Gene 3709 (Tetrahymena)

3709

Species: Tetrahymena
Alias: 4, 3709, PreTt03709, TTHERM_00656150, 96.m00178
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
3709.AA Protein None 300 None Fasta, JSON
3709.kin_dom Protein Kinase Domain None 169 None Fasta, JSON
3709.NA RNA None 903 None Fasta, JSON

Protein domain

Protein domains of 3709.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3709.AA Ciliate-E2a 56-224 40 2.7e-101 298.9 In-house 1-177 (275) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-177/275
Sequence Identity: 40% (72 aa)

YKFERKLGSGSFGSVTLGIPLNDPDKRVAIKTIQKESVQGIPQHYLKREVDIIKSLDHPNICKFLETYMDKENIYLVMEYCAGGTLK-ELIYSQNNNEF-
|||..|.|.|.|||| |   ..........| |.| ..|.....|...|..|...||||||.|. |.|.|. |.||||||| ||.|. .........|. 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-AVAKIMQKLFW-AVNYMHNNNIVHRDLKLENVIFS---TTNPATSDIKIIDFGLSKKVHDKQK-RRHTKVGSFNYM
  ...|||.|.| ...|||..||.|||||.||..|    ......||||||||||........| ....|.|.  |.
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYV
Kinase 3709.AA CDPK 56-206 43 5.1e-63 192.21 In-house 1-159 (271) Show / Hide 
Range on Protein: 56-206
Range on HMM: 1-159/271
Sequence Identity: 43% (69 aa)

YKFERKLGSGSFGSVTLGIPL-NDPDKRVAIKTIQKESVQGIPQ-HYLKREVDIIKSLDHPNICKFLETYMDKENIYLVME--YCAGGTLKELIYSQNN-
||....||.|.||.| ...   .. ..|||.|.|.| .|.   |   ...|..| |.|||||| |. |.| |. |.|.|||  ||.|| | . | .... 
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

NEFAVAKIMQKLFWAVNYMHNNNIVHRDLKLENVIFSTTNPATS---DIKIIDFGLSKK
.|.  |.||.... ||||.|.||||||||| ||. | . .. .    .||.||.|.|||
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKK
Kinase 3709.AA CAMK 61-224 23 2.5e-57 182.95 In-house 1-286 (425) Show / Hide 
Range on Protein: 61-224
Range on HMM: 1-286/425
Sequence Identity: 23% (68 aa)

KLGSGSFGSVTLGIPLNDPD-----------KRVAIKTIQKESVQ--------------------------GIPQHYLKREVDIIKS-------LDHPNI
.||.|||| | |.|  |..            ..|||| | |. ..                          .  .. ..||..| |.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CKFLETYMD-------------------KENIYLVM---EYCAGG----TLKELIYSQNN----------------NEFAVAKIMQKLFWAVNYMHNNNI
.|..|.| |                   ....|.||   ||| ||     | . | .. .                .|  ...... .  ||.|.|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKLENVIFSTTNPAT-------------SDIKIIDFGLSKKVHDKQ-----------------------KRRHTKVGSFNYM
||||||.||. ... |. .              .|||||||...|. ...                       .  .| .|.  ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM
Kinase 3709.AA Ciliate-E2 56-224 30 7.3e-57 193.73 In-house 1-223 (365) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-223/365
Sequence Identity: 30% (70 aa)

YKFERKLGSGSFGSVTLGIPLNDPDKR-----------------VAIKTIQKESVQGIPQHYLKREVDIIK----------------SLDHPNICKFLET
||| .|.|.|.|||| ..   ... .                  |.|| . .....     ..|.| .|..                .|.||||.|. |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YM--DKENIYLVMEYCAGGTLKELIYSQNNN------------EFAVAKIMQKLFW---------------AVNYMHNNN-IVHRDLKLENVIFSTTNPA
.   |..||||||||| ||.|...|.... .            |. ...||....                |..|.|..| |.|||.|.||..|      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

TSDIKIIDFGLSKKVHDK-QKRRHTKVGSFNYM
   |||||||||||..|. |.|.| |... .||
---IKIIDFGLSKKYDDDNQNRTH-KQQCKWYM
Kinase 3709.AA CAMKL 56-224 33 2.1e-52 165.48 In-house 1-200 (297) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-200/297
Sequence Identity: 33% (67 aa)

YKFERKLGSGSFGSVTLGIPLNDPDKRVAIKTIQKESVQGIPQHY-------------LKREVDIIKSLD---HPNICKFLETYMDKEN------IYLVM
|.... || |||| | |..    . ..|||| | |.  . .|.               ..||. | |.|.   ||||.|..|.. ..|.      |||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCAGGT--LKELIYSQNN-----NEFAVAKIMQKLFWAVNYMHNNNIVHRDLKLENVIFSTTNPATSDIKIIDFGLSKKVHD----KQKRRHTKVGSFN
||| ||   | . | .. .      |    .. . .  ||||.|...|||||.|.||. ..  .     |||||||.| .  .    . .  .|  || .
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YM
||
YM
Kinase 3709.AA CAMK-Unique 56-224 27 5.2e-52 169.88 In-house 1-242 (363) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-242/363
Sequence Identity: 27% (66 aa)

YKFERKLGSGSFGSVTLGIPLNDPDKRVAIKTIQKESVQGIPQHY------------------LKREVDIIKSLDHPNICKFLET----YMDKE------
||. | .|.|.|| |  ..    ..|. |.| ..|. .. . |.                   ||||..| |..||||| |....    . |..      
YKMHRIIGHGNFGHVYECMDRETGKKW-ACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------NIYLVMEYCAGGTLKELIYS---------------------QNNNE--FAVAKIMQKLFWAVNYMHNNNIVHRDLKLENVIFSTTNPA---
         ..|.||||| ||.|...| .                     .  .|    .. |||.|  ||.|||...||||||||||. ...  .    
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

---------TSDIKIIDFGLSKKVHDKQKRR--HTKVGSFNYM
          ..||..||||..... ....   .| .|.  ||
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYM
Kinase 3709.AA Pkinase 56-224 32 8.5e-52 183.2 Pfam 1-178 (293) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-178/293
Sequence Identity: 32% (60 aa)

YKFERKLGSGSFGSVTLGIPLNDPDKRVAIKTIQKESVQGIPQHYLKR--EVDIIKSLDHPNICKFLETYMDKENIYLVMEYCAGG----TLKELIY---
|...||.||||||.| ...  .... .||.|.| |..     . .. |  |. | |.|.||||........|| .||.||||| ||     |...|    
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SQNN--NEFAVAKIMQKLFWAVNYMHNNNIVHRDLKLENVIFS-TTNPATSDIKIIDFGLSKKV-HDKQKRRHTKVGSFNYM
. .    |  . ..|  .. ...|.|...|.|||||.||. .. . .... ..||.||||.|.. . ..   .| .|. .||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYM
Kinase 3709.AA ULK 56-224 28 4.8e-43 149.31 In-house 1-214 (324) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-214/324
Sequence Identity: 28% (60 aa)

YKFERKLGSGSFG-SVTLGIPLNDP--DKRVAIKTIQKESVQGIPQH--------YLKREVDIIKSLD---HPN--ICKFLETYMDK--ENIYLVMEYCA
|   ..||.||||  |  |.  ..   .. ||.| |.| . . ...          ||.|. |.| |.   |||  |.|... ....   |||..|||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLKELIYSQ----------NNNEFAVAKIMQKLFWAVNYMHNNNIVHRDLKLENVIFSTTNPATSD--------IKIIDFGLSKKVH---DKQKRRHT
||.|...|  .          . .|  . .... .  .  ..|..||.|||.|..|   .  .| | .        .|| |||..|.|      |  ..|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

KV------GSFNYM
 |      |.  ||
CVNEKRIKGTPLYM
Kinase 3709.AA ULK 56-224 27 7.2e-43 147.49 In-house 1-218 (329) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-218/329
Sequence Identity: 27% (60 aa)

YKFERKLGSGSFGSVTLGIPLNDP---DKRVAIKTIQKESVQGIPQH--------YLKREVDIIKSLD--------HPNICKFLETYMDK--ENIYLVME
|   ..||.|||| |  |.  ..    .. ||.| |.|.. . ...          ||.|..|.| |.        ||||.|... ....   |||..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCAGGTLKELIYSQ-----------NNNEFAVAKIMQKLFWAVNYMHNNNIVHRDLKLENVIFSTTNPATSD--------IKIIDFGLSKKVHDK---QK
|| ||.|...|  .           . .|  . .... .  .  ..| .||.|||.|..|.  .  .| | .        .|| |||..|.| .    |.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

RRHTKV------GSFNYM
  .| |      |.  ||
MMMTCVNEKRLCGTPLYM
Kinase 3709.AA STE 56-224 20 2.9e-38 132.74 In-house 1-229 (359) Show / Hide 
Range on Protein: 56-224
Range on HMM: 1-229/359
Sequence Identity: 20% (49 aa)

YKFERKLGSGSFGSVTLGIPLNDP--------------DKRVAIKTIQKESVQ-------------GIPQHY--LKREVDIIKSLD--HPNICKFLETYM
... .|.|.|.||.| ...  ...               ...||| . .|. .               ..    ...|..| | ..  |||| |.. .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DK-------ENIYLVMEYCAGGTLKELIYS-----QNNN----------EFAVAKIMQKLFWA-VNYMHNNNIVHRDLKLENVIFSTTNPATSDIKIIDF
..       ......|||..||.| ..| .     ...|          |  .|.| . .  .  .| |...|.|||.|  |. .         .|..||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF

GLSKKVHDK----------------QKRRHTKVGSFNYM
|..... |.                |..| | ||.  .|
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WM
Kinase 3709.AA CAMK1 56-139 36 7.5e-35 98.7 In-house 1-93 (276) Show / Hide 
Range on Protein: 56-139
Range on HMM: 1-93/276
Sequence Identity: 36% (34 aa)

YKFERKLGSGSFGSVTLGIPLNDP--DKRVAIKTIQ-KESVQG----IPQHYLKREVDIIKS---LDHPNICKFLETYMDKENIYLVMEYCAGG
|.|  ..|.|.|. |.|..  . .  .| .||| |  |.....      | .|..|..| |.   .||||| || | | ... .|||||.. ||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQK-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGG
Kinase 3709.AA S_TKc 56-298 22 7.3e-34 119.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 56-298
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

YKFERKLGSGSFGSVTLGIPLNDPDKRVAIKTIQKESVQGIPQHYLKREVDIIKSLDHPNICKFLETYMDKENIYLVMEYCAG--GTLKELIYSQNN---
|.. ||.|.|.||.| ...  .  ...|||| |            ..||..| |. .||||.|..... | ...|.||||| |  |.|...| ...    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

----NEFAVAKIMQKLFWAVNYMHNNNIVHRDLKLENVIFSTTNPATSDIKIIDFGLSKKVHDKQKRRHTKVGSFNYMGKQTTKQASK------------
    .|  ....|. .. |..|.|...|.||||| ||. ...       |||.||||....       .| .|. .||      . .|            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCIL

--LASMHSCWKQTSASQLVSKQAQITFEILSFNLFFDNQKPQKCSSTAN------TIKNAT--FGLWQFIY--------EYM
  ...    .           | | .|...              |. |         |. .   .  .           ...
YEMLCGYPPFP----------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3709.AA CAMK1 156-210 45 2.7e-22 61.57 In-house 111-166 (276) Show / Hide 
Range on Protein: 156-210
Range on HMM: 111-166/276
Sequence Identity: 45% (26 aa)

AKIMQKLFWAVNYMHNNNIVHRDLKLENVIFSTTNPATSDIK--IIDFGLSKKVHDK
..||.... ||.||| ..||||||| ||  .. ..   |.||  |.||||||.. ..
RHIMKQILSAVEYMHSKGIVHRDLKPENLLYY-DKDEDSKIKRSIADFGLSKIFDHD
Kinase 3709.AA Pkinase_Tyr 56-179 28 3e-19 65.8 Pfam 1-137 (270) Show / Hide 
Range on Protein: 56-179
Range on HMM: 1-137/270
Sequence Identity: 28% (39 aa)

YKFERKLGSGSFGSVTLGIPL---NDPDKRVAIKTIQKESVQGIP--QHYLKREVDIIKSL-DHPNICKFLETYM-DKEN--IYLVMEYCAGGTLKELIY
 .| .|||.|.||.| .|.      ...  ||.|.. ||.       .  . ||. | |.| .|||| ...   . ..|   ||.||||...| |..   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SQ--NNNEFAVAKIMQKLF---WAVNYMHNNNIVHRDL
..  ... . .  . |  .   .. .| ...|..||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 3709.AA TyrKc 56-254 17 1.1e-12 -17.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 56-254
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

YKFERKLGSGSFGSVTLGIPLNDPDKRVAIKTIQKESVQGIPQHYLKREVDIIKSL--DHPNICKFLETYMDK-------ENIYLVMEYCAGGTLKELI-
 ....|||.| || | .|.        ||.|......     .  . ||  | ..|  .|||| ...   ...       | ...||||...| ||. . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YSQNNNEFAVAKIMQKLFWAV------NYMHNNNIVHRDLKLENVIFSTTNPATSDIKIIDFGLSKKVHDK--------QKRR----HTK----------
.....      .  ..| ...      .| | .|..||||   |.  .  .     .|| |||||....|.         .|     ..|          
KHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

------------------------------------------------VGSFNYMGKQTT--------KQASKLASMHSCWKQ-----TSASQLVSKQ
                                                | . ..| .             .     | .||.       . |..... 
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF