Gene 19106 (Tetrahymena)
19106
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 19106.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19106.AA | Ciliate-A7 | 985-1120 | 29 | 8.6e-30 | 105.3 | In-house | 210-360 (360) | Show / Hide |
Range on Protein: 985-1120 Range on HMM: 210-360/360 Sequence Identity: 29% (46 aa) YKSRQSDYFSPEIIKYQTLVQ----NGASKNE---LSKDGIDQIDEKKADIFALGMTLFVCLFKTYPY-QQKCSMDDSL-FKYFYYPEKKVREQFWS--K .|.| .||.||||.. | . | | .. | . .||||.|.||.|...|. ||. |. ...|. .|.. .|.. ..| . ||. . WKYRCKQYFAPEIINC--LNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHY---FQKTYSKFWQWMQ FFITLEHYA---------NQFDDSRVHELKDLLEKMLNPNPDQRISINEVVSHQWL . . |.. .. .... ..||||.|||.||| ||..|... .| |. IQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF |
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| Kinase | 19106.AA | Ciliate-E2-Unclassified | 676-1120 | 11 | 5.4e-19 | 62.54 | In-house | 138-352 (352) | Show / Hide |
Range on Protein: 676-1120
Range on HMM: 138-352/352
Sequence Identity: 11% (52 aa)
EEIR-----LMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKD----HFVLADFGLAHYVLNTNQQQQLEKINNKEELKQKNISHILNNNLTSSSENLD
.... .. || . .|.|....|.| |||||||. . .. . ..|||.. . . |... .
QQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENIL-FDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQ----------------------------
QTQSLKQKPIFQIQNNLQLFSEDQVKQEEASDFKQVQMNISAKLEANQIFDNFQENCEFTTIESNSKEKTKQTVSDSRSQSSSSSCSSASFINISKNCSE
----------------------------------------------------------------------------------------------------
SKIKPCLHCYPHNLPDYLYANINIKQAQNQRIEESEEIITQDCDEDSELNEQNSFQEVYENVESKEDIDQDSSQMHQDKEINKKHESDLQQKNFKENQTN
|..
-------------------------------------------------------------------------------------------------QQK
SDNPTDNLCCMHLCDQFSYKSRQSDYFSPEIIKYQTLVQNGASKNELSKDGIDQIDEKKADIFALGMTLFVCLFKTYPYQQKCSMDDSLFKY-----FYY
... ..... . | .|.. | | .||... | . | .|.||..||. |. .|| .||...... .. .. .
MQIWKQQMMW-TFCGTPNYMP-Q--YTAPEVLQGQNYDHSKA---------------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA--
PEKKVREQFWSKFF---ITLEHYANQFDDSRVH-ELKDLLE----KMLNPNPDQRISINEVVSHQWL
.|.|. .... | .. .| .. ... | ||... |||. ||..||..... |.|.
----YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
|
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| Kinase | 19106.AA | Ciliate-A7 | 594-739 | 25 | 2.2e-16 | 56.05 | In-house | 25-206 (360) | Show / Hide |
Range on Protein: 594-739
Range on HMM: 25-206/360
Sequence Identity: 25% (46 aa)
VIKQITHHEQN-----------QHDKNCYNLYNEYTLQSNLSHEFILKPIQMQLIKNVHDHPNTKGGCYIIYPRAQSDLYDYYLSSSTL-FANIE-----
..| . |||.. .| .||.| |||. ....|. |..... ....| ...| | . |. || .| ... ..
IVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNEKIEN
-------EIRLMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKDH------FVLADFGLAHYVLNTNQQ------QQLEKI
..| . || . ..|.|.|| |.| |||||||| . | |||||.| ..... | |..
QCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQ
|
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| Kinase | 19106.AA | Ciliate-E2 | 992-1120 | 18 | 4.5e-16 | 51.64 | In-house | 253-365 (365) | Show / Hide |
Range on Protein: 992-1120 Range on HMM: 253-365/365 Sequence Identity: 18% (26 aa) YFSPEIIKYQTLVQNGASKNELSKDGIDQIDEKKADIFALGMTLFVCLFKTYPYQQKCSMDDSLFKYFYYPEKKVRE---QFWSKFFITLEHYANQFDDS | .|||.... . . .|.||..||..|. .||. .|. ... . .| ..... .. . YMAPEILNGKKYDNQ----------QKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-C RV-------HELKDLLEK----MLNPNPDQRIS-INEVVSHQWL . | |||. | ||. .|..||. .... |.|. KWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 19106.AA | CAMK | 676-748 | 24 | 1.7e-14 | 42.43 | In-house | 179-265 (425) | Show / Hide |
Range on Protein: 676-748 Range on HMM: 179-265/425 Sequence Identity: 24% (22 aa) EEIRLMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKD-----------------HFVLADFGLAHYVLNTNQQQQLEKINNKEELKQK .| | ...|| | |.|.|. . |||.|.||||| .. ..|||.| .. ... ........| . . REARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN |
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| Kinase | 19106.AA | S_TKc | 559-1120 | 10 | 4.6e-14 | 29.27 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 559-1120
Range on HMM: 1-231/231
Sequence Identity: 10% (58 aa)
KQMKKYIDKNCSGAAYSQYQPTSPLNGYLNHPKTLVIKQITHHEQNQHDKNCYNLYNEYTLQSNLSHEFILKPIQMQLIKNVHDHPNTKGGCYIIYPRAQ
.. . | | | | . . ||.| ....| . .. |..| | . . . |.. .
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCD
S---DLYDYYLSSSTLF----ANIEEIRLMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKDHFVLADFGLAHYVLNTNQQQQLEKINNKEELKQKNIS
||.|| . . . ..| .|.|| . ..|.|. ||.|.|.|||||. | ..||||| .
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------------------------
HILNNNLTSSSENLDQTQSLKQKPIFQIQNNLQLFSEDQVKQEEASDFKQVQMNISAKLEANQIFDNFQENCEFTTIESNSKEKTKQTVSDSRSQSSSSS
----------------------------------------------------------------------------------------------------
CSSASFINISKNCSESKIKPCLHCYPHNLPDYLYANINIKQAQNQRIEESEEIITQDCDEDSELNEQNSFQEVYENVESKEDIDQDSSQMHQDKEINKKH
----------------------------------------------------------------------------------------------------
ESDLQQKNFKENQTNSDNPTDNLCCMHLCDQFSYKSRQS-DYFSPEIIKYQTLVQNGASKNELSKDGIDQIDEKKADIFALGMTLFVCLFKTYPYQQKCS
. . .| .||.. . . .|.|. ..| .|. .| |..
---------------------------------TTFCGTPWYMAPEVL---------------------GYGKCKCDWWSCGCILYEMLCGYPPFP----
MDDSLFKYFYYPEKKVREQFWSKFFITLEHYANQFDDSRVHELKDLLEKMLNPNPDQRISINEVVS-------HQWL
.. .|| .|.||...|.|. .|..|... |. |.|.
QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 19106.AA | CAMK | 992-1120 | 18 | 1.8e-13 | 39.07 | In-house | 285-425 (425) | Show / Hide |
Range on Protein: 992-1120
Range on HMM: 285-425/425
Sequence Identity: 18% (31 aa)
YFS-PEIIKY------QTLVQNGASKNELSKDGIDQIDEKKADIFALGMTLFVCLFKTYPYQQKCSMDDS-----------LFK-----YFYYPEKKVRE
| . ||.... | . . . |. . . .|.|. ..| |...| ..|.. .| ... ||. ...|.... .
YMAAPEVLNGKGHCNMQ---N-A-T------DEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSP
-------QFWSKFFITLEHYANQFDDSRVH-----ELKDLLEKMLNPNPDQRISINEVVSHQWL
..|.. |. | | | |||. |||...|..|..| .. .|.|.
ISCNYGPEWWDD--ISDE----------FHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
|
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| Kinase | 19106.AA | Pkinase | 604-724 | 23 | 5.8e-13 | 46.92 | Pfam | 36-159 (293) | Show / Hide |
Range on Protein: 604-724 Range on HMM: 36-159/293 Sequence Identity: 23% (32 aa) NQHDKNCYNLYN--EYTLQSNLSHEFILKPIQMQLIKNVHDHPNTKGGCYIIYPRAQS-----DLYDYYLS--SSTLF-ANIEEIRLMMQQISSSVQYIH ..... .... . | . .|.|..|.. . . |. .|.. . .. ||. |.| ... | .|.. .| || . ..|.| HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------KDHIYMVMEYCEGGLYVMDLF-DYISTWRHGCFYFSEWECKFYMYQILRGLEYCH EEKGIVHCDIKPENIFKLAKDHF----VLADFGLA . .||.|.|.|||||. ..| ..||||| S-MGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 19106.AA | CAMKK | 1091-1120 | 43 | 1.3e-12 | 35.86 | In-house | 367-396 (396) | Show / Hide |
Range on Protein: 1091-1120 Range on HMM: 367-396/396 Sequence Identity: 43% (13 aa) HELKDLLEKMLNPNPDQRISINEVVSHQWL ..||||...||. ||..||.| ....|.|. EDLKDLIKRMLEKNPTKRITIPQIKVHPWV |
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| Kinase | 19106.AA | CAMKL | 1092-1120 | 37 | 1.8e-12 | 35.99 | In-house | 269-297 (297) | Show / Hide |
Range on Protein: 1092-1120 Range on HMM: 269-297/297 Sequence Identity: 37% (11 aa) ELKDLLEKMLNPNPDQRISINEVVSHQWL ...||. |||..||..|..| ....| |. DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 19106.AA | Pkinase | 1024-1120 | 15 | 1.9e-12 | 45.13 | Pfam | 191-293 (293) | Show / Hide |
Range on Protein: 1024-1120 Range on HMM: 191-293/293 Sequence Identity: 15% (17 aa) KKADIFALGMTLFVCLFKTYPYQQK---CSMDDSLFKYFYYPEKKVREQFWSK-------FFITLEHYANQFDDSRVH-ELKDLLEKMLNPNPDQRISIN .|.|....| .|. |.. |.... . .| ..... ......... . |.. | ... ... |.||.....|...| .|... PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE EVVSHQWL ... | |. QILQHPWF |
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| Kinase | 19106.AA | ULK | 1019-1120 | 19 | 2.2e-12 | 40.32 | In-house | 221-324 (324) | Show / Hide |
Range on Protein: 1019-1120 Range on HMM: 221-324/324 Sequence Identity: 19% (23 aa) DQ-----IDEKKADIFALGMTLFVCLFKTYPYQQK-CSMD----DSLFK---YFYYPEKKVREQFWSKFFIT---LEHYANQFDDSRV-HELKDLLEKML .| ...|.||. ||. .. .|. ||.. .. . . . . . ...| .... . .| . |.|||. .|| GQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQ--------------QIYIKNQPIQFPKPP-KDPKISPECKDLIRRML NPNPDQRISINEVVSHQWL ....|||. |. .| |. QYDEKDRISWEEIFNHPWF |
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| Kinase | 19106.AA | WEE | 676-734 | 26 | 5.9e-12 | 36.46 | In-house | 111-193 (297) | Show / Hide |
Range on Protein: 676-734 Range on HMM: 111-193/297 Sequence Identity: 26% (22 aa) EEIRLMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKD--------------------HFVLADFGLAHYVL----NTNQQQ ..|. ..|. ...||.. |.|| |||||||| |. . ..|||.. . |..|.| WMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQ |
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| Kinase | 19106.AA | CAMKL | 676-724 | 41 | 8.5e-12 | 33.78 | In-house | 127-176 (297) | Show / Hide |
Range on Protein: 676-724 Range on HMM: 127-176/297 Sequence Identity: 41% (21 aa) EEIRLMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKD--HFVLADFGLA .| | . .|| | |.|.|. . ||| ||||||| .. ..|||.. HEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 19106.AA | CAMKK-Unclassified | 1091-1120 | 46 | 1.1e-11 | 33.98 | In-house | 363-392 (392) | Show / Hide |
Range on Protein: 1091-1120 Range on HMM: 363-392/392 Sequence Identity: 46% (14 aa) HELKDLLEKMLNPNPDQRISINEVVSHQWL ||.|||..||.. ||. ||.| . |.|. HEFKDLIQKMCDKNPKKRITIDQMLVHPWF |
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| Kinase | 19106.AA | CAMKK | 679-738 | 21 | 9.8e-10 | 26.61 | In-house | 179-267 (396) | Show / Hide |
Range on Protein: 679-738 Range on HMM: 179-267/396 Sequence Identity: 21% (19 aa) RLMMQQISSSVQYIHEEKG-------------------IVHCDIKPENIFKLAKD---HFVLADFGLAHYVLNTNQQ--Q-----QLEK . .... ..|.| ... |.| ||||.|| . |...|||| .| . ..|. . |.|. WKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQREL |
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| Kinase | 19106.AA | ULK | 1092-1120 | 41 | 3.8e-09 | 28.15 | In-house | 301-329 (329) | Show / Hide |
Range on Protein: 1092-1120 Range on HMM: 301-329/329 Sequence Identity: 41% (12 aa) ELKDLLEKMLNPNPDQRISINEVVSHQWL |.|||. .|| ....|||. |. .| |. ECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 19106.AA | CAMKK-Unclassified | 682-725 | 26 | 4.8e-09 | 25.27 | In-house | 184-252 (392) | Show / Hide |
Range on Protein: 682-725 Range on HMM: 184-252/392 Sequence Identity: 26% (18 aa) MQQISSSVQYIHEEKG--------------------IVHCDIKPENIFKLAKDH-----FVLADFGLAH ..|.. .||.| . |.| ||||.|| | |..||||... FRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISV |
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| Kinase | 19106.AA | ULK | 676-738 | 29 | 1.1e-08 | 26.97 | In-house | 126-199 (324) | Show / Hide |
Range on Protein: 676-738 Range on HMM: 126-199/324 Sequence Identity: 29% (22 aa) EEIRLMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKD------------HFVLADFGLAHYVLNTNQQQQLEK .|.. ..|| . ...| ...|.|.||||.|| .. .. .||||.| | | |..||. . QEAIQFFKQICNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ |
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| Kinase | 19106.AA | ULK | 676-738 | 29 | 1.9e-08 | 25.71 | In-house | 130-203 (329) | Show / Hide |
Range on Protein: 676-738 Range on HMM: 130-203/329 Sequence Identity: 29% (22 aa) EEIRLMMQQISSSVQYIHEEKGIVHCDIKPENIFKLAKD------------HFVLADFGLAHYVLNTNQQQQLEK .|.. ..|| . ...| ...|.|.||||.|| .. .. .||||.| | | |..||... QEAIQFFKQILNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMM |
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| Kinase | 19106.AA | WEE | 1092-1120 | 37 | 9.7e-08 | 22.12 | In-house | 269-297 (297) | Show / Hide |
Range on Protein: 1092-1120 Range on HMM: 269-297/297 Sequence Identity: 37% (11 aa) ELKDLLEKMLNPNPDQRISINEVVSHQWL |||.|. |..|.|.||..... ..| | ELKQLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Kinase | 19106.AA | ULK | 1019-1058 | 22 | 8.3e-05 | 12.82 | In-house | 225-268 (329) | Show / Hide |
Range on Protein: 1019-1058 Range on HMM: 225-268/329 Sequence Identity: 22% (10 aa) DQ-----IDEKKADIFALGMTLFVCLFKTYPYQQKCSMDDSLFKY .| ...|.||. ||. .. .|. .|.. .|. | .. GQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQII |
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| Kinase | 19106.AA | Ciliate-E2 | 486-742 | 13 | 0.000316 | 10.39 | In-house | 53-225 (365) | Show / Hide |
Range on Protein: 486-742
Range on HMM: 53-225/365
Sequence Identity: 13% (39 aa)
NQQQQKQQQSQQQQQDQLRQKNISFQHSKNQPDLKLKKANSQTYNNHAIKQQQKNSNNNKEVQMNISSSSFNPKQMKKYIDKNCSGAAYSQYQPTSPLNG
......| ... | ....|..|. |
KIMKKNQIEQIKQEIHIMREINC-F---------------------------------------------------------------------------
YLNHPKTLVIKQITHHEQNQHDKNCYNLYNEYTLQSNLSHEFILKPIQMQLIKNVHDHPN--TKGGCYIIYPRAQS-DLYDYYLSSSTLFANI-------
. . ||. .. | . ... .. .|.. .| ||.|| .... . ..
----------------------------------YKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYF
--EEIRLMMQQISS---------------SVQYIHEEKGIVHCDIKPENIFKLAKDHFVLADFGLAHYVLNTNQ-----QQQLEKINNK
.||. .|.|| . ..|.|... |.| |||||||. ..||||. .. . || ||. .... |
TEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-K
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| Kinase | 19106.AA | CAMKK-Unclassified | 1024-1048 | 40 | 0.001718 | 6.89 | In-house | 312-336 (392) | Show / Hide |
Range on Protein: 1024-1048 Range on HMM: 312-336/392 Sequence Identity: 40% (10 aa) KKADIFALGMTLFVCLFKTYPYQQK ||||| .|| |.. ... |.. | KKADIWSLGVTFYCMVYHSLPFWHK |
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| Kinase | 19106.AA | WEE | 1011-1037 | 33 | 0.001765 | 7.62 | In-house | 202-228 (297) | Show / Hide |
Range on Protein: 1011-1037 Range on HMM: 202-228/297 Sequence Identity: 33% (9 aa) NELSKDGIDQIDEKKADIFALGMTLFV .|. . . .. .|||||.||.|... PEILQGYYHYTHLYKADIFSLGITIYE |
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| Kinase | 19106.AA | CAMKK | 1024-1048 | 44 | 0.154321 | 0.14 | In-house | 305-329 (396) | Show / Hide |
Range on Protein: 1024-1048 Range on HMM: 305-329/396 Sequence Identity: 44% (11 aa) KKADIFALGMTLFVCLFKTYPYQQK |.||| ||| ||. .|.. |.. . KAADIWALGVTLYCFVFGKCPFWHN |
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