Gene 22219 (Tetrahymena)

22219

Species: Tetrahymena
Alias: TTHERM_00215950, 3701.m00008, PreTt22219, 18.m00245, 22219, 517
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
22219.AA Protein None 337 None Fasta, JSON
22219.kin_dom Protein Kinase Domain None 242 None Fasta, JSON
22219.NA RNA None 1014 None Fasta, JSON

Protein domain

Protein domains of 22219.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22219.AA AGC 38-272 22 5.1e-61 155.49 In-house 29-395 (395) Show / Hide 
Range on Protein: 38-272
Range on HMM: 29-395/395
Sequence Identity: 22% (83 aa)

NQKEYALKAVLRDS--------IETHLELEH-------LMNERNALRELS----------HPGINK-MIDTIKDDQY--LYFLLEIVY----------GI
..| ||.| .  .          . |   ||       . .||| | ...          || | | .  . .|...  |||..| .           | 
TGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGC

PLHKLLQ-M-HNK-LDKGFVQLIAVQ-------IIKIIEYMHS-QGYIYRD-LKASNIIVDQYGKVTLIDLGYTKKIEN---------------------
 |.  || . ... .|   .. .| .       |.  .||.|| .|.|.|| ||  ||  |. | . | | |  |.. |                     
ELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKY

-------------------------------ELTNSFCG--TIHMIAPELYNESLEEQGYSYEVDVYS--IGILIFELTTGSAPFGYDEQ-----NCKQK
                               ..|..|||  | . .|||          |....| .|   |.|..|. ||  || |...       ...
QKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLGCLMYEMLTGYPPF-YGDNPQENRH-PFR

TLAGINQEIL-------NKIKDE--------------KNLIDLITILLEKDPKKRPK----------INNILSHPYF
. . . | |.       .|.|                ... |||. ||.|||.||.           .. | .||.|
NPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 22219.AA Ciliate-E2 36-272 23 2.3e-53 181.51 In-house 44-365 (365) Show / Hide 
Range on Protein: 36-272
Range on HMM: 44-365/365
Sequence Identity: 23% (77 aa)

YYNQKEYALKAVLRDSIETHLELEHLM----------NERNALRELSHPGINKMIDTIK--DDQYLYFLLEIVYGIPLHKLLQ------------MHNKL
....|.||.| .  . ||  .  .|.|          ||.| |..|.|| | ||... .  ||...|. .| . |  | ....              ...
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYF

DKGFVQLIAVQIIK---------------IIEYMHSQG-YIYRDLKASNIIVDQYGKVTLIDLGYTKKIENE----------------------------
.   .. |  ||..                .||.||..  |.||.| .||..     . .||.|. ||. ..                            
TEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQ

-----LTNSFCGTIHMIAPELYNESL-----EEQGYSYEVDVYSIGILIFELTTGSAPFGYDEQNCKQKTLAGINQEILN----------KIKDEKNLID
     ..|..||| .  ||| .|        ...||.|..|..|.|....|. .|  ||   .|....|     .. ...          . | ... .|
IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKD

LITI----LLEKDPKKRPK-INNILSHPYF
||      .|.|||.||.  .. || ||.|
LIKKFGKRMLQKDPEKRITGWEQILNHPWF
S_TKc 22219.AA S_TKc 16-272 25 2.4e-52 181.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

IQIGELIASTHGEGTKIYRAYYNQ--KEYALKAVLRDSIETHLELEHLMNERNALRELSHPGINKMIDTIKDDQYLYFLLEIVYG--IPLHKLLQMHNK-
 .|...|   .|   | |... .   ...|.| .           ||...|.. |..  || | |..|.. | ..||. .| . |    |..... ... 
YEILRKIG--KGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LDKGFVQLIAVQIIKIIEYMHSQGYIYRDLKASNIIVDQYGKVTLIDLGYTKKIENELTNSFCGTIHMIAPELYNESLEEQGYSY-EVDVYSIGI
     ..   .. .. ||.. .||.||.| |.|||| .|| .|.   . ..| |  ...     ..|||| . .|||.        ||.. ..|..|.|.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGC

LIFELTTGSAPFGYDEQNCKQKTLAGINQEILNKIKDEKNLIDLITILLEKDPKKRPKINNILS-------HPYF
...|. .|  ||                |....||.  . ..|.|  .|.|||.||| .  .|        ||.|
ILYEMLCGYPPFP-------------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22219.AA Ciliate-E2b 42-272 33 3.4e-47 141.52 In-house 28-272 (272) Show / Hide 
Range on Protein: 42-272
Range on HMM: 28-272/272
Sequence Identity: 33% (83 aa)

YALKAVLRD-SIETHLELEHLMNERNALRELSHPGINKMIDTIKDDQYLYFLLEIVYGIPLHKLLQMHN--KLDKGFVQLIAVQIIKIIEYMHSQGYIYR
||.|..     |.. .|. |...| | |. . || | | |.. ||||..||..| . |. |  ..   .   | .  .| .  .|....|| |.|. |||
YAMKCISKNQIIQQNMEK-HMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYR

DLKASNIIVDQYGKVTLIDLGYTKKI--ENE---LTNSFCGTIHMIAPELYN-ESLEEQGYSYEVDVYSIGILIFELTTGSAPFGYDEQNCKQKTLAGIN
|.| .||.||. | . |||.|  | .  .||    | . .|| |  |||. .      .||.|.||..|.||  .|.  |  |.. | |.  .     | 
DIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYE-----IY

QEILNK---------IKDEKNLIDLITILLEKDPKKRP--KINNILSHPYF
|||..|         .||..   .|.  .|.| |  |.   ..   |||.|
QEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 22219.AA Pkinase 38-272 25 6.8e-43 152.74 Pfam 23-293 (293) Show / Hide 
Range on Protein: 38-272
Range on HMM: 23-293/293
Sequence Identity: 25% (70 aa)

NQKEYALKAVLRDSIETHLELEHLM-NERNALRELSHPGINKMIDTIKDDQYLYFLLEIVYGI----PLHKLLQ--MHNKL--DKGFVQLIAVQIIKIIE
..|..|.| . .....   . .|.  .|   ...|.|| | ...|.  |....|. .| . |      |. ...  .|...  .   .. .. ||.. .|
TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

YMHSQGYIYRDLKASNIIVDQYGKV----TLIDLGYTK---KIENELTNSFCGTIHMIAPELYNESLEEQGYSYEVDVYSIGILIFELTTGSAPFGYD--
|.||.| |.|||| .|| .|. | .     ..| |  |      |. ...||||.. .|||. .   . |.|...||..|.|....|. .|  ||  .  
YCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCW

--EQNCKQKTLAGINQEILNKIKD----------------------EKNLIDLITILLEKDPKKRPKINNILSHPYF
  . ..... .. | . .|    .                      .....|.|. .|.||||||| .  || ||.|
HDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 22219.AA RSK 38-272 27 3.3e-41 143.2 In-house 23-278 (278) Show / Hide 
Range on Protein: 38-272
Range on HMM: 23-278/278
Sequence Identity: 27% (73 aa)

NQKEYALKAVLRDSIETH-LELEHLMNERNALRELS-HPGINKMIDTIKDDQYLYFLLEIVYGIPLHKLLQMHNK---LDKGFVQLIAVQIIKIIEYMHS
....|| | . .  | ..   ..| | ||| | .   || | .  .. .....||  .| . |  | . || .     ..   .. .. .|.. .|..|.
TGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQ

QGYIYRDLKASNIIVDQ---YGKVTLIDLGYTKK--IE-NELTNSFCGTIHMIAPELYNESLEEQGYSYEVDVYSIGILIFELTTGSAPFGYDEQNCKQK
|| |.|||| .||. |.    | . |.| |  |.  .. |..|..||.||. .|||. ..   . |..  .|..| |.|..|. ||  ||  ...     
QGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPND-----

TLAGINQEILNKIKDEK---NLI----------DLITILLEKDPKKRPK-----INNILSHPYF
      .||...|.  |   ..           |||. .|..||.||..     .. |..||.|
---NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 22219.AA CAMK 25-272 15 3.3e-39 123.48 In-house 1-425 (425) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-425/425
Sequence Identity: 15% (66 aa)

THGEGT--KIYRAYY--NQ------------KEYALKAVLRDSIE-------------------------THLELEHLMNERNALRELS-------HPGI
| |.|.  | ....   ..            ...| | . .. .                          .   .. ...| . .. |.       || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

NKMIDTIKD-------------------DQYLYFLL---EIVYGI----PLHKLLQMHNK---------------LDKGFVQLIAVQIIKIIEYMHSQGY
 |..... |                   |...|. .   | . |      |   .. | .               ..   .. .  ||.  ..|.||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IYRDLKASNIIVDQY-----------------GKVTLIDLGYTKKIE-------------------------NELTNSFCGTIHMIA-PELYNE------
. ||||  || .|.                  ... .|| |  .|..                         ... . |||| . .| ||. |       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----SLEEQGYSYEVDVYSIGILIFELTTGSAPFG--YDEQNCK--------QKTLAGINQEILNKIKDE-------------------------KNLID
    . |...|....|. |.|.. . . .|  ||   .|.. |.        ....  | .   . . ..                         .  .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LITILLEKDPKKRPKINNILSHPYF
||  .|..||.||..|  .|.|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22219.AA AktR 38-272 31 1.2e-38 134.73 In-house 24-268 (268) Show / Hide 
Range on Protein: 38-272
Range on HMM: 24-268/268
Sequence Identity: 31% (79 aa)

NQKEYALKAVLRDSIETHLELEHLMNERNALR-ELSHPGINKMIDTIKDDQYLYFLLEIVYGIPLHKLLQMHNKLDKGFVQLIAVQIIKIIEYMHSQ-GY
||| ||.| .    |.     .|. .||| .  . .||.| |. ...... .|.|..|.. |  |   |.  .|..   .. ...||.  .|| |..   
NQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNI

IYRDLKASNIIVDQYGKVTLIDLGYTK--KI--ENELTNSFCGTIHMIAPELYNESLEEQGYSYEVDVYSIGILIFELTTGSAPFGYDEQNCKQKTLAGI
||||||  ||  |. | | ..| |..|  ..  ..|...||||| . .|||  ...   .|. . || ...||.|.|. ||  ||  . .| .|. .  .
IYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK---KGHNKSVDWWAFGIFIYEMVTGCPPF--YHKNQNQMFQKIK

NQEILNKIKDEKNL----IDLIT-ILLEKDPKKRPK-----INNILSHPYF
...  ||... ...     |||.  || |.|.||..     .  | ||| |
IKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 22219.AA Ciliate-E2-Unclassified 59-272 22 3.3e-36 123.08 In-house 53-352 (352) Show / Hide 
Range on Protein: 59-272
Range on HMM: 53-352/352
Sequence Identity: 22% (69 aa)

EHLMNERN-------------ALRELSHPGINKMIDTIKDDQYLYFLLEIVYGIPLHKLLQ-------------MHNKLDKGF----VQ-----LIAVQI
.. ||...              |. . || | ||... .|.|..|. .| . |  |.. ..             ...| .| |    ..      .. ||
MKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQI

IKIIEYMHSQG-YIYRDLKASNIIVDQYG---KVTLIDLGYTKKIE-----------------NELTNSFCGTIHMI----APELYNESLEEQGYS----
.. .||.|...  |.||.| .||..|. |   .. .||.|  ||..                 ......||||.  .    |||.    |..|.|.    
LQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV----LQGQNYDHSKA

YEVDVYSIGILIFELTTGSAPFG--YDEQ---------------NCKQKTLAG-INQEILNK----IKDEKNLIDLIT----ILLEKDPKKRPKINNILS
|..|..| |....|. .|  ||.   .||               . .|. ... |..   ..     .  .. .|.|.     .|.|.|.||. .. || 
YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN

HPYF
||.|
HPWF
Kinase 22219.AA MSK 59-272 27 1.8e-31 103.61 In-house 45-277 (277) Show / Hide 
Range on Protein: 59-272
Range on HMM: 45-277/277
Sequence Identity: 27% (64 aa)

EHLMNERNALREL-SHPGINKMIDTIKDDQYLYFLLEIVYGIPLHKLLQMHNKLDKGFVQLIAVQIIKIIEYMHSQGYIYRDLKASNIIVDQY---GKVT
|| . || .|. . .|| | .  .. .|.  .|  .|.. |  |   .    . |   .. |  ...  ...||. | |.||||  ||  |     |.| 
EHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVK

LIDLGYTKKIENE---LTNSFCGTIHMIAPELYNESLEEQG-YSYEVDVYSIGILIFELTTGSAPFG--YDEQNCKQKTLAGINQEILNKIKDEK-----
||| |  .   ..    ..|.|.|.|  |||. ... ...| |.  .|..| |.. ... ||  ||    |    .... . | . |. .          
LIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQ

----NLIDLITILLEKDPKKRPKINNILSHPYF
    .  |||. ||.||||||.. | .. |   
NMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase 22219.AA CAMKL 68-272 23 2.9e-31 96.93 In-house 66-297 (297) Show / Hide 
Range on Protein: 68-272
Range on HMM: 66-297/297
Sequence Identity: 23% (56 aa)

LRELS---HPGINKMIDTIKDDQY------LYFLLEIVYGIP--LHKLLQMH----NKLDKGFVQLIAVQIIKIIEYMHSQGYIYRDLKASNIIVDQYG-
.. |.   || | |. ..| ....      .|  .| . |    |.  .. |     ... .  . .  ||.  ..|.||.| . ||.|. || .|. | 
MKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGN

-KVTLIDLGYTKKIE------NELTNSFCGTIHMIAPELYNESLEEQGYS-YEVDVYSIGILIFELTTGSAPFGYD-----EQNCKQKTLAGINQEILNK
 .. .|| |   ...      ... . |||. .  |||...    .. |  ..||. |.|.. . . .|  ||  |      .... . .  |..   . 
NNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGN--NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYP

-IKDEK-NLIDLITILLEKDPKKRPKINNILSHPYF
 |  .   ..|||  .|...|.|||.| .|..|| .
PIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 22219.AA STE 27-272 18 1.2e-30 105.44 In-house 8-359 (359) Show / Hide 
Range on Protein: 27-272
Range on HMM: 8-359/359
Sequence Identity: 18% (67 aa)

GEGT--KIYRAYYN-----------------QKEYALKAVLRDSIET--------------HLELEHLMNERNALRELS--HPGINKMIDTIKDD-----
|.|.  . |.|...                 .. .| | .  .. ..              | |.. ...| . .....  || | | ...  ..     
GKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHK

--QYLYFLLEIVYGIPLHKLLQ---MHNKLDK-----------GFVQLIAVQIIKI-IEYMHSQGYIYRDLKASNIIVDQYGKVTLIDLGYTKKIENE--
  ..|.  .| . |  | ....   ...| ..             .  |..||.|   .| ||...| ||.|..|| .     | |.| |  ......  
NDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMA

----------------LTNSFCGTIHMIAPELYNESLEE--QGYSYEVDVYSIGILIFELTTGSAPFGYDEQNCKQKTLAGINQEILN------------
                 .|.|.||    |||  .   .   .||.. .|..|.|..| |. ||  |.  |... .   .. .|. . .            
NIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW-HDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPP

-KIKDE---------------------KNLIDLITILLEKDPKKRPKINNILS--HPYF
 ...|.                     ....| |   |.|||.|||. .  |.  || .
PPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
TyrKc 22219.AA TyrKc 16-272 20 5.3e-11 -44.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

IQIGELIASTHGEGT--KIYRAYYNQKEYALKAVLRDSIETHLELEHLMNERNALREL--SHPGINKMIDTIKDD-------QYLYFLLEIVYGIPLHKL
|. |. .    |||   ..|.. ..  . | | .  |.      .| .|.| . ...|  .|| | ...  . ..       . |. ..| . .  |.. 
ITLGKKL----GEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LQMHNK-LDKGFVQLIAVQIIKIIEYMHSQGYIYRDLKASNIIVDQYGKVTLIDLGYTKKIENE-------LTNSF----CGT----IHMIAPELYNESL
|. | . |       ...|| .  || ||...| ||| | |. |.  . |   | | ...|...        . .     .|     |   ||    |..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP----ECI

EEQGYSYEVDVYSIGILIFELTT-GSAPFGYDEQ--NCKQKTLAGINQE-ILNKIKD---------EKNLIDLITILLEKDPKKRPKINNILSHPYF
 .  .. . ||.| |....|. | |  |   ..|     |  .. . |   . . ..          . . ....   . ||..||  ..|  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF