Gene 19629 (Tetrahymena)

19629

Species: Tetrahymena
Alias: 19629, PreTt19629, TTHERM_00486980, 661, 3680.m00124, 59.m00267
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2c

Sequence

Name Sequence Type Origin Length Description Download
19629.AA Protein None 5247 None Fasta, JSON
19629.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
19629.NA RNA None 31488 None Fasta, JSON

Protein domain

Protein domains of 19629.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19629.AA Ciliate-E2c 20-280 41 4.4e-162 544.77 In-house 1-310 (310) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-310/310
Sequence Identity: 41% (128 aa)

INLDNMVGKGSYGKVYLAYNCEDYQNQQLN---------NPICAKEIPRGLISDKIVK-SIRNEAQIQMSSKSPRVLKMYSFKQTKSNVYFFLEYCPDGD
|. .|..|.|||||||.||.||||||...|         ...|.|......|..|..| ||..|.........|...|.|..|||....|...|||..|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LKQLIYNS-NLTEKQIIYLFGQIAQALNELKDE-RVYHRDLKPENILIKDGGIKIADFGFSKIVTEFTKNNTQ-----VGTPLYMSPQALSSSYYDLEKN
|.|.||.. ...|||..|.|.||..|...|..| ...|||.|||||||..|.|||||||||||.......|||     .|||.||.||.|....|..||.
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DVWSAGCLLYEMVYKKLPWK---------------VNIDTSVGGLFQIIS---------------TGNINFPKE--VNVSQELKELINLMLEVDEEGRLD
|.||.|..||.|...||||.               .........|.|.|.               |.||.||..  .|.|||.|.||..||.||||.|.|
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WDDIINKEII
||.|.|.|.|
WDEIFNHECI
Kinase 19629.AA Ciliate-E2 20-280 25 2.8e-82 279.67 In-house 1-365 (365) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-365/365
Sequence Identity: 25% (95 aa)

INLDNMVGKGSYGKVYLAYNCEDYQNQ-----------------QLNNPICAKEI-PRGLISDKIVKSIR----------NEAQIQMSSKSPRVLKMYSF
... .. |.|..|.||.. . .. ...                 . .. .  | . ...... | ...|           || .|. . ..| ..||| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KQ--TKSNVYFFLEYCPDGDLKQLIYNS------------NLTEKQIIYLFGQIAQ---------------ALNELKDER-VYHRDLKPENILIKDGGIK
 |  ...|.|. .|||  |||...|.|.            ..|||.|.|.. ||.|               ||..|. .  . |||.||||||.    ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFSKIVTEFTKNNT--------------------------------QVGTPLYMSPQALSSSYYDL--------EKNDVWSAGCLLYEMVYKKLPW
|.|||.||..... .|.|                                ..||| ||.|. |..  ||         .| |.||.|..||||...|.|.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

KVNIDTSVGGLFQIISTGNINFP----------------KEVNVSQELKELINL----MLEVDEEGRLD-WDDIINKEII
           .|.|  ..|.||                .  ..||| | ||.     ||..|.| |.. |..|.| ...
-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19629.AA ULK 20-280 30 1.8e-79 270.32 In-house 1-329 (329) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-329/329
Sequence Identity: 30% (100 aa)

INLDNMVGKGSYGKVYLAYNCEDYQNQQLNNPICAKEIPRGLISDKIVK--------SIRNEAQIQMSSKSPR--------VLKMYSFKQTK--SNVYFF
..|... ||||.|||| ..| ..    . |  . .| |..  .. |           ...|| .|.   |||         . |.| ...|.   |.|..
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

LEYCPDGDLKQLIY-----------NSNLTEKQIIYLFGQIAQALNELKDERVYHRDLKPENILIKDGG-------------IKIADFGFSKIVTEFT--
.|||..|||.|.|            . .|.|...|  | ||.... || .... |||.||.||||..|              .|||||||.| |....  
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

--KNNTQV------GTPLYMSPQALS----SSYYDLEKNDVWSAGCLLYEMVYKKLPWKVNIDTSVG-----GLFQI-------ISTGNINFP---KEVN
   . |.|      ||||||.|| |.       |.  | |.|| ||..|||.| | |.. .  ..        |...       | . ...||   ....
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

VSQELKELINLMLEVDEEGRLDWDDIINKEII
.|.|.|.||  ||..||. | .|....| ...
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 19629.AA ULK 20-280 31 2.3e-79 269.96 In-house 1-324 (324) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-324/324
Sequence Identity: 31% (103 aa)

INLDNMVGKGSYG-KVYLAYNCEDYQNQQL--NNPICAKEIPRGLISDKIVK--------SIRNEAQIQMSSK---SPR--VLKMYSFKQTK--SNVYFF
..|... ||||.| ||| ..|     ...   |  . .| |..  ...|  .        ...|| ||.   |   .|   . |.| ...|.   |.|..
YCLNHCLGKGSFGVKVYKGRN-----KKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII

LEYCPDGDLKQLIYNS----------NLTEKQIIYLFGQIAQALNELKDERVYHRDLKPENILIKDGG-------------IKIADFGFSKIVTEF----
.|||..|||.|.| .           .|.|...|  | ||.... || .. . |||.||.||||..|              .|||||||.|.| .     
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

TKNNTQV------GTPLYMSPQALS----SSYYDLEKNDVWSAGCLLYEMVYKKLPWKVNIDTSVG----GLFQ-------IISTGNINFP---KEVNVS
... |.|      ||||||.|| |.       |.  | |.|| ||..|||.| | |.. .  ..       | .       .| . .|.||   |....|
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

QELKELINLMLEVDEEGRLDWDDIINKEII
.|.|.||  ||..||. | .|..|.| ...
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 19629.AA S_TKc 20-280 27 3.8e-68 233.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-231/231
Sequence Identity: 27% (77 aa)

INLDNMVGKGSYGKVYLAYNCEDYQNQQLNNPICAKEIPRGLISDKIVKSIRNEAQIQMSSKSPRVLKMYSFKQTKSNVYFFLEYCPD--GDLKQLIYNS
  . . .|||..||||.... .       .     |.|.         ..||.| || .. . | . |.| . |. ...|...|||.   |||...| . 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

N-------LTEKQIIYLFGQIAQALNELKDERVYHRDLKPENILIKDGGIKIADFGFSKIVTEFTKNNTQVGTPLYMSPQALSSSYYDLEKNDVWSAGCL
.       ..| .. ... ||..||. . . .. ||||||||||. .  |||.|||.....      .|..||| ||.|  |    |. .| |.|| ||.
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYEMVYKKLPWKVNIDTSVGGLFQIISTGNINFPKEVNVSQELKELINLMLEVDEEGRLDWDDIIN-------KEII
||||.. . |.       .  .|..|             |.|.|..|. .|..| | |.   .. .        . .
LYEMLCGYPPFP-----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19629.AA Pkinase 20-280 25 2.2e-58 205.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

INLDNMVGKGSYGKVYLAYNCEDYQNQQLNNPICAKEIPRGLISDKIVKSIRN--EAQIQMSSKSPRVLKMYSFKQTKSNVYFFLEYCPDG----DLKQL
. .   .|.||.|.||....  . .        . |.|..  ....  .. |.  |.||  . ..| ....| . ..|...|. .|||. |    ||. .
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IY---NSNL--TEKQIIYLFGQIAQALNELKDERVYHRDLKPENILIK-DGGI----KIADFGFSKI--VTEFTKNNTQVGTPLYMSPQALSSSYYDLEK
|    . ..  .|....  . ||...|. . .... |||||||||||. .| |    ||.|||..|       . ..| .||| ||.|  . .. |.  |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

NDVWSAGCLLYEMVYKKLPWKVN----IDTSVGGLFQIISTGNINFPKE-------------------VNVSQELKELINLMLEVDEEGRLDWDDIINKE
 |.||.||.||||. ...|..         .   ... |  . . |. .                   .|.|.|.|..|. .|..| . |. ...| . .
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

II
 .
WF
Kinase 19629.AA CAMK 25-276 21 1.6e-56 180.31 In-house 1-421 (425) Show / Hide 
Range on Protein: 25-276
Range on HMM: 1-421/425
Sequence Identity: 21% (91 aa)

MVGKGSYGKVYLAYNCEDYQNQQL------NNPICAKEIPRGLIS--------------------------DKIVKSIRNEAQIQMSSK-------SPRV
  |.||.|||.|... .. .....      .    .| |..  ..                          .|  |..|.| .| .. .        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKMYSFKQ------------TKSN--------VYFFL---EYCPDG----DLKQLIY-NSN---------------LTEKQIIYLFGQIAQALNELKDER
.|.| . .            | |.        .|...   |||. |    || . |  ...               .||..  ..| ||..|.. . .  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VYHRDLKPENILIKDGG------------------IKIADFGFSKIVTE------------------------FTKNNTQVGTPLYMS-PQALSS-----
. ||||||||||. | .                  |||.||||......                          | .|..||| ||. |  |..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------SYYDLEKNDVWSAGCLLYEMVYKKLPWKVN----------IDTSVGGLFQIISTGNINFPKEV----------------------NVSQELK
          |. .| |.||.|..|| |.  ..|.             |...   ||. | .|. .|| .                       .|||| |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELINLMLEVDEEGRLDWDDIIN
 ||. ||.|| | |.  ... |
DLIRKMLQVDPEKRMTIEQCLN
Kinase 19629.AA Ciliate-E2-Unclassified 20-280 25 1.7e-53 183.92 In-house 1-352 (352) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

INLDNMVGKGSYGKVYLAYNCEDY---------QNQQLNNPICAKEIPRGLISDKIVKSIR--------NEAQ-IQMSSKSPRVLKMYSFKQTKSNVYFF
 ..    |.|..||||.... ...         ..|. .  .  ... . . . |.....          ..| |  ....| ..||.  .|.| |.|. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCPDGDLKQLIYNS------------------NLTEKQII-----YLFGQIAQALNELKDE-RVYHRDLKPENILIKDGG----IKIADFGFSKIVTE
.|||..|||.| | ..                   .||.|..     ..| || |.|. |  .  . |||.||||||....|    |||.|||.||   .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

F----------------TKNNTQVGTPLYM----SPQALSS-SYYDL--EKNDVWSAGCLLYEMVYKKLPWKVNIDTS--------VGG------LFQII
.                 . .|..||| ||    .|  | .  |..   .| |.|| |..||||.. ..| . | ...        . .      |.|.|
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNI

STGNINFPKEVN------VSQELKELIN----LMLEVDEEGRLDWDDIINKEII
  .||.|||. .      .|.| |..||     ||... . |.....|.|  ..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19629.AA CAMKL 27-276 30 9.7e-52 163.32 In-house 8-293 (297) Show / Hide 
Range on Protein: 27-276
Range on HMM: 8-293/297
Sequence Identity: 30% (89 aa)

GKGSYGKVYLAYN-CEDYQNQQLNNPICAKEIPRGLIS-DKIVKS------------IRNEAQIQMSSK---SPRVLKMYSFKQTKSN------VYFFLE
||||.||| || .          .     | | .  |. | ..|.            || |.||... .    | . |.|   .|...      .| ..|
GKGSFGKVKLATHIRTT------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVME

YCPDGD--LKQLIYNSN-----LTEKQIIYLFGQIAQALNELKDERVYHRDLKPENILIKDGG---IKIADFGFSKIVTE-----FTKNNTQVGTPLYMS
||. |.  | . | .       ..|..   .| ||  |.| . . .. |||.||||||. . |   |||.||||| . ..       | .|. |.| ||.
YCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMA

PQALSS--SYYDLEKNDVWSAGCLLYEMVYKKLPWKVN-----IDTSVGGLFQIISTGNINFPKEVNVSQELKELINLMLEVDEEGRLDWDDIIN
|  ...    ||  | |.||.| .|| ||. .||..       ... .  |. .| .|  ..|. . || ... ||  ||.|. | |   ..| |
PEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase 19629.AA AGC 67-274 20 5.8e-45 113.02 In-house 52-389 (395) Show / Hide 
Range on Protein: 67-274
Range on HMM: 52-389/395
Sequence Identity: 20% (71 aa)

VKSIRNE------------AQIQMSSK----------SPRVLK-MYSFKQTKSN--VYFFLEYCP--------DGDLKQLIYNS------NLTEKQIIYL
|. . .|             .| .  .          .| . | ...  |.|..  .|| .||.|         |..  ....        ..|... . 
VEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFY

FGQ-------IAQALNELKD-ERVYHRD-LKPENILIKD-GGIKIADFGFSKIVTEF-------------------------------------------
. .       |. ||  | .   . ||| |||||||. . | ||..|||..|..                                              
AAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQE

--------TKNNTQVG--TPLYMSPQALSSSYYDLEKNDVWS--AGCLLYEMVYKKLPWKV-NID------TSVGGLFQIIS------TGNINFP-----
         ...| .|  || ||.|  |    |. .  | ||   |||.|||.. . |    | .      ..   .|| |       . .. ||     
DDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKA-CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDP

---KEVNVSQELKELINLMLEVDEEGRLD----------WDDI
   .....|.|.| ||. .|..| | ||            ..|
QFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEI
Kinase 19629.AA STE 20-280 20 6.7e-43 148.85 In-house 1-359 (359) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-359/359
Sequence Identity: 20% (74 aa)

INLDNMVGKGSYGKVYLAYNCEDY---QNQQL------NNPICAKEIP---------------RGLISDKIVKSIRNEAQIQMSSK--SPRVLKMYSFKQ
  .  ..|||..|.||.|.| ..    .....      .. .  |...                  . ......| .| .| . ..  .| . | |    
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TK-------SNVYFFLEYCPDGDLKQLIYN-----SNLT----------EKQIIYLFGQIAQA-LNELKDERVYHRDLKPENILIKDGGIKIADFGFSKI
 .       .... ..||.. | | ..| .      .|.          |.||.|   || .. |. | . .. |||.|| |||.    .|..|||....
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VTE-----------------FTKNNTQVGTPLYMSPQALSS------SYYDLEKNDVWSAGCLLYEMVYKKLPWKVNIDTSVGGLFQIIS----------
.|.                   |.|| |||| .|.|  ..       . || .| |.|| ||.. ||.  | ||    ....  .... .          
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---TGNINFPKEVN-----------------VSQELKELINLMLEVDEEGRLDWDDIIN--KEII
    .   .| ..                  .|.|.|. ||. |. | . | . .. ..   . |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19629.AA NEK 103-280 33 2.7e-38 132.63 In-house 86-286 (286) Show / Hide 
Range on Protein: 103-280
Range on HMM: 86-286/286
Sequence Identity: 33% (69 aa)

EYCP-DGDLKQL---IYNS-----NLTEKQIIYLFGQIAQALNELKDE-----RVYHRDLKPENILIK-DGG----IKIADFGFSKIVT-EFTKNNT-QV
|||   ||| |.   | .      .. |.||   | |.. ||... |.     .. |||.|| || .  ..     .|| ||| ||.   . .. .| ||
EYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQV

GTPLYMSPQALSSSYYDLEKNDVWSAGCLLYEMVYK--KLPWKVNIDTSVGGLFQIISTGNINFPK--EVN-VSQELKELINLMLEVDEEGRLDWDDIIN
||| ||||  ...  |. .| |.|| ||.||||.    | | . ..  .  .|.  |  | ...|.  . .  ||.|..||..|| .| | | . ..|..
GTPYYMSPEVCQNKPYN-NKSDIWSLGCVLYEMCTLKPKHPFEAWD-MNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILE

KEII
. .|
MPFI
Kinase 19629.AA TyrKc 20-280 20 7.8e-13 -15.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

INLDNMVGKGSYGKVYLAYNCEDYQNQQLNNPICAKEIPRGLISDKIVKSIRNEAQIQMSS--KSPRVLKMYSFKQTK-------SNVYFFLEYCPDGDL
| |. . | | .|.||..             .   | .  .      .. ...||.| ..   . | ....|    ..         ..  .||.| |||
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

KQLI-YNSN-LTEKQIIYLFGQIAQALNELKDERVYHRDLKPENILIKDGG-IKIADFGFSKIVTEF------TKNNTQ---VGTP--L---YMSPQALS
|. . .. . |. |. ..   |||.  . | . .. ||||   |.|..... .||.||| |. ...       ..  ..    |.   |    |.| .. 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

SSYYDLEKNDVWSAGCLLYEMV-YKKLPWKVNID--TSVGGLFQIISTGNINFPKEVN-------VSQELKELINLMLEVDEEGRLDWDDIINKEII
 . .  .| |||| | ...|.  | . |.   |    |   ... . .|.   . . .        ..|. ...    . | | |    .|  .|..
YGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 19629.AA AGC 20-37 50 4e-06 10.25 In-house 1-18 (395) Show / Hide 
Range on Protein: 20-37
Range on HMM: 1-18/395
Sequence Identity: 50% (9 aa)

INLDNMVGKGSYGKVYLA
 ..  ..||||.|||||.
FEFLKVIGKGSFGKVYLV
Kinase 19629.AA Pkinase_Tyr 97-166 32 0.001428 12.72 Pfam 81-156 (270) Show / Hide 
Range on Protein: 97-166
Range on HMM: 81-156/270
Sequence Identity: 32% (25 aa)

NVYFFLEYCPDGDLKQLIYNS-----NLTEKQIIYLFGQIAQALNELKDERVYHRDLKPENILIK-DGGIKIADFG
..|  .||.| |||.    .      .|| |...    |||.... | . .  ||||   |.|.. .. .||.|||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 19629.AA Pkinase_Tyr 20-38 31 0.025509 8.48 Pfam 1-19 (270) Show / Hide 
Range on Protein: 20-38
Range on HMM: 1-19/270
Sequence Identity: 31% (6 aa)

INLDNMVGKGSYGKVYLAY
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ITFGKKLGEGAFGEVYKGT
Kinase 19629.AA NEK 25-37 53 0.132934 1.89 In-house 6-18 (286) Show / Hide 
Range on Protein: 25-37
Range on HMM: 6-18/286
Sequence Identity: 53% (7 aa)

MVGKGSYGKVYLA
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KIGQGSFGKVYKV