Gene 22735 (Tetrahymena)

22735

Species: Tetrahymena
Alias: PreTt22735, 3808.m00392, TTHERM_00803640, 22735, 253, 136.m00105
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
22735.AA Protein None 585 None Fasta, JSON
22735.kin_dom Protein Kinase Domain None 361 None Fasta, JSON
22735.NA RNA None 1758 None Fasta, JSON

Protein domain

Protein domains of 22735.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22735.AA AGC 44-404 21 2.2e-81 209.39 In-house 1-395 (395) Show / Hide 
Range on Protein: 44-404
Range on HMM: 1-395/395
Sequence Identity: 21% (98 aa)

YKIIMEIGQGSFGKVYKAKKNTD----LNNKLYAIKRIKTQL-LQQEM--KSHQIFME-------------KLQLFFD----------FPGIPK-MHQCF
....  ||.||||||| ..|...     ..|.||.| .| .   .. .  . ...  |             .     .           | | | .| .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

SFQGC--FFFVMDFAS--------GGPFEQFLRFN---SNGSLSFKTIQFYVAE-------MVLILEYLHL-QGLAHRD-FKPENMVISQNKHLQLIDFG
  .     .|||....        || .| ||.      .|... ....|| ||       .|| |||||  .|  |||  ||||... .. |. | |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

T---LNDFCSNLVPEQLKSDITKKNEIKKQNLIKKGIIQEGQQLESEINPEIQQNVKQQDKDSGFFKYDEEQIQNLQSEQPSEFDQNIQCIASPLPVN--
    ... ... .. .  | ..| .. ....  .|.          . .   . |                               . .  .. .  |  
LCKEGMNDGEKGQQ-SQ-S-NMKFHW-HNKKY-QKS----------NMD---T-N-------------------------------K-CNPNNWQRNNMS

---------RKRLTTFCG--TNDYLSPEMLLEQKCDMNGDLWA--LGCIIYQMFTDKTPFHQKYIS--------YDQLKQRILNCN-----YEMLP----
         |.| .||||  | .|..||.|    ..   | |.  |||..|.| | ..||. .            ... |.|.|..      . .|    
QEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPED

-------KIPVVAQDIIQKLLVLQPDQRLG----GVFVHSNLQKQDIIESYKNLKSHPFF
       .. . |.|.|.|||.  |..|||    .. .          . .. .|.||.|
PQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGD----------KGAEEIKNHPWF
Kinase 22735.AA S_TKc 44-404 20 5.9e-53 183.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-404
Range on HMM: 1-231/231
Sequence Identity: 20% (74 aa)

YKIIMEIGQGSFGKVYKAKKNTDLNNKLYAIKRIKTQLLQQEMKSHQIFMEKLQLFFDFPGIPKMHQCFSFQGCFFFVMDFASG--GPFEQFLRFNSNGS
|.|. .||.|.||||||....    ....|||.|| . ...|.. ..          . | | |.. .|   .....||....|  |   .... .  . 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-EHIRREIQILKK---------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQNKHLQLIDFGTLNDFCSNLVPEQLKSDITKKNEIKKQNLIKKGIIQEGQQLESEINP
    ..  ...||...... |||.| .|  ||| ||||  ...  |. ..|||    .                                          
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

EIQQNVKQQDKDSGFFKYDEEQIQNLQSEQPSEFDQNIQCIASPLPVNRKRLTTFCGTNDYLSPEMLLEQKCDM-NGDLWALGCIIYQMFTDKTPFHQKY
                                                    |||||| .|..||.|   . .    | |..|||.| |.. ..||.   
----------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---

ISYDQLKQRILNCNYEMLPKIPVVAQDIIQKLLVLQPDQRLGGVFVHSNLQKQDIIESYKNLKSHPFF
  .... ..|.          .  | |.|.|.|.  |..|..           .. ..    |.||.|
-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPT---------A-EALQDEWDIKCHPWF
Kinase 22735.AA CAMK 49-377 14 1.9e-44 140.69 In-house 1-414 (425) Show / Hide 
Range on Protein: 49-377
Range on HMM: 1-414/425
Sequence Identity: 14% (72 aa)

EIGQGSFGKVYKAKKN-TD-LNN--------KLYAIKRIKTQLLQ------------------------------QEMKSHQIFMEKLQL---FFDFPGI
..|.||||||....   |  . .        . .||| |... |.                              ......   | |||    . | | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

PKMHQCFS------------FQGC--------FFFVM---DFASGG----PFEQFLRFNSN-------------GSLSFKTIQFYVAEMVLILEYLHLQG
 |... .             .  .        ...||   ...|||       .... ...             | .. .  ..|.  ..  ..|.| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LAHRDFKPENMVISQNK-----------------HLQLIDFGTLNDFCSNL----------------VPEQLKSDITKKNEIKKQNLIKKGIIQEGQQLE
 .||| ||||  ...|.                  . .||||  | | ..                 .                                
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW--------------------------------

SEINPEIQQNVKQQDKDSGFFKYDEEQIQNLQSEQPSEFDQNIQCIASPLPVNRKRLTTFCGTNDYLS-PEMLL--------------EQKCDMNGDLWA
                                                . |   . ..|||||  | . ||.|.              .. ..   | |.
------------------------------------------------TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWS

LGCIIYQMFTDKTPFHQKYI-----------SYDQLKQRILNCNYE-MLPKIPVV-----------------------AQDIIQKLLVLQPDQRL
.|.| | | . . ||  ..            .. .|...|....|.   |... .                       ..| |.|.|.  |..|.
CGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRM
Kinase 22735.AA AktR 44-404 23 1.4e-33 117.92 In-house 1-268 (268) Show / Hide 
Range on Protein: 44-404
Range on HMM: 1-268/268
Sequence Identity: 23% (86 aa)

YKIIMEIGQGSFGKVYKAKKNTDLNNKLYAIKRIKTQLLQQEMKSHQIFMEKLQLF--FDFPGIPKMHQCFSFQGCFFFVMDFASGGPFEQFLRFNSNGS
....  .|.| ||||| ..|.   |.|.||.| || . .... . |.. .|.  .    ..|.| |.|.||  . . ||.|..  ||  | |   .... 
FHVYKCLGKGAFGKVYLVQKKR-DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGG--ELFQHLKKKKK

LSFKTIQFYVAEMVLILEYLHLQ-GLAHRDFKPENMVISQNKHLQLIDFGTLNDFCSNLVPEQLKSDITKKNEIKKQNLIKKGIIQEGQQLESEINPEIQ
.| ....|| |...| ||||| .     || |||| .. .. |. ..|||  .                                               
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-----------------------------------------------

QNVKQQDKDSGFFKYDEEQIQNLQSEQPSEFDQNIQCIASPLPVN--RKRLTTFCGTNDYLSPEMLLE-QKCDMNGDLWALGCIIYQMFTDKTPFHQKYI
                                         ....  . . ..||||. |..|||... .  . . |.||.|. || | |  .|| .|  
----------------------------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQ

SYDQLKQRILNCNYEMLPKIPV--VAQDIIQ-KLLVLQPDQRLG-GVFVHSNLQKQDIIESYKNLKSHPFF
 .. .|..| . . .  . ...   ..|.|| |||   | .||| .             .. . .||||.|
NQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYC------------NGWEEIKSHPWF
Kinase 22735.AA PDK1 259-404 29 4.7e-33 98.19 In-house 170-307 (307) Show / Hide 
Range on Protein: 259-404
Range on HMM: 170-307/307
Sequence Identity: 29% (47 aa)

QIQNLQSEQPSEFDQNIQCIASPLPVNR----------KRLTTFCGTNDYLSPEMLLEQKCDMNGDLWALGCIIYQMFTDKTPFHQK-YISYDQLK--QR
|....|. ..              . |.           | ..|.||  | |||.| .  |.   |.||||||||||.. ..||  .      ...  |.
QQNQFQQQFQ--------------QHNKGMDKPEEDKQTRCKSFVGTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQK

ILNCNYEMLPK--IPVVAQDIIQKLLVLQPDQRLGGVFVHSNLQKQDIIESYKNLKSHPFF
|..| |   ..  .| .| |...||||. |. ||..          | .. |...| ||||
IMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSC---------DECGGYQQIKAHPFF
Kinase 22735.AA PDK1 44-191 32 6e-32 94.76 In-house 1-156 (307) Show / Hide 
Range on Protein: 44-191
Range on HMM: 1-156/307
Sequence Identity: 32% (51 aa)

YKIIMEIGQGSFGKVYKAK-KNT-DLNNKLYAIKRIKTQLLQQEMKSHQIFMEK--LQLFFD----FPGIPKMHQCFSFQGCFFFVMDFASGGPFEQFLR
.... .|| ||...||.|. | | .  || ||||     ..  | |  ... ||  ...       .||| |    |  . |  ||......| .   ..
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

FNSNGSLSFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQNKHLQLIDFGT
 .  ||..  ...||.|| ...||.||  | .||| ||||  .. . |....||||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGT
Kinase 22735.AA Ciliate-E2 44-191 26 1e-31 106.16 In-house 1-202 (365) Show / Hide 
Range on Protein: 44-191
Range on HMM: 1-202/365
Sequence Identity: 26% (56 aa)

YKIIMEIGQGSFGKVYKAKKNTD---------------------LNNKLYAIKRIKTQLLQQEMKSHQIF----------MEKLQLFFD-FPGIPKMHQC
||.|  ||||.||.|||.|.  .                      ..|.||.|..| . ..| ..  .|.          .||  |... .| | ||. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FS--FQGCFFFVMDFASGGPFEQFLRFN----------SNGSLSFKTIQ---------------FYVAEMVLILEYLHLQG-LAHRDFKPENMVISQNKH
|    . ....||....||  ..... |            .... | |.               ||.|...| ||||| ..   ||| |||| ..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LQLIDFGT
. .||||.
IKIIDFGL
Kinase 22735.AA Ciliate-E2b 44-191 34 1.9e-30 89.84 In-house 1-148 (272) Show / Hide 
Range on Protein: 44-191
Range on HMM: 1-148/272
Sequence Identity: 34% (51 aa)

YKIIMEIGQGSFGKVYKAKKNTDLNNKLYAIKRIKTQ-LLQQEMKSHQIFMEKLQL-FFDFPGIPKMHQCFSFQGCFFFVMDFASGGPFEQFLRFNSNGS
  .| . |.| || ||  ... .  ...||.| |.   ..||.|  | . .||  | . ..| | |  . |    .  |.|.| .|. ..  .|      
MIYIKKLGFGQFGSVYLVWNT-KNTKQYYAMKCISKNQIIQQNMEKH-MLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLL

LSFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQNKHLQLIDFGT
|| .  |||.|...|.||||| |.  .|| ||||. . .. .. |||.||
LSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGT
Kinase 22735.AA Ciliate-E2-Unclassified 44-190 26 1.1e-25 86.09 In-house 1-192 (352) Show / Hide 
Range on Protein: 44-190
Range on HMM: 1-192/352
Sequence Identity: 26% (51 aa)

YKIIMEIGQGSFGKVYKAKKNTDL--NNKLYAIKRIKTQLLQQEMKSHQIFMEKLQLF--------------------FDFPGIPKMHQCFSFQGCFFFV
||||  ||||.||||||.... .   . . |..| ..   .|.. |  .| .|.....                    .. | | ||. ||  . ....|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MDFASGGPFEQFLRFNSN---------------GSLSFKTIQ-----FYVAEMVLILEYLHLQG-LAHRDFKPENMVISQNK---HLQLIDFG
|... ||  .|... ...                 .. . ..     || |. .. ||||| ..   ||| |||| ....|.   .. .||||
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG
Kinase 22735.AA Ciliate-E2-Unclassified 286-404 22 1.7e-20 67.82 In-house 216-352 (352) Show / Hide 
Range on Protein: 286-404
Range on HMM: 216-352/352
Sequence Identity: 22% (35 aa)

RKRLTTFCGTNDYL----SPEMLLEQKCD----MNGDLWALGCIIYQMFTDKTPFHQKYISYDQ--------------LKQRILNCNYE---MLP-----
.....|||||. |.    .||.| .|. |       | |.||.|.|.| . . || ..    .|              |.| |...|..   . .     
QQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPK

KIPVVAQDIIQ----KLLVLQPDQRLGGVFVHSNLQKQDIIESYKNLKSHPFF
...  |.|.|.    |.|. .|..|.                ... .. ||.|
HWSPEAKDFINDLLQKMLKKNPNKRI----------------TFEQILNHPWF
Kinase 22735.AA Ciliate-E2 254-404 19 1e-19 64.38 In-house 205-365 (365) Show / Hide 
Range on Protein: 254-404
Range on HMM: 205-365/365
Sequence Identity: 19% (37 aa)

KYDEEQIQNLQSEQPSEFDQNIQ--------CIASPLPVNRKRLTTFCGTNDYLSPEMLLEQK---------CDMNGDLWALGCIIYQMFTDKTPFHQKY
|||........  | ..  .. .        ...  . .      |.|||  |..||.|  .|          |   |.|.||.|.|.| . |.||    
KYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD--QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----

ISYDQLKQRILNCNYE------------------MLPKIPVVAQDIIQK----LLVLQPDQRLGGVFVHSNLQKQDIIESYKNLKSHPFF
       | |..|...                     |..  ..|.|.|    .|. .|..|..               ... .. ||.|
------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---------------GWEQILNHPWF
Kinase 22735.AA MAST 119-248 26 4.7e-19 57.77 In-house 75-222 (334) Show / Hide 
Range on Protein: 119-248
Range on HMM: 75-222/334
Sequence Identity: 26% (39 aa)

FFVMDFASGGPFEQFLRFNSNGSLSFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQNKHLQLIDFG----TLNDFCSNLVPEQ-----LKSDIT
..||.. .|| . . |.  . |..   . ..|.||.|| ||||| .|  ||| ||.||.|. | |  | |||    ...|   .... .     ... ..
CMVMEYMEGGDCASLLH--MYGYFDEWMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTD

KKNEIKKQNLI-----------KKGIIQEGQQLESEINPEIQQNVKQQDK
  | ... .             .|..||. |.   ..  .. .. ..|.|
PMNKNQQDYSQFPGDFGINGNTNKNQIQQQQEQPQCQQQNMRPHNIHQNK
Kinase 22735.AA SGK 290-404 37 8.9e-19 54.18 In-house 183-283 (283) Show / Hide 
Range on Protein: 290-404
Range on HMM: 183-283/283
Sequence Identity: 37% (43 aa)

TTFCGTNDYLSPEMLLEQKCDMNGDLWALGCIIYQMFTDKTPFHQKYISYDQLKQRILNCNYEMLPKIPVVAQDIIQKLLVLQPDQRLGGVFVHSNLQKQ
.|||||  || ||.|. | .|   | | |||. | | . . ||  .  .  |. . |.|    . | . . | |.|| ||   |..|||         |.
FTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQ--QMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG--------TKR

DIIESYKNLKSHPFF
| .|     |.||||
DFME----IKNHPFF
Kinase 22735.AA RSK 287-404 31 6.2e-18 62.41 In-house 163-278 (278) Show / Hide 
Range on Protein: 287-404
Range on HMM: 163-278/278
Sequence Identity: 31% (40 aa)

KRLTTFCGTNDYLSPEMLL---EQK-CDMNGDLWALGCIIYQMFTDKTPFHQKYIS--YDQLKQRILNCN--YEML--PKIPVVAQDIIQKLLVLQPDQR
... |||.| .|. ||||     |.  | . |.| ||...| |.| ..||..   .   ... .||....   .|   ...   |.|.|.|.|   | .|
QWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKR

LG-GVFVHSNLQKQDIIESYKNLKSHPFF
|| |        .||. |    .|.||.|
LGCG--------PQDAEE----IKQHPWF
Kinase 22735.AA Pkinase 285-404 20 6.3e-15 53.87 Pfam 165-293 (293) Show / Hide 
Range on Protein: 285-404
Range on HMM: 165-293/293
Sequence Identity: 20% (30 aa)

NRKRLTTFCGTNDYLSPEMLL-EQKCDMNGDLWALGCIIYQMFTDKTPFHQK--------YISYDQLKQRILNCNYEMLPKIP-----------------
|   .|||||| .|..|| ..  |. .   | |..|||.|.|.. ..|| ..        .  ... ....|  ... .  |.                 
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWS

VVAQDIIQKLLVLQPDQRLGGVFVHSNLQKQDIIESYKNLKSHPFF
  ..|.| ..| . | .|..                 . .. ||.|
EECKDFIKWCLCKDPKKRPT----------------AEQILQHPWF
Kinase 22735.AA SGK 119-190 41 6.5e-14 38.89 In-house 101-170 (283) Show / Hide 
Range on Protein: 119-190
Range on HMM: 101-170/283
Sequence Identity: 41% (30 aa)

FFVMDFASGGPFEQFLRFNSNGSLSFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQNKHLQLIDFG
.||||.. ||  | |   .  ....     ||.|| |. ||||| |   .|| |||| .     |. | |||
YFVMDYVNGG--EMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFG
Kinase 22735.AA Pkinase 120-190 32 2e-13 48.58 Pfam 77-157 (293) Show / Hide 
Range on Protein: 120-190
Range on HMM: 77-157/293
Sequence Identity: 32% (26 aa)

FVMDFASGG----PFEQFLRFNSNGSL--SFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQNKHL----QLIDFG
.||... ||        ...  ..|..  | ....||. ...  |||.| .|  ||| ||||  |..| |.     ..|||
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG
Kinase 22735.AA RSK 121-190 38 2.7e-13 45.29 In-house 79-152 (278) Show / Hide 
Range on Protein: 121-190
Range on HMM: 79-152/278
Sequence Identity: 38% (29 aa)

VMDFASGGPFEQFLRFNSNGS---LSFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQ---NKHLQLIDFG
.|.. .||  | | .    ..   .| .. .|| || || .|.|| ||  ||| ||||..  .   . |. |.|||
IMEYCRGG--ELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFG
Kinase 22735.AA MAST 293-378 33 1.3e-11 33.39 In-house 225-320 (334) Show / Hide 
Range on Protein: 293-378
Range on HMM: 225-320/334
Sequence Identity: 33% (33 aa)

CGTNDYLSPEMLLEQK-CDMNGDLWALGCIIYQMFTDKTPFHQKYISYDQLKQRILNCN---YEMLPK--------IPVVAQDIIQKLLVLQPDQRLG
||| ||..|| .| |    .  | |..| |.|. ..  .|| ..  . . . | ||| |    |  ..        ....|||.|.||| . | .|||
CGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDD--TPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG
Kinase 22735.AA Ciliate-E2b 288-404 23 3.4e-09 24.28 In-house 161-272 (272) Show / Hide 
Range on Protein: 288-404
Range on HMM: 161-272/272
Sequence Identity: 23% (29 aa)

RLTTFCGTNDYLSPEMLL-----EQKCDMNGDLWALGCIIYQMFTDKTPFHQKYISYDQLKQRILNC----NYEMLPKIPVVAQDIIQKLLVLQPDQRLG
| .| .||  |. || .       .   .. |.|..| . | .   . |.  .     .. | |..     ..    |  .   ......|  .|  |||
RTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG

GVFVHSNLQKQDIIESYKNLKSHPFF
|              ||. |||||.|
G--------------SYSWLKSHPWF
Kinase 22735.AA SGK 44-75 31 8.9e-09 22.74 In-house 1-48 (283) Show / Hide 
Range on Protein: 44-75
Range on HMM: 1-48/283
Sequence Identity: 31% (15 aa)

YKIIMEIGQGSFGKVYKAKKNTD----------------LNNKLYAIK
 ...  ||.||||||| .|.  |                 . |.||.|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMK
Kinase 22735.AA MAST 44-78 37 8.5e-08 20.86 In-house 1-33 (334) Show / Hide 
Range on Protein: 44-78
Range on HMM: 1-33/334
Sequence Identity: 37% (13 aa)

YKIIMEIGQGSFGKVYKAKKNTDLNNKLYAIKRIK
...|  |. | .||||..|...   |...|.|.||
FEFIKPISKGAYGKVYLVKHKK--TNDRFAMKVIK
Kinase 22735.AA Pkinase 44-78 45 2e-07 27.34 Pfam 1-33 (293) Show / Hide 
Range on Protein: 44-78
Range on HMM: 1-33/293
Sequence Identity: 45% (16 aa)

YKIIMEIGQGSFGKVYKAKKNTDLNNKLYAIKRIK
|.|.  ||.||||.|||...  .  .|..|.|.||
YHIGRKIGSGSFGCVYKCHHKGT--GKIVAVKIIK
Kinase 22735.AA TyrKc 44-386 12 1e-06 -114.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 44-386
Range on HMM: 1-280/280
Sequence Identity: 12% (50 aa)

YKIIMEIGQGSFGKVYKAKKNTDLNNKLYAIKRIKTQLLQQEMKSHQIFMEKLQLFFDF----PGIPKMHQCFSFQ-------GCFFFVMDFASGGPFEQ
 . . ..| | ||.|||.. .        |.| .|          .. ||. ...   .    | | ... . . |       .  . || ....|   .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRFNSNGSLSFKTIQFYVAEMVLILEYLHLQGLAHRDFKPENMVISQNKHLQLIDFGTLNDFCSNLVPEQLKSDITKKNEIKKQNLIKKGIIQEGQQLE
.|| . .  |. |.   .        |||| ... |||    |  .. |.                                                  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------------------------------------------------

SEINPEIQQNVKQQDKDSGFFKYDEEQIQNLQSEQPSEFDQNIQCI-----ASPLPVN-----RKRLTTFC---GTND-----YLSPEMLLEQKCDMNGD
                                          .  |     .  .        .|   .     |...      ..|| . . |.    |
------------------------------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

LWALGCIIYQMFTD-KTPFHQ---KYISYDQLKQRILNCNYEMLPKI----------PVVAQDIIQKLLVLQPDQRLGGVFVHSNL
 |. |  .. .||. ..|      . .| ... ... . .. . |.           . . | |...    .|..|     .|. .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase 22735.AA RSK 47-75 36 0.005511 7.19 In-house 1-30 (278) Show / Hide 
Range on Protein: 47-75
Range on HMM: 1-30/278
Sequence Identity: 36% (11 aa)

IMEIGQGSFGKVYKAKKNT-DLNNKLYAIK
. . |||..|||.  .| |   ....|| |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMK
Kinase 22735.AA MAST 399-404 83 0.13209 0.57 In-house 329-334 (334) Show / Hide 
Range on Protein: 399-404
Range on HMM: 329-334/334
Sequence Identity: 83% (5 aa)

KSHPFF
|.||||
KQHPFF