Gene 10118 (Tetrahymena)

10118

Species: Tetrahymena
Alias: TTHERM_00077720, 3828.m01382, 136, 10118, PreTt10118, 5.m00469
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
10118.AA Protein None 636 None Fasta, JSON
10118.kin_dom Protein Kinase Domain None 262 None Fasta, JSON
10118.NA RNA None 1911 None Fasta, JSON

Protein domain

Protein domains of 10118.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 10118.AA PH 44-143 17 3e-06 28.23 SMART 1-82 (82) Show / Hide 
Range on Protein: 44-143
Range on HMM: 1-82/82
Sequence Identity: 17% (17 aa)

RSIEGTLFRKSIKKGYWKSNTYQLIGNKLIKFTAESGKPEKFANIENYRLEKIKLEEKGDKDIKYGFRLTHNCKFVELYARNKEHMLMWFELVKRQCVLT
  .||.| .||  |  ||     | .. |. .  .  || .. ......... .           .|...|  .  .......|.| .|..  .. .   
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK--KPKGSIPLSDCTVRE-P-----------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN
Kinase 10118.AA Ciliate-E2a 149-410 49 3e-177 526.27 In-house 1-275 (275) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-275/275
Sequence Identity: 49% (136 aa)

YSTIKLMGKGNFARVYYARSKLTGGEFAVKAFEKDKFAQIEIDRPALIKEISILRKMNHPGVIKMYEVYENETHIFLVNELLKGGELFHKLKGHGQFDEV
|..||..|||||..||.|. | || .||.|.|.| |..|..... ....||.|.|...|| .||.|||||.|....|| |...||||..|.| ...|.| 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--YVAQLMTTLL-DSIHYISQRNILHRDIKPENLILR--SKNND--TDLCLADFGLADYYDPK-GGYMFQRCGTPGYVAPEVLADKI------YDFKVDT
  .....|  || . .||. ||||.|||.||||....  |||..  .|....|||||...|.. . ||||.||||||||||||. |       || |.| 
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

FSAGVIMFILLTGSSPFKGKSYDEIVIKNYNCTIDFNYNEMGKYLSAECFDLLQKLLKKDPLERYSAIQALNHPWF
.|.|||..|||.|..|||||.|.||...|..| ||||..|. ...| ||.||..|.|.||| .|..|.||||||||
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 10118.AA CAMK1 149-410 37 1.6e-103 301.84 In-house 1-276 (276) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-276/276
Sequence Identity: 37% (103 aa)

YSTIKLMGKGNFARVYYARSKLT---GGEFAVKAFE-KDKFAQIEI-DRPALIKEISILRKM---NHPGVIKMYEVYENETHIFLVNELLKGGELFHKLK
|  .|  |.| |. || .  | |   | ..|.|... |.  .. .   . || .||.|..|    .|| .||.||.|| ..|. || ||..|||||..  
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

GHGQFDEVYVAQLMTTLLDSIHYISQRNILHRDIKPENLILRSKNNDTDLC--LADFGLADYYDPKGGYMFQRCGTPGYVAPEVLAD---KIYDFKVDTF
  |.. |   . .|  .|. ..|. ...| |||.||||| ...| .| ..   .|||||. ..|.. ..|...||||||||||||..   | || ..| .
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

SAGVIMFILLTGSSPFKGKS-YDEIVIKNYNCTIDFNYNEMGKYLSAECFDLLQKLLKKDPLERYSAIQALNHPWF
|.||| .|||.| .|| ... ..|.  |. .| ..|  .. ... . |  |.. ..|..|| .||.. |.|||||.
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 10118.AA Ciliate-E2 149-410 27 2.7e-98 332.88 In-house 1-365 (365) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-365/365
Sequence Identity: 27% (105 aa)

YSTIKLMGKGNFARVYYARSKLTGGEFA----------------VKAFEKDKFAQIEIDRPALIKEISILRKMN----------------HPGVIKMYEV
|  ||. |.|||. ||... .... .||                ||.... .  ... .  .. .||.|.|..|                || .|||||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--NETHIFLVNELLKGGELFHKLK------------GHGQFDEVYVAQLMTTLLD---------------SIHYISQRN-ILHRDIKPENLILRSKNN
..  ....|.|| |...||.||. .|            . ..|.|  ....|. .|.                ..|. ..| |.||||||||...     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

DTDLCLADFGLADYYDPK----------GGYMFQR----------------------CGTPGYVAPEVLA---------DKIYDFKVDTFSAGVIMFILL
   ....||||. .||..          . ||| .                      ||||||.|||.|           | ||.|.| .|.|||....|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGSSPFKGKSYDEIVIKNYNCTIDFNYNEMG-------------KYLSAECFDLLQK----LLKKDPLERYS-AIQALNHPWF
.|  ||         ... .| |||. .|..             |..| || ||..|    .|.||| .|.. . |.||||||
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 10118.AA CAMK 154-410 24 1.4e-95 308.49 In-house 1-425 (425) Show / Hide 
Range on Protein: 154-410
Range on HMM: 1-425/425
Sequence Identity: 24% (105 aa)

LMGKGNFARVYYARSKLTGGE------------FAVKAFEKDKFAQ------------------------IEIDRPALIKEISILRK-------MNHPGV
  |.|.|. |. .. |.|.|.            .|.|  .|.|                            . ||  . .||.|..|       ..|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKMYEVYEN-------------------ETHIFLVN---ELLKGGEL----FHKLKGHGQ---------------FDEVYVAQLMTTLLDSIHYISQRNI
||.|||||.                   ..|...|    |.  ||||    | ... ||.               |.|  .....  ... .||. ..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKPENLILRSKNNDTD--------------LCLADFGLADYYDPK-----------------------GGYMFQRCGTPGYVA-PEVLADKI----
 |||.||||. | ..|.|.|              . ..|||.| ..||.                       |  |  .||||.|.| ||||  |     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDFKVDTFSAGVIMFILLTGSSPFKGK-------------SYDEIVIKNYNCTIDFNYNEMGK-------------------YLSAECFD
          |..|.|  |.|||..|.|.| .|| |.             .. |.  |  ..  ||   .. .                   ..|.|| |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLQKLLKKDPLERYSAIQALNHPWF
|..|.|..|| .|... |.|||||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 10118.AA CDPK 149-410 38 1e-85 262.89 In-house 1-271 (271) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-271/271
Sequence Identity: 38% (107 aa)

YSTIKLMGKGNFARVYYARSK-LTGGEF-AVKAFEKDKFAQIE-IDRPALIKEISILRKMNHPGVIKMYEVYENETHIFLVNE--LLKGGELFHKLKGHG
|   |  |||.|  |. .  |  |. |  |.|  .|..  . | ...  ...|| ||..  || .||.||.|. | ....| |  ...||||| . .  |
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQ--FFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKG

QFDEVYVAQLMTTLLDSIHYISQRNILHRDIKPENLILRSKNNDT----DLCLADFGLADYYDPK----GGYMFQRCGTPGYVAPEVLADKIYDFKVDTF
.|.|   |. |. .|  . |. ..|| |||.||||. . ||..|.    .. . |.|.. ..|..    . .| |||||| |.|||||  | |. |.|  
HFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIW

SAGVIMFILLTGSSPFKGKSYDEIVIKNYNCTIDFNYNEMGKYLSAECFDLLQKLLKKDPLERYSAIQALNHPWF
|.|||..||| |. || ||.  ||. |  ..  .|.. |  .  | |. || .|.| .||  |.|| |||.||||
SCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEW-DHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 10118.AA S_TKc 149-410 30 1.9e-80 274.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-231/231
Sequence Identity: 30% (86 aa)

YSTIKLMGKGNFARVYYARSKLTGGEFAVKAFEKDKFAQIEIDRPALIKEISILRKMNHPGVIKMYEVYENETHIFLVNELLKG--GELFHKLKGHGQ--
|  ... ||| |..|| .| | || ..|.|                ...||.||.| .|| ..|.|.|... .|...| |.. |  |.||. .| .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDEVYVAQLMTTLLDSIHYISQRNILHRDIKPENLILRSKNNDTDLCLADFGLADYYDPKGGYMFQRCGTPGYVAPEVLADKIYDF-KVDTFSAGV
    |.|  .. .|  ... . |. ...|.|||.||||. | .      . ..|||||  .          |||| |.|||||    |.. |.|  | |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

IMFILLTGSSPFKGKSYDEIVIKNYNCTIDFNYNEMGKYLSAECFDLLQKLLKKDPLERYSAIQALN-------HPWF
|....|.|  ||     .. .. .  .             | |. |...|.|.||| .|..| .||.       ||||
ILYEMLCGYPPFP----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10118.AA Pkinase 149-410 30 1.6e-74 258.72 Pfam 1-293 (293) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-293/293
Sequence Identity: 30% (89 aa)

YSTIKLMGKGNFARVYYARSKLTGGEFAVKAFEKDKFAQIEIDRPALIKEISILRKMNHPGVIKMYEVYENETHIFLVNELLKGG----ELFHKLK--GH
| ...  |.|.|..|| .. | || ..||| ..|..    .  . ... ||.|....||| ....|...|...|| .| |.. ||    .||. ..   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GQF--DEVYVAQLMTTLLDSIHYISQRNILHRDIKPENLILR-SKNNDTDLCLADFGLADYY-DPKGGYMFQRCGTPGYVAPEVLA-DKIYDFKVDTFSA
| |  .|  .   |. .|  . |. ...|.|||.||||. .    ..|......|||||  .   ... |  .||||.|.||||.  .. |. ||| .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIMFILLTGSSPFKGK------SYDEIVIKNYNCTIDFNYN-----------------EMGKYLSAECFDLLQKLLKKDPLERYSAIQALNHPWF
|.|....|.|  ||.|.      . .... ..  . ..|..                  .  ...| || |.. ..|.||| .|..| |.|.||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 10118.AA CAMKL 149-410 30 1.2e-72 231.11 In-house 1-297 (297) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-297/297
Sequence Identity: 30% (93 aa)

YSTIKLMGKGNFARVYYARS-KLTGGEFAVKAFEKDKFAQIEIDRPA-----------LIKEISILRKMN---HPGVIKMYEVYENETH------IFLVN
|  .|  |||.|. |  |.  ..|| . |.|  .|.|   ... .             . .||.|....|   || .||.|||.|...|      |.|| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELLKGGE--LFHKL--KGHGQ--FDEVYVAQLMTTLLDSIHYISQRNILHRDIKPENLILRSKNNDTDLCLADFGLADYYDP----KGGYMFQRCGTPGY
|.  |||  ||...  .||.   ..|    .. . ... ..|. ...| ||||||||. | ...|   . ..|||.. .|.|    .|  .  .||.| |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

VAPEVLAD--KIYD-FKVDTFSAGVIMFILLTGSSPFKGKSY----DEIVIKNYNCTIDFNYNE-MGKYLSAECFDLLQKLLKKDPLERYSAIQALNHPW
 |||....  | || .|||  |.|||.. ...|  ||.. .|    .. . . |. ..   |..   ...| .| ||..|.|...| .|... | .||||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

F
.
M
Kinase 10118.AA CAMK-Unique 149-410 23 4.7e-63 206.92 In-house 1-363 (363) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-363/363
Sequence Identity: 23% (84 aa)

YSTIKLMGKGNFARVYYARSKLTGGEFAVKAFEKDKFAQIEIDRP-----------------ALIKEISILRKMNHPGVIKMYEV----YENET------
| .... |.|||  || .  . || ..|.| ..| . .....  .                  | .|..|... .||  || |..    .. ..      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQT-HGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------HIFLVNELLKGGELFHKLKG--------------------HGQFDE--VYVAQLMTTLLDSIHYISQRNILHRDIKPENLILRSKNN----
         ....| |.. ||.|| ..                       |.| |    ....|. ||  . |  . .| |||.|.||. ...  .    
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

---------DTDLCLADFGLADYYDPKGGY--MFQRCGTPGYVAP--------------EVLADKIYDFKV----DTFSAGVIMFILLTGSSPFKGKSYD
         .... |.||||. .|. .  .  |  .|||| |.||              ||..   || ..    |. | ||||...|.|..|| . . |
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------EIVIKNYNCTI-DFNYNEMGK--YLSAECFDLLQKLLKKDPLERYSAIQALNHPWF
        ||  .   . . .|    ..   | | |  |....... ||  | || ..| |.|.
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 10118.AA Ciliate-E2-Unclassified 149-410 24 1.1e-61 211.24 In-house 1-352 (352) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

YSTIKLMGKGNFARVYYARSKLTGGEF-----AVKAFEKD-KFAQIEIDRPALIKEIS----------------ILRKMNHPGVIKMYEVYENETHIFLV
|  ||  |.|.|. || .. | .. ..     . |. ... |  . ...    .||.                 ||. ..|| ..||... ... .|..|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

NELLKGG-----------------ELFHKLKGHGQFDEVYVA-----QLMTTLLDSI-HYISQRNILHRDIKPENLILRSKNNDTDLCLADFGLADYYDP
 |...||                 .|||..|   .|.|  ..     ...  .|. . ..... ||.||||||||... ....   ....|||.. .|. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

KGGY---------------MFQRCGTPGYV----APEVLADKIYD----FKVDTFSAGVIMFILLTGSSPFKGKSYDE---------------IVIKNY-
  ..               | ..||||.|     |||||  . ||    .|.| .| |||.. .|.|  ||.......               ....|  
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NCTIDFN-YNE--MGKYLSAECFDLLQ----KLLKKDPLERYSAIQALNHPWF
.. |.|. ...    | .| |. |...    |.|||.| .|... |.||||||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 10118.AA DCAMKL 149-358 38 2e-60 186.49 In-house 1-226 (279) Show / Hide 
Range on Protein: 149-358
Range on HMM: 1-226/279
Sequence Identity: 38% (87 aa)

YSTIKLMGKGNFARVYYARSKLTG-GEFAVKA---------FEKDKFAQIEIDRPALI-------KEISILRKMNHPGVIKMYEVYENETHIFLVNELLK
|.. .. |.|||| |. .| . ||  ..| |          |    | |  ||. ...        |.||..|..|| .|..||... |||..|| |. .
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQ--IDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQ

GGELFHKLKGHGQFDEVYVAQLMTTLLDSIHYISQRNILHRDIKPENLILRS-KNNDTDLCLADFGLADYYDPKGGYMFQRCGTPGYVAPEVLADKIYDF
|| ||  .   . | |   | .|| |   . |.  .|| ||||||||| .       . | |.||||| . .   | ..  |||| |||||.|. . |  
GGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGC

KVDTFSAGVIMFILLTGSSPFKGKSYDE
|||  .||||  ||| |  ||..   |.
KVDIWAAGVILYILLCGFPPFRSPDNDQ
Kinase 10118.AA RSK 152-410 28 2.5e-59 203.44 In-house 1-278 (278) Show / Hide 
Range on Protein: 152-410
Range on HMM: 1-278/278
Sequence Identity: 28% (81 aa)

IKLMGKGNFARVYYARSK---LTGGEFAVKAFEKDKFAQIEIDRPALIKEISILRKMN-HPGVIKMYEVYENETHIFLVNELLKGGELFHKLKGHGQ---
.|. |.| .  |.  | .    || ..|.|  .| |..| . |     .|..||   . || ... ..... |....|. |...||||| .|. ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEVYVAQLMTTLLDSIHYISQRNILHRDIKPENLILRSKNND-TDLCLADFGLADYYDPK-GGYMFQRCGTPGYVAPEVLA----DKIYDFKVDTFSAG
|.|  ... | ..   . .. |. | |||.|||| .. ... .   . | |||.. . ... .. .   |.|  |.|||.|.    .. .|  .| .| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VIMFILLTGSSPFKG---KSYDEIVIKNYNCTIDFNYNEMG--KYLSAECFDLLQKLLKKDPLERYS-----AIQALNHPWF
|.|. .||| .||.|   .. .||  .  .......   |.  .|||.|. ||..|.|..||  |..     | . ..||||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLT---MPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 10118.AA TyrKc 149-410 19 8.1e-14 0.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 149-410
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

YSTIKLMGKGNFARVYYARSKLTGGEFAVKAFEKDKFAQIEIDRPALIKEISILRKM--NHPGVIKMYEVYENE-------THIFLVNELLKGGELFHKL
 . .|  | |.| .|| .. |    . |||   .|.       | ....|..|..|   .|| ....| |   .         ...| |. ..| | . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KGHGQFDEVYVAQLMTTLLDS---IHYISQRNILHRDIKPENLILRSKNNDTDLCLADFGLADYYDPK------GGYMFQRC--GTPG-----YVAPEVL
. |.    . ...|    ..      |....|. |||.   |  . ...       .||||. . . .      . |  ..   |. .       |||..
RKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

ADKIYDFKVDTFSAGVIMF-ILLTGSSPFKG-----KSYDEIVIKNYNCTIDFNYNEMGKY--------LSAECFDLLQKLLKKDPLERYSAIQALNHPW
 .... .| | .| || |. |.  | .|  |     .| .|.    ...  . .. .  ..         ..| ... ..  . || .| .  .   |  
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV----IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

F
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F
Kinase 10118.AA DCAMKL 385-410 46 1.9e-08 21.81 In-house 254-279 (279) Show / Hide 
Range on Protein: 385-410
Range on HMM: 254-279/279
Sequence Identity: 46% (12 aa)

DLLQKLLKKDPLERYSAIQALNHPWF
|| ...|..||  ||.| | . ||| 
DLISHMLQVDPEKRYTAEQIMQHPWV
Kinase 10118.AA Pkinase_Tyr 149-244 23 0.000103 16.59 Pfam 1-106 (270) Show / Hide 
Range on Protein: 149-244
Range on HMM: 1-106/270
Sequence Identity: 23% (26 aa)

YSTIKLMGKGNFARVYYARSK----LTGGEFAVKAFEKDKFAQIE--IDRPALIKEISILRKM-NHPGVIKMYEVYE-NETH--IFLVNELLKGGELFHK
 . .|  |.|.| .|| .. |     |. . |||   |..  . .  ..  ....|..|.... .|| ....| |    . .  |..| |. ..| | . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCRE--DFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKGH---GQ
|. |   .|
LRKHREDKQ
Kinase 10118.AA Pkinase_Tyr 319-355 35 7.757904 0.07 Pfam 182-220 (270) Show / Hide 
Range on Protein: 319-355
Range on HMM: 182-220/270
Sequence Identity: 35% (14 aa)

APEVLADKIYDFKVDTFSAGVIMFILLT-GSSP-FKGKS
|||.......  | |  | || |. ..| | .| ..| |
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMS