRVVSNFKTLQRI-KVNKHPNIIQILGFCKSIKQKVYGEDISAYLIMEHCE-GNLDDYIQMMKKS
. ...                      ..|.|   .   .  . . .. .  .||||....| | . . . . ..   ...||... |.|.||..  .. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHRPK

GNQFTLTEIKKFFSQTISALEFLQSNLKIAHRDIKPENILVDKTN-FKIADL---DDSKID--------LNKTMEKSLVL--GTLSFMAPELLKAYNRMK
   ... .  .|  |  .  |.| |. .. |||.   |.||.. .  ||.|     | . |          ...|..       .  |||| .       
---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------

DRLSYNAYKSDVYSLGLCL--LYMCTFKKFSKDERLNGVINKTAYLKQVKQLRSQVKERY----------GSVLSKLIKMMLEMDAALRPDFTTLKNIA
.   ..  ||||.| | |.  ..    .  . ..    ... .  ...||| .   .  .            . . ..|.  . |.. || |.... . 
NYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
FU 18020.AA FU 907-957 28 1.4e-10 42.42 SMART 1-48 (48) Show / Hide 
Range on Protein: 907-957
Range on HMM: 1-48/48
Sequence Identity: 28% (15 aa)

QMICVQCDPSCLE-CTWGEANSCKKCKQDLYLLSLNQQTGMCVSDCPNYFRK
.  |. |.|.|.. |.   ...|..|.  .||...    | |||.||  . .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN----GTCVSQCPPGYYP
FU 18020.AA FU 961-1021 22 0.008442 15.74 SMART 1-48 (48) Show / Hide 
Range on Protein: 961-1021
Range on HMM: 1-48/48
Sequence Identity: 22% (14 aa)

INKCMKCPENCIT-CSSQPNKRQLETINSTAEQYVVCQKCSIEYYLLGDNLCVNVCPKDTIT
 ..|..| ..| | |..                   |..|.  |||.... ||  ||  . .
DGVCKPCHPECATGCWGPG--------------PDQCTSCPHGYYLHHNGTCVSQCPPGYYP