Gene 27680 (Tetrahymena)

27680

Species: Tetrahymena
Alias: 27680, 814, TTHERM_01071490, PreTt27680, 218.m00055
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
27680.AA Protein None 561 None Fasta, JSON
27680.kin_dom Protein Kinase Domain None 263 None Fasta, JSON
27680.NA RNA None 1686 None Fasta, JSON

Protein domain

Protein domains of 27680.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 27680.AA PH 21-65 36 5.5e-05 20.62 Pfam 1-45 (92) Show / Hide 
Range on Protein: 21-65
Range on HMM: 1-45/92
Sequence Identity: 36% (17 aa)

VLAEGYFSKKG-NYMSGKRYFKLYDNFIYYFDEKNSDHPKGYIKID
|  ||...||| .    ||.| | .| .||.....   |||.| ..
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLS
PH 27680.AA PH 21-127 17 7.1e-05 23.45 SMART 1-82 (82) Show / Hide 
Range on Protein: 21-127
Range on HMM: 1-82/82
Sequence Identity: 17% (19 aa)

VLAEGYFSKKGNYMSGKRYFKLYDNFIYYFDEKNSDHPKGYIKIDFDLHFEVIRQKTDKKDNSPSSIIGQPKGLRLDKLNAKTEITTNDEALILKWRDIL
|. ||. .||..    ||.| |.....||...|    ||| | ..    ...                    ....   .   .. ...|    .| . .
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P------------------CFEIHH-DRTYYFQCESEEEMQEWMQAI

RNKINQR
.. |.. 
QKAIHNN
Kinase 27680.AA Ciliate-E2a 133-395 51 8.70000000001e-182 539.84 In-house 1-275 (275) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-275/275
Sequence Identity: 51% (141 aa)

FKAHKKIGKGNFASVYLTERLEDSKQFAVKAFSKEAAYNQENGKEALINEIELMRALNHKNIIRLHEVFETENSLYMILDLLEGGQLYDKIKAKYKFTVE
.|..||||||||.|||| ..... ||||.|.|.| ..|.|..|||...||| .|| |.|.|||.|.||.|.||..|......|||.|||||| . .|. |
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--ESKYIMKGLL-EGIAEMHAKNIMHRDLKPENLIFK--TADS---LDLAIVDLGLATRA--DIEEFMFVRCGTPGFVAPEVINIKD--LKTKYDVICDI
  | . ||. || .|.. || .|||||||||||..||   ..|   .|. |.| ||||..  |....||..|||||.|||||.|.|.  ....||. ||.
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

FSLGLIFHILLLGRTPFNGKNYNEILAQNRASNISFEGTE-YLKLPLPAYDLLKKMLDNDPKTRITAKKALQHQFF
.|.|.||.||| |..||.||.||||| ||.. .|.|...| ..|......||.||||. ||| ||||. ||.|..|
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 27680.AA CAMK1 133-395 36 5.70000000001e-102 297.22 In-house 1-276 (276) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-276/276
Sequence Identity: 36% (103 aa)

FKAHKKIGKGNFASVYLTERLE---DSKQFAVKAFS-KEAAYN---QENGKEALINEIELMR---ALNHKNIIRLHEVFETENSLYMILDLLEGGQLYDK
.. .|.||.| |. ||| .. |   . ||.|.|... |..  .   |   .||| |||| |.    ..| ||| ..|..|..| .|....|. || | |.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ-K-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

IKAKYKFTVEESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTA-DSLDLA--IVDLGLATRADIEE-FMFVRCGTPGFVAPEVINIKDLKTKYDVIC
|  | ..| ..   ||| .|. .  ||.|.|.||||||||| ...  .  ...  | | ||... | .| .|. .|||||.|||||.. |   . ||  |
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKAC

DIFSLGLIFHILLLGRTPFNGKN-YNEILAQNRASNISFEGTEYLKLPLP-AYDLLKKMLDNDPKTRITAKKALQHQFF
|..| | |. ||| |  ||...| .||.....    . |   .  .     | |..|.||..||| |.|....|.| ..
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 27680.AA Ciliate-E2 133-395 28 3.5e-100 339.14 In-house 1-365 (365) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-365/365
Sequence Identity: 28% (108 aa)

FKAHKKIGKGNFASVYLTERLEDSKQFA----------------VKAFSKEAAYNQENGKEALINEIELMRALN----------------HKNIIRLHEV
.| .||||.|||.|||. .. .. ||||                ||.. ..  ....|..|.. .|| .|| .|                |.|||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TENSLYMILDLLEGGQLYDKIK------------AKYKFTVEESKYIMKGLLE---------------GIAEMHAKN-IMHRDLKPENLIFKTADS
|.  ..|..|.......|| |.| ||            .  .|| .| ||||| .|.               .. ..| || |.|||.||||..|     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LDLAIVDLGLATRADIE-----------EFMFVR----------------------CGTPGFVAPEVINIKD-----LKTKYDVICDIFSLGLIFHILLL
  . |.|.||....|..           ..|| .                      |||||..|||..| |.     ... ||  |||.||| |....| 
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GRTPFNGKNYNEILAQNRASNISFEGTE--------------YLKLPLPAYDLLKK----MLDNDPKTRIT-AKKALQHQFF
|..||        . |.   .|.|   |              ..|... . ||.||    ||. ||. ||| ....|.|..|
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 27680.AA CAMK 138-395 20 2.3e-84 271.65 In-house 1-425 (425) Show / Hide 
Range on Protein: 138-395
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

KIGKGNFASVYLTERLEDS------------KQFAVKAFSKEAAYN------------------------QENGKEALINEIELMRA-------LNHKNI
..|.|.|. |.| .. ..             ...|.|  .|. . .                        ... .. . .|||.|.        |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLHEVFE------------TENS--------LYMIL---DLLEGG----QLYDKIKAK---------------YKFTVEESKYIMKGLLEGIAEMHAKN
|.|.||.|            | .         .||..   .. .||     |.|.|...                .|| .| ..... ...... .| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDLKPENLIFKTADS---------------LDLAIVDLGLATRADI------------------------EEFMFVRCGTPGFVA-PEVINIKDL--
|.||||||||. . . ..                .. |.| |.|.. |                          . |  .||||...| |||.| |    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KTKYDVICDIFSLGLIFHILLLGRTPFNGK-------------NYNEILAQNRASNISFEGTEYLKLP--------------------LPAY
        |. |.  ||. |.| |  |.| |. ||.|.             |..|.. . .. . .|.  .  ...                      . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLKKMLDNDPKTRITAKKALQHQFF
||..|||  ||. |.|.. .|.|...
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 27680.AA S_TKc 133-395 27 1.6e-81 278.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-231/231
Sequence Identity: 27% (77 aa)

FKAHKKIGKGNFASVYLTERLEDSKQFAVKAFSKEAAYNQENGKEALINEIELMRALNHKNIIRLHEVFETENSLYMILDLLEG--GQLYDKIKAKYK--
.. ..||||| |..||.    .. ...|.|  .           | ...||....  .|.||..|..||.. ..|||......|  | |.| || . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVEESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTADSLDLAIVDLGLATRADIEEFMFVRCGTPGFVAPEVINIKDLKTKYDV-ICDIFSL
    |.  . ...|. ...... .| ..|.||||||||. . .     . | | |||..          |||| ..||||.       .|.   ||. |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSC

GLIFHILLLGRTPFNGKNYNEILAQNRASNISFEGTEYLKLPLPAYDLLKKMLDNDPKTRITAKKALQ-------HQFF
| |. ..| |..||   ...... . .              . .| |...|.|. ||. |.|| .|||       |..|
GCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 27680.AA Pkinase 133-395 29 6.7e-75 259.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FKAHKKIGKGNFASVYLTERLEDSKQFAVKAFSKEAAYNQENGKEALINEIELMRALNHKNIIRLHEVFETENSLYMILDLLEGG----QLYDKIK--AK
.. ..|||.|.|..||.  .  ..|..||| ..|. .  ...   ....||..|. |||.||.||...||.....||.....|||     |.| |.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YKF--TVEESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTADSL--DLAIVDLGLATR--ADIEEFMFVRCGTPGFVAPEVINIKDLKTKYDVICDI
 .|  . .| | .|. .|.|.. .|...|.||||||||. ..  . .  .. | | |||        . | ..||||...|||||.     ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDM

FSLGLIFHILLLGRTPFNGK------NYNEILAQNRASNISFEGTEYLKLP-----------------LPAYDLLKKMLDNDPKTRITAKKALQHQFF
.|.|.|....|.||.|| |.      . ........   ..|.  .    .                  .. |..|..|. ||| |.||. .||| .|
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 27680.AA CDPK 133-395 36 2.9e-67 205.43 In-house 1-271 (271) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-271/271
Sequence Identity: 36% (102 aa)

FKAHKKIGKGNFASVYL-TERLEDSKQF-AVKAFSKEAAYNQENGKEALINEIELMRALNHKNIIRLHEVFETENSLYMILD--LLEGGQLYDKIKAKYK
.| .|..|||.| .|.. .... .. .  |.|  .|    ..|  .. ..||||... | | |||.. |... |.  | ..   ...||.| |.|..| .
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQ-QQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH

FTVEESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTADSL-----DLAIVDLGLATRADIE-----EFMFVRCGTPGFVAPEVINIKDLKTKYDVIC
||  |. |||. .|  .. .| .||.||||||||. |.. ..      .. ..| |.... | .     . |  |||||  .||||     |. ||.  |
FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEV-----LQKKYNEKC

DIFSLGLIFHILLLGRTPFNGKNYNEILAQNRASNISFEGTEYLKLPLPAYDLLKKMLDNDPKTRITAKKALQHQFF
|| |.| |  ||| |. ||.||| .||... .  . |||| |  .    | || .|||  ||| |..|  ||||. |
DIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 27680.AA Ciliate-E2-Unclassified 133-395 24 5.9e-66 225.42 In-house 1-352 (352) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

FKAHKKIGKGNFASVYLTERLEDSKQFAVKAFSKEAAYN---QENGKEALINEIELMRALN-------------------HKNIIRLHEVFETENSLYMI
.| .|.||.|.|..||. .. .. ...| |  .|   |.   ..| .  ..||.. |  ..                   | .|......|.... .|..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LDLLEGGQLYDKIKAKYK-----------------FTVEESK-----YIMKGLLEGIAEMHAKN-IMHRDLKPENLIFKTADS-LDLAIVDLGLATRAD-
....||| | . || . |                 || ...|     .... .|.|.  .| || | |||.||||..|.   . . . | |.|.. . . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------IEEFMFVRCGTPGFV----APEVINIKDLKTKYD----VICDIFSLGLIFHILLLGRTPFNGKNYNE---------------ILA
               ... |  .||||..     ||||.     . .||      |||.||| |.. .| |. ||...|...               .| 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ----GQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLY

QNR-ASNISFEGTEY----LKLPLPAYDLLK----KMLDNDPKTRITAKKALQHQFF
||  . ||.|   .      ...  | |...    |||...|. |||....|.|..|
QNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 27680.AA CAMK-Unique 133-395 23 2.2e-57 187.87 In-house 1-363 (363) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-363/363
Sequence Identity: 23% (87 aa)

FKAHKKIGKGNFASVYLTERLEDSKQFAVKAFSKEAAYNQENGK----------------EALINEIELMRALNHKNIIRLHEV----FETEN-------
 | |. ||.|||  || .   |  | .|.| . |... |  .                    | .|..... ..| |||.| ..    |....       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------SLYMILDLLEGGQLYDKIKA--------------------KYKFTV--EESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTA--D----
         .|.......|| |.|.| .                    . .|.    ..  ||  ||. .| || ..| |||||.||. ...   |    
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------SLDLAIVDLGLATRAD--IEE-FMFVRCGTPGFVAP--------------EVINIKDLKTKYDVIC----DIFSLGLIFHILLLGRTPFNGK
         ... . | ||..  .  ...  | ..|||| ..||              ||||      .||  |    || ||| | ...| |..||.. 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN----MQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCE

NYN--------EILAQNRASNI-SFEGTEYLK---LPLPAYDLLKKMLDNDPKTRITAKKALQHQFF
. .        ||..  .. .. .|.   .         |.|..|. .  ||. |..|| .|.||..
CEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 27680.AA RSK 136-395 25 5.8e-57 195.56 In-house 1-278 (278) Show / Hide 
Range on Protein: 136-395
Range on HMM: 1-278/278
Sequence Identity: 25% (71 aa)

HKKIGKGNFASVYLTERL---EDSKQFAVKAFSKEAAYNQENGKEALINEIELMRALN-HKNIIRLHEVFETENSLYMILDLLEGGQLYDKIKAKYK---
.|  |.| . .|.|  .       ...|.|  .|  . . .   .    |.. . . . |..|..||..|.||  ||.|.....|| |..... .     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTVEESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTAD-SLDLAIVDLGLATRADIE--EFMFVRCGTPGFVAPEVINIKDLKTK-YDVICDIFSLG
|. .| ...|  .   .  .| . | |||||||| ..   . .  . ..| |..  ....  . .   |.|  ..|||...  . . . .|  ||..|||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

LIFHILLLGRTPFNG---KNYNEILAQNRASNISFEGTEYLKLPLPAYDLLKKMLDNDPKTRIT-----AKKALQHQFF
 . . .| |..|| |   .| .||... .  ..|... .  .|  .| ||..|||  ||. |..     |.  .||..|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 27680.AA CAMKL 133-395 23 1.5e-56 178.96 In-house 1-297 (297) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-297/297
Sequence Identity: 23% (72 aa)

FKAHKKIGKGNFASVYLTER-LEDSKQFAVKAFSKEAAYNQENGKEA-----------LINEIELMRALN---HKNIIRLHEVFETENS------LYMIL
..  | .|||.|. | | .  .   .. |.|   |. . | .. |             .  ||..|. ||   |.|||.|.||.||..       .|...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DLLEGGQ--LYDKIKAK----YKFTVEESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTADSLDLAIVDLGLATRAD-I----EEFMFVRCGTPGFV
 . .||   |.|.|...     ... .| . . . ...... .| ..| |||.||||. .   ..  . |.| |...  . .    ....  .||.| . 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVINIKDLKTKYD-VICDIFSLGLIFHILLLGRTPFNGKNY------NEILAQNRASNISFEGTEYLKLPLPAYDLLKKMLDNDPKTRITAKKALQHQ
|||...    ...||    || |.| |   .. |. ||.. .|      |  .  ..     .. . ..... .. ||..|||  .|. |.|..  ..| 
APEIFQGN--NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

FF
..
WM
Kinase 27680.AA RSK 133-395 28 1.3e-54 187.71 In-house 1-271 (271) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-271/271
Sequence Identity: 28% (78 aa)

FKAHKKIGKGNFASVYLTERL---EDSKQFAVKAFSKEAAYNQENGKEALINEIELMRALNHKNIIRLHEVFETENSLYMILDLLEGGQLYDKIKAKYKF
.  |..||.| |  ||.  .       ...|.|   | .  . .       .|  ..|  .| .|..||.||..| ..|||.|...|| | |.. ..  |
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMF

TVEESKYIMKGLLEGIAEMHAKNIMHRDLKPENLIFKTA--DSLDLAIVDLGLATRA-DIEEFMFVRCGTPGFVAPEVINIKDLKTKYDVICDIFSLGLI
. .| | .|  ..   .  | . | |||||||| ..     .   . |.|.|.|  . | ..     |.|  ..||||..    .  .|..||..|.| .
SEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLK----RQGHDQACDWWSFGVL

FHILLLGRTPFNGKNYNE---ILAQNRASNISFEGTEYLKLPLPAYDLLKKMLDNDPKTRITA-----KKALQHQFF
... | |.||| .|. ..   |..      .|. .    ..  .| ||| .||. ||  | .|     . ..|| .|
MYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 27680.AA Pkinase_Tyr 133-258 26 1.2e-13 46.9 Pfam 1-137 (270) Show / Hide 
Range on Protein: 133-258
Range on HMM: 1-137/270
Sequence Identity: 26% (37 aa)

FKAHKKIGKGNFASVYLTERL----EDSKQFAVKAFSKEAAYNQENGKEALINEIELMRAL-NHKNIIRLHEVFE-TENS--LYMILDLLEGGQLYDKIK
 .  ||.|.|.| .||. .      ..  . |||   || |  ..| .|....|...|. | .|.||.||. |    . .  .|... . ..| |.|  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

A----KYKFTVEESKYIMKGLLEGIAEMHAKNIMHRDL
.    | ..|...   .     .| .  ..||. ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 27680.AA TyrKc 133-395 21 1.1e-11 -34.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 133-395
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FKAHKKIGKGNFASVYLTERLEDSKQFAVKAFSKEAAYNQENGKEALINEIELMRAL--NHKNIIRLHEVFETE-------NSLYMILDLLEGGQLYDKI
 .  ||.| |.|  ||. .      | |||   ..|       .|....|...|. |  .|.||.||. |  ..         |.... . ..| | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

-KAKYKFTVEESKYIMKGLLEGIAEMHAKNIMHRDLKPEN-LIFKTADSLDLAIV---DLGLATRADIE-------EFMFVRC--GTPGFV-----APEV
 | . |.....  ...    .| .  | ||. ||||   | |. .        .|   | ||.   . .       .   ..   |. . .     |||.
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

INIKDLKTKYDVICDIFSLG-LIFHILLLGRTPFNG-----KNYNEILAQNRASNISFEGTEYL-----KLPLPAYDLLKKMLDNDPKTRITAKKALQHQ
|     . |.    |..| | ... |. .| .|  |     ..  |.... .. .      ...       |   |.. |.  . ||. | | .    |.
I----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

FF
.|
CF