Gene 4750 (Tetrahymena)

4750

Species: Tetrahymena
Alias: 25.m00214, PreTt04750, 3694.m00001, 4750, 577, TTHERM_00277070
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
4750.AA Protein None 596 None Fasta, JSON
4750.kin_dom Protein Kinase Domain None 280 None Fasta, JSON
4750.NA RNA None 1791 None Fasta, JSON

Protein domain

Protein domains of 4750.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4750.AA Ciliate-E2a 66-345 36 1.2e-150 446.61 In-house 1-275 (275) Show / Hide 
Range on Protein: 66-345
Range on HMM: 1-275/275
Sequence Identity: 36% (108 aa)

YKFLKKLGNGAFGSVMLAQQTKPPFNKVAIKIIDKKSVKGTPSFYLKREVDIIKQLDHPNICRFLETYMDKDHIYLVMEYLSGGTLRDKFINKE-ELTE-
|||.||.|.|.||||.|||. . .......|.|.| ........|...|..|..|||||||... |.|.|....||||||..||.| ||....  . .| 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

YQISQVMQKLFY-AINYLHTRNIVHRDLKLENVVYT--STD--ENAEIKIIDFGLSKKLNVRSSRKRHTKVGSAYYMELGGIFNFKLIKLARRFILFLNI
..|...||.|.. ...|.| |||.|||||.||. ..  |..  .|..||||||||... .  . .....|.|...|.                     ..
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAP-------------------EV

YKAPEVLLHEKYERECDMWSLGVMMYFLLSRELPFED------LDQIEQGKFNFDAPV-WNYVSDEAKDMIRNILLVNTKKRLKLSQALDHKWF
.. .|||.|..|   |||||.||..|.||. ..||.       | |... |..|. |. |...|.|.||...  | .. |||..  |||.|.||
LNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 4750.AA Ciliate-E2 66-345 30 9.8e-99 334.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 66-345
Range on HMM: 1-365/365
Sequence Identity: 30% (115 aa)

YKFLKKLGNGAFGSVMLAQQTKPPFN-----------------KVAIKIIDKKSVKGTPSFYLKREVDIIK----------------QLDHPNICRFLET
|||.||.|.|.|||| .... | . .                 ||.|||. .|..|    ...|.| .|..                ||.||||... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YM--DKDHIYLVMEYLSGGTLRD------KFINKE-----ELTEYQISQVMQKLFY---------------AINYLHTRN-IVHRDLKLENVVYTSTDEN
.   |...|||||||..||.|.|      |. |.|      .||..|...|.....               |..||| .| |.|||.|.||...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

AEIKIIDFGLSKKLNVRSSRKRHTKVGSAYYMELGGIFNFKLIKLARRFILFLNI---------YKAPEVLLHEK---------YERECDMWSLGVMMYF
  |||||||||||..  . ...| |...  ||. ..  .    ...  .|.. |.         |.|||.|  .|         |  .||.|||||..|.
--IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD--QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

LLSRELPFEDLDQIEQGKFNFDAP--------------VWNYVSDEAKDMIRN----ILLVNTKKRLK-LSQALDHKWF
.|. ..||  ..||.|.|..|. |               |...|.|.||.|..    .| .. .||.   .|.|.|.||
MLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 4750.AA CDPK 66-345 38 1.4e-97 299.88 In-house 1-271 (271) Show / Hide 
Range on Protein: 66-345
Range on HMM: 1-271/271
Sequence Identity: 38% (113 aa)

YKFLKKLGNGAFGSVMLAQQT-KPPFNKVAIKIIDKKSVKGTPS-FYLKREVDIIKQLDHPNICRFLETYMDKDHIYLVME--YLSGGTLRDKFINKEEL
||. |.|| |.||.| ....  |    .||.||| |..||       ...|..| |||||||| .. |.| |....|.|||  |..|| | |. |.| ..
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

TEYQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDENA----EIKIIDFGLSKKLNVR---SSRKRHTKVGSAYYMELGGIFNFKLIKLARRFIL
|| . ...|.... |.|| | .|||||||| ||. ..| ....    .||.||.|.||| .      . |  ...|  ||.                   
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYI-------------------

FLNIYKAPEVLLHEKYERECDMWSLGVMMYFLLSRELPF------EDLDQIEQGKFNFDAPVWNYVSDEAKDMIRNILLVNTKKRLKLSQALDHKWF
      ||||| .  |. .|| ||.|| .| ||. . ||      | ..... ||..|. | |. .||||||.||. | .. |||.. .|||.|.||
------APEVLQKK-YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 4750.AA S_TKc 66-345 31 6.9e-81 275.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 66-345
Range on HMM: 1-231/231
Sequence Identity: 31% (92 aa)

YKFLKKLGNGAFGSVMLAQQTKPPFNKVAIKIIDKKSVKGTPSFYLKREVDIIKQLDHPNICRFLETYMDKDHIYLVMEYLSG--GTLRDKFINKEE---
|..|.|.| ||||.|.... .|    .||||||.           ..||..| |. .||||....... | ||.|.||||..|  |.|.|   ..     
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEYQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDENAEIKIIDFGLSKKLNVRSSRKRHTKVGSAYYMELGGIFNFKLIKLARRFILFLN
   ..| ..  .|. .. |..|.| ..|.||||| ||.  ..     .|||.||||...|        .| .|. .||                      
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYM----------------------

IYKAPEVLLHEKYER-ECDMWSLGVMMYFLLSRELPFEDLDQIEQGKFNFDAPVWNYVSDEAKDMIRNILLVNTKKRLKLSQALD-------HKWF
   |||||   .| . .||.||.|...| .|... ||.  .. .  |           |.||||.||..| .. .||.   .||        | ||
---APEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4750.AA Ciliate-E2-Unclassified 66-345 25 1.5e-66 227.37 In-house 1-352 (352) Show / Hide 
Range on Protein: 66-345
Range on HMM: 1-352/352
Sequence Identity: 25% (95 aa)

YKFLKKLGNGAFGSVMLAQQ--TKPPF--NKVAIKIIDKK-SVKGTPSFYLKREVDIIKQ-------------------LDHPNICRFLETYMDKDHIYL
||..|..|.|.||.| ..|.  .|  .   | ..||...|   . .    ...| .....                   ..||.| .....  ||..||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYLSGGTLRDKFINKEE-----------------LTEYQIS-----QVMQKLFYAINYLHTRN-IVHRDLKLENVVYTSTDENAEIKIIDFGLSKKLN
||||. ||.|..   ...                  .||.|..     . .  .  ...|||  | |.|||.|.||.....  .| .|||||||.|||..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

VR--------------SSRKRHTKVGSAYYM-ELGGIFNFKLIKLARRFILFLNIYKAPEVLLHEKYERE----CDMWSLGVMMYFLLSRELPFE-----
                .. . .|..|. .|| .                      | |||||  ..|. .    ||.||||| .|..|  ..||.     
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ----------------------YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCE

-----------------DLDQIEQGKFNFDAPVW----NYVSDEAKDMIR----NILLVNTKKRLKLSQALDHKWF
                  ...| |....|.   |      .|.||||.|.     .| .| .||. ..|.| | ||
QHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 4750.AA CAMK1 66-218 40 3.9e-62 179.38 In-house 1-164 (276) Show / Hide 
Range on Protein: 66-218
Range on HMM: 1-164/276
Sequence Identity: 40% (67 aa)

YKFLKKLGNGAFGSVMLAQQTKPP--FNKVAIKIID-KKSVKGTPS---FYLKREVDIIK---QLDHPNICRFLETYMDKDHIYLVMEYLSGGTLRDKFI
|.| |..|.|||. | |... . .    ..|||.|| ||..|.       .|..|..| |   ..|||||  | | | ...|.|||||...|| | |. .
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

NKEELTEYQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDENAEIK--IIDFGLSKKLN
 |.  || . . .|.... |..|.| ..||||||| ||  | . ||...||  |.||||||...
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFD
Kinase 4750.AA CAMK 71-235 24 4.4e-60 191.98 In-house 1-286 (425) Show / Hide 
Range on Protein: 71-235
Range on HMM: 1-286/425
Sequence Identity: 24% (70 aa)

KLGNGAFGSVMLAQQTKPPF-----------NKVAIKIIDKKSVKG-------------------------TPSFY-LKREVDIIKQ-------LDHPNI
.|| |.|| | |..... .             |||||||||| .|.                           .   ..||..| |.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CRFLETYMD-------------------KDHIYLVM---EYLSGG----TLRDKFINKEE---------------LTEYQISQVMQKLFYAINYLHTRNI
....|.| |                   ..|.|.||   || |||     | |. . ..                .|| . ..... .  |..|.| .||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKLENVVYTSTDEN--------------AEIKIIDFGLSKKLNVRS----------------------SRKRHTKVGSAYYM
||||||.||. ... ...              . |||||||...|..  .                        | .| .|. .||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM
Kinase 4750.AA CAMKL 66-235 35 1.5e-56 178.93 In-house 1-200 (297) Show / Hide 
Range on Protein: 66-235
Range on HMM: 1-200/297
Sequence Identity: 35% (72 aa)

YKFLKKLGNGAFGSVMLAQQTKPPFNKVAIKIIDKKSVKGTPSFY-------------LKREVDIIKQLD---HPNICRFLETYMDKDH------IYLVM
|...| || |.|| | ||. .. .  ||||||||||  .  |                ..||. | |.|.   ||||....|.. ...|      |||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYLSGGT--LRDKFINKEE----LTEYQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDENAEIKIIDFGLSKKLN---VRSSRKRHTKVGSAYY
|| |||   | |. .....    ..| .  .  . .  |.||.| ..|||||.|.||.  .. . |  |||||||.| .     . . .| .|  ||  |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

M
|
M
Kinase 4750.AA CAMK-Unique 66-235 25 2.3e-49 161.02 In-house 1-242 (363) Show / Hide 
Range on Protein: 66-235
Range on HMM: 1-242/363
Sequence Identity: 25% (63 aa)

YKFLKKLGNGAFGSVMLAQQ--TKPPFNKVAIKIIDKKSVKGTPSFY------------------LKREVDIIKQLDHPNICRFLET----YMDKD----
||... .|.|.|| |  ..   |.    | |.|.. |. ..                        ||||..| | .||||| .....    . |..    
YKMHRIIGHGNFGHVYECMDRETG---KKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLC

-----------HIYLVMEYLSGGTLRDKFIN--------------------KEELTE--YQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTST-DE-
           ..|.||||. ||.| |...                     .  ..|  ......||.|  |..|.|  .||||||||||... .  .. 
DLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDN

-----------NAEIKIIDFGLSKKLNVRSSRKRH---TKVGSAYYM
           |  ||..||||....|  .....|   | .|. .||
NHHRDFPYDWSNWHIKLCDFGLCCHYN--HNKMCHMMQTMCGTPCYM
Kinase 4750.AA Pkinase 66-235 34 1.1e-45 162.59 Pfam 1-178 (293) Show / Hide 
Range on Protein: 66-235
Range on HMM: 1-178/293
Sequence Identity: 34% (62 aa)

YKFLKKLGNGAFGSVMLAQQTKPPFNKVAIKIIDKKSVKGTPSFYLKR--EVDIIKQLDHPNICRFLETYMDKDHIYLVMEYLSGG----TLRDKFI--N
|....|.| |.||.| ...  . .  .||.|||.|.. |     .. |  |. | | |.||||.|......||||||.||||. ||     | |     .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KEEL--TEYQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDEN-AEIKIIDFGLSKKLNVRSSRKRHTKVGSAYYM
.  .  .| ..  .|  .. ...|.| ..|.|||||.||. . ..... | .||.||||.|...  ...  .| .|. .||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM
Kinase 4750.AA ULK 66-235 26 7.4e-41 142.06 In-house 1-214 (324) Show / Hide 
Range on Protein: 66-235
Range on HMM: 1-214/324
Sequence Identity: 26% (57 aa)

YKFLKKLGNGAFG-SVMLAQ-QTKPP-FNKVAIKIIDKKSVKGTPSF--------YLKREVDIIKQLD---HPN--ICRFLETYMDKDH--IYLVMEYLS
|   ..|| |.||  |  .  . .     .||.|.||||. .  ..          ||.|. |.|.|.   |||  |..... .....|  ||..|||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLRDKFINKEELTEYQ----------ISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDE---------NAEIKIIDFGLSKKLNV--RSSRKRH
||.|..   .. .|.| .          . |... .  .  .|| .||.|||.|..|   .  ..         |  .|| |||..|...    .  ...
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TKV------GSAYYM
| |      |. .||
TCVNEKRIKGTPLYM
Kinase 4750.AA RSK 69-235 27 1.2e-38 134.7 In-house 1-175 (278) Show / Hide 
Range on Protein: 69-235
Range on HMM: 1-175/278
Sequence Identity: 27% (48 aa)

LKKLGNGAFGSVMLAQQT--KPPFNKVAIKIIDKKSVKGTP--SFYLKREVDIIKQLD-HPNICRFLETYMDKDHIYLVMEYLSGGTLRDKFINKEE---
|| || |..|.| | . .  .      | |...|. .. .     . ..|..| .    ||.|..  ... .....||.|||..|| | ..  ...    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LTEYQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDEN-AEIKIIDFGLSKKLNVRSSRKRHTKVGSAYYM
..|   ...| ..  |. .||.. |.|||||.||..|.. . | ..||..|||..|... . . . .| .... ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYM
Kinase 4750.AA CAMK 259-345 27 9.6e-37 115.42 In-house 285-425 (425) Show / Hide 
Range on Protein: 259-345
Range on HMM: 285-425/425
Sequence Identity: 27% (39 aa)

YKA-PEVLLH--------------EKYERECDMWSLGVMMYFLLSRELPFED-------------------LDQIEQGKFNFDAPV------------WN
| | ||||.               . | ..|||||.||..|..|. ..||..                   . .| .||..|. |             |.
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD

YVSDE--------AKDMIRNILLVNTKKRLKLSQALDHKWF
 .|||        .||.||..| |. .||....|.|.|.|.
DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 4750.AA CAMK1 259-345 39 8.4e-29 80.81 In-house 179-276 (276) Show / Hide 
Range on Protein: 259-345
Range on HMM: 179-276/276
Sequence Identity: 39% (39 aa)

YKAPEVLLH---EKYERECDMWSLGVMMYFLLSRELPFEDLD-Q------IEQGKFNFDAPVWNYVSDE-AKDMIRNILLVNTKKRLKLSQALDHKWF
| |||||     . |  .||||| ||  |.||    || | . .      |  ....|. | |...||. ||| |.. | |. |||.  .|.|.|.|.
YVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 4750.AA CAMKL 259-345 29 8.5e-29 88.9 In-house 199-297 (297) Show / Hide 
Range on Protein: 259-345
Range on HMM: 199-297/297
Sequence Identity: 29% (30 aa)

YKAPEVLLH--EKYE-RECDMWSLGVMMYFLLSRELPFEDLD-----------QIEQGKFNFDAPVWNYVSDEAKDMIRNILLVNTKKRLKLSQALDHKW
| |||...   ..|. .. |.||.||..|...  .|||.| .             .. .  .  |.|..|| ...|.|| .| || .|| .. | . |.|
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

F
.
M
Kinase 4750.AA CAMK-Unique 258-345 29 8.6e-29 92.01 In-house 240-363 (363) Show / Hide 
Range on Protein: 258-345
Range on HMM: 240-363/363
Sequence Identity: 29% (36 aa)

IYKAP--------------EVLLHEKYEREC----DMWSLGVMMYFLLSRELPF----ED----------LDQIEQGKF-NFDAPVWNY---VSDEAKDM
.|.||              ||.   .| . |    | |||||.||..|. ..||    ||          .. | .|.. ||| ..|.    .|.|||| 
CYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDF

IRNILLVNTKKRLKLSQALDHKWF
. . . |  ..|......|.| |.
VKCCMTVDPDHRWSAKELLEHQWI
Kinase 4750.AA RSK 259-345 36 3.8e-27 96.43 In-house 174-278 (278) Show / Hide 
Range on Protein: 259-345
Range on HMM: 174-278/278
Sequence Identity: 36% (38 aa)

YKAPEVLL---HEK-YERECDMWSLGVMMYFLLSRELPFED---------LDQIEQGKFNFDAPVWNYVSDEAKDMIRNILLVNTKKRLK-----LSQAL
| |||.|    ... . . || ||||| || .|.  .||           ...|..|||... | |.|.|.|||| ||  | .. .|||.     ... .
YMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIK

DHKWF
.|.||
QHPWF
Kinase 4750.AA Pkinase 259-345 29 5.4e-21 75.32 Pfam 177-293 (293) Show / Hide 
Range on Protein: 259-345
Range on HMM: 177-293/293
Sequence Identity: 29% (34 aa)

YKAPEVLL-HEKYERECDMWSLGVMMYFLLSRELPFEDL------------DQIEQGKFNFDAPVWNYVS-----------------DEAKDMIRNILLV
| ||||.. ...| ...||||.|...| .|....|| .             ..| .... || | |. .|                 .|.|| |...| .
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

NTKKRLKLSQALDHKWF
. |||.   |.| |.||
DPKKRPTAEQILQHPWF
Kinase 4750.AA Pkinase_Tyr 66-224 31 1.8e-20 69.92 Pfam 1-175 (270) Show / Hide 
Range on Protein: 66-224
Range on HMM: 1-175/270
Sequence Identity: 31% (57 aa)

YKFLKKLGNGAFGSVMLAQQT---KPPFNKVAIKIIDKKSVKGTPSFY-----LKREVDIIKQL-DHPNICRFLETYM-DKDH--IYLVMEYLSGGTLRD
 .|.|||| ||||.|...  .   . .  .||.|.. |    |. .       . ||. | ||| .|||| |..   . ....  ||.||||  .| |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

KFIN----KEELTEYQISQVMQKLFYAINYLHTRNIVHRDLKLENVVYTSTDENAEIKIIDFGLSKKL-------NVRSSRK
   .    |. ||  .. |  .    . .||. .|..||||   |.  |.   |  .|| ||||.. .        .|.. |
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGK
Kinase 4750.AA ULK 258-345 26 3.8e-20 68.21 In-house 212-324 (324) Show / Hide 
Range on Protein: 258-345
Range on HMM: 212-324/324
Sequence Identity: 26% (30 aa)

IYKAPEVLL----HEKYE-RECDMWSLGVMMYFLLSRELP----FEDLD---------------QIEQGKFNFD---APVWNYVSDEAKDMIRNILLVNT
.| ||..|     ...|   .||.||||...| .|  . |    |.|..               .|.. ...|.   . .   .|.| || ||  | .. 
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPK--ISPECKDLIRRMLQYDE

KKRLKLSQALDHKWF
|.|    . ..|.||
KDRISWEEIFNHPWF
Kinase 4750.AA TyrKc 66-345 21 3.7e-14 6.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 66-345
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

YKFLKKLGNGAFGSVMLAQQTKPPFNKVAIKIIDKKSVKGTPSFYLKREVDIIKQL--DHPNICRFLETYMDK-------DHIYLVMEYLSGGTLRDKFI
 ...||||.|||| |.... .     .||.| . . .        . ||  | ..|  .|||| |..   ...       . ...|||| ..| |.|   
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NKEELTEYQISQVMQKLFY-----AINYLHTRNIVHRDLKLENVVYTSTDENAEIKIIDFGLSKKLNVR---SSRKRHTKVGSAYYMEL---GGI--FNF
....     ..      |        .||| .|..||||   |. ...      .|| |||||...              . . ||.     ||   .  
KHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-------ESKDYYRKKEHKGGKTMLPI

KLIKLARRFILFLNIYKAPEVLLHEKYERECDMWSLGVMMYFLLSR-ELPFED-----------LDQIEQGKFNFDAPVWNY------VSDEAKDMIRNI
.                |||.. . |.  . | || ||.|. .... . | ..           . ...||.   . |  .|       .||  ....  
R--------------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM-PQPPNDYPMSFVCCPDEMYQIMKQC

LLVNTKKRLKLSQALDHKWF
   . ..|   |.   |. |
WHEDPEDRPTFSEI--HECF
Kinase 4750.AA Pkinase_Tyr 261-284 41 0.930326 3.19 Pfam 182-205 (270) Show / Hide 
Range on Protein: 261-284
Range on HMM: 182-205/270
Sequence Identity: 41% (10 aa)

APEVLLHEKYERECDMWSLGVMMY
|||.. . |.  . | || || |.
APECINYGKFTTKSDVWSFGVLMW
Efhand 4750.AA efhand 403-431 31 5.1e-05 22.77 Pfam 1-29 (29) Show / Hide 
Range on Protein: 403-431
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

TPKNLFRNIDKDQNGVITADELRLCLYEL
  |..|. .|||..| |. .|.. .. .|
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 4750.AA EFh 403-431 34 0.001316 19.23 SMART 1-29 (29) Show / Hide 
Range on Protein: 403-431
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

TPKNLFRNIDKDQNGVITADELRLCLYEL
  | .|| .||| .| |. .|.. .. .|
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 4750.AA EFh 487-515 27 0.078462 5.41 SMART 1-29 (29) Show / Hide 
Range on Protein: 487-515
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

KLQQIFHYLNSTETGYITQEDLKDIMARE
.....|  .     |||. |..||.|.. 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 4750.AA efhand 487-515 24 0.504788 8.16 Pfam 1-29 (29) Show / Hide 
Range on Protein: 487-515
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

KLQQIFHYLNSTETGYITQEDLKDIMARE
.|...|  .     |||. |.....|.. 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 4750.AA efhand 539-553 33 23.550971 2.05 Pfam 15-29 (29) Show / Hide 
Range on Protein: 539-553
Range on HMM: 15-29/29
Sequence Identity: 33% (5 aa)

GKLNFDDFCKAMGFE
|...|..||..|   
GYIDFEEFCEMMKKL