Gene 28437 (Tetrahymena)

28437

Species: Tetrahymena
Alias: TTHERM_00158470, 1161, 13.m00396, PreTt28437, 28437, n.28437
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2c

Sequence

Name Sequence Type Origin Length Description Download
28437.AA Protein None 671 None Fasta, JSON
28437.kin_dom Protein Kinase Domain None 390 None Fasta, JSON
28437.NA RNA None 2016 None Fasta, JSON

Protein domain

Protein domains of 28437.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28437.AA Ciliate-E2c 16-296 43 4.3e-180 604.58 In-house 1-310 (310) Show / Hide 
Range on Protein: 16-296
Range on HMM: 1-310/310
Sequence Identity: 43% (136 aa)

IDRNKILGTGGFASVYLGYYAKGKSNSSEE---------MNQLFAIKEISINNEFEITNSLIREINMLRHLKNRHIIQFIDAKKTENHFYLIMEYCSEGT
||||.|||.|....||..||.....|....         .......|.|...||..|..|.||||||..|....|||.|.|||.|..|.|||||||..||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEDLVRHK-QLNEDQILTYFNQIVYALKYLYSK-KIFHRDIKPKNILLHNGEIKLVDFGLSKIIADQNINITQGFNTCVGTPQFMAPEMLKGIGWQE-KS
||....|| ..||.|.|.||.||..|.|||... .||||||||.|||.|||.||..|||.|||..|.||..|||||||.|||..|||..|.|..... ||
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DIWSLGSTLYYMIFKELPWD---------------QYSTSSMAILEQIERIFGIPQASAAGVSPPTQPVSSSPQ--INKQGEQQQILEKQISQEPSLQEN
||||||.|||||....|||.               ......|..|.|.......||||||||||.||.......  .|...|..|...|...........
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

NSNERNDPQN
.....|....
WDEIFNHECI
Kinase 28437.AA Ciliate-E2 16-405 20 5.6e-85 288.62 In-house 1-365 (365) Show / Hide 
Range on Protein: 16-405
Range on HMM: 1-365/365
Sequence Identity: 20% (101 aa)

IDRNKILGTGGFASVYLG--YYAKGKSNSSEEMNQL---------FAIKEISINNE----FEITNS---LIREIN----------MLRHLKNRHIIQFID
.. .|..|.|.|.|||..  .  . ...   .. |.         ..||.. ...      |....   ..||||          .|..|.. .||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

AKK--TENHFYLIMEYCSEGTLEDLVRHK------------QLNEDQILTYFNQIVY---------------ALKYLYSKK-IFHRDIKPKNILLHNGEI
. .  ..|..||.||||. |.|.|. ...            ...| .|.... ||..               ||.|| ||. |.|||||| |||.    |
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KLVDFGLSKIIADQNINIT---------------------------QGFNTCVGTPQFMAPEMLKGIG---------WQEKSDIWSLGSTLYYMIFKELP
|..||||||.. |.|.|.|                           . |||..||| .||||.|.| .         . .|.|||||| .||.|.|...|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

WDQYSTSSMAILEQIERIFGIPQASAAGVSPPTQPVSSSPQINKQGEQQQILEKQISQEPSLQENNSNERNDPQNQNDKKVSQNENQITQQDMQRSMLEA
.                                                                                                   
F---------------------------------------------------------------------------------------------------

SIKNQKNTIKNPHGSLDLLKDQKSNKKKVYDQIDEKLKYLLPKDKNNSE----------SIQVSEKTLRLLDS----MLQVDIEKRIG-WEELFSIPSI
                               |. .. |. .|. .....            ..|...  |.      |||.| ||||. ||...  | .
------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 28437.AA Ciliate-E2b 16-223 33 7.8e-74 223.75 In-house 1-211 (272) Show / Hide 
Range on Protein: 16-223
Range on HMM: 1-211/272
Sequence Identity: 33% (73 aa)

IDRNKILGTGGFASVYLGYYAKGKSNSSEEMNQLFAIKEISIN--NEFEITNSLIREINMLRHLKNRHIIQFIDAKKTENHFYLIMEYCSEGTLEDLVRH
..  | || | | ||||.           . .|..|.| ||.|   ..... ....|.| |. ..   |..||...|...| |..||.|... |.|..| 
MIYIKKLGFGQFGSVYLVWNT-------KNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIRE

KQ---LNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLHN-GEIKLVDFGLSKIIADQNINITQGFNTCVGTPQFMAPEMLK-----GIGWQEKSD
     |.. . . |. .|. .|.|| ...| .||||| ||.... | .||.|.|..|.. ..|  .|  | | .||| .|||| ..     | |   |.|
IGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTF-TIIGTPHYMAPEIIQSLQPGGKGYTYKVD

IWSLGSTLYYMIFKELPWD
|||.| .|| .... .||.
IWSVGICLYEFMCGYVPWA
Kinase 28437.AA ULK 16-405 21 1.2e-73 251.0 In-house 1-324 (324) Show / Hide 
Range on Protein: 16-405
Range on HMM: 1-324/324
Sequence Identity: 21% (96 aa)

IDRNKILGTGGFA-SVYLGY-YAKGKSNSSEEMNQLFAIKEIS----INNEFE-----ITNSLIREINMLRHLK------NRHIIQFIDAKKTE--NHFY
.  |..|| | |.  || |.   ...       ||..|.| |.    .... |     . ..|..||. .. ||      . ||....| ..|   |..|
YCLNHCLGKGSFGVKVYKGRNKKTNT------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIY

LIMEYCSEGTLEDLVRHKQ----------LNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLHNGE-------------IKLVDFGLSKIIAD--Q
.|||||  |.||..   ..          |.|.... .| ||. ..|.|....| |||||| |||.|||              .|. |||..|.. .  .
IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNM

NINITQGFNTCV------GTPQFMAPEMLK----GIGWQ-EKSDIWSLGSTLYYMIFKELP---WDQYSTS----SMAIL--EQIERIFGIPQASAAGVS
. ...|   |||      ||| .|||. |.    ..     |.||||||  .|.|.. . |   |  ...     ..     |                 
EQQMCQ---TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKE-----------------

PPTQPVSSSPQINKQGEQQQILEKQISQEPSLQENNSNERNDPQNQNDKKVSQNENQITQQDMQRSMLEASIKNQKNTIKNPHGSLDLLKDQKSNKKKVY
                                                                                                    
----------------------------------------------------------------------------------------------------

DQIDEKL--KYLLPKDKNNSESIQVSEKTLRLLDSMLQVDIEKRIGWEELFSIPSI
 |  . .  .  ....|.. .....|...  |.  |||.| ..|| |||.|..| .
-Q--QIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 28437.AA S_TKc 16-409 19 1.2e-72 248.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-409
Range on HMM: 1-231/231
Sequence Identity: 19% (78 aa)

IDRNKILGTGGFASVYLGYYAKGKSNSSEEMNQLFAIKEISINNEFEITNSLIREINMLRHLKNRHIIQFIDAKKTENHFYLIMEYCSE--GTLEDLVRH
 .  ...| |.|..||...  |         ....|||.|.        ....|||..|.. .  .|....|.  . .|.|..||||.   |.| |. ..
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

KQ-------LNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLHNGEIKLVDFGLSKIIADQNINITQGFNTCVGTPQFMAPEMLKGIGWQE-KSDI
..       ..| ..  |. ||. ||.|. |..| |||.|| |||| . .||. ||||....           .|..||| .||||.|   |.   |.|.
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGSTLYYMIFKELPWDQYSTSSMAILEQIERIFGIPQASAAGVSPPTQPVSSSPQINKQGEQQQILEKQISQEPSLQENNSNERNDPQNQNDKKVSQN
||.| .|| |.  . |..      ......|                                                                     
WSCGCILYEMLCGYPPFP----QMQMMFKKIG--------------------------------------------------------------------

ENQITQQDMQRSMLEASIKNQKNTIKNPHGSLDLLKDQKSNKKKVYDQIDEKLKYLLPKDKNNSESIQVSEKTLRLLDSMLQVDIEKRIGWEELFS---I
                                                                     |.  . ... .||.| |||..  |..     
---------------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

PSIHEFL
  .|...
IKCHPWF
Kinase 28437.AA ULK 16-405 21 5.6e-71 242.11 In-house 1-329 (329) Show / Hide 
Range on Protein: 16-405
Range on HMM: 1-329/329
Sequence Identity: 21% (96 aa)

IDRNKILGTGGFASVYLGYYAKGK---SNSSEEMNQLFAIKEIS----INNEFE-----ITNSLIREINMLRHLK--------NRHIIQFIDAKKTE--N
.  |..|| | |.     .. ||.   .. . . |...|.| |.    .... |     . ..|..||  .. ||        . .|....| ..|   |
YCLNHCLGKGSFG-----KVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHN

HFYLIMEYCSEGTLEDLVRHKQ-----------LNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLHNGE-------------IKLVDFGLSKIIA
..|.|||||  |.||..   ..           |.|.... .| ||. ..|.|....| |||||| |||.|||              .|. |||..| . 
NIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD

DQ--NINITQGFNTCV------GTPQFMAPEMLK----GIGWQ-EKSDIWSLGSTLYYMIFKELP---WDQYSTSSMAILEQIERIFGIPQASAAGVSPP
.   ......   |||      ||| .|||. |.    ..     |.||||||  .|.|.. . |   |  ...  . | . |.  . .||         
NDNMEQQMMM---TCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQ---------

TQPVSSSPQINKQGEQQQILEKQISQEPSLQENNSNERNDPQNQNDKKVSQNENQITQQDMQRSMLEASIKNQKNTIKNPHGSLDLLKDQKSNKKKVYDQ
                                                                                                    
----------------------------------------------------------------------------------------------------

IDEKLKYLLPKDKNNSESIQVSEKTLRLLDSMLQVDIEKRIGWEELFSIPSI
   . |   .. ... ...|.|...  |.  |||.| ..|| |||||..| .
---QIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 28437.AA Pkinase 16-405 19 3e-65 227.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-405
Range on HMM: 1-293/293
Sequence Identity: 19% (81 aa)

IDRNKILGTGGFASVYLGYYAKGKSNSSEEMNQLFAIKEISINNEFEITN-SLIR--EINMLRHLKNRHIIQFIDAKKTENHFYLIMEYCSEG----TLE
. . ...| |.|..||...  .           ..|.|.|.  .| .  . ...|  || ....|.  .|....|.  ...| |..||||  |     | 
YHIGRKIGSGSFGCVYKCHHKGTGK--------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

DLVR---HKQL--NEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLH-NGEI----KLVDFGLSKIIADQNINITQGFNTCVGTPQFMAPEMLK-GI
|...   |. .   |...  |. ||. .|.|..|..| |||.|| |||.. ||.|    |. ||||.| .    .   . ..| .||| .|||| .. | 
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQ

GWQEKSDIWSLGSTLYYMIFKELPWDQYSTSSMAILEQIERIFGIPQASAAGVSPPTQPVSSSPQINKQGEQQQILEKQISQEPSLQENNSNERNDPQNQ
..  |.|.||.| .||.|.....|...    .   ..|...|. | ..     .| . ..| .. ..                                 
YYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------------------

NDKKVSQNENQITQQDMQRSMLEASIKNQKNTIKNPHGSLDLLKDQKSNKKKVYDQIDEKLKYLLPKDKNNSESIQVSEKTLRLLDSMLQVDIEKRIGWE
                                                                    . ... . .||  . .....|..| .||...|
--------------------------------------------------------------------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELFSIPSI
...  | .
QILQHPWF
Kinase 28437.AA Ciliate-E2-Unclassified 16-405 21 1.9e-64 220.42 In-house 1-352 (352) Show / Hide 
Range on Protein: 16-405
Range on HMM: 1-352/352
Sequence Identity: 21% (96 aa)

IDRNKILGTGGFASVYLGYYAKGKSNS--SEEMNQLFAIKEISINNEFEITNSLIREIN---------------MLRHLKNRHIIQFIDAKKTENHFYLI
   .|..|.|||..||. .  | |      ..|..   .|  .|.|. || |..... |                |..... .|. ...........|..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCSEGTLEDLVRH------------------KQLNEDQIL-----TYFNQIVYALKYLYSKK-IFHRDIKPKNILLHNG----EIKLVDFGLSKIIAD
||||  |.|..  ..                  |.. | |..     .|| ||. .|.|| .|. | |||||| |||..|.    .||. |||.|| . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

QN-----------INITQGFNTCVGTPQFM----APEMLKGIGWQ----EKSDIWSLGSTLYYMIFKELPWDQYSTSS--MAILEQIERIFGIPQASAAG
.|           |.. | ..|..|||..|    |||.|.| .      .|.||||||  ||.|.| ..| ....  .    | ..|  ..         
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNA---------

VSPPTQPVSSSPQINKQGEQQQILEKQISQEPSLQENNSNERNDPQNQNDKKVSQNENQITQQDMQRSMLEASIKNQKNTIKNPHGSLDLLKDQKSNKKK
               ..  .|.|..|.|.. .. . .                                                               
--------------YRKQLYQNIKQKNIQFPKFPWQQ---------------------------------------------------------------

VYDQIDEKLKYLLPKDKNNSESIQVSEKTLRLLDSMLQVDIEKRIGWEELFSIPSI
. ...... | ..                 .|| .||.....|||..|...  | .
IPKHWSPEAKDFIN----------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 28437.AA STE 16-405 18 2.9e-60 206.5 In-house 1-359 (359) Show / Hide 
Range on Protein: 16-405
Range on HMM: 1-359/359
Sequence Identity: 18% (90 aa)

IDRNKILGTGGFASVYLGYYAK---GKSNSSEE-----MNQLFAIKEISINNE----------------FEITNSLIREINMLRHLK--NRHIIQFIDAK
 .. ...| |.| .||.... |   .   . |.     .....|||.....|.                 |. .....||.......    .|...... 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

KTE-------NHFYLIMEYCSEGTLEDLVRHK-----QLN----------EDQILTYFNQIVYA-LKYLYSKKIFHRDIKPKNILLHNGEIKLVDFGLSK
  |       .. ...|||.. |.|.|...||     .||          |.|| ..  ||. . |.|| |..| |||||| ||||    .||.|||...
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

IIADQNINI----------TQG--FNTCVGTPQFMAPEMLKG------IGWQEKSDIWSLGSTLYYMIFKELPW---DQYSTSSMAILE-----QIERIF
...| . ||          |..   ||.|||| .||||....       |  .|.|||||| |.  |.  . ||      .   |.. .     |     
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ-----

GIPQASAAGVSPPTQPVSSSPQINKQGEQQQILEKQISQEPSLQENNSNERNDPQNQNDKKVSQNENQITQQDMQRSMLEASIKNQKNTIKNPHGSLDLL
                                                                                                    
----------------------------------------------------------------------------------------------------

KDQKSNKKKVYDQIDEKLKYLLPKDKNNSE--------------SIQVSEKTLRLLDSMLQVDIEKRIGWEELFS--IPSI
           .|.   ..   |. ... .              . ..|..    ..  || | .||   ..| .   | |
----------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 28437.AA CAMK 21-223 21 2.3e-59 189.62 In-house 1-335 (425) Show / Hide 
Range on Protein: 21-223
Range on HMM: 1-335/425
Sequence Identity: 21% (73 aa)

ILGTGGFASVYLGYYAKGKS------NSSEEMNQLFAIKEISINNEFE---------------------------ITNSLIREINMLRH-------LKNR
.||.|.|. |.|..  . .         ... .| .||| |. .   .                              .. |||.....       |. .
TLGRGSFGKVKLCIHKNTTGKERVHHI-YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP

HIIQFIDAKK------------TENH--------FYLIM---EYCSEG----T-LEDLVRHKQ---------------LNEDQILTYFNQIVYALKYLYS
.||.....              | ..        .|..|   |||| |      .. .|.|..               ..|..  .|| ||. |..|. |
NIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

KKIFHRDIKPKNILL-HN-----------------GEIKLVDFGLSKIIADQNINI-------------------TQGFNTCVGTPQFMA-PEMLKGIG-
..| |||.|| |||| .|                 . ||..|||..... . . |                    .| ..|..||| .|| ||.|.| | 
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------WQEKSDIWSLGSTLYYMIFKELPWD
               .|.|.||.|  || |   ..|..
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
Kinase 28437.AA CAMKL 14-239 30 4.7e-55 174.06 In-house 1-257 (297) Show / Hide 
Range on Protein: 14-239
Range on HMM: 1-257/297
Sequence Identity: 30% (83 aa)

YQIDRNKILGTGGFASVYLGYY-AKGKSNSSEEMNQLFAIKEIS---INNEFEITNS-----------LIREINMLRHLK---NRHIIQFIDAKKTENH-
|.| .   ||.|.|. | |.              ..  ||| |    |.|.  ...            . |||. ...|.     .||.. .   |..| 
YRIGK--TLGKGSFGKVKLATHIRTT--------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHD

-----FYLIMEYCSEGT--LEDLV---RHKQ--LNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLH-NG--EIKLVDFGLSKIIADQNINITQGF
     .||.||||| |   | | .   .|.   . |..   || ||| |..|. |..| |||||| ||||  ||   ||..|||.| .. .. ..  | .
IETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKL

NTCVGTPQFMAPEMLKG--IGWQ-EKSDIWSLGSTLYYMIFKELPWDQYST-----SSMAILEQIERI
.|. |.| .||||...|        | ||||.| .|| |.. .||.|. .      .    |. ....
KTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMC
Kinase 28437.AA STE11 16-209 30 7.4e-51 175.27 In-house 1-225 (303) Show / Hide 
Range on Protein: 16-209
Range on HMM: 1-225/303
Sequence Identity: 30% (71 aa)

IDRNKILGTGGFASVYLGYYAKGKSNSSEEMNQLFAIKEISINNEF-------EITNS------LIREINMLRHLKNRHIIQFIDAKK---TENHFYLIM
  . .|.|.| | .||...  .         ..|.|.|.| |.|.        .. .|      .  ||....||.  .|.......     ..|.. .|
WQKGEIIGKGAFGTVYKCMNVD--------TGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFM

EYCSEGTLEDLVRHKQ----LNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLHN-GE-IKLVDFGLSKIIADQNINITQ------GFNTCVGTPQ
|||..|.|... |||.    ..|  |  | .|| ..|.|| |..| |||||. ||||   |  .||.||| .| .| .. . ..      . ..  |||.
EYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPY

--------FMAPEMLKGIG---WQEKSDIWSLG
        .||||..|. |      |.||||||
NSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLG
Kinase 28437.AA Pkinase_Tyr 16-168 26 5.4e-17 58.18 Pfam 1-161 (270) Show / Hide 
Range on Protein: 16-168
Range on HMM: 1-161/270
Sequence Identity: 26% (44 aa)

IDRNKILGTGGFASVYLGYYAKGKSNSSEEMNQLFAIKEISINNEFEI--TNSLIREINMLRHL-KNRHIIQFIDAKK-TENH--FYLIMEYCSEGTLED
|  .| || | | .||.|..      . .. ..  |.| .  .   |     ...||......| .. .|.... .    . .   |..|||.  | | |
ITFGKKLGEGAFGEVYKGTWKG----DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

LVRHK-----QLNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLH-NGEIKLVDFGLSKII
  | .     .|.  ..| .  ||  .. || ||.. |||.  .|.|.. |. .|  ||||.. |
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 28437.AA TyrKc 16-409 15 9.8e-14 -0.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-409
Range on HMM: 1-280/280
Sequence Identity: 15% (65 aa)

IDRNKILGTGGFASVYLGYYAKGKSNSSEEMNQLFAIKEISINNEFEITNSLIREINMLRHL--KNRHIIQFIDAKKTE-------NHFYLIMEYCSEGT
|  .|.|| | |  ||.| .            .  |.| .  .        ..||......|  .. .|.... .  ..          ...|||.. | 
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LEDLVRHKQ--LNEDQILTYFNQIVYALKYLYSKKIFHRDIKPKNILLHNGE-IKLVDFGLSKIIADQ------NINITQGF--NTC-VGTPQFMAPEML
| |  | ..  |. .. | .  ||     || ||.. |||.   |.|....  .|  |||||. | |          ...    ..  .     |||| .
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

KGIGWQEKSDIWS----------LGSTLYY-MIFKELPWDQ--YSTSSMAILEQIERIFGIPQASAAGVSPPTQPVSSSPQINKQGEQQQILEKQISQEP
.     .|||.||          .| . |. ||.. .....      .   ..| . .   |  |                                   
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS-----------------------------------

SLQENNSNERNDPQNQNDKKVSQNENQITQQDMQRSMLEASIKNQKNTIKNPHGSLDLLKDQKSNKKKVYDQIDEKLKYLLPKDKNNSESIQVSEKTLRL
                                                                                         .   ...  ..
-----------------------------------------------------------------------------------------FVCCPDEMYQI

LDSMLQVDIEKRIGWEELFSIPSIHEFL
  .  . | |.|   .|.      ||..
MKQCWHEDPEDRPTFSEI------HECF
Kinase 28437.AA Ciliate-E2c 369-405 41 4.3e-08 24.56 In-house 272-310 (310) Show / Hide 
Range on Protein: 369-405
Range on HMM: 272-310/310
Sequence Identity: 41% (16 aa)

SES--IQVSEKTLRLLDSMLQVDIEKRIGWEELFSIPSI
.|.  . .|...  |.  |||||.|||| |.|.|  . |
PENYEQNISQEVKQLIHKMLQVDEEKRIDWDEIFNHECI
Kinase 28437.AA Ciliate-E2b 378-403 19 0.027191 2.96 In-house 247-272 (272) Show / Hide 
Range on Protein: 378-403
Range on HMM: 247-272/272
Sequence Identity: 19% (5 aa)

TLRLLDSMLQVDIEKRIGWEELFSIP
.|..| .| .|. .....|....   
MLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 28437.AA CAMKL 372-394 43 0.119035 0.87 In-house 265-286 (297) Show / Hide 
Range on Protein: 372-394
Range on HMM: 265-286/297
Sequence Identity: 43% (10 aa)

IQVSEKTLRLLDSMLQVDIEKRI
..||    .|. .||||. |||.
YHVS-DCRDLIRKMLQVNPEKRP