Gene 20266 (Tetrahymena)

20266

Species: Tetrahymena
Alias: 53.m00168, 415, TTHERM_00455370, 20266, PreTt20266, 3712.m00029
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
20266.AA Protein None 284 None Fasta, JSON
20266.kin_dom Protein Kinase Domain None 233 None Fasta, JSON
20266.NA RNA None 855 None Fasta, JSON

Protein domain

Protein domains of 20266.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20266.AA CAMK 46-273 17 2.2e-62 199.54 In-house 1-425 (425) Show / Hide 
Range on Protein: 46-273
Range on HMM: 1-425/425
Sequence Identity: 17% (74 aa)

YISKGQFGMVWKMKELKSE------------KIVAVKQINKEDVIK-------------------------QNMYTNLKREIEIQSHLM-------HKHI
 . .|.|| | . .. ..             . ||.| |.|. . .                         ...  |..||||| ..|        |..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IECYGYYTT-------------------DLKVFIIL---EYAQKG-----------------------------------------SLTTALSYLRERKV
| .| .| .                   | ......   ||.. |                                          .  |. |. ....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKLENILIDYN-----------------GDVKLGDFGCSVIDFYQKG------------------------RSTFCGTVDYLS-PEILS-------
 |||.|.||||.|.|                 ...|. ||| . . .  ..                         .|||||  | . ||.|.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------IKQQGVEADVWALGVVFYELLYQAPPFQGEDKLQKMN-------------NIYDQKWSFLDN-------------QRQISNQ--------AKN
       ..  | ..|.|..||. | .|   |||.|..  . ..             .|   |..| .                 ||..        .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLLQLLNPDKEKRFKPHQIIESEYI
|. ..|..| |||.. .|. . . .
LIRKMLQVDPEKRMTIEQCLNHPWM
S_TKc 20266.AA S_TKc 41-273 25 7.9e-59 202.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 41-273
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

FQRLNYISKGQFGMVWKMKELKSEKIVAVKQINKEDVIKQNMYTNLKREIEIQSHLMHKHIIECYGYYTTDLKVFIILEYAQK--GSLTT----------
.. |. | || || |.| .. |. .|||.|.|.           ...|||.| ..  |..|. .|... .  ......||.    |.| .          
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-----------------ALSYLRERKVLHRDIKLENILIDYNGDVKLGDFGCSVIDFYQKGRSTFCGTVDYLSPEILSIKQQGV-EADVWALGVVFYELL
                 || |. .....|||.| ||||.|    .|..||| . .       .||||| .|..||.|   . |  ..|.|..|...||.|
RFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

YQAPPFQGEDKLQKMNNIYDQKWSFLDNQRQISNQAKNLLLQLLNPDKEKRFKPHQIIE-------SEYI
.  |||.  .  . ...|              | .||... ..|. | |||    .. .        ...
CGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20266.AA Ciliate-E2 41-273 21 2.3e-57 195.5 In-house 1-365 (365) Show / Hide 
Range on Protein: 41-273
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

FQRLNYISKGQFGMVWKMKELKSE-----------------------KIVAVKQINKEDVIKQNMYTNLKREIE----------IQSHLMHKHIIECYGY
.  .. | .|.|| |.|.|  |                         ||.|.|...| ... ...  .. |||.          |...| |..||..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YT--TDLKVFIILEYAQKGSLTT------------------------------------------------ALSYLRERK-VLHRDIKLENILIDYNGDV
.   .| ......||.| |.|                                                  || || ... ..|||||.||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGC--SVIDFYQKGR------------------------------STFCGTVDYLSPEILSIKQ---------QGVEADVWALGVVFYELLYQAPP
|. |||    . |..|...                               |.|||  |..||||. |.          . ..|.|.|||..||.|.  ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGEDKLQKMNNIYDQKWSFLDNQ---------------RQISNQAKNLLLQ----LLNPDKEKRFK-PHQIIESEYI
|        ...| ..|..|  ..                ..|...|.|. .    .|. | |||.  . ||.. ...
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 20266.AA AGC 129-261 25 3.1e-55 140.21 In-house 165-373 (395) Show / Hide 
Range on Protein: 129-261
Range on HMM: 165-373/395
Sequence Identity: 25% (55 aa)

ALSYLRE-RKVLHRD-IKLENILIDYNGDVKLGDFGCSVIDF------------------------------------YQKGR---------------ST
|| || . ... ||| .|.||||.| .| .|| ||| . .                                       |. .               .|
ALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWT

FCG--TVDYLSPEILSIKQQGVEADVWA--LGVVFYELLYQAPPFQGE----------DKLQKMNNIY--------DQKWS-----FLDNQRQISNQAKN
|||  | .|..||||     | ..| |.  ||...||.|.  |||.|.          .. .....|         ..|.      . . .|..|..||.
FCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKD

LLLQLLNPDKEKR
|. .||..| |||
LIKKLLCKDPEKR
Kinase 20266.AA Aur 129-273 37 1.5e-52 136.65 In-house 113-257 (257) Show / Hide 
Range on Protein: 129-273
Range on HMM: 113-257/257
Sequence Identity: 37% (56 aa)

ALSYLRERKVLHRDIKLENILID-YNGDVKLGDFGCSVIDFYQKGRSTFCGTVDYLSPEILSIKQQGVEADVWALGVVFYELLYQAPPFQG-EDKLQKMN
|| |. .... ||||| ||||.|  ||..|..|||.||.   .. |.|||||.||..||. . .. . . |.|.|||  |||.  .|||.. |.. ... 
ALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESNENHDETYD

NIY-DQKWSFLDNQRQISNQAKNLLLQLLNPDKEKRFKPHQIIESEYI
.|    . .| ..   ||  || |  ..|  | ..|    || .   |
RIKNKVDIQFPSH---ISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 20266.AA ULK 41-273 24 4.9e-48 165.78 In-house 1-329 (329) Show / Hide 
Range on Protein: 41-273
Range on HMM: 1-329/329
Sequence Identity: 24% (79 aa)

FQRLNYISKGQFGMVWKMKELKSE----KIVAVKQINKE-DVIKQNMYT------NLKREIEIQSHLM--------HKHIIECYGYYTTDLK--VFIILE
..  . . ||.|| | | .  |..    ..||.|.| |.   .|.|...       ||.||.|.  |         |..|.. | .. |.    ..||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAQKGSLTTALS--------------------------------YLRERKVLHRDIKLENILIDYN------------GDVKLGDFGCSVI-DFY----Q
| . | | . ..                                .|..... |||||..||||. .            | .|..||| .   |      |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KGRSTF-----CGTVDYLSPEILS----IKQQG-VEADVWALGVVFYELLYQAPP----FQGEDKLQKMNN----------IYDQKWSFLD--NQRQISN
   ..      |||  | .|.||.     |...  ..|.| ||..|||.||  ||    |. .........          | .|.  | .  |. |||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

QAKNLLLQLLNPDKEKRFKPHQIIESEYI
. |.|. ..|  | ..|.  ..... . .
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20266.AA ULK 41-273 24 7.3e-48 165.32 In-house 1-324 (324) Show / Hide 
Range on Protein: 41-273
Range on HMM: 1-324/324
Sequence Identity: 24% (80 aa)

FQRLNYISKGQFG-MVWKMKELKSE---KIVAVKQINKE-DVIKQNMYT------NLKREIEIQSHLM---HKH--IIECYGYYTTDLK--VFIILEYAQ
..  . . ||.||  | | .  |..   ..||.|.|.|    .|.|...      .||.||.|.  |    |..  |.. | .. |.    ..||.|| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGSLTTALS-------------------------------YLRERKVLHRDIKLENILIDYN------------GDVKLGDFGCSVI-DFY---QKGRST
 | | . .                                .|..... |||||..||||  .            | .|..||| . . | .   |  . |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

FC------GTVDYLSPEILS----IKQQG-VEADVWALGVVFYELLYQAPPFQGE-DKLQ----KM-NN-------IYDQKWSFLD--NQRQISNQAKNL
..      ||  | .|.||.     |...  ..|.| ||..|||.||  .||..   ...    |. ||       |..|.  | .  .. .||.. |.|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

LLQLLNPDKEKRFKPHQIIESEYI
. ..|  | ..|.  ..|.. . .
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 20266.AA Ciliate-E2-Unclassified 41-273 21 1.7e-47 162.79 In-house 1-352 (352) Show / Hide 
Range on Protein: 41-273
Range on HMM: 1-352/352
Sequence Identity: 21% (74 aa)

FQRLNYISKGQFGMVWKMKELKSEKIVAVKQINKEDVIKQNMYTN----LKREIEIQSH----------------LMHKHIIECYGYYT--TDLKVFIIL
.  .  | .|.|| |.|... |  .. | |...|  ..||. . |    .  ..|....                |.|.|..  . .|.  .. ...|..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAQKGSLTT--------------------------------------------ALSYLRERK-VLHRDIKLENILIDYNG---DVKLGDFGCSV-----
||.. |.|                                              .|.|| . . ..|||||.||||.| ||    .|. ||| |      
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------IDFYQKGRS-TFCGTVDYL----SPEILSIKQQG----VEADVWALGVVFYELLYQAPPFQGEDKLQ----------------KMNNIYD
          ...... .. |||||  |.    .||.|  ....     ..|.|.|||..||.|.. .||..... |                  .||..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

QKWSFLD-NQ----RQISNQAKNLLL----QLLNPDKEKRFKPHQIIESEYI
....|   ..     ..|..||...     ..|. . .||  . ||..  ..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20266.AA Pkinase 129-273 27 1.8e-39 140.67 Pfam 120-293 (293) Show / Hide 
Range on Protein: 129-273
Range on HMM: 120-293/293
Sequence Identity: 27% (49 aa)

ALSYLRERKVLHRDIKLENILIDYNGDV----KLGDFGCSVI--DFYQKGRSTFCGTVDYLSPEILS-IKQQGVEADVWALGVVFYELLYQAPPFQGE--
.| |. .....|||.|.|||||| ||..    |..|||..       .   .||||| .|..||..   .  | ..|.|..|...||.|   |||.|.  
GLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCW

----DKLQKMNNIYDQKWSFLDNQR------------------QISNQAKNLLLQLLNPDKEKRFKPHQIIESEYI
    |..|....| . ...|   .                    .|  .| ..  .|..| .||  ..|| .....
HDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 20266.AA CAMKL 129-273 29 1.8e-37 117.06 In-house 139-297 (297) Show / Hide 
Range on Protein: 129-273
Range on HMM: 139-297/297
Sequence Identity: 29% (49 aa)

ALSYLRERKVLHRDIKLENILIDYNGD--VKLGDFGCS-----VIDFYQKGRSTFCGTVDYLSPEILSI--K-QQGVEADVWALGVVFYELLYQAPPFQG
|..|. .... |||||.||||.|.||.  .|. ||| |     .|. . .  .||||.  | .|||..   |   | ..|.|..||. | ... . || .
AVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDD

ED-----------KLQKMNNIYDQ-KWSFLDNQRQISNQAKNLLLQLLNPDKEKRFKPHQIIESEYI
..           ....|   |   .|...      | ....|. ..|... |||.. ||| . .  
DTYNKQGKDNIYLYWKIMCG-YYPPIWYHV------S-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 20266.AA Aur 49-126 44 2.9e-35 90.11 In-house 9-86 (257) Show / Hide 
Range on Protein: 49-126
Range on HMM: 9-86/257
Sequence Identity: 44% (35 aa)

KGQFGMVWKMKELKSEKIVAVKQINKEDVIKQNMYTNLKREIEIQSHLMHKHIIECYGYYTTDLKVFIILEYAQKGSL
|| || |   .. |. .|.| |...||. .|..|. .|.|||.||||| | .|...|||.  | ....|||||. |.|
KGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGEL
Kinase 20266.AA PLK-Unclassified 129-273 35 2.8e-32 113.57 In-house 118-264 (264) Show / Hide 
Range on Protein: 129-273
Range on HMM: 118-264/264
Sequence Identity: 35% (52 aa)

ALSYLRERKVLHRDIKLENILIDYNGDVKLGDFGCSV-IDFYQKGRSTFCGTVDYLSPEILSIKQ--QGVEADVWALGVVFYELLYQAPPFQGEDKLQKM
|| ||  ... ||| || ||... |  ||..||| .. . ..   . |.|||  | .||||  |.   . | |.|..|.. | ||   |||...|  |  
ALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYTLLIGKPPFETKDVKQTY

NNIYDQKWSFLDNQRQISNQAKNLLLQLLNPDKEKRFKPHQIIESEYI
 .|  .. ||   . .|| .||.|. . ||.. ..|.   || .. . 
KKIKCNQYSF-PEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 20266.AA STE 129-273 21 1.9e-28 97.61 In-house 163-359 (359) Show / Hide 
Range on Protein: 129-273
Range on HMM: 163-359/359
Sequence Identity: 21% (44 aa)

A-LSYLRERKVLHRDIKLENILIDYNGDVKLGDFGCSVIDFY-----------------QKGRSTFCGTVDYLSPEILSI------KQQGVEADVWALGV
. |.|| . .. |||||  |||.     ||| |||.. .                    |. | ||.||  . .||...       |. .. .|.| || 
GLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGC

VFYELLYQAPPFQGEDKLQKMNNIY----------------DQKWSFLDN----------------QRQISNQAKNLLLQLLNPDKEKRFKPHQIIE--S
.  |..   ||.  .  .. | .|                 ..  .. |.                ... |   |. . . |. | .|| ...| ..   
TIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEH

EYI
. |
PFI
Kinase 20266.AA CAMKL 41-126 22 1.5e-19 58.89 In-house 1-110 (297) Show / Hide 
Range on Protein: 41-126
Range on HMM: 1-110/297
Sequence Identity: 22% (25 aa)

FQRLNYISKGQFGMVWKMKE-LKSEKIVAVKQINKE----DVIKQNMYTN--------LKREIEIQSHLM---HKHIIECYGYYTTDLK------VFIIL
.. .  . || || |   .  .  .. ||.| |.|.    | .....  .        ..|||.|...|    |..||  |  ..|. .      .....
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAQKGS--L
||.. |.  |
EYCSGGEMDL
Kinase 20266.AA Pkinase 41-126 28 6.8e-18 64.36 Pfam 1-91 (293) Show / Hide 
Range on Protein: 41-126
Range on HMM: 1-91/293
Sequence Identity: 28% (26 aa)

FQRLNYISKGQFGMVWKMKELKSEKIVAVKQINKEDVIKQNMYTNLK-REIEIQSHLMHKHIIECYGYYTTDLKVFIILEYAQKG----SL
....  | .| || |.| .. ...||||||.|.|..  ..  .|... .||.|  .| |..|...|...... .. ...||...|    .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL
Kinase 20266.AA STE 41-127 22 1e-14 48.46 In-house 1-125 (359) Show / Hide 
Range on Protein: 41-127
Range on HMM: 1-125/359
Sequence Identity: 22% (28 aa)

FQRLNYISKGQFGMVWKMKELK---------------SEKIVAVKQINKEDV--------------IKQNMYTNLKREIEIQSHLM--HKHIIECYGYYT
....  | || || | | .  |               . .|.|.||.|.|.               . ..   ....||.| ...   |..|...||.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TDL-------KVFIILEYAQKGSLT
 .        ...|..||   |||.
KEGHNHKNDDELWICMEYMDGGSLD
Kinase 20266.AA AGC 41-124 15 3e-12 26.47 In-house 1-126 (395) Show / Hide 
Range on Protein: 41-124
Range on HMM: 1-126/395
Sequence Identity: 15% (20 aa)

FQRLNYISKGQFGMVWKMKEL------KSEKIVAVKQINKED-VIKQN--MYTNLKRE------------IEIQSHLM----------HKHIIE-CYGYY
|. |  |.|| || |.  ..        ..|. |.| ..|.. ... .  |  . ..|             .| ...           |  |.   .  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

TTDLK--VFIILEYAQ--------KG
 .. .  .....||..         |
QDKDHTYLYFVMEYMPRYVNDLYCGG
Kinase 20266.AA TyrKc 41-273 20 4.9e-12 -28.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 41-273
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FQRLNYISKGQFGMVWKMKELKSEKIVAVKQINKEDVIKQNMYTNLKREIEIQSHL--MHKHIIECYGYYTTD-------LKVFIILEYAQKGSLTTAL-
 . .  .  |.|| |.| .       |||| ....          . ||..| ..|   |..|. .||. |..         ..|..||. .|.|   | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

----------------------SYLRERKVLHRDIKLENILIDYNGDVKLGDFGCSVIDF----------YQKG----RSTFCGTVDYLSPEILSIKQQG
                      .|| .... |||.   |.|.. |. || .||| |              | .      . .   .  ..|| .  .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VEADVWALGVVFYELL-YQAPPFQGEDKLQKMNNI----YDQKWSFLDNQRQ--------ISNQAKNLLLQLLNPDKEKRFKPHQIIESEYI
 . |||. ||. .|.. | ..|  |. .  .|.|.    | ..   ..             .    .. .|  . | |.|    .|   |..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 20266.AA Pkinase_Tyr 41-126 26 9.9e-11 36.96 Pfam 1-94 (270) Show / Hide 
Range on Protein: 41-126
Range on HMM: 1-94/270
Sequence Identity: 26% (25 aa)

FQRLNYISKGQFGMVWKMKEL----KSEKIVAVKQINKEDVIKQN-MYTNLKREIEIQSHL-MHKHIIECYGYYT-TDLK--VFIILEYAQKGSL
 . .  . .|.||.|.| .      . .  |||| . ||.  ... .   . ||..| ..|  |..|. .||  |  .    ..|..||...|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 20266.AA PLK-Unclassified 41-126 31 1.8e-09 31.63 In-house 1-86 (264) Show / Hide 
Range on Protein: 41-126
Range on HMM: 1-86/264
Sequence Identity: 31% (27 aa)

FQRLNYISKGQFGMVWKMKELKSEKIVAVKQINKEDVIKQNMYTNLKREIEIQSHLMHKHIIECYGYYTTDLKVFIILEYAQKGSL
 .|.  . || |  . ..|.... || |.| | |    |.  .  |. ||.|.. | ||.|   .     .  | | |||   |.|
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTL
Kinase 20266.AA Pkinase_Tyr 129-162 38 0.035593 7.99 Pfam 123-156 (270) Show / Hide 
Range on Protein: 129-162
Range on HMM: 123-156/270
Sequence Identity: 38% (13 aa)

ALSYLRERKVLHRDIKLENILIDYNGDVKLGDFG
...|| ...  |||.   |.|.. |. || .|||
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFG