Gene 18056 (Tetrahymena)
18056
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 18056.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 18056.AA | TKL | 511-791 | 18 | 1.7e-35 | 124.25 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 511-791
Range on HMM: 1-364/364
Sequence Identity: 18% (70 aa)
LGKGGFCAVFKSKVGE----------KEMAQKVFEYD-LDECSS----------------IMAETLEGIFNEIKILLKVNTFSNQQFIRLFGISFDIRRN
.|.|||. |.| | |..| |.| . ||... .. |. | |.. .. . .. . ... |...... .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
EMSGRD---QFIFAIFMELI--GT-YDKNRFITCDLKKFINSTRTKPNYIKKCIELSLQIAEGIETLYNNN--------IIHSDLKPQNILLDSNQN---
. ... . ..| ||.. |. .. . . . ..|.|| |.. | ..| ||| |||..|||.|.| .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS
-----------IKIIDFGTSKFN----NKPYTH--------------DTNILGFTPRYCPLEHFDME----------------RLTPTTDVWSFGCLLFE
.|| |||.|.|. |. | |. . |||... | .... .. .||.||| .|.|
NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWE
MITGNEPWKGIKNLQDV---------RKALENKQ-----SLWL-HYQSQVSQQETQHINPEIIKLIEKCTSY--ENRPHPSYVTEKI
..|. .|...... . . .. .... . |. |. . .. |...||...| .. |.|| . .....
ILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 18056.AA | AGC | 636-725 | 24 | 2.9e-28 | 68.84 | In-house | 161-301 (395) | Show / Hide |
Range on Protein: 636-725 Range on HMM: 161-301/395 Sequence Identity: 24% (36 aa) QIAEGIETLYN-NNIIHSD-LKPQNILLDSNQNIKIIDFGTSKFNNKPY--------------------------------------------------T .|. ..| | . ..||| | ||| |||||.. .||. ||| .| ... . CIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRD HDTNILGF-TPRYCPLEHFDMERLTPTTDVWS--FGCLLFEMITG . . |. || | . | . ... | || .|||..||.|| RTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTG |
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| Kinase | 18056.AA | Ciliate-E2 | 612-775 | 20 | 1.6e-25 | 84.55 | In-house | 120-344 (365) | Show / Hide |
Range on Protein: 612-775
Range on HMM: 120-344/365
Sequence Identity: 20% (51 aa)
DLKKFINSTRTKPNYI---------KKCIELSLQIAE---------------GIETLYNNN-IIHSDLKPQNILLDSNQNIKIIDFGTSKFNN-------
||...|.. ..| | . |...... ||.. ..| | ..| ||| |.||.|||. |||||||.||...
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRT
-----KPYTHDTN-------ILGF------------TPRYCPLEHFDMER---------LTPTTDVWSFGCLLFEMITGNEPWKGIKNLQDVRKALENKQ
| |. | .... || | . | . .. . |.||.|..|.||..|. |. |
HKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------Q
SLWLHYQSQVSQQE--------------TQHINPEIIKLIEK----C
. . . ...| .... .| . || | .
QQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM
|
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| Kinase | 18056.AA | Pkinase | 630-775 | 27 | 8.8e-25 | 88.71 | Pfam | 110-273 (293) | Show / Hide |
Range on Protein: 630-775 Range on HMM: 110-273/293 Sequence Identity: 27% (47 aa) CIELSLQIAEGIETLYNNNIIHSDLKPQNILLDSNQNI----KIIDFGTSKFN-NKPYTHDTNILGFTPRYCPLEHFD-MERLTPTTDVWSFGCLLFEMI |. .||..|.| .....||| ||||.|||.|.| .| ||.||| .|. . ... .. . ||.|.. | . .| |.||.||.|.||. CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML TGNEPWKGI---KNLQDVRKALENKQSLWLHYQSQVS--------------QQETQHINPEIIKLIEKC .|. |..| .| | .. .... . ||.... . . ...| ...|..| CGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWC |
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| S_TKc | 18056.AA | S_TKc | 505-795 | 22 | 1.3e-24 | 88.96 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 505-795
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)
FDHSQRLGKGGFCAVFKSKVGE--KEMAQKVFEYDLDECSSIMAETLEGIFNEIKILLKVNTFSNQQFIRLFGISFDIRRNEMSGRDQFIFAIFMELIGT
.. . .|||.| |.| . . ...| |. | | .||.|| | ..|... | . ..||....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK----HHPNIVKLYDVFQD-----------DHLYMVMEYCDG
YDKNRFITCDLKKFINSTRTKPNY----IKKCIELSLQIAEGIETLYNNNIIHSDLKPQNILLDSNQNIKIIDFGTSKFNNKPYTHDTNILGFTPRYCPL
. ||...| . ...... . . ||....| . ...||| ||||.|||||. .|||.||| ... . . || |..
D------LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAP
EHFDMERLTP-TTDVWSFGCLLFEMITGNEPWKGIKNLQDVRKALENKQSLWLHYQSQVSQQETQHINPEIIKLIEKCTSY--ENRPHPSYVTE-----K
| . .. |.||.||.|.||..| |. ..| . | . || . .|.|| . |.|| . . |
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK
INEIL
. . .
CHPWF
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| Kinase | 18056.AA | Ciliate-E2-Unclassified | 628-775 | 23 | 9.1e-23 | 75.82 | In-house | 138-332 (352) | Show / Hide |
Range on Protein: 628-775 Range on HMM: 138-332/352 Sequence Identity: 23% (47 aa) KKCI-----ELSLQIAEGI-ETLYNNNIIHSDLKPQNILLDSNQ---NIKIIDFGTSKFNNKP---YTHD---------TNIL---GFTPRYC----PLE .... . || .|. ..||||| |.||.|||.|.|. .||||||| ||..... . .. ... ||.| . | QQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE HFDMERLTPT----TDVWSFGCLLFEMITGNEPWKGIKNLQ-----------DVRKALENKQSLWLHYQSQVSQQETQ------HINPEIIKLIE----K .. . . |.||.|..|.||..|. | .. . | . .|| . .| ...... |..|| . .|. | VLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA-----YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK C . M |
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| Kinase | 18056.AA | CAMK | 636-731 | 24 | 9e-22 | 66.3 | In-house | 187-336 (425) | Show / Hide |
Range on Protein: 636-731 Range on HMM: 187-336/425 Sequence Identity: 24% (37 aa) QIAEGIETLYNNNIIHSDLKPQNILLDSNQ-----------------NIKIIDFGTS--KFNNKPYT--------------------HDTNILGFTPRYC ||..... . ..||.| |||| |||||.| |||||||| . .. .. .. . . || |. QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM P-LEHFDM--------------ERLTPTTDVWSFGCLLFEMITGNEPWKG . | . . .| .|.|| |..|. | .| |. | AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYG |
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| Kinase | 18056.AA | Ciliate-E3 | 625-723 | 37 | 6.8e-21 | 62.13 | In-house | 93-202 (202) | Show / Hide |
Range on Protein: 625-723 Range on HMM: 93-202/202 Sequence Identity: 37% (42 aa) NYIKKCIELSL--------QIAEGIETLYNNNIIHSDLKPQNILLDSNQN---IKIIDFGTSKF--NNKPYTHDTNILGFTPRYCPLEHFDMERLTPTTD .||| .... || .|. . ||||||.||.|||.|.|.| ||| ||| ||. .|| .|| | |.|| | ..| | | HYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTH-TQYQGWTPFYAAPEQNDQQQISKESD VWSFGCLLFEMI | | . ... YYSVGAVFCQLC |
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| Kinase | 18056.AA | TKL-Unique | 628-746 | 28 | 1.1e-20 | 69.78 | In-house | 110-254 (290) | Show / Hide |
Range on Protein: 628-746 Range on HMM: 110-254/290 Sequence Identity: 28% (42 aa) KKCIELSLQIAEGIETLYNNN--IIHSDLKPQNILLDSN-----QNIKIIDFGTSKFNNKPYTHDTN--------ILGFTPRYCPLEHFDM--ERLTPTT .. . . ..|| | ..| ... ||| |||..|.|.|.| ||||.|||.||||.| . .| ..|. . | . | . . QQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKS DVWSFGCLLFEMITGNE------PWKGIKNLQDVRKALE---NKQ ||.||| | |..|. | .|. |. .. . |.. DVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYR |
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| Kinase | 18056.AA | CMGC | 608-685 | 18 | 3.9e-16 | 48.63 | In-house | 136-285 (513) | Show / Hide |
Range on Protein: 608-685
Range on HMM: 136-285/513
Sequence Identity: 18% (27 aa)
FITCDLKKFINSTRT-----KPNYI---------------KKCIE----LSLQIAEGIE--TLYNNN--IIHSDLKPQNILLDSNQN-------------
.. .||...| .... .|.. .|.. . || .|.. . .. ||| ||||.|||...|
YMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWN
-------IKIIDFGTSKFNNKP------------------------YTHD
.||.||| ... ... |||.
PCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHY
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| Kinase | 18056.AA | ULK | 612-677 | 30 | 1.4e-14 | 47.4 | In-house | 106-191 (329) | Show / Hide |
Range on Protein: 612-677 Range on HMM: 106-191/329 Sequence Identity: 30% (26 aa) DLKKFINSTRT------KPNYIK--KCIELSLQIAEGIETLYNNNIIHSDLKPQNILLDSNQN------------IKIIDFGTSKF ||...|. .. ..... ..|. ||..| |. .|||| |.||||||.. .| .|| ||| .|. DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH |
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| Kinase | 18056.AA | ULK | 612-677 | 30 | 1.6e-14 | 48.01 | In-house | 103-187 (324) | Show / Hide |
Range on Protein: 612-677 Range on HMM: 103-187/324 Sequence Identity: 30% (26 aa) DLKKFINSTRT-----KPNYIK--KCIELSLQIAEGIETLYNNNIIHSDLKPQNILLDSNQN------------IKIIDFGTSKF ||...|. .. ..... ..|. ||..| |...|||| |.||||||. .| .|| ||| .|. DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH |
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| Kinase | 18056.AA | Pkinase_Tyr | 631-744 | 31 | 2.3e-12 | 42.48 | Pfam | 114-231 (270) | Show / Hide |
Range on Protein: 631-744 Range on HMM: 114-231/270 Sequence Identity: 31% (37 aa) IELSLQIAEGIETLYNNNIIHSDLKPQNILLDSNQNIKIIDFGTSKFN-NKPYT-HDTNILGFTPRYCPLEHFDMERLTPTTDVWSFGCLLFEMIT-GNE .. ..|||.| | | ..|.|| || |.|...| .|| ||| .. |. | . . . . ...| . . | .|||||| |..|..| | . LQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ P-WKGIKNLQDVRKAL-EN | ..|. ..| ... |. PTYPGM-SNEEVYEYIYED |
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| Kinase | 18056.AA | TyrKc | 505-791 | 23 | 5.3e-12 | -28.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 505-791
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)
FDHSQRLGKGGFCAVFKSKVGEKEMAQKVFEYDLDECSSIMAETLEGIFNEIKILLKVNTF--SNQQFIRLFGISFDIRRNEMSGRDQFIFAIFMELIGT
. || | |. |.| . . | |. | .| . .|..|. | . ... .||.|. . || |. .| .|.. |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----------REDFMREARIMCK---LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-G-
YDKNRFITCDLKKFINSTRTKPNYIKKCIELSLQIAEGIETLYNNNIIHSDLKPQNILLDSNQNIKIIDFGTSKFNNKP---------YTHDTNILG---
|||... ..| | |. .. ..|||.| | | .|.|| || |.|...|. .|| ||| |.. |.. . |
---------DLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM
FTPRYCPLEHFDMERLTPTTDVWSFGCLLFEMIT-GNEPWKGI----KNLQDVRKALENKQSLWLHYQ-----SQVSQQETQHINPEIIKLIEKCTSY--
. | ...| .. . |. .|||||| ...|. | | .|. |. .. |.|.. ... . . . .|. .....| .
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-------VCCPDEMYQIMKQCWHEDP
ENRPHPSYVTEKI
|.|| | . |..
EDRPTFSEIHECF
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| Kinase | 18056.AA | ULK | 709-759 | 28 | 4.6e-08 | 24.33 | In-house | 236-301 (329) | Show / Hide |
Range on Protein: 709-759 Range on HMM: 236-301/329 Sequence Identity: 28% (19 aa) TTDVWSFGCLLFEMITGNEP---WKGIK-NLQDVRKALEN---------KQSLWLH---YQSQVSQQ ..|.||.||...||..| | | . .|| ..| ..| || | .. |.|.. KCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPE |
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| Kinase | 18056.AA | ULK | 710-775 | 25 | 9.9e-08 | 23.57 | In-house | 233-304 (324) | Show / Hide |
Range on Protein: 710-775 Range on HMM: 233-304/324 Sequence Identity: 25% (19 aa) TDVWSFGCLLFEMITGNEP---WKGIK-NLQDVRKALENK--QSLWLHYQSQVSQQ---ETQHINPEIIKLIEKC .|.||.||...||..| | | . .|. . | ..|. | . . .. .. . . ..| ||.. || .. CDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQ-QIYIKNQPIQFPKPPKDPKISPECKDLIRRM |
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| Kinase | 18056.AA | CMGC | 707-728 | 37 | 2e-06 | 16.35 | In-house | 313-341 (513) | Show / Hide |
Range on Protein: 707-728 Range on HMM: 313-341/513 Sequence Identity: 37% (11 aa) TPTTDVWSFGCLLFEMITG-------NEP |.. |.||.|| ..||.|| .| TTPIDMWSVGCIFAEMYTGYQSLIFRGKP |
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| Kinase | 18056.AA | Ciliate-E3 | 505-521 | 41 | 0.028173 | 3.25 | In-house | 1-17 (202) | Show / Hide |
Range on Protein: 505-521 Range on HMM: 1-17/202 Sequence Identity: 41% (7 aa) FDHSQRLGKGGFCAVFK .. .| ||.|.| |.| YTVQQILGCGQFGRVYK |
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| Kinase | 18056.AA | Ciliate-E2-Unclassified | 505-521 | 35 | 0.049394 | 2.87 | In-house | 271-287 (352) | Show / Hide |
Range on Protein: 505-521 Range on HMM: 271-287/352 Sequence Identity: 35% (6 aa) FDHSQRLGKGGFCAVFK . . .|.|||. |.| YKIIKQIGQGGFGKVYK |
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| Kinase | 18056.AA | Ciliate-E2 | 505-538 | 17 | 0.068689 | 2.25 | In-house | 1-52 (365) | Show / Hide |
Range on Protein: 505-538 Range on HMM: 1-52/365 Sequence Identity: 17% (9 aa) FDHSQRLGKGGFCAVFKSKV-GEKEMA-----------------QKVFEYDL .. . .|.|.| |.| || .... .|...| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAM |
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| Kinase | 18056.AA | TKL-Unique | 507-550 | 27 | 0.216264 | 0.89 | In-house | 1-43 (290) | Show / Hide |
Range on Protein: 507-550 Range on HMM: 1-43/290 Sequence Identity: 27% (12 aa) HSQRLGKGGFCAVFKSKVGEKEMAQKVFEYDLDECSSIMAETLE . .| ||...|.| | .. | |.|. . . |..| ...| FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFE |
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