Gene 5330 (Tetrahymena)

5330

Species: Tetrahymena
Alias: PreTt05330, 5330, TTHERM_00351160, 36.m00294, 3703.m00155, 481
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AGC-Sar
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
5330.AA Protein None 892 None Fasta, JSON
5330.NA RNA None 2679 None Fasta, JSON
5330.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of 5330.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP_binding 5330.AA cNMP_binding 214-292 34 3.7e-16 58.09 Pfam 8-91 (91) Show / Hide 
Range on Protein: 214-292
Range on HMM: 8-91/91
Sequence Identity: 34% (29 aa)

EYIFKQGDAASTYFIIEKGECFVEINGEVKK-----KLNMGDAFGELALLYGA-PRSASVKADGICGLWGIDRSTFRKAVEEIVR
|.||.|||...  .|...|.. |.  .|  .      |  || |||.||...  ||.|.|.| . | .| |.|..||. ...   
EVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 5330.AA cNMP 190-302 27 9.3e-13 49.63 SMART 1-123 (123) Show / Hide 
Range on Protein: 190-302
Range on HMM: 1-123/123
Sequence Identity: 27% (34 aa)

VFSLLNEVNRDKVIGKMFY-CENSEEYIFKQGDAASTYFIIEKGECFVEIN---------GEVKKKLNMGDAFGELALLYGAPRSASVKAD-GICGLWGI
.|. |.|  . ... .|.       ||||.|||.... .||..|.  |            . . . |. || |||||||  .||.|...|    | .| |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRSTFRKAVEEIVRTEFEENRNFI
|.  |. ..... .   .. ....
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 5330.AA cNMP_binding 325-413 29 1e-20 73.78 Pfam 1-91 (91) Show / Hide 
Range on Protein: 325-413
Range on HMM: 1-91/91
Sequence Identity: 29% (27 aa)

TQVFKKGDCIVNEGDMASSYYIIKKGKVGIFQGNNEKP---IRTMGPEDSFGEQALYENS-KRGATVKALDDEVRCIALGRDTIQKVLGDKIQ
.. .|||. |. .|| ... ||...||| ... . .     ....|| | ||| || .|. .| |||.|  ....|... |....... .  .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQQHPE
CNMP 5330.AA cNMP 307-423 19 3e-15 57.9 SMART 1-123 (123) Show / Hide 
Range on Protein: 307-423
Range on HMM: 1-123/123
Sequence Identity: 19% (24 aa)

FFTTMTTAQKDAITNVLITQVFKKGDCIVNEGDMASSYYIIKKGKVGIFQG-------NNEKPIRTMGPEDSFGEQALYENSKRGATVKALDDEVRCIAL
.|.... ..  .. ... ......|..|. .|| ... ||| .|.| ...         .|. ....|| |.||| ||  .. | |...|.   ...  .
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

GRDTIQKVLGDKIQVVMYNNVMRW
 .. ..  |..  |  ...   . 
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 5330.AA cNMP_binding 448-534 20 0.001437 14.84 Pfam 1-91 (91) Show / Hide 
Range on Protein: 448-534
Range on HMM: 1-91/91
Sequence Identity: 20% (19 aa)

QIQYKKGDLIFKKEQPCKKLIFVLES--CLVNKSNQKK-----VVDKGHAFGEQWLFEQNKNKVLDDDLIMEDKGLLGEISHEQLVECIGGPIE
 ..||||. ||.. .||  . .||.    ..  . . .     .. .|  |||  ||...       . . ..   . .|..|.. ...    |
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQ--NPRTATVVALTDCECWRIPREDFRQLMQQHPE
Kinase 5330.AA Ciliate-E2b 568-825 65 2.2e-202 620.47 In-house 1-272 (272) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-272/272
Sequence Identity: 65% (178 aa)

MIYIKKLGFGQFGSVYLVKN-KHDSQFYALKVIQKAQVIQQNLEKHLIQEKKVLEVAQFPFMMKFIKTFKDNQNVYFLLEYVKGMELFDVIREIG--LLN
||||||||||||||||||.| |...|.||.|.|.|.|.||||.|||..|||.|||....||.||||..|||.|..||..|...||||||||||||  ||.
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

TYDSQFYIASLLLNIEYLHTNSIIYRDIKPENIIIDYKGYMKLIDMGTAKFLKGSSG---KTFTIIGTPHYMAPEILT-----GAGYTYSVDLWSIGICL
||||||||||..|..||||...|||||||||||..|.|||||||||||||.......   .|||||||||||||||..     | ||||.||.||.||||
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

YEFMCGGVPFAEDVEDPYEIYEDIIHK--NLDFPSFLKDKLA-KNIMNQLLNKQPQLRLGGSFAALKANQWF
||||||.||.||||.||||||..||.|  ...|||..|||.| |..|.|.|.|.|..|||||...||...||
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 5330.AA AGC 568-825 24 1.1e-104 271.0 In-house 1-395 (395) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-395/395
Sequence Identity: 24% (98 aa)

MIYIKKLGFGQFGSVYLVKNKH-----DS-QFYALKVIQKAQ-VIQQN--LEKHLIQE------------KKVLEVAQ----------FPFMMK-FIKTF
   .| .| | || ||||. |.     |. ..||.||..|.  ... .   ..| . |            ...|| ..           ||  |    .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDNQN--VYFLLEYVK----------GMELFDVIR---EIGLLNTYDSQFYIAS-------LLLNIEYLHT-NSIIYRD-IKPENIIIDYKGYMKLIDMG
.|...  .||..||..          |.|||  ..     | ..   ..||.|        ..| .||||  . ||.|| .||||| .| .|. || | |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKFLKGSS--------------------------------------------------GKTFTIIG--TPHYMAPEILTGAGYTYSVDLWS--IGICLY
 .| ....                                                    .| |. |  ||.|||||||    |....| ||   |...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFMCGGVPFAE-DVE-------DPYEIYEDII------HKNLDFP----------SFLKDKLAKNIMNQLLNKQPQLRLG--GS------FAALKANQWF
|...|  ||   ...       .|.|... |.      .... ||          ... .. ||.....||.| |  |||  |.      .  .|.  ||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWF-SPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 5330.AA Ciliate-E2 568-825 26 1.4e-90 307.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-365/365
Sequence Identity: 26% (101 aa)

MIYIKKLGFGQFGSVYLVKN-----------------------KHDSQFYALKVIQKAQVIQQNLEKHLI----------QEKKVLEVAQFPFMMKFIKT
 . |||.|.|.|||||..|.                       | ....||.|...| |..|.. |.|..          .||..||  ..|. .|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DNQNVYFLLEYVKGMELFD-------------------VIREIGLLNTYDSQ-------FYIASLLLNIEYLHTNS-IIYRDIKPENIIIDYKGYM
|.  |..|.|. .||..|..|||                   ...||. . ..  |       ||||...| .|||| .  ||.||||||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLIDMGTAKFLKGSSG-------------------------------KTFTIIGTPHYMAPEILTGAG---------YTYSVDLWSIGICLYEFMCGGVP
|.||.|..|... ..                                 ..||.|||.||||||| | .         |.|..|.||.|..|||...|  |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FAEDVEDPYEIYEDIIHK-NLDFP----------------SFLKDKLA-KNIMNQ----LLNKQPQLRLGGSFAALKANQWF
|           ...|.. ..|||                |..|  .  |.....    .|.|.|. |.. ..  .. ..||
F-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-GWEQILNHPWF
Kinase 5330.AA PKA 568-825 36 1.6e-78 267.22 In-house 1-263 (263) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-263/263
Sequence Identity: 36% (97 aa)

MIYIKKLGFGQFGSVYLVKNKHDSQFYALKVIQKAQVIQQNLEKHLIQEKKVLEVAQFPFMM-KFIKTFKDNQNVYFLLEYVKGMELFDVIREIGLLNTY
   |. || | || |.|...||. ..||.|.. |..... . . | . ||..|   ..||   | . ||.|... |...||| | |.|. .|  | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DSQFYIA-SLLLNIEYLHTNSIIYRDIKPENIIIDYKGYMKLIDMGTAKFLKGSSGKTFTIIGTPHYMAPEILTGA-GYTYSVDLWSIGICLYEFMCGGV
...||.|    | .||||.  ||||| ||||| || .|. |. | | || ...    |.|. ||| |.||||...  |.  ||| |. ||  ||.. |  
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFAEDVEDPYEIYEDIIHKNLDFPSFLKDKL--AKNIMNQLLNKQPQLRLGGSFA---ALKANQWF
|| ..  || .||| |.   ..||...  ..   |   ..||.. .  |.|   .     |   ||
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 5330.AA S_TKc 568-825 29 3.1e-73 250.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

MIYIKKLGFGQFGSVYLVKNKHDSQFYALKVIQKAQVIQQNLEKHLIQEKKVLEVAQFPFMMKFIKTFKDNQNVYFLLEYVKG--MELFDVIREIGL---
   ..|.| | ||.||....|.. . .|.|.|           .|...| ..|.  . |.  |.. .| | ...|. .||. |   .|||.|.. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNTYDSQFYIASLLLNIEYLHTNSIIYRDIKPENIIIDYKGYMKLIDMGTAKFLKGSSGKTFTIIGTPHYMAPEILTGAGYTY-SVDLWSIGICLYE
   ..  . .||.. ... .||.| . ||.||.||||| .|     |..| | |..|        |..|||.|||||.|   ||.. ..| ||.|..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

FMCGGVPFAEDVEDPYEIYEDIIHKNLDFPSFLKDKLAKNIMNQLLNKQPQLRLGGSFAAL-----KANQWF
..||  ||     ....... |            .. ||......|.| |. |..   |       |. .||
MLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5330.AA AktR 569-825 35 6.3e-68 231.98 In-house 2-268 (268) Show / Hide 
Range on Protein: 569-825
Range on HMM: 2-268/268
Sequence Identity: 35% (95 aa)

IYIKKLGFGQFGSVYLVKNK-HDSQFYALKVIQKAQVIQQNLEKHLIQEKKVLE-VAQFPFMMKFIKTFKDNQNVYFLLEYVKGMELFDVIREIGLLNTY
 ..| || | || ||||. |  . ..||.|.| |   |..|...|.|.|....|  ...||. |. ..|... . .|..||..| |||.... .. ..  
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

DSQFYIASLLLNIEYLHTN-SIIYRDIKPENIIIDYKGYMKLIDMGTAK--FLKGSSGKTFTIIGTPHYMAPEILTG-AGYTYSVDLWSIGICLYEFMCG
...||.|  || .|||| .  |||||.||||| .|  |. |..| | .|  | .  . |. .. |||.|||||..|   |...|||.|..|| .|| . |
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTG

GVPFAEDVEDPYEIYEDIIHKNLDFPSFLKD-KLAKNIMN-QLLNKQPQLRLG-G--SFAALKANQWF
  ||  .      ....|.  .. ||   .  . .|.. . .||.| |. ||| .  ..  .|   ||
CPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 5330.AA SGK 569-825 32 8.2e-67 205.2 In-house 2-283 (283) Show / Hide 
Range on Protein: 569-825
Range on HMM: 2-283/283
Sequence Identity: 32% (94 aa)

IYIKKLGFGQFGSVYLVKNKHD------------------SQFYALKVIQKAQVI-------QQNLEKHLIQEK-KVLEVAQFPFMMKFIKTFKDNQNVY
...|..| | || ||.|| | |                   .|||.||.||...|       . ...||   |. ..|     ||  .    |   .  |
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

FLLEYVKGMELFDVIREIGLLNTYDSQFYIASLLLNIEYLHTNSIIYRDIKPENIIIDYKGYMKLIDMGTAKFLKGSSGKTFTIIGTPHYMAPEILTGAG
| ..|| | |.|  ..  . .    . || | . . .||||   ||||| |||||  | .|. .| | | .|     . .|||. ||| |.|||.| ...
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQP

YTYSVDLWSIGICLYEFMCGGVPFAEDVEDPYEIYEDIIHKNLDFPSFLKDKLAKNIMNQLLNKQPQLRLGGS--FAALKANQWF
.  .|| |..|. |||.| |  ||     .  . |. ||.. | .| .   . |. ....||.| |. |||    |.  |  ..|
HDRTVDWWCLGCVLYEMMYGLPPFYS--RNKQQMYDNIINQPLQIPPQMSND-AWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 5330.AA RSK 571-825 31 1.3e-66 227.64 In-house 1-278 (278) Show / Hide 
Range on Protein: 571-825
Range on HMM: 1-278/278
Sequence Identity: 31% (89 aa)

IKKLGFGQFGSVYLVKNK---HDSQFYALKVIQKAQVIQQNL-EKHLIQEKKVLEVAQ-FPFMMKFIKTFKDNQNVYFLLEYVKGMELFDVIREIGL---
.| || | .|.|.|.. .      | || ||..|| ..| .   .|  .| ..||  |  ||  .   .|.... .|  .||..| |||. ... .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LNTYDSQFYIASLLLNIEYLHTNSIIYRDIKPENIIIDY---KGYMKLIDMGTAKFLKGS-SGKTFTIIGTPHYMAPEILT----GAGYTYSVDLWSIGI
.   . .||.| . | .|.||.  ||.||.|||||. |     |  ||.| | .| .. . ...| | ..| .|||||.|.    . |.. ..|.|| |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

CLYEFMCGGVPFAE--DVEDPYEIYEDIIHKN--LDFP--SFLKDKLAKNIMNQLLNKQPQLRLG---GSFAALKANQWF
 .||   | .||.   | ... || . | ...  |..|  ..|  . ||.. ...| . |. |||   .  . .|...||
LMYEMLTGCPPFQGPND-NNRKEIMKRIQKGKFSLTMPNWQYL-SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 5330.AA Pkinase 568-825 27 1.3e-62 219.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

MIYIKKLGFGQFGSVYLVKNKHDSQFYALKVIQKAQVIQQNLEKHLI-QEKKVLEVAQFPFMMKFIKTFKDNQNVYFLLEYVKGM----ELFDVIR--EI
   ..|.| | ||.||. ..| ... .|.|.| |     . .. |.  .| ...   . |.  ... .| |....|. .||. |     .|||.|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GLL--NTYDSQFYIASLLLNIEYLHTNSIIYRDIKPENIIIDYKGYM----KLIDMGTAKFL-KGSSGKTFTIIGTPHYMAPEILT-GAGYTYSVDLWSI
| .     . .||.  .|  .||.| ..||.||.||||| || .|.     |..| | ||..   ... . |. |||.|||||..  | .|...|| ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GICLYEFMCGGVPFA-E----DVEDPYEIYEDIIHKNLDFPSFLKD--------------------KLAKNIMNQLLNKQPQLRLGGSFAALKANQWF
|. |||..||  ||  .    .  |...... | .. |.|... ..                    . .| ... .|.| |. |..  .. ..   ||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF
Kinase 5330.AA Ciliate-E2-Unclassified 569-825 28 4.9e-62 212.42 In-house 2-352 (352) Show / Hide 
Range on Protein: 569-825
Range on HMM: 2-352/352
Sequence Identity: 28% (99 aa)

IYIKKLGFGQFGSVYLVKNKHDSQFYALKVIQKAQVIQQNLEKHL---------IQEKK-------------VLEVAQFPFMMKFIKTFKDNQNVYFLLE
. ||..| |.||.||....| . |.||.| . |.|.. |.. ..          ...||              |   . || .|.. .|.| ||.|. .|
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YVKGMELFDVIREI-----------------GLLNTYDSQ-----FYIASLLLNIEYLHTNS-IIYRDIKPENIIIDYKG---YMKLIDMGTAKFLKGSS
|..| .|.. |..                    .  . ..     ||.| .|. .|||| .  ||.||||||||..| .|   | |.|| | .|... ..
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

GK---------------TFTIIGTPHYM----APEILTGAGYT----YSVDLWSIGICLYEFMCGGVPF-AEDVEDPY-------------EIYEDIIHK
..               . |..||| ||    |||.| | .|     |..| || |..|||.. |  || ... |. .             ..|..|. |
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

NLDFPSFLK-------DKLAKNIMN----QLLNKQPQLRLGGSFAALKANQWF
|..||.| .       .. ||.. |    ..|.|.|  |.  .|  ..  .||
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI--TFEQILNHPWF
Kinase 5330.AA PKG 568-825 35 8.4e-61 208.32 In-house 1-260 (260) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-260/260
Sequence Identity: 35% (94 aa)

MIYIKKLGFGQFGSVYLVKNKHD-SQFYALKVIQKAQVIQQNLEKHLIQEKKVLEVAQFPFMMKFIKTFKDNQNVYFLLEYVKGMELFDVIREIGLLNTY
.  |  || | || | ||. .|. |. .|||...|.... .  . | . ||.... .. .|  .  .||.|.  ||.|.|   | ||  ..|. |    .
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

DSQFYIASLLLNIEYLHTNSIIYRDIKPENIIIDYKGYMKLIDMGTAKFLKGSSGKTFTIIGTPHYMAPEILTGAGYTYSVDLWSIGICLYEFMCGGVPF
 ..||.|  .   .|||   ||||| ||||.. | .||.||.| | ||.. |...|| |  ||| | ||||    |   ||| |. ||  .| . |  ||
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKI-GQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPF

AEDVEDPYEIYEDIIH--KNLDFPSFLKDKLAKNIMNQLLNKQPQLRLGGS---FAALKANQWF
     ||  .|  |      ..||..   . |.|.. .|   .|  |||      .  |  .||
S--GSDPMKTYNIILKGIDMWEFPRKIT-RWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase 5330.AA Delta 568-825 31 3.2e-57 196.42 In-house 1-259 (259) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-259/259
Sequence Identity: 31% (82 aa)

MIYIKKLGFGQFGSVYLVKNKHDSQFYALKVIQKAQVIQQNLEKHLIQEKKVLEVA-QFPFMMKFIKTFKDNQNVYFLLEYVKGMELFDVIREIGLLNTY
 .. | || | || | |.  |.  ..||.| ..|  |..       . |..|| .| . ||. ... ||. .....| .||. | .|   | ...  . .
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

DSQFYIASLLLNIEYLHTNSIIYRDIKPENIIIDYKGYMKLIDMGTAKFLKGSSGKTFTIIGTPHYMAPEILTGAGYTYSVDLWSIGICLYEFMCGGVPF
 ..|| . ... ...||.. |||||.| .|...|. | .|. | | .|      .|. |  ||| |.||||. |  |. ||| || |. .|| . |  ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

AEDVEDPYEIYEDIIHKNLDFPSFLKDKLAKNIMNQLLNKQPQLRLGG---SFAALKANQWF
  . ||  |... |.. .  .| ... | ||.....|....|. |||        ... ..|
HGEDED--ELFWSICNDRPWYPRWIT-KEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase 5330.AA TyrKc 568-825 19 2.7e-11 -39.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 568-825
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

MIYIKKLGFGQFGSVYLVKNKHDSQFYALKVIQKAQVIQQNLEKHLIQEKKVLEVA--QFPFMMKFIKTFKDN-------QNVYFLLEYVKGMELFDVIR
   .|||| |.|| ||. . |   .  | |....        .. ...| ...     . |   ...    .        . .. ..||...  | | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EIGLLNTYDSQFYIASLLLNI----EYLHTNSIIYRDIKPENIIIDYKGYMKLIDMGTAKFLKGS-----SGKTFTI---IGTP-----HYMAPEILTGA
. .      .     |  . |    |||| . .| ||.   |. .. .. .|  | | .....       |... .     |.        |||| .   
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYTYSVDLWSIGICLYE-FMCGGVPFAEDVE---DPYEIYEDIIHKNLDFPSFL---------KDKLAKNIMNQLLNKQPQLRLGGSFAALKANQWF
 .|   | || |.|..| |  |. |  ....   ...|..|.. . .   .             |.. . || |  . .|  |   .|...   . |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRP--TFSEI--HECF