Gene 22078 (Tetrahymena)
22078
Group:
TKL
Family:
TKL-ciliate5
Sequence
Protein domains of 22078.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22078.AA | TKL | 440-676 | 18 | 9.5e-37 | 128.41 | In-house | 111-364 (364) | Show / Hide |
Range on Protein: 440-676
Range on HMM: 111-364/364
Sequence Identity: 18% (56 aa)
NQVCLVSKYYELGSLAELIQKHHNVLESSRSSGTSSFPIASDNKSLNKNDQNNNLYGKRLNINSTSVDSFDFKFSYETKMKIAISIAKTMAKLHKIG---
.| |.| |.. ||| .... . ....|..||. |. || .
GQLCIVMEYCPGGSLLHYLH-------------------------------------------------------WHQRCRWALDIARGMNYLHSMNPKW
-----IIHGHLSSSNILFDTNYE--------------VKISDIGLTSLKKLISY-------------------RFGYQN-KTHFTAPEHLQEKSL---IV
||| | |.||| | |.. .||.| || .. . . . | . . ||| |... |
CTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKV
--------QNPKTKSDIYSFAFILWELFMEREAFSNLSLEDLK---------KTIILDNSRPKIPEV----------GPIPKEVATIIRYCWLLNPNERP
.|.|.|||. .|||.. .. .... .. . . ..... || ||.. ..|.... .. || .|..||
GIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP
EFGVILANL
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SFQEILKRL
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| Kinase | 22078.AA | TKL-Unique | 512-676 | 29 | 6.3e-25 | 84.95 | In-house | 106-290 (290) | Show / Hide |
Range on Protein: 512-676
Range on HMM: 106-290/290
Sequence Identity: 29% (57 aa)
KFSYETKMKIAISIAKTMAKLHKIG--IIHGHLSSSNILFDTN-----YEVKISDIGLTSLKKLISYRFGY----------QNKTHFTAPEHLQEK-SLI
|.... ..|.|| ||. | || . |||. | |||.| | | . .||.| || ... |. . . . ||| | ...
KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY
VQNPKTKSDIYSFAFILWELFMEREA-------FSNLSLEDLKKTIIL--DNSRPKIPEVGPIPKEVATIIRYCWLLNPNERPEFGVILANL
.|||.|||...|||.. .|. ..... | ..... .|.||.||. .||| .|. || .| .|| | |. |
----SEKSDVYSFGIVLWEIA-TRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNH--CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
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| Kinase | 22078.AA | RIPK | 532-676 | 25 | 9.2e-22 | 70.92 | In-house | 123-290 (290) | Show / Hide |
Range on Protein: 532-676 Range on HMM: 123-290/290 Sequence Identity: 25% (43 aa) LHKIG--IIHGHLSSSNILFDTNYEVKISDIGLTSLKKLISYRFG----------YQNKTH-----FTAPEHLQEKSLIVQNP----KTKSDIYSFAFIL || .. ||| | .||| | |. |||.| || . . | ... .. | . .|||. . . .| .|.|.||||... LHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMW-SHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT---DNKKPIKVVTPKYDVYSFAIVM WELFMEREAFSNLSLEDLKKTIILDNSRPKIPEV---GPIP---KEVATIIRYCWLLNPNERPEFGVILANL ||.. ...... .. . . . .||....| |.| .. .. || .||.|| | . WEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT |
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| Kinase | 22078.AA | RGC | 539-678 | 24 | 7e-19 | 63.12 | In-house | 109-300 (300) | Show / Hide |
Range on Protein: 539-678 Range on HMM: 109-300/300 Sequence Identity: 24% (47 aa) HGHLSSSNILFDTNYEVKISDIGL-----TSLKKLISYR--------FGYQN-------KTHFTAPEHLQ-EKSLIVQN--PKT-----KSDIYSFAFIL ||.|.|.| . | . |||.| || ...|. . .. . .|. | . |||||| ... .. . | | |.|||. |. HGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIM WELFMEREAFSNL-------SLEDLKKTIILDN-----------SRPKIPEVG-----PIPKEVATIIRYCWLLNPNERPE-FGVILANLKR |.. .... . .| . || .. ||.|.| .. .. ...| || .| |||. | | .||. YEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT |
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| Kinase | 22078.AA | Dicty4-Unclassified | 519-676 | 30 | 8.8e-19 | 60.93 | In-house | 112-263 (263) | Show / Hide |
Range on Protein: 519-676 Range on HMM: 112-263/263 Sequence Identity: 30% (49 aa) MKIAISIAKTMAKLHKIGIIHGHLSSSNILFDTNYEVKISDIGLTSLKKLISYRFGYQNKT---HFTAPEHLQEKSLIVQNPKTKSDIYSFAFILWELFM .|.|..||. |. || .|| . ||||| | .. .|| |.|. |.. | ..|| | | |||.||.| .|.|| IKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGIS---RVIDFNFNMTTIAGTPKWESPECLMHESY-----NQKSDVYSYAMMLYELAT EREAFSNLS-LEDLKKTIILDNSRPKIPEVGPIPKEVATIIRYCWLLNPNERPEFGVILANL | . .. . |||||. .. . | || || || . | | GDEPYQEIQSIMNAARSVCDKKLRPKIPDN--CDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | 22078.AA | RGC | 539-678 | 24 | 8.8e-19 | 63.12 | In-house | 109-300 (300) | Show / Hide |
Range on Protein: 539-678 Range on HMM: 109-300/300 Sequence Identity: 24% (47 aa) HGHLSSSNILFDTNYEVKISDIGL-----TSLKKLISYR--------FGYQN-------KTHFTAPEHLQ-EKSLIVQN--PKT-----KSDIYSFAFIL ||.|.|.| . | . |||.| || ...|. . .. . .|. | . |||||| ... .. . | | |.|||. |. HGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIM WELFMEREAFSNL-------SLEDLKKTIILDN-----------SRPKIPEVG-----PIPKEVATIIRYCWLLNPNERPE-FGVILANLKR |.. .... . .| . || .. ||.|.| .. .. ...| || .| |||. | | .||. YEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT |
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| Kinase | 22078.AA | LRRK | 599-678 | 28 | 1.2e-12 | 40.99 | In-house | 261-351 (351) | Show / Hide |
Range on Protein: 599-678 Range on HMM: 261-351/351 Sequence Identity: 28% (26 aa) TKSDIYSFAFILWELFMER-EAFSNLS------LEDLKKTIILDNSRPKIP-E-VGP--IPKEVATIIRYCWLLNPNERPEFGVILANLKR .|.|.|||. ||||| . .| ... .. . . .|.. ||.|| . .| . .. . | || .|..|| | |. |. EKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| TyrKc | 22078.AA | TyrKc | 361-676 | 16 | 1.5e-12 | -19.79 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 361-676 Range on HMM: 1-280/280 Sequence Identity: 16% (61 aa) VLFEKK------KKTRESQLKDSFRDSNASGDRVVDDEYDVLAFRILPIDTLSSYILQEVNQDINKLKRY--HIKNISKISKLAIDN-------NQVCLV . ..|| . .. ..| ..| . . ... . .. .... | .|| .. ... ....| ITLGKKLGEGAFGEVYKGTWK-----------------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV SKYYELGSLAELIQKHHNVLESSRSSGTSSFPIASDNKSLNKNDQNNNLYGKRLNINSTSVDSFDFKFSYETKMKIAISIAKTMAKLHKIGIIHGHLSSS | ..|.| . ..||.. .. ... .... ||. |. ||. ..|| | MEYMPHGDLKDYLRKHRPK------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAAR NILFDTNYEVKISDIGLTSLKKLI--------SYRFGY--QNKT----HFTAPEHLQEK--SLIVQNPKTKSDIYSFAFILWELF-MEREAFSN-----L |.| . |. ||||| ||. . || . || .||| .... . ||||..|| .||.| . .. . NCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-------TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMM SLEDLKKTIILDNSRPKIPE-VGP-----IPKEVATIIRYCWLLNPNERPEFGVILANL | ... . . . .|. |. | |.|. .|.. || .|..|| | | . SNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 22078.AA | Dicty5 | 600-680 | 32 | 3.8e-11 | 34.59 | In-house | 183-260 (260) | Show / Hide |
Range on Protein: 600-680 Range on HMM: 183-260/260 Sequence Identity: 32% (26 aa) KSDIYSFAFILWELFMEREAFSNLSLEDLKKTIILDNSRPKIPEVGPIPKEVATIIRYCWLLNPNERPEFGVILANLKRIN | |.|||. .|||.| |.. |. . .. || || .| | . .| || | || | |.. ...| KCDVYSFGIVLWEMFTRKEPYDNINNWNI-PVMVMKGERPTIPKD--CPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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| Kinase | 22078.AA | TK-Unique | 521-614 | 27 | 4.1e-11 | 34.67 | In-house | 136-233 (294) | Show / Hide |
Range on Protein: 521-614 Range on HMM: 136-233/294 Sequence Identity: 27% (28 aa) IAISIAKTMAKLHK--IGIIHGHLSSSNILFDTNYEVKISDIGLTS-LKKLISYRFG---YQNKTHFTAPEHLQEKSLIVQNP-KTKSDIYSFAFILWEL .|. ||. |. |.. .|.|..|...|.|. ....||.| |.. . . | . ||| |.. .. ||||..||. ..||. FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY---HGMYHTTKSDVWSFGVLMWEI F | F |
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| Kinase | 22078.AA | RAF | 512-568 | 36 | 4.7e-10 | 30.62 | In-house | 96-152 (275) | Show / Hide |
Range on Protein: 512-568 Range on HMM: 96-152/275 Sequence Identity: 36% (21 aa) KFSYETKMKIAISIAKTMAKLHKIGIIHGHLSSSNILFDTNYEVKISDIGLTSLKKL || ....|| |.. | ||. .|||..|.| ||. . |.| | || ..|.. KFDMNWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRC |
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| Kinase | 22078.AA | Dicty5 | 514-561 | 41 | 3.8e-08 | 24.14 | In-house | 102-149 (260) | Show / Hide |
Range on Protein: 514-561 Range on HMM: 102-149/260 Sequence Identity: 41% (20 aa) SYETKMKIAISIAKTMAKLHKIGIIHGHLSSSNILFDTNYEVKISDIG .| ... .|| ||. | || ..||| | | |.| |...|| | | AYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFG |
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| S_TKc | 22078.AA | S_TKc | 344-679 | 17 | 6.1e-08 | -60.5 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 344-679
Range on HMM: 1-231/231
Sequence Identity: 17% (62 aa)
KQLKKKEKKRGFGFIQKVLFEKKKKTRESQLKDSFRDSNASGDRVVDDEYDVLAFRILPIDTLSSYILQEVNQDINKLKRYHIKNISKISKLAIDNNQVC
.. .| | .|| |. | . | |.. . . . |. ||. | .|| |. | . ..
YEILRKIGKGAFGKVYKCRHKK--------------------------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLY
LVSKYYEL--GSLAELIQKHHNVLESSRSSGTSSFPIASDNKSLNKNDQNNNLYGKRLNINSTSVDSFDFKFSYETKMKIAISIAKTMAKLHKIGIIHGH
.| | . |.| ..|.|. .|.|. . ... |.. .. .|. ||||
MVMEYCDGDLGDLFDYIKKRGRHGL-------------------------------------------RFPFPE-HARFYMYQICCALEYCHSHGIIHRD
LSSSNILFDTNYEVKISDIGLTSLKKLISYRFGYQNKT-----HFTAPEHLQEKSLIVQNPKT-KSDIYSFAFILWELFMEREAFSNLSLEDLKKTIILD
| .|||.|. ..||.| || . .| .. ||| | . |.|..|. ||.|.. . |. .. . | |
LKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--
NSRPKIPEVGPIPKEVATIIRYCWLLNPNERPEFGVILA------NLKRI
..|. .|| |. .|..|| .|. . .
------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 22078.AA | RAF | 647-676 | 36 | 9.5e-08 | 22.63 | In-house | 246-275 (275) | Show / Hide |
Range on Protein: 647-676 Range on HMM: 246-275/275 Sequence Identity: 36% (11 aa) IPKEVATIIRYCWLLNPNERPEFGVILANL .|||. .. || .|.||| | |.. . CPKEMKELLMECWSYQPEERPSFQQIMKMI |
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| Kinase | 22078.AA | Pkinase_Tyr | 599-676 | 32 | 1.2e-07 | 26.48 | Pfam | 193-270 (270) | Show / Hide |
Range on Protein: 599-676 Range on HMM: 193-270/270 Sequence Identity: 32% (26 aa) TKSDIYSFAFILWELFM-EREA-FSNLSLEDLKKTIILDNSRPKIPEVGPIPKEVATIIRYCWLLNPNERPEFGVILANL ||||..|| .||.| .. . ..| |.... | |. | ..|| |.|. .... || .|..|| | |. | TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENC--PDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 22078.AA | LRRK | 443-564 | 20 | 2e-06 | 18.68 | In-house | 131-226 (351) | Show / Hide |
Range on Protein: 443-564 Range on HMM: 131-226/351 Sequence Identity: 20% (28 aa) CLVSKYYELGSLAELIQKHHNV-L---ESSRSSGTSSFPIASDNKSLNKNDQNNNLYGKRLNINSTSVDSFDFKFSYETKMKIAISIAKTMAKLHKIG-- |.| | .|.| ........ . ..| .| |||. ||| |..||. CMVMEYAPHGDLYHFLHNKKQDGFHFMK--------------------------------------------AHISWMLKLKIALQIAKGMEYLHSHNPP IIHGHLSSSNILF---D---------TNYEVKISDIGLTS ||| | | ||| . ... .||.| |... IIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR |
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| Kinase | 22078.AA | TK-Unique | 648-676 | 34 | 9e-06 | 16.05 | In-house | 266-294 (294) | Show / Hide |
Range on Protein: 648-676 Range on HMM: 266-294/294 Sequence Identity: 34% (10 aa) PKEVATIIRYCWLLNPNERPEFGVILANL ..|. ....|| ..| ||| | |. | SHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | 22078.AA | Pkinase_Tyr | 439-563 | 20 | 0.00534 | 10.78 | Pfam | 80-158 (270) | Show / Hide |
Range on Protein: 439-563 Range on HMM: 80-158/270 Sequence Identity: 20% (25 aa) NNQVCLVSKYYELGSLAELIQKHHNVLESSRSSGTSSFPIASDNKSLNKNDQNNNLYGKRLNINSTSVDSFDFKFSYETKMKIAISIAKTMAKLHKIGII | |...| | ..|.| . .|| . . ... ... .... ||| |. |. ...| N-QIYIVMEYMPHGDLLDYLRKHR---------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCI HGHLSSSNILFDTNYEVKISDIGLT | | |.| . | |||.| ||. HRDLAARNCLVTENNVVKICDFGLA |
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| Kinase | 22078.AA | TKL-Unique | 437-465 | 16 | 0.145953 | 1.5 | In-house | 66-107 (290) | Show / Hide |
Range on Protein: 437-465 Range on HMM: 66-107/290 Sequence Identity: 16% (7 aa) I----DNNQVCLVSKYYELGSLAELIQ---------KHHNVL . .... |.|. |...||| .... . .. | MDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKL |
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