Gene 19121 (Tetrahymena)

19121

Species: Tetrahymena
Alias: 85.m00114, PreTt19121, 19121, 3725.m00007, 352, TTHERM_00614730
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
19121.AA Protein None 367 None Fasta, JSON
19121.kin_dom Protein Kinase Domain None 210 None Fasta, JSON
19121.NA RNA None 1104 None Fasta, JSON

Protein domain

Protein domains of 19121.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19121.AA Ciliate-E1 36-228 26 1.2e-44 143.19 In-house 1-202 (202) Show / Hide 
Range on Protein: 36-228
Range on HMM: 1-202/202
Sequence Identity: 26% (58 aa)

LGEGDYSLVYKASKDNTS---------VAIKIYKQYKDDYEKENEI-LKKLKGQDYVIQKVDQIVDKKIKMKAIVTELYDCSLEDIKK------------
.|.|..|.|.|| ..|..           . .|.| ....|..... ..|.|...|.|| .|.| ........|..|...|||.|  .            
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

--LNKFNFIQVIALTYQLLKALQVLNQQNVIHSDIKPANILYSSDKKMFVLCNSYLKTDIFIHYLMQINFKADFGLSHQLKNPKLQNTNYTLMGNIYYQS
   |.|.| |......||...|. | |.|.||.||||.|||.... . .|.|                    |||.|..||| ..|...|. . . ||..
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--------------------DFGISKFLKNNQNQQCQYKGYTHYYYPP

PEVY------NGQKPYTLKVDVF
....      | ..... |.|..
EQYNCPEQEHNKNQKINYKSDIY
Kinase 19121.AA Ciliate-A8 30-161 40 8.4e-42 141.95 In-house 1-151 (151) Show / Hide 
Range on Protein: 30-161
Range on HMM: 1-151/151
Sequence Identity: 40% (61 aa)

YKLENILGEGDYSLVYKA--SKDNTSVAIKIYKQ-------YKDDYEKENEILKKLKGQDYVIQKVDQIVDKKIKMKAIVTELYDC--------SLEDIK
|| . .|..|| |.|  |  ....  ||||| |.       ..   ||. ... |.|.. |..|  ..|.||.... |||||..||        .|. | 
YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL

K--LNKFNFIQVIALTYQLLKALQVLNQQNVIHSDIKPANILYSSDKKMFV
.  ||||.| |..|||||||| |.|. ... ||.|||| |||||. |  |.
ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI
Kinase 19121.AA S_TKc 30-300 23 2.6e-27 97.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

YKLENILGEGDYSLVYKASKDN--TSVAIKIYKQYKDDYEKENEILKKLKGQDYVIQKVDQIVDKKIKMKAIVTELYDC---SLED-IKKLNK------F
|.. ...|.| .. |||. . .    ||||| |   .. ..| .||||  . .....  | ..|   .   .|.|. |    .| | ||| ..      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NFIQVIALTYQLLKALQVLNQQNVIHSDIKPANILYSSDKKMFVLCNSYLKTDIFIHYLMQINFKADFGLSHQLKNPKLQNTNYTLMGNIYYQSPEVYNG
.  ..  ..||...||. . ....|| |.||.||| ..                       |   .||||. ||         .|. |  .| .|||   
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------------HIKI---CDFGLARQL---------TTFCGTPWYMAPEVL--

QKPYTL-KVDVFSIGVLVLEILTQNN-FDVLKVQKLHTQSLMEAFPELKYHENKNFIQNILSNMVNHVAEKRLDPDQLLY------NIEQF
  .|.  |.|. |.|... | |.    |.   .|..  . .            . ... ..... .   |||.   ..|       . . |
--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19121.AA Ciliate-E2 30-294 17 1.4e-24 81.27 In-house 1-360 (365) Show / Hide 
Range on Protein: 30-294
Range on HMM: 1-360/365
Sequence Identity: 17% (68 aa)

YKLENILGEGDYSLVYKASKDNT-------------------------SVAIKIYKQYKDDYE-KENEILKKLK---------------GQDYVIQKVDQ
||. ...|.| .. |||......                          .|.||.|...  .  .|. |.....                 ...|. .. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IVDKKIKMKAIVTELYDC-SLED------IKKLNK------FNFIQVIALTYQLLK---------------ALQVLNQQN-VIHSDIKPANILYSSDKKM
  .|. .   .|.|...  .|.|      .|....      |.  ... ...|.|.               ||. | ..| .|| |||| |||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FVLCNSYLKTDIFIHYLMQINFK-ADFGLSHQLKNP-----------KLQNTN-------------------YTLMGNIYYQSPEVYNG--------QKP
                      | .||||| .....           .... .                   .|. |. .|..||..||        ||.
---------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG

YTLKVDVFSIGVLVLEILTQNN-FDVLKVQKLHTQSLMEAFPEL-------------KYHENKNFIQNILSN----MVNHVAEKRLD-PDQLL
|. |.|..|.||.  | |. .  |     |. . |   . ...              ....  .  ......    | .   |||.. ..|.|
YDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 19121.AA STE 30-239 20 1.5e-23 80.1 In-house 1-263 (359) Show / Hide 
Range on Protein: 30-239
Range on HMM: 1-263/359
Sequence Identity: 20% (59 aa)

YKLENILGEGDYSLVYKASKDNTS-----------------VAIKIYK---------------------QYKDDYEKENEILKKLKG-QDYVIQKVDQIV
...  ..|.| .  |||| . ...                 .|||. .                     . .....|| .|.||..   .....  .  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DK----KI-KMKAIVTELYDC-SLEDIKKLNK---------------FNFIQVIALTYQLLKA-LQVLNQQNVIHSDIKPANILYSSDKKMFVLCNSYLK
..    |      |. |. |  ||.|| | ..               |.  |... ..|.||. |. | ....|| ||||||||                
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

TDIFIHYLMQINFKADFGLSHQLKN--------------PKLQNTNYTLMGNIYYQSPEVYNG-----QKPYTLKVDVFSIGVLVLEILT
          .   .|||.. || .                 |  ..|. |   . .||| ..      |.|. |.|. |.| ...| .|
--------VKL---CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT
Kinase 19121.AA Ciliate-E2-Unclassified 30-241 21 6.6e-21 69.27 In-house 1-267 (352) Show / Hide 
Range on Protein: 30-241
Range on HMM: 1-267/352
Sequence Identity: 21% (62 aa)

YKLENILGEGDYSLVYKASKDNT---------SVAIKIY-KQYKD-DYEKENE--ILKKLKGQDYVIQK------------------VDQIVDKKIKMKA
||.  ..|.| .. |||. ....         ......  ||..  | |. ||  .....|. . .  |                  ..  .... .   
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQR-KYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

IVTELY-DCSLED-IKKLNK-----------------FNFIQVI-----ALTYQLLKALQVLNQQN-VIHSDIKPANILYSSDKKMFVLCNSYLKTDIFI
||.|.  . .|.. ||| .|                 |   |..      ...|.|..|. | ..| .|| |||| |||.....|               
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------------

HYLMQINFK---ADFGLSHQLKNP---------KLQNT----NYTLMGNIYYQ----SPEVYNGQKPYT---LKVDVFSIGVLVLEILTQN
      |..   .|||.| .....         |.|..     .| .|...|.    .|||. ||....    |.|..| ||.  |.|...
------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase 19121.AA CMGC 30-239 15 1e-19 60.62 In-house 1-330 (513) Show / Hide 
Range on Protein: 30-239
Range on HMM: 1-330/513
Sequence Identity: 15% (56 aa)

YKLENILGEGDYSLVYKASKDNTS----------------VAIKIYKQYKDDYE----------------KENEILKKLK----------------GQDY
|.  . .||| |. |||.   .|                 ||||. |. . . |                 | .|||.|.                   .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIQKVDQIVDKK---------------IKMKAIVTELYDCSLEDIKKLNKFNFIQ---------------------VIALT------YQLLKALQ--VLN
...  | ...|.                .   .|.|. |..| .. | |.|..                       .  ..      ||.|..|    . 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

QQN--VIHSDIKPANILYSSD----------KKMFVLCNSYLKTDIFIHYLMQINFK-------------ADFGLSHQLKNPKLQNT-------------
...  .|| |.||.||| ...          .                        .             .||||. .. ... ...             
SHWGNIIHRDLKPENILINHNCELITRMMWKS------------------------EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKD

------NYTLMGNIYYQSPEVYNGQ---------KPYTLKVDVFSIGVLVLEILT
      ...     .| .||.  |          . || ..|. |.|    |..|
DKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYT
Kinase 19121.AA Ciliate-C5 32-237 26 4.2e-19 59.31 In-house 3-191 (260) Show / Hide 
Range on Protein: 32-237
Range on HMM: 3-191/260
Sequence Identity: 26% (56 aa)

LENILGEGDYSLVYKASKDNTSVAIKIYKQYKDDYEKENEILKKLKGQDYVIQKVDQIVDKKIKMKAIVTELYDCSLEDI-----KKLNKFNFIQVIALT
|   . .| .  |. |  ..  ||.|  |   .  . |..|.| ||   ||..........|      ..  | |.| ||     ..       |.| . 
LTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIGFA

YQLLKALQVLNQQNVIHSDIKPANILYSSDKKMFVLCNSYLKTDIFIHYLMQINFKADFGLSHQLKNPKLQNTNYTLMGNIY-YQSPEVYNGQKPYTLKV
 |.    . ..|.|.||||.|| |||| |. | | ||                    |.| | ..|.       | | |    |  ||. .    . .| 
IQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLC--------------------DYGESKSFKD---GSKTYDLKGFTRKYAAPEITDDNGFFNIKY

DVFSIGVLVLEI
|.. .|...||.
DIYGLGIILLEL
Kinase 19121.AA Pkinase 30-156 25 2.5e-15 55.26 Pfam 1-144 (293) Show / Hide 
Range on Protein: 30-156
Range on HMM: 1-144/293
Sequence Identity: 25% (37 aa)

YKLENILGEGDYSLVYKASKDNTS--VAIKIYKQYKDDYEK--------ENEILKKLKGQDYVIQKVDQIVDKKIKMKAIVTELYDC-----SLEDIKK-
|... ..|.| .. |||. . .|.  ||.|| |  ... .|        | .|.|.| . .....  |   | | ..  .|.|. ..     .| |. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIY-MVMEYCEGGLYVMDLFDYIST

--LNKF--NFIQVIALTYQLLKALQVLNQQNVIHSDIKPANILYSSD
   ..|     ...   ||.|..|. . ....|| |.||.|||....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN
Kinase 19121.AA CAMK 35-156 15 9.6e-14 39.95 In-house 1-215 (425) Show / Hide 
Range on Protein: 35-156
Range on HMM: 1-215/425
Sequence Identity: 15% (34 aa)

ILGEGDYSLVYKASKDNTS--------------VAIKIYK-------------------------------QYKDD-YEKENEILKKLKG------QDYV
.||.| .. |...   ||               |||||..                               ... .  ..| ||.|||.|         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQKVDQIVDKKI--------KMKA----------IVT---ELYDCS------LEDIKKLNK---------------FNFIQVIALTYQLLKALQVLNQQN
|.  . . |..           .           .|.   |. .        .. |..  .               |.  ..  .  |.. |.. . ..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHSDIKPANILYSSD
..| |.|| |||....
IVHRDLKPENILLDDN
Kinase 19121.AA TKL 183-239 26 5.7e-13 43.05 In-house 196-284 (364) Show / Hide 
Range on Protein: 183-239
Range on HMM: 196-284/364
Sequence Identity: 26% (24 aa)

ADFGLSHQLKNPKLQN-----------------TNYTLMGNIYYQSPEVYNGQ---------------KPYTLKVDVFSIGVLVLEILT
.|||||  ... . .|                 |..|  |.... .||| .||               ..|. |.||.| |..  ||||
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT
Kinase 19121.AA CAMK 183-233 19 2.4e-12 35.36 In-house 238-323 (425) Show / Hide 
Range on Protein: 183-233
Range on HMM: 238-323/425
Sequence Identity: 19% (17 aa)

ADFGLSHQLKNPKLQN---------------------TNYTLMGNIYYQS-PEVYNG-------------QKPYTLKVDVFSIGVL
.|||.. ...  . ..                       .|  |  .| . ||| ||             ...|. |.|. |.||.
IDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase 19121.AA ULK 30-152 25 4.8e-10 31.91 In-house 1-158 (324) Show / Hide 
Range on Protein: 30-152
Range on HMM: 1-158/324
Sequence Identity: 25% (40 aa)

YKLENILGEGDYS-LVYKA--SKD---NTSVAIKIYK------QYKDDY--------EKENEILKKLK--GQDY--VIQKVDQIVDKKIKMKAIVTELYD
| | ..||.| .   |||.   |.   |  ||.|.        ......        ..| .|.||||     .  ...  |   ..  .   |..|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

C-SLEDIKKLN-KFNFIQ----------VIALTYQLLKALQVLNQQNVIHSDIKPANIL
.  ||.. | | |... .          .|   .|.. ... |...|.|| ||||.|||
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNIL
Kinase 19121.AA Pkinase 183-239 35 1.4e-09 34.93 Pfam 154-207 (293) Show / Hide 
Range on Protein: 183-239
Range on HMM: 154-207/293
Sequence Identity: 35% (20 aa)

ADFGLSHQLKNPKLQNTNYTLMGNIYYQSPEVYNGQKPYTLKVDVFSIGVLVLEILT
.||||. |..    .  ..|. | ..| .||| .|...|. |||..|.|... | |.
CDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC
Kinase 19121.AA TyrKc 30-300 19 3.3e-09 -73.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

YKLENILGEGDYSLVYKASKDNTSVAIKIYK--QYKDDYEKENEILKKL-KGQDYVIQKVDQIVDK-----KIKMKAIVTELYDC-SLEDIKKLNK--FN
 .|. .|||| .  |||.  . . ||.|  |    . |  .| .|..|| .  . ... .  ....      |.   ||.|. .  .| |  . ..  ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

FIQVIALTYQLLKALQVLNQQNVIHSDIKPANILYSSDKKMFVLCNSYLKTDIFIHYLMQINFKADFGLSHQLKNP-------KLQNTNY--TLM--GNI
  . .   .|  .  . | ..|.|| |.   |.|.....                   . |   .|||||  ...        .   .           |
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------TVKI---SDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

YYQSPEVYNGQKPYTLKVDVFSIGVLVLEILT--QNNFDV-----LKVQKLHTQSLMEAFPELKYH-------ENKNFIQNILSNMVNHVAEKRLDPDQL
   .||. |  | .| | ||.| ||.  ||.|  |          .. | .. .      ..   .       .    . .| .   .. .|.|    ..
RWMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

LYNIEQF
   .|.|
---HECF
Kinase 19121.AA ULK 183-299 17 9.1e-09 27.3 In-house 180-324 (324) Show / Hide 
Range on Protein: 183-299
Range on HMM: 180-324/324
Sequence Identity: 17% (26 aa)

ADFGLSHQLKNP-KLQNTNYTLM------GNIYYQSPEVYN---GQKPYT-LKVDVFSIGVLVLEILT-QNN----FDVLK--VQKLHTQ----SLMEAF
||||.. .. |. . |. ..|.       |  .| .|.. .   .||||.  |.|..|.|..  |.|. .      |  ..  .|||  .     ...  
ADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKN

PELKYHENK------NFIQNILSNMVNHVAEKRLDPDQLLYNIEQ
  ...  ..      . ...... |     ..| . .... .   
QPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 19121.AA TKL 36-156 16 4.5e-08 25.16 In-house 1-176 (364) Show / Hide 
Range on Protein: 36-156
Range on HMM: 1-176/364
Sequence Identity: 16% (30 aa)

LGEGDYSLVYKASKDN----------TSVAIKIYKQYKDDY----------------------------EKENEILKKLKG--QDYVIQKVDQIVDKK--
.|.| .. |||.   .          . ||.|..|.  ||                             ..|.| .. ..    . ..| .    . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-IKMK--------AIVTELYDC-S-LEDIKKLNKFNFIQVIALTYQLLKALQVLNQQN--------VIHSDIKPANILYSSD
 . |.        .||.|.... | |...       . | . . ..  .... | ..|        .|| |.|..|||  ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN