Gene 11132 (Tetrahymena)

11132

Species: Tetrahymena
Alias: 1053, 3824.m02893, 3.m01702, PreTt11132, TTHERM_00046530, 11132
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AGC-Sar
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
11132.AA Protein None 808 None Fasta, JSON
11132.kin_dom Protein Kinase Domain None 252 None Fasta, JSON
11132.NA RNA None 2427 None Fasta, JSON

Protein domain

Protein domains of 11132.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP_binding 11132.AA cNMP_binding 103-188 32 3.4e-21 75.41 Pfam 1-91 (91) Show / Hide 
Range on Protein: 103-188
Range on HMM: 1-91/91
Sequence Identity: 32% (30 aa)

YCEVPMNDFIFKQSDNATSFFILERGAMEVIVNEKSKR-----ELKAGDGFGELALLYNA-PRSASVKALDHCYLWGIDRNTFRRAVEEMIT
  ... ...||.| | ...|.|.. | ..|.. ... |     .|..|| |||.||..|  ||.|.|.||. | .| |.|..||. ...   
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 11132.AA cNMP 85-198 26 7.4e-18 66.57 SMART 1-123 (123) Show / Hide 
Range on Protein: 85-198
Range on HMM: 1-123/123
Sequence Identity: 26% (33 aa)

FIFFYQKAQRVELTIKMFYCEVPMNDFIFKQSDNATSFFILERGAMEVIVN---------EKSKRELKAGDGFGELALLYNAPRSASVKAL-DHCYLWGI
.     .... ||  .|.  ..| .. ||.| | ...|.|...|...|..          |.  ..|..|| ||||||| ..||.|...|.   | .| |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRNTFRRAVEEMITKEYEENRKFM
|.. |.......  . |.. ... 
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 11132.AA cNMP_binding 221-306 32 4.5e-22 78.42 Pfam 1-91 (91) Show / Hide 
Range on Protein: 221-306
Range on HMM: 1-91/91
Sequence Identity: 32% (30 aa)

VQKFYKNQVIVTEGDPASSFYIIKEGNVTVWKGNKEVR-----KLYKGDSFGEQALYYNT-VRQMTVRAEDEVKCLALGRDTLTKVLGDQVH
|... |..||. .|||...|||...| | | | ... |      | .|| ||| || .|.  |  ||.|.....|... |... ... .   
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 11132.AA cNMP 203-316 23 1.1e-17 66.03 SMART 1-123 (123) Show / Hide 
Range on Protein: 203-316
Range on HMM: 1-123/123
Sequence Identity: 23% (29 aa)

FFHNLTNEQKDAIAAVLIVQKFYKNQVIVTEGDPASSFYIIKEGNVTVWKG---------NKEVRKLYKGDSFGEQALYYNTVRQMTVRAE-DEVKCLAL
.| ||. ..  ...... .... ....|. .|||...|||| .| | | |           ..|. | .||.||| ||  .. |  ..||    .... .
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

GRDTLTKVLGDQVHAVTFRNLQKW
 .. .   |... ..   . .|  
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 11132.AA cNMP_binding 341-428 17 0.004142 13.26 Pfam 1-91 (91) Show / Hide 
Range on Protein: 341-428
Range on HMM: 1-91/91
Sequence Identity: 17% (17 aa)

ISSYKAGDIIMKKGTVANQKIVVIIEGSLKKAKSGMT-------VASKAQAWGEEYMLDQNKNKTFDDDIVMETDGVIAEITSENFVECIGGQLE
. .||.|..|...|    . . ....|..|  | .         . .. .  ||  .....   ..  ..| .|| ....|  | | ...    |
VRHYKKGEVIFHQGDP-CDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQ--NPRTATVVALTDCECWRIPREDFRQLMQQHPE
Kinase 11132.AA Ciliate-E2b 482-741 62 6.00000000001e-194 594.44 In-house 2-272 (272) Show / Hide 
Range on Protein: 482-741
Range on HMM: 2-272/272
Sequence Identity: 62% (169 aa)

QQFKKTAFGQFGPVYLVKA-NYDKNLYALKSFNKVQISEQSLEKYICQEKVVLEIVNFPFIIQYARSFKDSFDVYFLVEYVKGIELFDVIRDIG--LLNT
   ||  |||||.||||.. ...|..||.|...| ||..|..||...||| |||..|.|||....|||||. ..||..|...|.|||||||.||  ||.|
IYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLST

YDSQFYVASMILILEYLHHQNVIYRDMKPENIMVDENGYLKLIDLGTAKFLKGRHGLGNRTFTIIGTPHYMAPEIIC-----GKGYNCYVDLWSVGICLY
||||||.||..|.|||||.||.||||.||||||||..||.||||.||||..........|||||||||||||||||.     ||||...||.||||||||
YDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLY

EFMCGMVPFGEEAEDPYEIYEDIIKK--EINYPSYLKDKKA-KKLMDQLLSRVPEVRLGGSYQTLKSNPWF
|||||.||..|...||||||..||||  ||..|||.|||.| ||||.|.|...|||||||||..|||.|||
EFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 11132.AA AGC 490-741 24 2e-97 251.82 In-house 10-395 (395) Show / Hide 
Range on Protein: 490-741
Range on HMM: 10-395/395
Sequence Identity: 24% (97 aa)

GQFGPVYLVKAN------YDKNLYALKSFNKVQ-ISEQS--LEKYICQE------------KVVLEIVN----------FPFIIQ-YARSFKDSFD--VY
| || ||||. .        . .||.|  .|   | .     ....  |            . .|| .|           |||..    ||.|     .|
GSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLY

FLVEYVK----------GIELFDVIR---DIGLLNTYDSQFYVAS-------MILILEYLHH-QNVIYRD-MKPENIMVDENGYLKLIDLGTAKFLKGRH
|. ||..          | |||  ..   . | ..   ..|| |        ..| |||||  ...|.|| .|||||. ||.|..|| | | .| .....
FVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDG

GL-----------------------------------------------GNRTFTIIG--TPHYMAPEIICGKGYNCYVDLWS--VGICLYEFMCGMVPF
.                                                ..|| |. |  ||.||||||.    |.  .| ||  .|...||...|  ||
EKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPF

GEEA--------EDPYEIYEDII------KKEINYPSYL---------KDKKAKKLMDQLLSRVPEVRLG--GS------YQTLKSNPWF
  .         ..|.|... |.      .... .|...          .. || |. .|| . || |||  |.      .. .|. |||
YGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 11132.AA Ciliate-E2 489-741 25 4.5e-78 265.67 In-house 9-365 (365) Show / Hide 
Range on Protein: 489-741
Range on HMM: 9-365/365
Sequence Identity: 25% (95 aa)

FGQFG-----PVYLVKANY------------------DKNLYALKSFNKVQISEQSLEKYIC----------QEKVVLEIVNFPFIIQYARSFK--DSFD
.|.||      |..|. ..                  ....||.|...| || ... |..|.          .|| .||..|.|.||..  .|.  |   
QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN

VYFLVEYVKGIELFD-------------------VIRDIGLLNTYDSQ-------FYVASMILILEYLHHQN-VIYRDMKPENIMVDENGYLKLIDLGTA
.|.  ||..| .|||                   ... |. . ..  |       ||.|..|| ||||| .| .|.|| |||||..     .|.||.|..
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS

K----------------FLKGRHGLGNRTFT-------------IIGTPHYMAPEIICGKG---------YNCYVDLWSVGICLYEFMCGMVPFGEEAED
|                 ..  ..  .||..             |.|||.||||||. ||.         |.  .|.||.|..|||...|  ||      
KKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------

PYEIYEDIIKKEINYP----------------SYLKDKKA-KKLMDQ----LLSRVPEVRLGGSYQTLKSNPWF
    .. |....|..|                |..|  .  | |. .    .| . || |.. ... .. .|||
----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-GWEQILNHPWF
Kinase 11132.AA PKA 481-741 36 3.7e-69 236.06 In-house 1-263 (263) Show / Hide 
Range on Protein: 481-741
Range on HMM: 1-263/263
Sequence Identity: 36% (99 aa)

NQQFKKTAFGQFGPVYLVKANYDKNLYALKSFNKVQISEQSLEKYICQEKVVLEIVNFPFII-QYARSFKDSFDVYFLVEYVKGIELFDVIRDIGLLNTY
 ....    | || |.|..   ..| ||.|  .| .|     .  .. || .|  ...|||. .   .|.|.   |.. ||| | |.|. .|  | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DSQFYVA-SMILILEYLHHQNVIYRDMKPENIMVDENGYLKLIDLGTAKFLKGRHGLGNRTFTIIGTPHYMAPEIICGK-GYNCYVDLWSVGICLYEFMC
...||.|   .| |||||.|| |||| |||||. |.||..|. | | || ...      ||.|. ||| |.||||| .| |..  || |. ||  ||.. 
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD------RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLA

GMVPFGEEAEDPYEIYEDIIKKEINYPSYLKDKKA---KKLMDQLLSRVPEVRLGGSY---QTLKSNPWF
|  || ..  || .||| |.. .|..|... |..|   | | ..||.. .. |.|      .  |  .||
GYPPFYDHNRDPMQIYEKICNGKIKFPRHF-DSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 11132.AA S_TKc 481-741 28 1.8e-64 221.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 481-741
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

NQQFKKTAFGQFGPVYLVKANYDKNLYALKSFNKVQISEQSLEKYICQEKVVLEIVNFPFIIQYARSFKDSFDVYFLVEYVKG--IELFDVIRDIGL---
 .  .|   | || ||... . .. ..|.|  .          . |..|  .|.  . |.|...  .| |  ..|.  ||. |   .|||.|.. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNTYDSQFYVASMILILEYLHHQNVIYRDMKPENIMVDENGYLKLIDLGTAKFLKGRHGLGNRTFTIIGTPHYMAPEIICGKGYNC-YVDLWSVGIC
   ..  . .||.. ... |||.| ...|.|| |||||..||   .|..| | |..|           |..|||.|||||..   ||..  .| ||.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYEFMCGMVPFGEEAEDPYEIYEDIIKKEINYPSYLKDKKAKKLMDQLLSRVPEVRLGGSYQTL-----KSNPWF
|||..||  ||     ....... |            .. || .....| . || |..           |. |||
LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11132.AA AktR 490-741 36 3.1e-63 216.4 In-house 10-268 (268) Show / Hide 
Range on Protein: 490-741
Range on HMM: 10-268/268
Sequence Identity: 36% (94 aa)

GQFGPVYLVKAN-YDKNLYALKSFNKVQISEQSLEKYICQEKVVLE-IVNFPFIIQYARSFKDSFDVYFLVEYVKGIELFDVIRDIGLLNTYDSQFYVAS
| || ||||. .  .. .||.|.  |  | |. ..... .|. ..| ..|.|||..   .|..    .|. ||..| |||.... .. ..  ...|| | 
GAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQ

MILILEYLHHQ-NVIYRDMKPENIMVDENGYLKLIDLGTAKFLKGRHGLGNRTFTIIGTPHYMAPEIICG-KGYNCYVDLWSVGICLYEFMCGMVPFGEE
..| ||||| . |.||||.|||||. ||.|..|..| | .| .. .|    .. .. |||.|||||.|   ||.|  ||.|..|| .|| . |. ||  .
ILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDE-KAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHK

AEDPYEIYEDIIK-KEINYPSYLKDKKAKKLMD-QLLSRVPEVRLG-G--SYQTLKSNPWF
      ....|.  ....||||.  ...|.|   .|| . |. ||| .  . . .|| |||
NQNQMFQKIKIKQQNKFPYPSYF-SSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 11132.AA Akt 492-741 34 3.2e-58 184.66 In-house 12-264 (264) Show / Hide 
Range on Protein: 492-741
Range on HMM: 12-264/264
Sequence Identity: 34% (90 aa)

FGPVYLVKANYDKNLY-ALKSFNKVQISEQSLEKYICQEKVVLEIVNFPFIIQYARSFKDSFDVYFLVEYVKGIELFDVIRDIGLLNTYDSQFYVASMIL
|| |.||| . ....| |.|.  | .| ..   ... .|. .|. .|.|||..   || ..   ||  .|..| |||  ..  .  .     ||.| .||
FGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIIL

ILEYLHHQNVIYRD-MKPENIMVDENGYLKLIDLGTAKFL-KGRHGLGNRTFTIIGTPHYMAPEIICGKGYNCYVDLWS-VGICLYEFMCGMVPFGEEAE
 .|.||..|.|||| .|||||..|..|...| | | .|   . .|    .| |. ||| |.||||. |.|.   || |. .|. .||.|||. || .  .
AIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDH---DKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYN--Q

DPYEIYEDIIKKEINYP--SYLKDKKAKKLMDQLLSRVPEVRLG---GSYQTLKSNPWF
|  . .. |  .....|  ... ....| |  .||.. |. |||   .  | .|. |||
DHHQMFKKIKNQPVKFPDKDWI-SPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 11132.AA SGK 490-741 32 9.8e-57 173.51 In-house 10-283 (283) Show / Hide 
Range on Protein: 490-741
Range on HMM: 10-283/283
Sequence Identity: 32% (90 aa)

GQFGPVYLVKANYD------------------KNLYALKSFNKVQIS-------EQSLEKYICQEK-VVLEIVNFPFIIQYARSFKDSFDVYFLVEYVKG
| || ||.||   |                  . .||.|  .| .|           ..|.|  |. |.|  .. |||..   .|      ||  .|| |
GSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLYFVMDYVNG

IELFDVIRDIGLLNTYDSQFYVASMILILEYLHHQNVIYRDMKPENIMVDENGYLKLIDLGTAK-FLKGRHGLGNRTFTIIGTPHYMAPEIICGKGYNCY
 |.|  ..  . .    . ||.|  .. ||||| |..|||| |||||. |  |...| | | .|   |      . |||. ||| |.|||.. .... . 
GEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTN----DTTFTFCGTPEYLAPEVLRKQPHDRT

VDLWSVGICLYEFMCGMVPFGEEAEDPYEIYEDIIKKEINYPSYLKDKKAKKLMDQLLSRVPEVRLGGS--YQTLKSNPWF
|| |. |. |||.| |. ||  .  .  . |. ||..... | .    .|. |. .|| . |. |||        |. |.|
VDWWCLGCVLYEMMYGLPPF--YSRNKQQMYDNIINQPLQIPPQMS-NDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 11132.AA Ciliate-E2-Unclassified 490-741 25 3.9e-53 182.63 In-house 10-352 (352) Show / Hide 
Range on Protein: 490-741
Range on HMM: 10-352/352
Sequence Identity: 25% (86 aa)

GQFGPVYLVKANYDKNLYALKSFNKVQISEQSLEKY----ICQEKVVLEI------------------VNFPFIIQYARSFKDSFDVYFLVEYVKGIELF
|.|| ||... . .| .||.|  .|.||  | . ..    . ..| . ..                   . |||. .   |.| . .|.  ||..| .|.
GGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLW

DVIRDI-----------------GLLNTYDSQ-----FYVASMILILEYLHHQN-VIYRDMKPENIMVDENG---YLKLIDLGTAKFLKGRHGLG-----
. |..                    .  . ..     || |  .. ||||||.| .|.|| |||||..|.||   |.|.||.| .|...   .       
QYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQ

-------NRTFTIIGTPHYM----APEIICGKGYN----CYVDLWSVGICLYEFMCGMVPF-GEEAEDPY-------------EIYEDIIKKEINYPSYL
       ... |..||| ||    |||...|..|.      .| ||.|..|||.. |  || ..  |. .             ..|..|..|.|..|.. 
KMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFP

K-------DKKAKKLMDQLLSRVPEVRLG--GSYQTLKSNPWF
.       ...|| .  .||.. ......   ... ..  |||
WQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 11132.AA PKG 490-698 40 6.5e-53 182.11 In-house 10-213 (260) Show / Hide 
Range on Protein: 490-698
Range on HMM: 10-213/260
Sequence Identity: 40% (85 aa)

GQFGPVYLVKANYDK-NLYALKSFNKVQISEQSLEKYICQEKVVLEIVNFPFIIQYARSFKDSFDVYFLVEYVKGIELFDVIRDIGLLNTYDSQFYVASM
| || | ||..| .|   .|||  .| .| ..  .  |  || ...  . .||..  | |.|.  ||.| |   | ||  ..|| |    . ..||.|  
GGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDKTTRFYCACV

ILILEYLHHQNVIYRDMKPENIMVDENGYLKLIDLGTAKFLKGRHGLGNRTFTIIGTPHYMAPEIICGKGYNCYVDLWSVGICLYEFMCGMVPFGEEAED
.  ..||| .|.|||| ||||.| |..||.||.| | ||..    | | .| |  ||| | |||||  ||    || |. ||  .| . |  ||  .. |
VEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKI----GQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPF--SGSD

PYEIYEDIIK
|  .|  | |
PMKTYNIILK
Kinase 11132.AA RSK 485-741 30 1e-49 171.46 In-house 1-278 (278) Show / Hide 
Range on Protein: 485-741
Range on HMM: 1-278/278
Sequence Identity: 30% (86 aa)

KKTA-FGQFGPVYLVKAN---YDKNLYALKSFNKVQISEQSL-EKYICQEKVVLEIVN-FPFIIQYARSFKDSFDVYFLVEYVKGIELFDVIRDIGL---
 | .  | .| |.|..       . .|| |  .|  |       ..  .|  .|| ..  |||...  .|..   .|   ||..| |||. ..  .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LNTYDSQFYVASMILILEYLHHQNVIYRDMKPENIMVDE---NGYLKLIDLGTAKFLKGRHGLGNRTFTIIGTPHYMAPEIIC----GKGYNCYVDLWSV
.   . .|| |  .| .|.|| | .|.|| |||||. |.   .| .||.| | .| .  |   ...| | ..| .|||||..     ..|..  .|.|| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GICLYEFMCGMVPFGE-EAEDPYEIYEDIIKKE--INYP--SYLKDKKAKKLMDQLLSRVPEVRLG---GSYQTLKSNPWF
|. .||   | .||   . ... || . | |..   . |  .||  . || |  ..| | |. |||   .  . .|..|||
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL-SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 11132.AA Pkinase 490-741 26 8.9e-49 173.16 Pfam 10-293 (293) Show / Hide 
Range on Protein: 490-741
Range on HMM: 10-293/293
Sequence Identity: 26% (78 aa)

GQFGPVYLVKANYDKNLYALKSFNKVQISEQSLEKYIC-QEKVVLEIVNFPFIIQYARSFKDSFDVYFLVEYVKGI----ELFDVIR--DIGLL--NTYD
| || ||. .   .  ..|.| ..|. .... ..  .  .|  ..  .| |.|... ..| |. ..|.  ||. |     .|||.|.  . | .     .
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWE

SQFYVASMILILEYLHHQNVIYRDMKPENIMVDENGYL----KLIDLGTAKFLKGRHGLGNRTFTIIGTPHYMAPEIIC-GKGYNCYVDLWSVGICLYEF
 .||.  ..  |||.| ...|.||.|||||..|.||..    |..| | ||...  .  .  . |. |||.|||||.|  |..|   || ||.|. |||.
CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

MCGMVPFGEE----AEDPYEIYEDIIKKEINYPSYLKD--------------------KKAKKLMDQLLSRVPEVRLGGSYQTLKSNPWF
.||  || ..      |...... | .... .... ..                    . .|.... .| . |. |..   . ..  |||
LCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF
Kinase 11132.AA TyrKc 482-735 18 1.1e-08 -82.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 482-735
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

QQFKKTAF-GQFGPVYLVKANYDKNLYALKSFNKVQISEQSLEKYICQEKVVLEIV--NFPFIIQ-YARSFKDS------FDVYFLVEYVKGIELFDVIR
 ...|.   |.|| ||. ...      | |. ..        .. ...|  ..  .  . | |.. |.   ...        .. ..||...  | | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DIGLLNTYDSQFYVASMILI-LEYLHHQNVIYRDMKPENIMVDENGYLKLIDLGTAKFLKGR------HGLGNRTFTIIGTP----HYMAPEIICGKGYN
. .   . .   . .  |    ||||..|.| ||    |..|.||.  |  | | .....        .     . .  |        |||| |  . ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

CYVDLWSVGICLYE-FMCGMVPFGEEAE---DPYEIYEDIIKKEINYPSYL--------KDKKAKKLMDQLLSRVPEVR-----LGGSYQTL
   | || |.|..| |  |. |  ....   ...|..|.. . .   .             ..  ..| |   . || |     .   .. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF