24612

Species: Tetrahymena
Alias: 83, TTHERM_01446960, 24612, PreTt24612, 395.m00006
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
24612.AA Protein None 1725 None Fasta, JSON
24612.kin_dom Protein Kinase Domain None 26 None Fasta, JSON
24612.NA RNA None 5178 None Fasta, JSON

Protein domain

Protein domains of 24612.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24612.AA Ciliate-E1 626-799 24 1e-16 51.29 In-house 1-202 (202) Show / Hide
Range on Protein: 626-799
Range on HMM: 1-202/202
Sequence Identity: 24% (50 aa)

INSGGEADIFV----NLD-EQVAFRVLKVDDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKINEQT-YFIHLMQICSMSLYKQYV----------
| .|.....|     |   .|||  . .. ..    ... |... .....  ..   .|  ... .. .|   .| ... |..||...            
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK--FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQ

---TVDEFSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILIIN-GQYKFTDFGASQK-ISIYNPFNKPKMWTNGYVPQNIIN-------KNKPF--Y
   .  .|...|...|.|  .. || |.|. |.|.|||| |||| | |.|...||| |.. ..  |   . |  |. | |.. .|       ||..    
CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

HDIY
 |||
SDIY

Kinase 24612.AA Ciliate-B2 620-763 27 1.3e-14 30.65 In-house 1-151 (197) Show / Hide
Range on Protein: 620-763
Range on HMM: 1-151/197
Sequence Identity: 27% (43 aa)

FKLGYYINSGGEADIFVNL-------DEQVAFRVLKV---DDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKINEQTYFIHLMQICSMSLYKQYV
. |. |||.||.  |.           . .||... .    |.. . .   |.. .|.|. . ..  . | |.   .|||.   .  |..|  || .   
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQH---EIKIMKMFEYNINVVKY-IDHI---QINETID-VLIMEKCECSLKQELQ

----TVDEFSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILII-NGQYKFTDFGAS
    .. .|  . .....|  .  || .| . | | |||| |||.  ||.|...||| |
KIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGIS

Kinase 24612.AA Ciliate-C6 738-768 45 2.2e-10 33.01 In-house 157-189 (306) Show / Hide
Range on Protein: 738-768
Range on HMM: 157-189/306
Sequence Identity: 45% (15 aa)

IYHSDIKPGNILIING--QYKFTDFGASQKISI
| | |||| ||||...   |. .|||..|....
IAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQ

Kinase 24612.AA Ciliate-A1 642-764 22 6.3e-10 29.91 In-house 28-149 (301) Show / Hide
Range on Protein: 642-764
Range on HMM: 28-149/301
Sequence Identity: 22% (28 aa)

VAFRVLKVDDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKIN--EQTYFIHLMQICSMSLYKQYVTVDE-FSIEQILNIVFTSLHFLISLRQKYI
..  .... .   .|. . |.. .|.    | |       .|... |  |  ..|  |  |   .  .|.   .  . |.|  |       ....  . |
LCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQ---QLYYNTNNKECMFII--MEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNI

YHSDIKPGNILII-NGQYKFTDFGASQ
 |.|.||.||||    ..|. |.| |.
LHRDLKPQNILIHFDDKWKICDLGMSK

Kinase 24612.AA Ciliate-E2c 733-770 48 4.1e-08 24.62 In-house 130-168 (310) Show / Hide
Range on Protein: 733-770
Range on HMM: 130-168/310
Sequence Identity: 48% (19 aa)

LRQK-YIYHSDIKPGNILIINGQYKFTDFGASQKISIYN
| ..  |.| |||| |||| ||. |  ||| |... . |
LHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDN

Kinase 24612.AA S_TKc 620-847 13 1.1e-07 -64.08 SMART 1-231 (231) Show / Hide
Range on Protein: 620-847
Range on HMM: 1-231/231
Sequence Identity: 13% (36 aa)

FKLGYYINSGGEADIFVNLD----EQVAFRVLKVDDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKINEQTYFIHLMQICSM---SLYKQYVTVD
....  | .|. .  .   .    ..||  ..|       .. . |.|  |   .  .|  |  .          ...   |  |.    .|..  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG

E------FSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILIINGQYKFTDFGASQKISIYNPFNKPKMWTNGYVPQNIINKNKPFYH---DIYSV--
       |.  ..  ..   .  |  . .. | | |.|| |||. . . | .||| . ..       .    |  |..  ..    .. .   |..|.  
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

------------AKTIEIILNKLKTHPTIKDTLKKLVNQLMKDDEN--SVNIDCFQ-------LPQV
              ... ...|..      . .| ....... | .      ...|        | .
ILYEMLCGYPPFP-QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 24612.AA Ciliate-E2b 733-763 37 4.3e-07 17.77 In-house 118-149 (272) Show / Hide
Range on Protein: 733-763
Range on HMM: 118-149/272
Sequence Identity: 37% (12 aa)

LRQKYIYHSDIKPGNILIIN-GQYKFTDFGAS
| ...| . |||| ||.. . |. |  |.|..
LHNQNIIYRDIKPENIMVDHKGYMKLIDMGTA

Kinase 24612.AA Ciliate-E3 663-763 27 3e-06 16.05 In-house 51-153 (202) Show / Hide
Range on Protein: 663-763
Range on HMM: 51-153/202
Sequence Identity: 27% (29 aa)

QNVKLFQDENHILDLNISHLLEDKINEQTYFIHLMQICSMSLYKQYVTVDEFSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILIINGQ----YKFT
|  ...|. |.   . .   . |. |.  .||  .. ||    . |.   . . . |. |.   .  .| . .| | |||||| |||. . .     |. 
QEFQNCQQINSQNVVKCHDQYYDQQNK-MIFI-VQEYCSNGDLYHYIKQQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKIC

DFGAS
|||.|
DFGES

Kinase 24612.AA ULK 730-770 35 5e-06 17.33 In-house 139-192 (324) Show / Hide
Range on Protein: 730-770
Range on HMM: 139-192/324
Sequence Identity: 35% (19 aa)

LISLRQKYIYHSDIKPGNILIINGQ-------------YKFTDFGASQKISIYN
.  |... | | |||| |||| |||             .| .||| ....  .|
FKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNN

Kinase 24612.AA ULK 730-767 35 6e-06 16.96 In-house 143-193 (329) Show / Hide
Range on Protein: 730-767
Range on HMM: 143-193/329
Sequence Identity: 35% (18 aa)

LISLRQKYIYHSDIKPGNILIINGQ-------------YKFTDFGASQKIS
.  |... | | |||| |||| |||             .| .||| .....
FKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD

Kinase 24612.AA IKK 713-762 36 1.7e-05 14.98 In-house 111-164 (297) Show / Hide
Range on Protein: 713-762
Range on HMM: 111-164/297
Sequence Identity: 36% (21 aa)

E-FSIEQILNIVFTSLHFLISLR-QKYIYHSDIKPGNILII---NGQ--YKFTDFGA
| . ..|... .   .|.   |. |. | | ||||||| .     |.  || ||||.
EGHEFLQVCRDCCAGMHH---LHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGY