Gene 7237 (Tetrahymena)

7237

Species: Tetrahymena
Alias: 668, 7237, 46.m00292, 3679.m00142, TTHERM_00421130, PreTt07237
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
7237.AA Protein None 769 None Fasta, JSON
7237.kin_dom Protein Kinase Domain None 247 None Fasta, JSON
7237.NA RNA None 2310 None Fasta, JSON

Protein domain

Protein domains of 7237.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7237.AA ULK 422-668 31 7.7e-79 268.23 In-house 1-324 (324) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-324/324
Sequence Identity: 31% (103 aa)

FSMNKKIGQGAFS-QVFLGH-KRLNP-NFPVAVKIIDLQKQSKF-------------QEEIEICLKIN--GNKN--ILRIYDYHLEKSN-NKCYLFLEFC
...|...|.|.|  .|. |  |. |  |  ||.|.||..|..|.             . ||.|  |..   ..|  | . ||. .| || | .|...|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDW-FETSNHNNIYIIMEYC

EGGNLESINN------------TITRRQAIIYFRQILDGMKELLRHKIIHRDIKLENILINEGQ-------------IKISDFGLSKQVQNNLLDVNSI-
.||.||.. .            ...  .||..|.||. |.|||  |.|||||||..||||..||             .||.|||..|.|.|| .. . . 
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

-KC------GTPSTMAPEIFFSH--TSYPS-YNNKCDVWSLAVILHEMFYKVHPFNMN-KEML----------------RKFQRIQVEHKC------DIV
  .      ||| .|||.|. ..     .. |  |||.||| .|..|| |   ||. .  .                   | | ||   ..      . .
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDY--KCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

EDFLSKSLVYNQKKRMSLEEIFNHKIY
.|.... |.|..|.|.| ||||||.. 
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 7237.AA ULK 422-668 29 2.1e-74 253.5 In-house 1-329 (329) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-329/329
Sequence Identity: 29% (98 aa)

FSMNKKIGQGAFSQVFLGHKRLNP---NFPVAVKIIDLQKQSK-------------FQEEIEICLKIN---GNKN----ILRIYDYHLEKSN-NKCYLFL
...|...|.|.| .|. | .  .    |  ||.|.||.||...             .. ||.|  |..   ..||    | . ||. .| || | .|...
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDW-FETSNHNNIYIIM

EFCEGGNLESINN-------------TITRRQAIIYFRQILDGMKELLRHKIIHRDIKLENILINEGQ-------------IKISDFGLSKQVQNNLLD-
|.|.||.||.. .             ...  .||..|.||| |.|||  |.|||||||..||||..||             .||.|||..|.|.|.... 
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

--VNSIK-----CGTPSTMAPEIFFSH--TSYPS-YNNKCDVWSLAVILHEMFYKVHPFNMN-KEML-----RKFQ----------RIQVEHK-------
    . .     |||| .|||.|. ..     .. |  |||.||| .|..|| |   ||. .  .       . ..           .. . .       
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDY--KCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

-CDIVEDFLSKSLVYNQKKRMSLEEIFNHKIY
  . ..|.... |.|..|.|.| ||.|||.. 
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 7237.AA S_TKc 422-668 30 1.8e-71 244.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

FSMNKKIGQGAFSQVFLGHKRLNPNFPVAVKIIDLQKQSKFQEEIEICLKINGNKNILRIYDYHLEKSNNKCYLFLEFCEG--GNLESINNT--------
. . .|||.|||..|......   .  ||.|||.     ... ||.|. |  . .|| ..||.  .   .. |...|.|.|  |.| ..           
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-ITRRQAIIYFRQILDGMKELLRHKIIHRDIKLENILINEGQIKISDFGLSKQVQNNLLDVNSIKCGTPSTMAPEIFFSHTSYPSYNN-KCDVWSLAVIL
 ..  .|  |..||..... . .|.|||||.| ||||..| .|||.||||..|.        .  ||||  ||||..       .|.  |||.||. .||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCIL

HEMFYKVHPFNMNKEMLRKFQRIQVEHKCDIVEDFLSKSLVYNQKKRMSLEEIFN-------HKIY
 ||..   ||    .| . |..|      . . ||..| |... .||..  |...       |   
YEMLCGYPPFP---QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7237.AA Ciliate-E2 422-668 23 5.6e-62 211.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FSMNKKIGQGAFSQVFLGHKRLNPNFP----------------------VAVKIIDLQKQSKFQEEIEIC---------------LKINGNKNILRIYDY
.  .||||||.|..|... ......                        .|.||.  ..   .  || |.               |... ..||...|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HLEKSNNKCYLFLEFCEGGNLES-INNT-------------ITRRQAIIYFRQILD---------------GMKELLRHK-IIHRDIKLENILINEGQIK
  ||..|..|| .|.|.||.|.. |.|              .| .... ...|||.               ....|   . |||||||.||||.    ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

ISDFGLSKQVQ------------NNLLDVNSIK-------------------CGTPSTMAPEIFFSHTSY-----PSYNNKCDVWSLAVILHEMFYKVHP
|.||||||...            ..... .. .                   ||||  |||||. .   .       |. |||.||| |||.|| .. .|
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNMNKEMLRKFQRIQV-EHKCDIVE-----------------------DFLSK----SLVYNQKKRMS-LEEIFNHKIY
|         .| |.  . . .  |                       |...|     |.....||..  |.|.||.. 
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 7237.AA CAMK 427-668 19 1.1e-61 197.24 In-house 1-425 (425) Show / Hide 
Range on Protein: 427-668
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

KIGQGAFSQVFLGHKRLNPN-----------FPVAVKIID-------------------------------LQKQSKFQEEIEICLKING------NKNI
..|.|.|..|.|.  .....             ||.||||                                ... ... ||||. |..|       .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRIYDYHLEKS-----------------NNKCYLFL---EFCEGGNL-ESINNTITRR---------------------QAIIYFRQILDGMKELLRHKI
...|..   ..                 ....|...   |.|.|| | . . . |...                     .|  |||||..... .  |.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKLENILINE------------------GQIKISDFGLSKQVQNNLLDVNS----------------------IKCGTPSTMA-PEIFFS--HTSY
.|||.|.||||...                  ..|||.|||...... .  . .                         ||||. || ||.. .  | ..
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------PSYNNKCDVWSLAVILHEMFYKVHPFNMN---------------KEMLRKFQRIQV--EHKC-------------------------DIVED
        | |. |||.||. |||  |     ||.                 .|...| .. .   ...                          . . |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLSKSLVYNQKKRMSLEEIFNHKIY
...| |... .|||..|.. ||. .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 7237.AA Ciliate-E2-Unclassified 422-668 24 3.7e-56 192.89 In-house 1-352 (352) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

FSMNKKIGQGAFSQVFLGHKRLNPNFPVAVKIID-------LQKQSKFQEEIEICLKINGNK-------------------NILRIYDYHLEKSNNKCYL
. ..|.||||.|..|..  .. .  .  | |..        .|...|  |.. . . .| .|                   ......... ... ...|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

FLEFCEGGNLESINNT--------------------ITRRQAI-----IYFRQILDGMKELLRHK-IIHRDIKLENILINEG----QIKISDFGLSKQVQ
 .|.||||.|. . .                     .| .||.      ||.|||.| . | . . |||||||.||||....    .|||.|||.||. |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

NN------------LLDVNSI--KCGTPSTM----APEIFFSHTSYPS--YNNKCDVWSLAVILHEMFYKVHPFNMNK------------------EMLR
.|             .. . .  .||||..|    |||.. ..  . |  |  |||.||| |||.|| .  .||. |.                  ....
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAY--KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

KFQRIQVE-----------HKCDIVEDFLS----KSLVYNQKKRMSLEEIFNHKIY
...  ...           |  . ..||..    | |..|..||...|.|.|| . 
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 7237.AA Pkinase 422-665 28 2.5e-52 184.97 Pfam 1-290 (293) Show / Hide 
Range on Protein: 422-665
Range on HMM: 1-290/293
Sequence Identity: 28% (84 aa)

FSMNKKIGQGAFSQVFLGHKRLNPNFPVAVKIIDLQKQSKFQE-------EIEICLKINGNKNILRIYDYHLEKSNNKCYLFLEFCEGG----NLE----
.   .|||.|.|..|...|.. ..   ||||||....... ..       ||.| ... . .||.|.||.  .  ....|. .|.||||     |     
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

-SINNTI--TRRQAIIYFRQILDGMKELLRHKIIHRDIKLENILIN-EGQI----KISDFGLSKQVQNNLLDVNSIKCGTPSTMAPEIFFSHTSYPSYNN
 . ....  . .... |..||| |.. . ...|||||.|.|||||. .|.|    ||.||||.||.. .  ....  ||||  ||||.     ... |  
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIR---GGQYYGP

KCDVWSLAVILHEMFYKVHPFNMNK------EMLRKFQRIQV--------EHKC-------------------DIVEDFLSKSLVYNQKKRMSLEEIFNH
|.|.||. .||.||. .  ||  ..      ... ...||          .  .                   .   ||... | .. ||| . |.|..|
KVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase 7237.AA CAMKL 422-668 27 3.7e-49 154.94 In-house 1-297 (297) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-297/297
Sequence Identity: 27% (84 aa)

FSMNKKIGQGAFSQVFLGHKRLNPNFPVAVKIIDLQKQSK--FQE----------------EIEICLKIN--GNKNILRIYDYHLEKSN----NKCYLFL
. . | .|.|.|..| |.. .....  ||.|||| .| ..  . .                ||.|  ..|  . .|| ..|.    ...    .|.||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCEGGN---LESINNT------ITRRQAIIYFRQILDGMKELLRHKIIHRDIKLENILIN-EG--QIKISDFGLSKQVQ---NNLLDVNSIKCGTPSTM
| |.||.   .. | .       .. ..|  |||||..... . .|.|.|||||.||||.   |  .|||.|||.| . .   ..  .  .. ||.|. |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEIFFS-HTSYPSYNNKCDVWSLAVILHEMFYKVHPFN---------MNKEMLRKFQRIQVEHKC---DI--VEDFLSKSLVYNQKKRMSLEEIFNHKI
||||| . ...|  .  | |.||. |||  | .   ||.          |.  |.. .... .. .   ..  ..|...| |. | .||.....| ||. 
APEIFQGNNKPY--DGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPW

Y
.
M
Kinase 7237.AA STE 422-668 19 3.3e-46 159.84 In-house 1-359 (359) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-359/359
Sequence Identity: 19% (72 aa)

FSMNKKIGQGAFSQVFLGHKRLNP--------------NFPVAVKIIDL--------------------QKQSKFQEEIEICLKING-NKNILRIYDYHL
.   .|||.||| .|... .. |.              .. .|.|...|                    ... ....||.|. | |   .|| . |....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----EKSNNKCYLFLEFCEGGNLESINN-----------------TITRRQAIIYFRQILDG-MKELLRHKIIHRDIKLENILINEGQIKISDFGLSKQ
     .|.........|...|| |..| .                 ..   | ... |||| | .. | .|.|||||||  |||.    .|..|||...|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VQN---------------NLLDVNSIKCGTPSTMAPEIFFSHTSY--PSYNNKCDVWSLAVILHEMFYKVHPF---NMN---KEMLRKF-----------
...               .    .   .|||  ||||.    ..   . |. |||.|||   . ||    .|.   .      ......           
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

-----QRIQV------------------EHKCDIVEDFLSKSLVYNQKKRMSLEEIFN--HKIY
      ...                   ..  .   ||..| |... .|| . ..  .  |.  
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 7237.AA TKL 428-643 21 9.9e-40 138.31 In-house 1-312 (364) Show / Hide 
Range on Protein: 428-643
Range on HMM: 1-312/364
Sequence Identity: 21% (68 aa)

IGQGAFSQVFLGHKRLNP-------NFPVAVKIIDLQ--------------------------KQSKFQEEIEICLKING---NKNILRIYDYHLEKSNN
||.|.|..|. |. | ..       . .||||..  .                          ..|.|....|  ...       ||.... | .. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KCYLFLEFCEGGN-LESINNTITRRQAIIYFRQILDGMKELLRHK--------IIHRDIKLENILINE-GQ--------------IKIS
           ....  |.|.||. |. ..      | .   ..|  ||  |  ..        |||||.| .|||..| ..              .||.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC

DFGLSKQVQNNLLDV------------------NSIKCGTPSTMAPEIFFSHTSYP------------SYNNKCDVWSLAVILHEMFYKVHPFNMNKEML
|||||. ....  .                   .. .||||  ||||..  .. |.            .|. ||||.| ...| |..   .|.  ...| 
DFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMP

RKFQRIQVEHKCDIVED
..||.  .|    .| |
MIFQDP-FEEMFMMVCD
Kinase 7237.AA Ciliate-E2c 422-619 29 1.2e-36 126.02 In-house 1-219 (310) Show / Hide 
Range on Protein: 422-619
Range on HMM: 1-219/310
Sequence Identity: 29% (66 aa)

FSMNKKIGQGAFSQVFLG-------HKRLN---------PNFPVAV---KIIDLQKQS-KFQEEIEICLKINGNKNILRIYDYHLEKSNNKCYLFLEFCE
.. |.  |.| . .|...          .|          . . ..   ..|.. ..      ||..  . | ...|...||    .  .. ||..|.|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMN-HPHIIKFYDAK--QTDKHIYLIMEYCN

GGNLESI--NN-TITRRQAIIYFRQILDGMKELLRH-KIIHRDIKLENILINEGQIKISDFGLSKQVQNNLLDVNS---IKCGTPSTMAPEIFFSHTSYP
||.||.   ..  .. .| . || ||. ..|.|    .|.||||| |||||..|.||| |||.||..|.     ..     ||||  |||.|  .     
GGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEG---KN

SYNNKCDVWSLAVILHEMFYKVHPF
 |  | |.||| | | .| ..  |.
YYTEKSDIWSLGVTLYYMLCYKLPW
Kinase 7237.AA CMGC 422-613 20 9.9e-35 110.87 In-house 1-329 (513) Show / Hide 
Range on Protein: 422-613
Range on HMM: 1-329/513
Sequence Identity: 20% (69 aa)

FSMNKKIGQGAFSQVFLG-HKRLN------------PNFPVAVKIIDLQKQSKFQ---------------EEIEICLKIN---------------GNKN-
.   ||||.|....|. . .|| |             |  ||.|.| ...  . |                ||.|  ..|                ..| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ILRIYDYHLEKS---------------NNKCYLFLEFCEGGNLESINNTITR------------------------RQAII----YFRQILDGMK--ELL
|...||.   |                .|. ||  |...   .. | |. ..                         . ..    |..||| |.|   . 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RHK--IIHRDIKLENILINE---------------------GQIKISDFGLSKQVQNNL--------------------LDVNSIKCGTPSTMAPEIFFS
.|.  |||||.| ||||||.                     |..|| ||||.... ..                     .  ..    |    |||| ..
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

HTSY------PSYNNKCDVWSLAVILHEMF
 . |        |. ..|.||.. |. ||.
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMY
Kinase 7237.AA Pkinase_Tyr 422-566 27 6.7e-17 57.87 Pfam 1-163 (270) Show / Hide 
Range on Protein: 422-566
Range on HMM: 1-163/270
Sequence Identity: 27% (45 aa)

FSMNKKIGQGAFSQVFLGHKR---LNPNFPVAVKII--DLQKQ----SKFQEEIEICLKINGNKNILRIYDYHL-EKSNNKCYLFLEFCEGGNLESI---
 ...||.|.||| .|..|. .    |.. |||||..  .  ..     .| .|..|  ..  ..||.| |   . ..  |. |. .|....|.| .    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----NNTITRRQAIIYFRQILDGMKELLRHKIIHRDIKLENILIN-EGQIKISDFGLSKQVQN
    .. .|  . . . .|| .||  | ....||||.   |.|.. ....||.||||.. ..|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN
Kinase 7237.AA TyrKc 422-668 22 2.5e-16 41.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 422-668
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

FSMNKKIGQGAFSQVFLGHKRLNPNFPVAVKIIDLQKQSKFQEEIEICLKI-NGNKNILRIYDYHLEK-----SNNKCYLFLEFCEGGNLESIN----NT
 ...||.| ||| .|..|. .     .|||| .   ..  | .|..|  |.   ..||.|.| . ...     .    .. .|....|.| .      ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ITRRQAIIYFRQILDGMKELLRHKIIHRDIKLENILINEGQ-IKISDFGLSKQVQNN-LL----DVNSIKCGTPST-------MAPEIFFSHTSYPSYNN
.. .. . .  || .||  | ....||||.   |.|..|.. .||||||||. . .        |. . | .  .        |||| .     |  .. 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTT

KCDVWSLAVILHEMF-------YK-----VHPFNMNKEMLRKFQRIQVEH--------KCDIVEDFLSKSLVYNQKKRMSLEEIFNHKIY
| ||||  | . |.|       .      . .. . .   . . . | ..          | . .  ..   .. ..| . .||  |.. 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 7237.AA Ciliate-E2c 641-668 35 0.000182 11.67 In-house 283-310 (310) Show / Hide 
Range on Protein: 641-668
Range on HMM: 283-310/310
Sequence Identity: 35% (10 aa)

VEDFLSKSLVYNQKKRMSLEEIFNHKIY
| ... | |..  .|| . .||||| . 
VKQLIHKMLQVDEEKRIDWDEIFNHECI
Kinase 7237.AA CMGC 643-668 34 0.002197 5.95 In-house 488-513 (513) Show / Hide 
Range on Protein: 643-668
Range on HMM: 488-513/513
Sequence Identity: 34% (9 aa)

DFLSKSLVYNQKKRMSLEEIFNHKIY
|.|.| |.|. .||.. |.. .|   
DLLKKMLQYDPDKRITAEQALQHPYF
Kinase 7237.AA Pkinase_Tyr 582-613 37 0.089729 6.63 Pfam 181-208 (270) Show / Hide 
Range on Protein: 582-613
Range on HMM: 181-208/270
Sequence Identity: 37% (12 aa)

MAPEIFFSHTSYPSYNNKCDVWSLAVILHEMF
|||| ..       .. | ||||  | . |.|
MAPECINYGK----FTTKSDVWSFGVLMWEIF