Gene 4137 (Tetrahymena)

4137

Species: Tetrahymena
Alias: TTHERM_00585310, 4137, 3675.m00081, 80.m00183, PreTt04137, 687
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
4137.AA Protein None 595 None Fasta, JSON
4137.kin_dom Protein Kinase Domain None 263 None Fasta, JSON
4137.NA RNA None 1788 None Fasta, JSON

Protein domain

Protein domains of 4137.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 4137.AA PH 37-145 15 1.5e-05 25.67 SMART 1-82 (82) Show / Hide 
Range on Protein: 37-145
Range on HMM: 1-82/82
Sequence Identity: 15% (17 aa)

LIIADYFSKQGKIMKSKRYFELYPTQIYYYSEKDHNQPKGYTDLSFELCFELMREKVAENKDKKDDKVKLGKPKGIKLDKSGCVCELYSPEDKVLIKWRD
.|.  . .|..|    ||.| |.. ..||| .|           .   .. |   .| | .             ....   . . ... . .. . .| .
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK-----------KPKGSIPLSDCTVRE-P-------------CFEIHH-DRTYYFQCESEEEMQEWMQ

ALRKILNQR
|..| ... 
AIQKAIHNN
PH 4137.AA PH 37-143 14 0.000438 17.38 Pfam 1-92 (92) Show / Hide 
Range on Protein: 37-143
Range on HMM: 1-92/92
Sequence Identity: 14% (16 aa)

LIIADYFSKQG-KIMKSKRYFELYPTQIYYYSEKDHNQPKGYTDLSFELCFELMREKVAENKDKKDDKVKLGKPKGIKLDKSGC-VCELYSPEDKVLIKW
.|.  ...|.| .    ||.| | ....||| ...          .   .. |   .| . .|        ..| ....   .  . ... . .. .  |
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK---------YRPKGSIPLSDCQVTKVPDN-------KRPHCFQIRT-DRRTYYFQAESEEEMNDW

RDALRKILN
 .|..... 
MQAIQSACR
Kinase 4137.AA Ciliate-E2a 151-413 52 1e-188 560.56 In-house 1-275 (275) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-275/275
Sequence Identity: 52% (146 aa)

FRAHKKIGKGNFASVYLAERLEDEKMFAVKAFSKEAAYAQEKGKEALLNEIDLMRALDHPNIMKLHEVFETENSLYFILDLLEGGQLYDKMKSKHRYTSE
....||||||||.|||||..... |.||.|.|.| ..| |.||||.. |||..|| ||||||.||.||.|.||..|......|||.||||.| ..|...|
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--EIKDILRGLL-EGCAHMHQKRIMHRDLKPENVLFK--DPQG---KQIVIADLGLATRC--DLPEYLFVRCGTPGFVAPEVVNIKN--LNTTYDPICDL
  ||.||.. || .|...|||. ||||||||||.|||  ....   ..|.|.| ||||..  | ..|.|..|||||.||||| |.|   ... ||  ||.
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

FSIGLMFHILLIGKSPFDGKTYNDILSQNRACNIKFDSVE-YLKLPLQTYDLLKKMLEKDPKNRINAADALKHPFF
.|.|..|.||| ||.||.|||||.|| ||..|.| |.. | ..|......||.|||||||||.||.|..||.||.|
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 4137.AA CAMK1 151-413 37 1.2e-104 305.11 In-house 1-276 (276) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-276/276
Sequence Identity: 37% (105 aa)

FRAHKKIGKGNFASVYLAERLE---DEKMFAVKAFS-KEAAYA---QEKGKEALLNEIDLMR---ALDHPNIMKLHEVFETENSLYFILDLLEGGQLYDK
.  .|.||.| |. |||... |   ..| .|.|... |..      | | .|||.|||. |.    .||||| |..|..|..| .|....|. || | |.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ-K-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

MKSKHRYTSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDP-QGKQIV--IADLGLATRCDLPE-YLFVRCGTPGFVAPEVVNIKNLNTTYDPIC
   |. || ..  .| . .|.   .||.| |.|||||||| |..|.  . .|.  ||| ||....|  | ... .|||||.|||||.. |   . ||  |
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKAC

DLFSIGLMFHILLIGKSPFDGKT-YNDILSQNRACNIKFDSVEYLKLPLQ-TYDLLKKMLEKDPKNRINAADALKHPFF
|..|||  . ||| | .|| ... .| .....  | . |.| .  .   |   |..|.|||.|||.|......|.||..
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 4137.AA Ciliate-E2 151-413 27 1.6e-104 353.56 In-house 1-365 (365) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-365/365
Sequence Identity: 27% (103 aa)

FRAHKKIGKGNFASVYLAERLEDEKMFA----------------VKAFSKEAAYAQEKGKEALLNEIDLMR----------------ALDHPNIMKLHEV
.  .||||.|||.|||.... .. |.||                ||.. ..  . .....|....||..||                 |.||||.|..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TENSLYFILDLLEGGQLYDKMKSK-----------HRYTSEEIKDILRGLLE---------------GCAHMHQKR-IMHRDLKPENVLFKDPQGK
|.  ..|..|.......|| |.| .|..           ...| .|||.| . .|.               .  ..|.|  |.|||.||||.||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

QIVIADLGLATRCDLP-----------EYLFVR----------------------CGTPGFVAPEVVNIKN-----LNTTYDPICDLFSIGLMFHILLIG
 | |.|.||....| .           .|.| .                      |||||..|||..| |.     . . ||  ||..|.| .....| |
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KSPFDGKTYNDILSQNRACNIKFDSVE--------------YLKLPLQTYDLLKK----MLEKDPKNRIN-AADALKHPFF
| ||        . |.  |.|.|.. |              ..|..... ||.||    ||.|||..||. . ..|.||.|
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 4137.AA CAMK 156-413 20 2.3e-86 278.2 In-house 1-425 (425) Show / Hide 
Range on Protein: 156-413
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

KIGKGNFASVYLAERLEDE------------KMFAVKAFSKEAAYA------------------------QEKGKEALLNEIDLMRA-------LDHPNI
..|.|.|. |.|... ..             . .|.|  .|. .                          ..| .. ...||..|.        ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MKLHEVFE------------TENS--------LYFIL---DLLEGG----QLYDKMKSK---------------HRYTSEEIKDILRGLLEGCAHMHQKR
 ||.||.|            | .         .|...   .. .||     |.|. ...               .|.| .| . . | .... ...|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDLKPENVLFKDPQG---------------KQIVIADLGLATRCDLPE------------------------YLFVRCGTPGFVA-PEVVNIKNL--
|.||||||||.|. |  .                .| |.| |.|...|  |                         .  .||||...| |||.| |    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------NTTYDPICDLFSIGLMFHILLIGKSPFDGK-------------TYNDILSQNRACNIKFDSVEYLKLP--------------------LQTY
        .. |.| ||  |.| .  |.| |..||.|.             ...... . ....  |.. .  ...                     .  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLKKMLEKDPKNRINAADALKHPFF
||..|||..||..|......|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 4137.AA S_TKc 151-413 27 6.9e-84 285.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

FRAHKKIGKGNFASVYLAERLEDEKMFAVKAFSKEAAYAQEKGKEALLNEIDLMRALDHPNIMKLHEVFETENSLYFILDLLEG--GQLYDKMKSKHR--
.. ..||||| |..||..   .. . .|.|  .           | ...||....  .|||| ||..||.. ..||.......|  | |.| .|.. |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----YTSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDPQGKQIVIADLGLATRCDLPEYLFVRCGTPGFVAPEVVNIKNLNTTYDP-ICDLFSI
    ..  ... ... .... ...|...|.||||||||.|. .    .| |.| |||..          |||| ..||||.        |..  ||  |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSC

GLMFHILLIGKSPFDGKTYNDILSQNRACNIKFDSVEYLKLPLQTYDLLKKMLEKDPKNRINAADALK-------HPFF
| .. ..| |. ||.  ... .. . .              . .  |...|.|.|||..|. | .||.       ||.|
GCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4137.AA Pkinase 151-413 28 2.6e-74 257.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

FRAHKKIGKGNFASVYLAERLEDEKMFAVKAFSKEAAYAQEKGKEALLNEIDLMRALDHPNIMKLHEVFETENSLYFILDLLEGG----QLYDKMK--SK
.. ..|||.|.|..||.. .  ..|..||| ..|. .  ...   ..|.|| .|. |.|||| .|...||.....|......|||     |.| ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HRY--TSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDPQGKQ---IVIADLGLATR--CDLPEYLFVRCGTPGFVAPEVVNIKNLNTTYDPICD
 ..  . .|.|.... .|.| ...|...|.||||||||.|..  .|     . |.| |||        . . ..||||...||||..    .. |.| .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVD

LFSIGLMFHILLIGKSPFDGK------TYNDILSQNRACNIKFDSVEYLKLP-----------------LQTYDLLKKMLEKDPKNRINAADALKHPFF
 .|.|......| |. ||.|.      . . .. ... . ..||. .    .                     |..|..|.|||| |..|...|.||.|
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 4137.AA CDPK 151-413 33 1.6e-66 203.14 In-house 1-271 (271) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-271/271
Sequence Identity: 33% (92 aa)

FRAHKKIGKGNFASVYLAERL---EDEKMFAVKAFSKEAAYAQEKGKEALLNEIDLMRALDHPNIMKLHEVFETENSLYFILD--LLEGGQLYDKMKSKH
.  .|..|||.| .|...       .|. .|.|  .|     .|. .. ..|||.... |||||| |. |... |.  |...   ...||.| |. ..| 
YKIKKVLGKGHFGQVRKVKHKQKTNQER-VAMKIIPKSRVKDKEQ-QQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKG

RYTSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLF--KDPQG---KQIVIADLGLATRCDLP-----EYLFVRCGTPGFVAPEVVNIKNLNTTYDPI
..|  |  .| | .|   ...|.. |.||||||||.||  |..     ..|.. | |.....|       ...  |||||  .||||     |.  |.  
HFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEV-----LQKKYNEK

CDLFSIGLMFHILLIGKSPFDGKTYNDILSQNRACNIKFDSVEYLKLPLQTYDLLKKMLEKDPKNRINAADALKHPFF
||. |.|    ||| |  || ||. ..|. . . .. .|.  |  .   .  || .|||..|||.|. |..||.|| |
CDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 4137.AA Ciliate-E2-Unclassified 151-413 23 5.1e-63 215.67 In-house 1-352 (352) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-352/352
Sequence Identity: 23% (82 aa)

FRAHKKIGKGNFASVYLAERLEDEKMFAVKAFSKEAAYAQEKGKEA--------LLNEID-------------LMRALDHPNIMKLHEVFETENSLYFIL
.. .|.||.|.|..||.... .. . .| |  .|   |.| . ..          .|..              ... ..||.|.|....|.... .|...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DLLEGGQLYDKMKSK-----------------HRYTSEEIK-----DILRGLLEGCAHMHQK-RIMHRDLKPENVLFKDPQGK--QIVIADLGLATRCDL
...||| | . .|..                 .. | ...|     .... .|.|  ..|.|  | |||.||||.||.. .||  .| |.|.|.. . . 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDN-NGKNYYIKIIDFGISKKYQQ

----------------PEYLFVRCGTPGFV----APEVVNIKNLNTT--YDPICDLFSIGLMFHILLIGKSPFDGKTYND---------------ILSQN
                .. .  .||||..     ||||   .| ...  |   || .| |  .. .| |. ||.......               .| ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAY--KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

R-ACNIKFDSVEY----LKLPLQTYDLLK----KMLEKDPKNRINAADALKHPFF
  ..||.|.. .      ... .  |...    |||.|.|..||.. ..|.||.|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 4137.AA CAMKL 151-413 26 1.3e-62 198.63 In-house 1-297 (297) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-297/297
Sequence Identity: 26% (80 aa)

FRAHKKIGKGNFASVYLAER-LEDEKMFAVKAFSKEAAYAQEKGKEA-----------LLNEIDLMRALD---HPNIMKLHEVFETENS------LYFIL
.|  | .|||.|. | ||.  .  ... |.|   |. .   .. |             .  || .|. |.   ||||.||.||.||..       .| ..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DLLEGGQ--LYDKMKSK----HRYTSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDPQGKQIVIADLGLATRCD-L----PEYLFVRCGTPGFV
 . .||   |.|. ...     | . .| . . | .... ...|...| |||.||||.|. . .  .| |.| |... ..       . |  .||.| . 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVVNIKNLNTTYD-PICDLFSIGLMFHILLIGKSPFDGKTYN-----DILSQNRACNIKFDSV-EYLKLPLQTYDLLKKMLEKDPKNRINAADALKHP
|||...    |. || |  |  |.| .   .. |. |||. |||     .|    .  ..       ..... .  ||..|||...|. |... . ..||
APEIFQGN--NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

FF
..
WM
Kinase 4137.AA CAMK-Unique 151-413 21 5.4e-62 203.36 In-house 1-363 (363) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-363/363
Sequence Identity: 21% (79 aa)

FRAHKKIGKGNFASVYLAERLEDEKMFAVKAFSKEAAYAQEKGKE-----------------ALLNEIDLMRALDHPNIMKLHEV----FETEN------
 . |. ||.|||  || .   | .| .|.| . |...   .|.|.                  | .|..... .||||| || ..    |....      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTH-GNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------SLYFILDLLEGGQLYDKMKS--------------------KHRYTS--EEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDP-Q----
          .| ......|| |.|.. .                    . ...    ..  | . ||.  |.||.. | |||||.||.... . .    
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

---------GKQIVIADLGLATRCD-LPEY--LFVRCGTPGFVAP--------------EVVNIKNLNTTYDPIC----DLFSIGLMFHILLIGKSPFDG
          . |...| ||..  .   ..  . ..|||| ..||              ||.|    .  ||  |    |. |.| . ...| |..|||.
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN----MQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDC

KTYN--------DILSQNRACNI-KFDSVEYLK---LPLQTYDLLKKMLEKDPKNRINAADALKHPFF
 . .         |..  ..... .||.  .        . .|..|. .. ||. |..|. .|.|...
ECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 4137.AA ULK 151-413 25 6.7e-57 195.36 In-house 1-329 (329) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-329/329
Sequence Identity: 25% (84 aa)

FRAHKKIGKGNFASVYLAERLEDE----KMFAVKAFSKEAAYAQEKG------KEALLNEIDLMRALD--------HPNIMKLHEVFETE--NSLYFILD
.  ....||| |. || ..  ...    ...|.|  .|.    ...       .. | |||..|. |.        |||| ||...|||   | .|.|..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LLEGGQLYDKMKSKHR----------YTSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDPQGK----------QIVIADLGLATRCDLP-----
. .|| | . .| ...           . .|.. ... .|.|. ..|...|.|||.||.|.| ...|.|          .. ||| |.|  .| .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-EYLFV----RCGTPGFVAPEVVNIKNLNTTYDPI-CDLFSIGLMFHILLIGKSPFDGKTYNDILSQNRACN---------------IKFDSV-EYLKLP
 .. .|     |||| . ||.... .  .  |.   ||..|.| .|. .| || || .  .||   |.   .               ..|. . .  .. 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

LQTYDLLKKMLEKDPKNRINAADALKHPFF
 .. ||...||..|.| ||.  . ..||.|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 4137.AA RSK 154-413 26 1.6e-55 190.79 In-house 1-278 (278) Show / Hide 
Range on Protein: 154-413
Range on HMM: 1-278/278
Sequence Identity: 26% (75 aa)

HKKIGKGNFASVYLAERL---EDEKMFAVKAFSKEAAYAQEKGKEALLNEIDLMRALD-HPNIMKLHEVFETENSLYFILDLLEGGQLYDKMKSKHR---
.|  |.| . .|.|  .      .. .|.|  .|  . . .|  .  . |.. . .   ||.| .||..|.||  || |.....|| |... . . .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YTSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDPQGK--QIVIADLGLATR--CDLPEYLFVRCGTPGFVAPEVVNIKNLNTTYDPICDLFSIG
 . .| ..... .     |.||. | ||||||||.|. | .     |.. | |..    ||  . .   |.|  ..|||...  | . ..|  ||..| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

LMFHILLIGKSPFDG---KTYNDILSQNRACNIKFDSV--EYLKLPLQTYDLLKKMLEKDPKNRIN-----AADALKHPFF
   . .| |..|| |   .. ..|. . . ... ...   .||  . .  ||..|||..||..|..     |.. ..||.|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAK--DLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 4137.AA Pkinase_Tyr 151-276 25 6.7e-16 54.47 Pfam 1-137 (270) Show / Hide 
Range on Protein: 151-276
Range on HMM: 1-137/270
Sequence Identity: 25% (35 aa)

FRAHKKIGKGNFASVYLAERL----EDEKMFAVKAFSKEAAYAQEKG--KEALLNEIDLMRAL-DHPNIMKLHEVFE-TENS--LYFILDLLEGGQLYDK
 .  ||.|.|.| .||...      ...   |||   ||  .| ..   .|....|. .|. | .|||| .|. |    . .  .| .. . ..| |.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

MKS----KHRYTSEEIKDILRGLLEGCAHMHQKRIMHRDL
 ..    |.. | ... .. .   .|... ..|.. ||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 4137.AA TyrKc 151-413 20 1.3e-13 -2.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 151-413
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FRAHKKIGKGNFASVYLAERLEDEKMFAVKAFSKEAAYAQEKGKEALLNEIDLMRAL--DHPNIMKLHEVFETE-------NSLYFILDLLEGGQLYDKM
 .  ||.| |.|  ||...      . |||   ..|       .|....|. .|. |  .|||| .|. |  ..         |. .. . ..| | |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KSKHR-YTSEEIKDILRGLLEGCAHMHQKRIMHRDLKPENVLFKDPQGKQIVIADLGLATRCDLPEY-------LFVRC----GTPGFV-----APEVVN
.....  . ..  ..     .|... |.|.. ||||   |.| ....  .. |.| ||.   |. ..          |     |. . .     |||.  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLS--RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

IKNLNTTYDPICDLFSIG-LMFHILLIGKSPFDG-----KTYNDILSQNRACNIKFDSVEYL-----KLPLQTYDLLKKMLEKDPKNRINAADALKHPFF
      .. .  | .| | .|. |.  |..|  |     ..  ... . .. .      ...       |   |.. |.  . ||..| . ..   | .|
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF