Gene 21888 (Tetrahymena)

21888

Species: Tetrahymena
Alias: 21888, 117.m00140, PreTt21888, 919, TTHERM_00726230
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
21888.AA Protein None 791 None Fasta, JSON
21888.kin_dom Protein Kinase Domain None 138 None Fasta, JSON
21888.NA RNA None 2376 None Fasta, JSON

Protein domain

Protein domains of 21888.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21888.AA S_TKc 272-542 13 1.5e-08 -51.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 272-542
Range on HMM: 1-231/231
Sequence Identity: 13% (43 aa)

LVKIGELGRGGFGSVSIYYDNVTRNKIAVKEFNSLKEYQQEKNILQKIQFQELFLEVKKYTCQLIDFNDYNYTLALEMGFSTL--QEAAQILNLQKTG--
  .. ..|.|.||.|   ... |  . |.|. .  .  ..| .||.|           .. ..|.|. .    | . | .      .  ...  ....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK---------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSIPNLINFLNSMVCFCIELHKIKYYHGDIKPQNIIITINQNSSEFQQSFGICEFVEANIKFIDFG--------------------SFSN-DVDCY-
   |.      ..  ..|    .|. .  | |.||.|| ..                    .|| .|||                    ...   .| . 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWS

-----YEYVSAKYKCLFFEEIFQEQQLTWEQILFAEIYSCCKTCIYTMSLELQNEYILFNKSQVDQQNPNQEQKLKLFDFLDLFLTQNPS----QNNILQ
     || .. .           ..|.....|.                                           . ||..  |. .|.       .||
CGCILYEMLCGYPPFP-------QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

DG--ISLQKLV
|.  | .   .
DEWDIKCHPWF
Kinase 21888.AA Ciliate-E1 278-459 17 4.1e-08 22.97 In-house 1-202 (202) Show / Hide 
Range on Protein: 278-459
Range on HMM: 1-202/202
Sequence Identity: 17% (36 aa)

LGRGGFGSVSIY--YDNVTRNKIAVKEFNSLK-EYQQEKNILQKIQFQELFLEVKKYTCQLIDFN--DYNYTLALEMGF--STLQEAAQ---------IL
.|.|.|. | .   . | ..... . .    . ..... .......  .  .. ..|. |.||.   |.||. .. . .   .|..  |         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

NLQKTGFSIPNLINFLNSMVCFCIELHKIKYYHGDIKPQNIIITINQNSSEFQQS-FGICEF-VEANIKFIDFGSFSNDVDCYYEYV------SAKYKCL
. ..  |.. ....    ..   ||||  . .|.|||||||.|  |.. .... . |||. |  . ... ...  . . . ....|         ..|  
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILI--NNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN

FFEEIF
.  .|.
YKSDIY
Kinase 21888.AA Ciliate-E2 386-433 30 9e-06 15.74 In-house 175-201 (365) Show / Hide 
Range on Protein: 386-433
Range on HMM: 175-201/365
Sequence Identity: 30% (15 aa)

ELHKIK-YYHGDIKPQNIIITINQNSSEFQQSFGICEFVEANIKFIDFG
.||. .   | ||||.||..                      || ||||
YLHSKNNIIHRDIKPENILF----------------------IKIIDFG
Kinase 21888.AA Ciliate-A5 387-405 52 1.3e-05 15.58 In-house 115-133 (275) Show / Hide 
Range on Protein: 387-405
Range on HMM: 115-133/275
Sequence Identity: 52% (10 aa)

LHKIKYYHGDIKPQNIIIT
|.. ...||||.||||..|
LQQNNICHGDIRPQNICLT
Kinase 21888.AA STE 272-321 17 1.9e-05 15.31 In-house 1-81 (359) Show / Hide 
Range on Protein: 272-321
Range on HMM: 1-81/359
Sequence Identity: 17% (14 aa)

LVKIGELGRGGFGSVSIYYDN------VTRNK---------IAVKEFN----------------SLKEYQQEKNILQKIQF
. .|...|.|.||.|   ...       | ..         .|.|. |                . |  .....||. |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKI
Kinase 21888.AA CAMKL 387-433 36 2.2e-05 12.95 In-house 143-174 (297) Show / Hide 
Range on Protein: 387-433
Range on HMM: 143-174/297
Sequence Identity: 36% (17 aa)

LHKIKYYHGDIKPQNIIITINQNSSEFQQSFGICEFVEANIKFIDFG
.|. .  | |||| || .. |.|.               ||| ||||
CHSHGIVHRDIKPENILLDENGNN---------------NIKIIDFG
Kinase 21888.AA CAMK 277-320 17 4e-05 11.68 In-house 1-89 (425) Show / Hide 
Range on Protein: 277-320
Range on HMM: 1-89/425
Sequence Identity: 17% (16 aa)

ELGRGGFGSVSIYYDNVTR------------NKIAVKEFN---------------------------------SLKEYQQEKNILQKIQ
.||||.|| |   ..  |              | |.|  .                                 ..|. ..| .|..|.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQ
Kinase 21888.AA CAMKL-Unclassified 270-301 37 5.4e-05 12.84 In-house 1-30 (290) Show / Hide 
Range on Protein: 270-301
Range on HMM: 1-30/290
Sequence Identity: 37% (12 aa)

YKLVKIGELGRGGFGSVSIYYDNVTRNKIAVK
| .|..  .| |||| | .    .|. |.|.|
YNIVQV--IGEGGFGQVQLAEHKQTQEKFAIK
Kinase 21888.AA Ciliate-E2b 272-321 30 6.3e-05 11.09 In-house 1-59 (272) Show / Hide 
Range on Protein: 272-321
Range on HMM: 1-59/272
Sequence Identity: 30% (18 aa)

LVKIGELGRGGFGSVSIYYD-NVTRNKIAVKEFNSL--------KEYQQEKNILQKIQF
.. | .||.| ||||      . |..  | | ...         |  .||||.|.|...
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNH
Kinase 21888.AA STE 387-433 27 7.2e-05 13.27 In-house 168-192 (359) Show / Hide 
Range on Protein: 387-433
Range on HMM: 168-192/359
Sequence Identity: 27% (13 aa)

LHKIKYYHGDIKPQNIIITINQNSSEFQQSFGICEFVEANIKFIDFG
||. .. | ||||.|| .                      .| .|||
LHSHHIIHRDIKPANILL----------------------VKLCDFG
Kinase 21888.AA CMGC 387-434 20 0.000109 10.31 In-house 198-250 (513) Show / Hide 
Range on Protein: 387-434
Range on HMM: 198-250/513
Sequence Identity: 20% (14 aa)

LHKIK--YYHGDIKPQNIIITINQNS-------SEFQQSFGICEFVEAN----------IKFIDFGS
.|. .    | |.||.|| |. |  .       |              .          .| .|||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKS--------------EDWNPCQKNGRLKICDFGL
Kinase 21888.AA CAMKL 270-315 24 0.000206 9.83 In-house 1-59 (297) Show / Hide 
Range on Protein: 270-315
Range on HMM: 1-59/297
Sequence Identity: 24% (15 aa)

YKLVKIGELGRGGFGSVSIYYD-NVTRNKIAVKEFN--SLK-EYQQEKN-----------I
|...|  .||.|.|| |    .   |. | |.|  .   .. . . .||           |
YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRI
Kinase 21888.AA Pkinase 272-304 27 0.000305 16.08 Pfam 1-33 (293) Show / Hide 
Range on Protein: 272-304
Range on HMM: 1-33/293
Sequence Identity: 27% (9 aa)

LVKIGELGRGGFGSVSIYYDNVTRNKIAVKEFN
..... .|.|.||.| . ..  |. . |||...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK
Kinase 21888.AA STE20 272-321 21 0.001032 9.79 In-house 1-57 (288) Show / Hide 
Range on Protein: 272-321
Range on HMM: 1-57/288
Sequence Identity: 21% (12 aa)

LVKIGELGRGGFGSVSIYYDNVTRNK----IAVKEFNSLKEY---QQEKNILQKIQF
  .. ..|.|..|.|   |.. | ..    .|.|  |  |.    .....|.. |..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISI
Kinase 21888.AA Ciliate-E2 272-338 14 0.004753 6.29 In-house 1-100 (365) Show / Hide 
Range on Protein: 272-338
Range on HMM: 1-100/365
Sequence Identity: 14% (15 aa)

LVKIGELGRGGFGSVSIYYDNVTRNKIAVKEFNSLKEYQQE------------KNILQKIQFQELFLEVKKY-----------------------TCQLI
  .|  .|.|.||||    .  .....| | ..  |  |.             ..|..| | .... | . .                        ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DF
..
EC
Kinase 21888.AA CMGC 272-313 17 0.006337 4.41 In-house 1-55 (513) Show / Hide 
Range on Protein: 272-313
Range on HMM: 1-55/513
Sequence Identity: 17% (10 aa)

LVKIGELGRGGFGSVSIYYD--------------NVTRNKIAVKEFNSLKEYQQEK
  .|. .|.| .| |   .|              . | ...|.| . . . |. ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQA
Kinase 21888.AA CAMK 387-433 31 0.006892 4.34 In-house 195-241 (425) Show / Hide 
Range on Protein: 387-433
Range on HMM: 195-241/425
Sequence Identity: 31% (17 aa)

LHKIKYYHGDIKPQNIIITINQNSSE-------FQQSFGICEFVEANIKFIDFG
.|. .  | |.|| || .. | ..|.       |           .||| ||||
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIF-D------WNNNNIKIIDFG
Kinase 21888.AA Ciliate-E2b 386-405 40 0.020787 3.32 In-house 117-136 (272) Show / Hide 
Range on Protein: 386-405
Range on HMM: 117-136/272
Sequence Identity: 40% (8 aa)

ELHKIKYYHGDIKPQNIIIT
.||. .  ..|||| ||...
YLHNQNIIYRDIKPENIMVD
Kinase 21888.AA STE20 387-405 47 0.054869 3.41 In-house 133-151 (288) Show / Hide 
Range on Protein: 387-405
Range on HMM: 133-151/288
Sequence Identity: 47% (9 aa)

LHKIKYYHGDIKPQNIIIT
||. .. | ||| .|| .|
LHSNHIIHRDIKADNILLT