Gene 18323 (Tetrahymena)
18323
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 18323.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 18323.AA | Ciliate-E1 | 308-481 | 21 | 7.7e-25 | 78.0 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 308-481 Range on HMM: 1-202/202 Sequence Identity: 21% (43 aa) INSGGEADIFTH---QYD-ESIAYRVIKLDGDEDLNEQLKELYSVKELQEQNILNLNNSHLVEYKV-EDTKYIIHVMQKCQMSLQDEIS----------- | .|.....| .. ...| .|.. . .. |....|.. ..... . . . ...|. .. . .| ....|..||.|... IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --SKKVFSLRETLRFISTAFHVLIVLRQKYIYHSDIKPGNILKIDDNNYKLSDFGASQQVNFIDPY-CDYEMHTPGYIPQNQ----------TKSLPFYH .. |. . .. | ... || |.|. |.|.|||| |||. ...||...||| |.. . . . |.|. .| | |..| .. . QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIY ||| DIY |
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| Kinase | 18323.AA | Ciliate-B2 | 378-484 | 30 | 1.3e-22 | 49.91 | In-house | 79-197 (197) | Show / Hide |
Range on Protein: 378-484
Range on HMM: 79-197/197
Sequence Identity: 30% (36 aa)
VMQKCQMSLQDEIS----SKKVFSLRETLRFISTAFHVLIVLRQKYIYHSDIKPGNILKIDDNNYKLSDFGASQQVNFIDPYCDYEMHTPGYIPQNQTKS
.|.||. ||..|. .| | .. | . || .| . | | |||| |||. .||...||| | . . .| | . | .
IMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK-DNQQIKIKGFTKKYASPEQMEC
L---------PFYHDIYSFG
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DHNQTFVTNIDFQSDIYSMG
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| Kinase | 18323.AA | Ciliate-C6 | 411-450 | 52 | 2.2e-11 | 36.58 | In-house | 147-188 (306) | Show / Hide |
Range on Protein: 411-450 Range on HMM: 147-188/306 Sequence Identity: 52% (22 aa) VLIVLRQ-KYIYHSDIKPGNILKIDD-NNYKLSDFGASQQVN .| .. | | |||| ||| .|| |||.|||||..|| . TLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLF |
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| Kinase | 18323.AA | Ciliate-A1 | 420-457 | 42 | 6.7e-09 | 26.36 | In-house | 122-159 (301) | Show / Hide |
Range on Protein: 420-457 Range on HMM: 122-159/301 Sequence Identity: 42% (16 aa) IYHSDIKPGNILKIDDNNYKLSDFGASQQVNFIDPYCD | |.|.||.||| .|. .|. |.| |.| . || ILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCD |
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| S_TKc | 18323.AA | S_TKc | 302-552 | 14 | 1.1e-08 | -49.46 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 302-552
Range on HMM: 1-231/231
Sequence Identity: 14% (40 aa)
FQLGDHINSGGEADIFTHQY---DESIAYRVIKLDGDEDLNEQLKELYSVKELQEQNILNLNNSHLVEYKVEDTKYIIHVMQKCQM---SLQDEISSKKV
......| .|. . . . .. | .|| . ..|. |. . || .| . ... || | .| | | ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR
------FSLRETLRFISTAFHVLIVLRQKYIYHSDIKPGNILKIDDNNYKLSDFGASQQVNFIDPYCDYEMHTPGYIPQNQTKSLPFYH---DIYSFGKT
|. .. ... . | . .. | | |.|| ||| .|. . |..||| . |. . || |.. .. . |..|.| .
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENIL-LDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI
IQKLLM-----QLENHSEISDCLNQFIKEEICKDDKNSINVDCLEQPRKFINILMNFVNYEVI-----EVFL-------EEYL
. .| . .. ... .. ....... ... |.. ...
LYEMLCGYPPFP-----QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | 18323.AA | Ciliate-E3 | 412-448 | 51 | 2.1e-08 | 22.63 | In-house | 116-155 (202) | Show / Hide |
Range on Protein: 412-448 Range on HMM: 116-155/202 Sequence Identity: 51% (21 aa) LIVLRQKYIYHSDIKPGNILKIDDNN----YKLSDFGASQQ .| . .| | |||||| ||| .| || | .|||.| | MIAIHEKNIIHSDIKPDNIL-VDKNNNQLIIKICDFGESKQ |
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| Kinase | 18323.AA | MOK | 420-458 | 46 | 1e-06 | 16.19 | In-house | 121-158 (283) | Show / Hide |
Range on Protein: 420-458 Range on HMM: 121-158/283 Sequence Identity: 46% (18 aa) IYHSDIKPGNILKIDDNNYKLSDFGASQQVNFIDPYCDY |.| |.|| ||| | . ||.|||. | || .| IFHRDVKPENIL-IKQDHLKLADFGSCRSVYSKQPYTEY |
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| Kinase | 18323.AA | Ciliate-A5 | 411-444 | 41 | 2e-06 | 18.33 | In-house | 111-144 (275) | Show / Hide |
Range on Protein: 411-444 Range on HMM: 111-144/275 Sequence Identity: 41% (14 aa) VLIVLRQKYIYHSDIKPGNILKIDDNNYKLSDFG |. .|.|. |.| ||.| ||. .|. .|| |.. VCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMN |
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| Kinase | 18323.AA | LKB | 420-444 | 56 | 2e-06 | 15.1 | In-house | 125-149 (265) | Show / Hide |
Range on Protein: 420-444 Range on HMM: 125-149/265 Sequence Identity: 56% (14 aa) IYHSDIKPGNILKIDDNNYKLSDFG . | ||||||.| || |..||| VVHKDIKPGNLLLTHDNTLKICDFG |
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| Kinase | 18323.AA | RAN | 420-444 | 62 | 4e-06 | 16.5 | In-house | 170-195 (324) | Show / Hide |
Range on Protein: 420-444 Range on HMM: 170-195/324 Sequence Identity: 62% (17 aa) IYHSDIKPGNILKID--DNNYKLSDFG ||| |||| ||| || | | .| |.| IYHCDIKPENIL-IDGIDWNIYLCDWG |
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| Kinase | 18323.AA | Ciliate-E8 | 420-446 | 48 | 5e-06 | 14.91 | In-house | 110-138 (138) | Show / Hide |
Range on Protein: 420-446 Range on HMM: 110-138/138 Sequence Identity: 48% (14 aa) IYHSDIKPGNIL-KI-DDNNYKLSDFGAS | |.|.| ||| . || . |. ||| | IIHCDFKLNNILVQRNDDTKIKIIDFGFS |
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