Gene 11511 (Tetrahymena)

11511

Species: Tetrahymena
Alias: 946, PreTt11511, 11511, 1.m00559, TTHERM_00000030
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
11511.AA Protein None 556 None Fasta, JSON
11511.kin_dom Protein Kinase Domain None 182 None Fasta, JSON
11511.NA RNA None 1671 None Fasta, JSON

Protein domain

Protein domains of 11511.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11511.AA Ciliate-E2a 142-331 44 4.7e-121 358.05 In-house 43-247 (275) Show / Hide 
Range on Protein: 142-331
Range on HMM: 43-247/275
Sequence Identity: 44% (92 aa)

QKELMNEINLLRRINHEKVVKSYEFFQTESQYKLVLHYYEGGSLEQKLEKSKGFTLF--QICDMMRQIL-QGFSYLHQNNIMHRDLKPDNILFF--DKES
....|||||..|...|  . | ||....|..|.||..|.|||.|..|. ..| |. .  .|||.|.|.| ||..|.||.|||||||||.||||   .|.|
KEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNS

---FDVVISDMGLSQDV--NEN-FVFKKCGTPGYVAPEILNSIT---GTDYGVKSDIFSCGCLFYRLVMGQPLFEGKSHVEVLEENRKCKIDLSSTE-FK
   .|..|.|.||....  .|. ..|.|||||||||||.||.     ...|..| |..|||. ||.|..|.|.|.||.. |.|..|.|||||....| ..
IQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWE

KLPQQ
|....
KCSKE
Kinase 11511.AA Ciliate-E2 129-331 23 1.2e-68 234.36 In-house 1-332 (365) Show / Hide 
Range on Protein: 129-331
Range on HMM: 1-332/365
Sequence Identity: 23% (82 aa)

YEVISFVGNGSFS-----QK-----------------------------------------ELMNEINLLRRIN----------------HEKVVKSYEF
|..|   |.|.|.     ..                                         ....||...|.||                |  ..| ||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TESQYKLVLHYYEGGSLEQKLEKS-----------KGFTLFQICDMMRQILQ---------------GFSYLHQNN-IMHRDLKPDNILFFDKESF
||  ... . ||. |..||.|.. ....           | ||...|...|.||||               .. |||..| |.|||.||.||||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

DVVISDMGLSQDVNE------------NFVFKK----------------------CGTPGYVAPEILNSIT------GTDYGVKSDIFSCGCLFYRLVMG
 . |.|.|||.....            .. | |                      ||||||.||||||.        ...|. |.||.|.|...|....|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

QPLFEGKSHVEVLEENRKCKIDLSSTE--------------FKKLPQQ
.| |        .... .||||... |              .||..|.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQE
Kinase 11511.AA CAMK 129-326 20 7.8e-50 158.35 In-house 56-372 (425) Show / Hide 
Range on Protein: 129-326
Range on HMM: 56-372/425
Sequence Identity: 20% (66 aa)

YEVISFVGNGS-------FSQKELMNEINLLRR-------INHEKVVKSYEFFQ------------TESQ--------YKLVL---HYYEGG----SLEQ
|  |.. ....       ...|....||.....       ..|. ..| ||...            | |.        . .|.    | .||     | .
Y-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFD

KLEKSKG---------------FTLFQICDMMRQILQGFSYLHQNNIMHRDLKPDNILFFDKES---------------FDVVISDMGLSQDVNEN----
.. . ..               ||  . . ..|||...  |.|..||.||||||.|||. |...               ... |.| |... ....    
YIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNF

---------------------FVFKKCGTPGYVA-PEILNSIT-----------GTDYGVKSDIFSCGCLFYRLVMGQPLFEGK-------------SHV
                          ||||.|.| ||.||. .            . || |.|. |||.. | .. | | |.|.             .  
MCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDY

EVLEENRKCKIDLSSTEFK
| .|  .|.| |  . .|.
ELFEKIMKGKYDFPPPYFS
Kinase 11511.AA CAMK1 142-319 33 1.7e-47 136.07 In-house 49-235 (276) Show / Hide 
Range on Protein: 142-319
Range on HMM: 49-235/276
Sequence Identity: 33% (63 aa)

QKELMNEINLLR---RINHEKVVKSYEFFQTESQYKLVLHYYEGGSLEQKLEKSKGFTLFQICDMMRQILQGFSYLHQNNIMHRDLKPDNILFFDK-ESF
|. |.|||. ..   .|.|. ..| ||...... . ||. .  || |  .  . . .|  . .. |.|||.   |.|...|.|||||| |.|. || | .
QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDS

DVV--ISDMGLSQDVNEN--FVFKKCGTPGYVAPEILNSITGTDYGVKSDIFSCGCLFYRLVMGQPLFEGKS-HVEVLEENRKCKID
...  |.| |||. ....  . .. ||||||||||.|. .  . |. . |..|.|. .| |  | | | ... . | .| . ||...
KIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYE
Kinase 11511.AA Pkinase 142-324 29 1.2e-45 162.46 Pfam 42-241 (293) Show / Hide 
Range on Protein: 142-324
Range on HMM: 42-241/293
Sequence Identity: 29% (60 aa)

QKELMN--EINLLRRINHEKVVKSYEFFQTESQYKLVLHYYEGG----SLEQKLE--KSKGF--TLFQICDMMRQILQGFSYLHQNNIMHRDLKPDNILF
.... .  || ...|.||. .|. |..|.... . .|. | |||    .|   ..  ....|  .  .....|.|||.|  |.|...|.||||||.|||.
DQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI

FDKESF--DVVISDMGLS----QDVNENFVFKKCGTPGYVAPEILNSITGTDYGVKSDIFSCGCLFYRLVMGQPLFEGK------SHVEVLEENRKCKID
 ..     .| |.| ||.       |. .    ||||.|.|||...  .|..|| |.|..||||..| .. |.|.| |.      .. ............
DNNGHIDACVKICDFGLAKQFDY-NNS-MTT-FCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLH

LSSTE
 .. .
FDWPW
Kinase 11511.AA Ciliate-E2-Unclassified 129-331 21 5.1e-45 154.09 In-house 1-320 (352) Show / Hide 
Range on Protein: 129-331
Range on HMM: 1-320/352
Sequence Identity: 21% (71 aa)

YEVISFVGNGSFSQKELMNEIN---------------------------------------------------LLRRINHEKVVKSYEFFQTESQYKLVL
|..|   |.|.|..  .. ...                                                   .|. ..|. .|| .. ||..    .|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

HYYEGGSLEQKLEKSKG-----------------FTLFQIC-----DMMRQILQGFSYLHQNN-IMHRDLKPDNILFFDKES-FDVVISDMGLSQDVN--
 | |||.|.| ..|.|.                 || .|..     ....|||||..|||..| | |||.||.|||| .. . . . |.| |.|   .  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------ENFVFKKCGTPGYV----APEILNSITGTDYG----VKSDIFSCGCLFYRLVMGQPLFEGKSHVE---------------VLEEN
               ..    .||||.|     |||.|    |  |.     |.||.|.|...| ...|.. |....  .                |..|
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL---QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

RKCK-IDLSSTEF----KKLPQQ
 | | |. .. ..    |.....
IKQKNIQFPKFPWQQIPKHWSPE
Kinase 11511.AA S_TKc 129-365 23 7.3e-42 146.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 129-365
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

YEVISFVGNGSFSQ-------------------KELMNEINLLRRINHEKVVKSYEFFQTESQYKLVLHYYEG--GSLEQKLEKSKG------FTLFQIC
||..  .| |.|..                   . ...||..|.. .|. .|| |..||. . . .|. | .|  |.| . ..| ..      |.  ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

DMMRQILQGFSYLHQNNIMHRDLKPDNILFFDKESFDVVISDMGLSQDVNENFVFKKCGTPGYVAPEILNSITGTDYGV-KSDIFSCGCLFYRLVMGQPL
 .|.||...  |.|...|.||||||.|||. .     . |.| ||.  .        |||| |.|||.|       ||  |.|. ||||..| .. |.|.
FYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-----TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPP

FEGKSHVEVLEENRKCKIDLSSTEFKKLPQQNSMQNNNNIFAKTYKINVEYFIDQILL-N---------SQ-------TPFF
|.   ..... .. .                                 .  ||...|  .          |        |.|
FP---QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 11511.AA STE 139-299 26 9.8e-38 130.85 In-house 69-266 (359) Show / Hide 
Range on Protein: 139-299
Range on HMM: 69-266/359
Sequence Identity: 26% (54 aa)

SFSQKELMNEINLLRRIN--HEKVVKSYEFFQTE-------SQYKLVLHYYEGGSLEQKLE-K-SKGFT------------LFQICDMMRQILQG-FSYL
.  ......||..... |  |. .|| |  .  |       ..  ... | .||||.. .. | ..|..              ||. . ||||.|  .||
HEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYL

HQNNIMHRDLKPDNILFFDKESFDVVISDMGLSQDVNE---------------NFVFKK---CGTPGYVAPEILNS-ITG--TDYGVKSDIFSCGCLFYR
|...|.|||.||.|||.       | ..| |..  ...               . . |    .||| . |||...   .|   .|..|.|| | ||.   
HSHHIIHRDIKPANILL-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE

LVMGQP
.. |.|
MATGKP
Kinase 11511.AA ULK 145-299 30 2.8e-35 122.64 In-house 57-250 (324) Show / Hide 
Range on Protein: 145-299
Range on HMM: 57-250/324
Sequence Identity: 30% (59 aa)

LMNEINLLRRIN---HEK--VVKSYEFFQTE--SQYKLVLHYYEGGSLEQKLEKSKG---------FTLFQICDMMRQILQGFSYLHQNNIMHRDLKPDN
|.|||.... ..   |.   .|| |..|.|     . ... | .|| ||| ..| |.         ..  ..   ..||..|| .||..||.|||.||.|
LKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQN

ILFFD-KESFDVV---------ISDMGLSQDVNEN-FVFKKC----------GTPGYVAPEILNSI-TGTDYG-VKSDIFSCGCLFYRLVMGQP
||  . ....|           |.| |... |..| .   .|          ||| | ||.||..   . .|.  |.||.| ||.|| .. |..
ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKY
Kinase 11511.AA ULK 139-299 28 3e-35 120.53 In-house 40-254 (329) Show / Hide 
Range on Protein: 139-299
Range on HMM: 40-254/329
Sequence Identity: 28% (62 aa)

SFSQKE-----------LMNEINLLRRIN--------HEKVVKSYEFFQTE--SQYKLVLHYYEGGSLEQKLEKSKG----------FTLFQICDMMRQI
...||.           |.||| ......        |. .|| |..|.|     . ... | .|| ||| ..| |.          ..  ..   ..||
KMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQI

LQGFSYLHQNNIMHRDLKPDNILFFD-KESFDVV---------ISDMGLSQDVNEN------FVFKK-----CGTPGYVAPEILNSI-TGTDYG-VKSDI
|.|| .||..||.|||.||.|||  . ....|           |.| |... |...      ..  .     |||| | ||.||..   . .|.  |.||
LNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDI

FSCGCLFYRLVMGQP
.| ||.|| .. |.|
WSLGCIFYEMLYGKP
Kinase 11511.AA TKL 147-292 22 3.9e-30 105.7 In-house 74-280 (364) Show / Hide 
Range on Protein: 147-292
Range on HMM: 74-280/364
Sequence Identity: 22% (48 aa)

NEINLLRRINHEKVVKSYEFFQTESQ-------------YKLVLHYYEGGSLEQKLEKSKGFTLFQICDMMRQILQGFSYLHQNN--------IMHRDLK
.||....|..|. .|. . . . ...             . .|  |..||||.  |       . |.|.....| .| .|||..|        | |||||
EEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLK

PDNILFFDK------------ESFDVVISDMGLSQDVNENF---------------------VFKKCGTPGYVAPEILNSI-------------TGTDYG
..||| ...            .  .. |.|.|||.......                       ..||||.. |||.|.                | .| 
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

VKSDIFSCGCLFY
 |.|..| | ...
EKCDVYSFGIVLW
Kinase 11511.AA RSK 146-322 31 3.6e-28 99.91 In-house 48-236 (278) Show / Hide 
Range on Protein: 146-322
Range on HMM: 48-236/278
Sequence Identity: 31% (60 aa)

MNEINLLRRIN-HEKVVKSYEFFQTESQYKLVLHYYEGGSLEQKLEKSKG---FTLFQICDMMRQILQGFSYLHQNNIMHRDLKPDNILFFDKE-SFDVV
| |.| | |.. |  .|. .. ||||.   |.. | .|| |  .|.| |    |.    |. |..|    ..|||  | ||||||.|||. |.. .  ..
MTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIK

ISDMGLSQD-VNE-NFVFKK-CGTPGYVAPEILNSIT-GTDYGVKSDIFSCGCLFYRLVMGQPLFEG---KSHVEVLEENRKCKIDLSS
..| |..   ... |.  .. |.|  |.|||.|.    .  ..   |..| |.| | . .|.| | |   ... |...  .|.|..|..
LTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTM
TyrKc 11511.AA TyrKc 72-334 16 2.7e-11 -40.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)

IKILEQL-----------TYSTLYNDDACYLKLSKFGKETFVKMSPDALDQVDKLLKNIIFKQDFSDSYEVISFVGNGSFSQKELMNEINLLRRI--NHE
|. ...|           |..                 .  |||  .                                  ....|.|.......  .|.
ITLGKKLGEGAFGEVYKGTWK----------------IQVAVKMLKEDA--------------------------------REDFMREARIMCKLGGHHP

KVVKSYEFFQTE-------SQYKLVLHYYEGGSLEQKLEKSKG-FTLFQICDMMRQILQGFSYLHQNNIMHRDLKPDNILFFDKESFDVVISDMGLSQDV
 .|. |    ..        .. .|. | ..|.| . | |... ... . .... || .| .|||..|. ||||   |.|  ..    | ||| ||| |.
NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDI

NEN-------FVFKKC---GTPG-----YVAPEILNSITGTDYGVKSDIFSCGCLFYRLV-MGQPLFEG-----KSHVEVLEENRKCKIDLSSTE-----
 .         . .|    |. .       ||| .       .  |||..| | . . .   ||.  .|     .|  ||.|  .. .      .     
YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS

-------------------------FKKLPQQNSM
                         |. .     .
FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 11511.AA Pkinase_Tyr 142-224 25 1.7e-07 26.05 Pfam 47-137 (270) Show / Hide 
Range on Protein: 142-224
Range on HMM: 47-137/270
Sequence Identity: 25% (23 aa)

QKELMNEINLLRRI-NHEKVVKSYEFFQ-TESQ--YKLVLHYYEGGSLEQKLEK----SKGFTLFQICDMMRQILQGFSYLHQNNIMHRDL
....|.|..... . .|...|. |      . .  . .|. | ..|.|   | |     . .|. ....| .|| .| .||...|. ||||
REDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 11511.AA CAMK1 129-141 46 0.042929 1.81 In-house 1-13 (276) Show / Hide 
Range on Protein: 129-141
Range on HMM: 1-13/276
Sequence Identity: 46% (6 aa)

YEVISFVGNGSFS
||...  |.|.||
YEFGKEIGRGAFS
Kinase 11511.AA Pkinase 129-141 38 8.086965 0.44 Pfam 1-13 (293) Show / Hide 
Range on Protein: 129-141
Range on HMM: 1-13/293
Sequence Identity: 38% (5 aa)

YEVISFVGNGSFS
|.... .| |||.
YHIGRKIGSGSFG