Gene 15541 (Tetrahymena)
15541
Sequence
Protein domains of 15541.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 15541.AA | Ciliate-E2a | 194-391 | 44 | 2.5e-126 | 373.86 | In-house | 64-275 (275) | Show / Hide |
Range on Protein: 194-391 Range on HMM: 64-275/275 Sequence Identity: 44% (94 aa) LYEIYEDENNIYLITELFQGKDMKSKLSDCLILDEK--TISEIMWRLL-QGLHHMHSKGIFHRDIKLENIQFR--NSQNI--TDVCLTNFYMADFVDPK- |||.||||||.||..|...|.....|.. | ..|. |..||. || ||||.||...|.|||.|.||| |. ....| .|... .|..|.|.|.. LYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDE GKQTYKKCGTAGFIAPEIFKSKH------YDQKIDIFSLGIVFYILMFGKMPFDAPTVDQILQLNEQCEIDFTSNDCAIKCTSSAIDLLKKMLNKDPSQR .|. ..||||.|..|||....|. ||.| |..|.|..||||..||.||.. |...|||.|..|.||| ...| ||.....||.||||.|||..| KKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKR ANAFQLINHTWF .| |. ||.|| ITAQQALNHPWF |
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| Kinase | 15541.AA | Ciliate-E2 | 194-391 | 28 | 2e-74 | 253.59 | In-house | 97-365 (365) | Show / Hide |
Range on Protein: 194-391
Range on HMM: 97-365/365
Sequence Identity: 28% (82 aa)
LYEIYE--DENNIYLITELFQGKDMKSKLS------------DCLILDEKTISEIMWRLLQ---------------GLHHMHSKG-IFHRDIKLENIQFR
.|| .. |.|||||..|..||.|... . | . ..|| |..||. .|| .|...|||. |.|||||.||| |
MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-
NSQNITDVCLTNFYMADFVDPK----------GKQTYKK----------------------CGTAGFIAPEIFKSKH---------YDQKIDIFSLGIVF
.... | .. ..|.. .. .. | |||.|. ||||...| || |.||.|||...
-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
YILMFGKMPFDAPTVDQILQLNEQCEIDFTSNDCA-------------IKCTSSAIDLLKK----MLNKDPSQRAN-AFQLINHTWF
|...||| || .| ..||.||| .... |.. ...||.|| ||.|||..| . . |..|| ||
YEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 15541.AA | CAMK | 194-391 | 19 | 1.1e-54 | 174.3 | In-house | 103-425 (425) | Show / Hide |
Range on Protein: 194-391
Range on HMM: 103-425/425
Sequence Identity: 19% (62 aa)
LYEIYED-------------------ENNIYLIT---ELFQGKDMKSKLSDCLI-------------------LDEKTISEIMWRLLQGLHHMHSKGIFH
|||.||| ....|... |. .| .. | | .. ..|. . ... .....|..||..| |
LYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVH
RDIKLENIQFRNS--------------QNITDVCLTNFYMADFVDPK-----------------------GKQTYKKCGTAGFIA-PEIFKSKH------
||.|.||| . .. .| .. .. | .| ..||. |. . ||| ...| ||....|.
RDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN
--------YDQKIDIFSLGIVFYILMFGKMPFDAPTVDQILQ----------LNEQ-CEIDFTSNDCAIKCTS---------------------SAIDLL
|..|.|. |.|.. ||. |..||.... ..|.. | |. .. ... . .. .| ...||.
ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLI
KKMLNKDPSQRANAFQLINHTWF
.|||..||..|... | || |.
RKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 15541.AA | Ciliate-E2-Unclassified | 194-391 | 23 | 1.1e-48 | 167.05 | In-house | 86-352 (352) | Show / Hide |
Range on Protein: 194-391
Range on HMM: 86-352/352
Sequence Identity: 23% (64 aa)
LYEIYEDENNIYLITELFQGKDMKSKLSDC-----------------LILDEKTIS-----EIMWRLLQGLHHMHSKG-IFHRDIKLENIQFRNSQNITD
.... .|..|||...|...|.|.. .... |..|. .. ... .|||| ..|.|. | |||||.||| | |...
MFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYY
VCLTNFYMADFVDPKGKQTYKK----------------CGTAGFI----APEIFKSKHYD----QKIDIFSLGIVFYILMFGKMPFDAPTVDQ-------
.... | . . . ... .. ||| ... |||......|| |.||.|||...| ..||. ||.... .|
IKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQ
---------ILQLNEQCEIDFTSND---CAIKCTSSAIDLLK----KMLNKDPSQRANAFQLINHTWF
..| |..|.| . . . .|.|... |||.|.|..| .. |..|| ||
WINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 15541.AA | CAMK-Unique | 194-391 | 21 | 7e-48 | 156.03 | In-house | 81-363 (363) | Show / Hide |
Range on Protein: 194-391 Range on HMM: 81-363/363 Sequence Identity: 21% (60 aa) LYEI----YEDEN---------------NIYLITELFQGKDMKSKLSD--------------------CLILDE--KTISEIMWRLLQGLHHMHSKGIFH ||.. ..|.. ..|...|. ||.|..... . .. | .. || .||. . .|||..| | LYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVH RDIKLENIQFRNSQN-------------ITDVCLTNFYMADFVDPKGKQT--YKKCGTAGFIAP--------------EIFKSKHYDQKI----DIFSLG ||.||||| ...| . ... |..| .. .. . . . . ||| ..|| |. . |||. || ||| RDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLG IVFYILMFGKMPFDAPTVD--------QILQLNEQCEI-DFTSNDCAIK--CTSSAIDLLKKMLNKDPSQRANAFQLINHTWF . |.. .|..|||... | |.. .... .| . . . .|.|..|. .. ||..| .| .|. | |. VIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | 15541.AA | Pkinase | 194-391 | 26 | 8e-48 | 169.99 | Pfam | 65-293 (293) | Show / Hide |
Range on Protein: 194-391
Range on HMM: 65-293/293
Sequence Identity: 26% (62 aa)
LYEIYEDENNIYLITELFQGK----DMKSKLS--DCLIL--DEKTISEIMWRLLQGLHHMHSKGIFHRDIKLENIQFRNSQNI-TDVCLTNFYMADFV-D
||...||...||...|. .| | .. .| . . .|... .|. .|.|| ..||.|| |||.|.||| . | .| ..|... | | ..
LYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY
PKGKQTYKKCGTAGFIAPEIFK-SKHYDQKIDIFSLGIVFYILMFGKMPFDAP------TVDQILQLNEQCEIDFTSNDCAIKCT---------------
.. .. ||| ...|||. . ...|..|.|..|.|...|....|. ||. . .|..... .....| |. .|.
-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHF---DWPWWCSISYFFFRHWHFHWTF
----SSAIDLLKKMLNKDPSQRANAFQLINHTWF
....|..|..|.|||..| .| |. .| ||
HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 15541.AA | CAMKL | 194-391 | 28 | 3.1e-43 | 135.72 | In-house | 80-297 (297) | Show / Hide |
Range on Protein: 194-391 Range on HMM: 80-297/297 Sequence Identity: 28% (63 aa) LYEIYEDENN------IYLITELFQGKD--MKSKL---SDCL-ILDEKTISEIMWRLLQGLHHMHSKGIFHRDIKLENIQFRNSQN----ITDVCLTNFY |||..|.... |||..|. .| . . .. .. ..|. . . .. .....||.|| |||||.||| . ...| |.| . |.| LYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMY M-ADFVDPKGKQTYKKCGTAGFIAPEIFKS--KHYD-QKIDIFSLGIVFYILMFGKMPFDAPTV-----DQILQLNEQCEIDFTSNDCAIKCTSSAIDLL . ....|. ||. . |||||.. |.|| .|.|| |.|.. | ...|..|||..|. | | | .. .. . . .. ...||. RPC--IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLI KKMLNKDPSQRANAFQLINHTWF .|||...|..|... |. || |. RKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 15541.AA | CAMK1 | 232-391 | 31 | 2e-42 | 121.13 | In-house | 111-276 (276) | Show / Hide |
Range on Protein: 232-391 Range on HMM: 111-276/276 Sequence Identity: 31% (53 aa) SEIMWRLLQGLHHMHSKGIFHRDIKLENIQFRNSQNITDVC--LTNFYMADFVDPKGKQTYKKCGTAGFIAPEIFKS---KHYDQKIDIFSLGIVFYILM ..|| .|. ...|||||| |||.| ||. ... . .. . | . ..|.. .. ||| |..|||... |.||...|..| |...||| RHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILL FGKMPFDAPT-VDQILQLNEQCEIDFTSN--DCAIKCTSS-AIDLLKKMLNKDPSQRANAFQLINHTWF .| || . . ....... ||..| |. | . .. | |..|.||..||..| .. | .|| |. CGYPPFYDENVDNELFEKIKKCEYEFPSPWWD---NISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| S_TKc | 15541.AA | S_TKc | 117-391 | 19 | 2.6e-35 | 124.56 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 117-391 Range on HMM: 1-231/231 Sequence Identity: 19% (59 aa) NQPEE-------GVVAEYIPIN---SCFLKKIKYSDNSYSNYKYGIRLQRGEHKSELFTENSDTFNKWHDEIKRFYIATPVSIVLEWLYEIYEDENNIYL . . |.| . .. . .|.|| .. ||. || ||....| ...|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------------------EHIRREIQILKK-HHPNIVK--LYDVFQD-DHLYM ITELFQG--KDMKSKLSDCLI------LDEKTISEIMWRLLQGLHHMHSKGIFHRDIKLENIQFRNSQNITDVCLTNFYMADFVDPKGKQTYKKCGTAGF ..|. | |... . .. ..| .. .|. ....| ..||.|| |||.| ||| . . . .. | .| .. . ||| . VMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWY IAPEIFKSKHYDQ-KIDIFSLGIVFYILMFGKMPFDAPTVDQILQLNEQCEIDFTSNDCAIKCTSSAIDLLKKMLNKDPSQRANAFQLIN-------HTW .|||.. .|. |.|. |.|...|... |. ||. ........ ...|.|...|.|.|||..| | .. . | | MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW F | F |
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| Kinase | 15541.AA | RSK | 194-391 | 26 | 1.9e-32 | 114.12 | In-house | 66-278 (278) | Show / Hide |
Range on Protein: 194-391 Range on HMM: 66-278/278 Sequence Identity: 26% (57 aa) LYEIYEDENNIYLITELFQGKDMKSKLSDCLI---LDEKTISEIMWRLLQGLHHMHSKGIFHRDIKLENIQFRN-SQNITDVCLTNFYMADFVDPK-GKQ |.. ...| .|||.|. | .. .|. . ..|.. ...| . . |.|..|| |||.|.||| . . | | . || | . ... ... LHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQW TYKKCGTAGFIAPEIFK---SKH-YDQKIDIFSLGIVFYILMFGKMPFDA---PTVDQILQLNEQCEIDFTSN--DCAIKCTSSAIDLLKKMLNKDPSQR |.. |.|. ..|||. | . .|. |..|||.. | . .|. || . . ..|.. .......|. . . . | ||..||| .||..| TMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQ---YLSQEAKDLIRKMLHRDPHKR AN-----AFQLINHTWF . | .. .| || LGCGPQDAEEIKQHPWF |
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| Kinase | 15541.AA | AGC | 285-391 | 24 | 3.6e-31 | 76.53 | In-house | 258-395 (395) | Show / Hide |
Range on Protein: 285-391 Range on HMM: 258-395/395 Sequence Identity: 24% (35 aa) KGKQTYKKCG--TAGFIAPEIFKSKHYDQKIDIFS--LGIVFYILMFGKMPFDAPTVD----------QILQLNE------QCEIDFTSNDCA-----IK |...|. || |. ..||||. |.. |. | ||...| ...|. || . ... .. |. . .... | ... . . KRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRW CTSSAIDLLKKMLNKDPSQRAN----------AFQLINHTWF .. | ||.||.|.|||..| | .. || || FSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | 15541.AA | CDPK | 283-391 | 33 | 1.4e-21 | 63.19 | In-house | 161-271 (271) | Show / Hide |
Range on Protein: 283-391 Range on HMM: 161-271/271 Sequence Identity: 33% (38 aa) DPK----GKQTYKKCGTAGFIAPEIFKSKHYDQKIDIFSLGIVFYILMFGKMPFDAPTVDQILQLNEQCEIDFTSNDCAIKCTSSAIDLLKKMLNKDPSQ |.. .|. ...||| ||||. . | |..| || |.|.. ||| | || . . .|.. . .. .| .. .....|.|| .|||..|| . DQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFE-GPEWDHISDEAKDLIRKMLCYDPKK RANAFQLINHTWF | | | .| || RMSAQQALQHPWF |
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| Kinase | 15541.AA | CDPK | 194-260 | 34 | 7.3e-17 | 48.46 | In-house | 66-134 (271) | Show / Hide |
Range on Protein: 194-260 Range on HMM: 66-134/271 Sequence Identity: 34% (24 aa) LYEIYEDENNIYLITE--LFQGKDMKSKLSDCLILDEKTISEIMWRLLQGLHHMHSKGIFHRDIKLENI .|| |.||.|.|...| . | . . . ..|| ..|| .|. . ..||..| |||.| ||| IYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENI |
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| Kinase | 15541.AA | AGC | 194-260 | 21 | 3.3e-13 | 29.01 | In-house | 96-186 (395) | Show / Hide |
Range on Protein: 194-260 Range on HMM: 96-186/395 Sequence Identity: 21% (20 aa) LYEIYEDENN--IYLITELFQ---------GK-DMKSKLS---DCLILDEKTISEIMWR-------LLQGLHHMHS-KGIFHRD-IKLENI |. ..|... .|.. |. . | .. . | .. ..||... .. .. .|...|| .|| ||| .|.||| LHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENI |
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| TyrKc | 15541.AA | TyrKc | 148-391 | 14 | 6.8e-08 | -95.0 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 148-391 Range on HMM: 1-280/280 Sequence Identity: 14% (44 aa) YKYGIRLQRGEH-----------------KSELFTENSDTFNKWHDEIKRFYIATPVSI------VLEWLYEIYEDE------NNIYLITELFQGKDMKS . | | .|. |.. ..|.. .. .. . . ... .....|. . | |. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMC-----KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD KLSDCLI-LDEKTISEIMWRLLQGLHHMHSKGIFHRDIKLENIQFRNSQNITDVCLTNFYMADFVDPK-----GKQTYKK----CGTAGF----IAPEIF | .. | |. ...| .| . |||.. |||. |. . . | . | .. ... . |..|.| .| . . ||| . YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI KSKHYDQKIDIFSLGIVFY-ILMFGKMPFDA-----PTVDQILQLNEQCEIDFTSND-----CAIKCTSSAIDLLKKMLNKDPSQRANAFQLINHTWF . . . | |..| |.. . |. .|..| . ...... .| . . |.. .. |. . ||..| . .. | | NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 15541.AA | CAMK1 | 194-213 | 50 | 5e-06 | 13.42 | In-house | 73-92 (276) | Show / Hide |
Range on Protein: 194-213 Range on HMM: 73-92/276 Sequence Identity: 50% (10 aa) LYEIYEDENNIYLITELFQG .||.||..| .||..|| .| FYEWYESDNHFYLVMELVTG |
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