Gene 12851 (Tetrahymena)

12851

Species: Tetrahymena
Alias: TTHERM_00653640, 95.m00097, 3825.m02505, PreTt12851, 12851, 171
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
12851.AA Protein None 1433 None Fasta, JSON
12851.kin_dom Protein Kinase Domain None 1393 None Fasta, JSON
12851.NA RNA None 4302 None Fasta, JSON

Protein domain

Protein domains of 12851.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12851.AA MARK 1149-1415 47 5.3e-155 509.94 In-house 1-262 (262) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-262/262
Sequence Identity: 47% (130 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQKRKNVAREVKILSKIKHLNIIRLYDVIE--TNSQ-LHLLMEYPCSTPLNAHIKSKPHRK
. ..|..| ||||.|.......|..|.|.|.|||.||.|||..||| ||..|..|..| |||.|..|||  |... ..| ||| ....|  .||..|...
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LCEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNT-QTVKLIDFGFSIALAPGTKLNIFCGTPSYMAPEIVNKKDYT-FPVDTWALGILLFKAL
|.||||..||.|.|.||.|||.|.|||||||.||.| |.|. . .|.|||||||   ||.|||.|||||.||||||..||.|. ..||.|.||..|.  .
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

NGNFPFREFQVINKYTKNLGQDDKELYRRINSCKLDFQPHVSSQARSLISKILRHNSNERYTPEQILQDEWF
 |.|||.          . .||.||||..|...| |. .||| ..|.||...| .| .|| | |.|....|.
CGYFPFD----------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 12851.AA CAMKL 1149-1415 37 1e-131 422.71 In-house 1-297 (297) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-297/297
Sequence Identity: 37% (113 aa)

FIFGKVLGLGSYAVVRVVQD-QNTKEKYALKTYEKKKLQ-DPQKRKN-----------VAREVKILSKIK---HLNIIRLYDVIETNSQ------LHLLM
...||.|| ||...|.  .. ..|.||.| | ..|||.. ||...||           . ||..|.....   | |||.||.|||| .       ..| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYPCSTP--LNAHIKSKPHRK--LCEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNTQ-TVKLIDFGFSIALAP-----GTKLNIFCGTPSYM
|| ..    |  .|....||.  . |.||. .| |.|.||.|||.. |||||||.||.| |.|   ..|.||||||.   |     | ||..|||.|.||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEIVNK--KDYT-FPVDTWALGILLFKALNGNFPFREFQVINKYTKNLGQDDKELYRRINSCKLDFQP---HVSSQARSLISKILRHNSNERYTPEQIL
||||...  |.|  ..|| |..|..|.  . |..||..  .  |    .|.|.. ...... |   . |   ||| ..|.||.|.| .| ..|.| .||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K----QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

QDEWF
...|.
NHPWM
Kinase 12851.AA CAMK 1154-1415 25 1.6e-113 367.27 In-house 1-425 (425) Show / Hide 
Range on Protein: 1154-1415
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

VLGLGSYAVVRVVQDQNTK------------EKYALKTYEKKKLQD-------------------------PQKRKNVAREVKILSK-------IKHLNI
.|| ||...|. ... ||.            .|.| | ..||||.|                         |..|||| ||..|..|       ..| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYDVIE------------TNSQ--------LHLLM---EYPCST----PLNAHIKSKPH-------------RKLCEEEAKVIFSQLVEAVKYCHRKS
|.||.|.|            | |.        ... |   ||         |  .|.....             ....|.||. .| |...||.||| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKLENVLYDSNT----------------QTVKLIDFGFSIALAP------------------------GTKLNIFCGTPSYMA-PEIVNKKD---
|||||.|.||.|.|.|                  ..|.|||||.. . |                        | |.. |||||.||| ||..|.|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YTFPVDTWALGILLFKALNGNFPFREFQVINKYTKN--LGQDDKELYRRINSCKLDFQPH----------------VSSQ--------A
           |....| |..|..|.  | | .||..    . .  .  .|..|.||...| ..| || |.                .| .        .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

RSLISKILRHNSNERYTPEQILQDEWF
..||.|.|. . ..|.| ||.|...|.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 12851.AA S_TKc 1149-1415 27 7.7e-86 292.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQKRKNVAREVKILSKIKHLNIIRLYDVIETNSQLHLLMEYPCST---PLNAHIKSKPHRK
. .....| |....|. ... .|....|.|             ... ||..||.| .| ||..||||... . |.. ||| |..    |  .||......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEY-CDGDLGDLFDYIKKRGRHG

----LCEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNTQTVKLIDFGFSIALAPGTKLNIFCGTPSYMAPEIVNKKDYTF-PVDTWALGILLF
    . | .|. .. |...|..|||.. |.|||.| ||.| |.   ..|..|||..  |      . ||||| |||||..    |.. ..| |..|..|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

KALNGNFPFREFQVINKYTKNLGQDDKELYRRINSCKLDFQPHVSSQARSLISKILRHNSNERYTPEQILQ-------DEWF
  | |  ||.              ........|           |..|...|.|.|. . ..|.|  ..||       ..||
EMLCGYPPFP--------------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12851.AA Aur 1149-1415 32 1.9e-82 217.2 In-house 1-257 (257) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-257/257
Sequence Identity: 32% (87 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQKRKNVAREVKILSKIKHLNIIRLYDVIETNSQLHLLMEYPCSTPLNAHIKSKPHRKLCE
| .|| || |..  |. ... .|. ..|||  .|. ..  .  ... ||.|| |. .| ||...|.  . .    |..||     |  .....| ... |
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

EEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNTQTVKLIDFGFSIALAPGTKLNIFCGTPSYMAPEIVNKKDYTFPVDTWALGILLFKALNGNFP
..|  ...|. .|..|||.| |.||||| ||.| |.   ..|. ||| |.   .  . . ||||  ||.||.|. ... . || |.||.|..  ..|  |
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FREFQVINKYTKNLGQDDKELYRRIN-SCKLDFQPHVSSQARSLISKILRHNSNERYTPEQILQDEWF
| .            ....| |.||   ....| .|.|  |. ||||||.|....| | .||..  |.
FESN-----------ENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 12851.AA Pkinase 1149-1415 28 2.2e-82 284.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQKRKNVAR--EVKILSKIKHLNIIRLYDVIETNSQLHLLMEYPCST----PLNAHIKSKP
. .|...| ||...|.  ....| ...|.|. .|.  ....|... .|  |..|. ...| ||.||||. |... ... |||   .     | ..|. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

HRKL--CEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNTQT---VKLIDFGFSIA--LAPGTKLNIFCGTPSYMAPEIVN-KKDYTFPVDTWA
|...   |.|.| .. |......|||...|.|||.|.||.|.|.| ..   ||..|||..    . ... .. ||||| |||||...  ..|. .|| |.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILLFKALNGNFPFREFQVINKYTKNLGQDDKELYRRINSCKLDFQPHVS---------------------SQARSLISKILRHNSNERYTPEQILQDE
.|..|.  |.|..||..       .     |......|| ...|.|.   .                     . ....|...|. . ..|.|.|||||..
CGCILYEMLCGRPPFPG----HC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

WF
||
WF
Kinase 12851.AA AGC 1149-1415 20 3.9e-80 206.07 In-house 1-395 (395) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-395/395
Sequence Identity: 20% (83 aa)

FIFGKVLGLGSYAVVRVVQDQ------NTKEKYALKTYEKKK---LQDPQKRKNVARE------------VKILSKIK----------HLNIIR-LYDVI
| | ||.| ||.  |. |..        |.. ||.|  .||.   . . .. ... .|             .||.|..          | .|.. |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETNSQ--LHLLMEYPC--------STPLNAHIKSK---PHRKLCEEEAKVIFSQ-------LVEAVKYCHR-KSIVHRD-IKLENVLYDSNTQTVKLIDF
....   |...||| .           .  ..  .     ... ||.|. ....       .| |. | |. . |.||| .|.||.| |..   .|| ||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-GHIKLTDF

GFSIALAPG---------------------------------------------------TKLNIFCG--TPSYMAPEIVNKKDYTFPVDTWA--LGILL
|..  .  .                                                    . . |||  || ||||||.    |....| |.  ||.|.
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

FKALNGNFPFREF---QVINKYTKNLGQ----DDKELYRRIN------SCKLDFQ----------PHVSSQARSLISKILRHNSNERYT----------P
.  | |  ||.     . .        .    . .|.. .|       ..|. |           ...|..|..||.| |  . ..| .           
YEMLTGYPPFYGDNPQE-N--------RHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGA

EQILQDEWF
|.| . .||
EEIKNHPWF
Kinase 12851.AA Ciliate-E2 1149-1415 22 4.4e-71 242.46 In-house 1-365 (365) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-365/365
Sequence Identity: 22% (90 aa)

FIFGKVLGLGSYAVVRVVQD-----------------------QNTKEKYALKTYEKKKLQDPQKRKNVAREVK----------ILSKIKHLNIIRLYDV
..| |..| |....|. ...                       .... .||.|...|....   . ... ||..          ||....| |||..|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--TNSQLHLLMEYPCSTPLNAHIKSKPHRKLCE---------EEAKVIFSQLVE---------------AVKYCHRKS-IVHRDIKLENVLYDSNTQT
 .  ... . | |||     |  .||.... ...|         .|.| |. |...               |..|.| |  |.|||||.||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

VKLIDFGFSI---------------ALAPGTKLNI------------------FCGTPSYMAPEIVNKKD---------YTFPVDTWALGILLFKALNGN
.|.||||.|                 . .  | ..                  .|||| ||||||.|.|.         |.. .| |.||..|.  | |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FPFREFQVINKYTKNLGQDDKELYRRINSCKLDFQ------------------PHVSSQARSLISK----ILRHNSNERYT-PEQILQDEWF
.||                    .. |  ||.||.                   ..| ..  ||.|    .|  . ..|.| .||||. .||
PPF--------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 12851.AA Ciliate-E2-Unclassified 1149-1415 25 3e-68 233.07 In-house 1-352 (352) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQKRKNV--------AREVK--------------ILSKIKHLNIIRLYDVIETNSQLHLLM
....|..| |....|. .|. ..|..||.|.  |.. .. .. .|.        . . |              ||. ..|..|...... ..   . . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYPCSTPLNAHIKSKPH---------------RKLCEEEAK-----VIFSQLVEAVKYCHRKS-IVHRDIKLENVLYDSNTQ--TVKLIDFGFSIALA--
||     |  .||....               ... |..||      .| |.... .|.|.|  |.|||||.||.|.|.| .   .|.||||.|. .   
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------PGTKLNIFCGTPSYM----APEIVNKKDYT----FPVDTWALGILLFKALNGNFPFREFQVINKY---TKNLGQ--DDKELYRRIN
              .  ... |||||.||    |||.  .. |     . .| |.||..|.  | |..||   . . ..   |... .  ..|.||. |.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIK

SCKLDFQP--------HVSSQARSLIS----KILRHNSNERYTPEQILQDEWF
 ....|..        |.| .|  .|.    |.|  | |.|.|.||||.  ||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 12851.AA RSK 1152-1415 30 2.5e-67 230.02 In-house 1-278 (278) Show / Hide 
Range on Protein: 1152-1415
Range on HMM: 1-278/278
Sequence Identity: 30% (88 aa)

GKVL---GLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQK-RKNVAREVKILSKIK-HLNIIRLYDVIETNSQLHLLMEYPCSTPLNAHIKSKPH-RK
 |||   | |.. ..| ... .|.  || |  .|.|.   ||  . . .|..||. .. | .|..|... .|.. |.| |||     |  |.. . |   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LCEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDS--NTQTVKLIDFGFSIALAPG--TKLNIFCGTPSYMAPEIVN---KKD-YTFPVDTWALGI
..|.||.......| ||.. | . |.|||.|.||.|||.  |  ..||.||||.  . .    ... ||.|  |||||...   ..  ..  .| | ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLFKALNGNFPFRE-FQVINKYTKNLGQDDKELYRRINSCK--LDFQ--PHVSSQARSLISKILRHNSNERYT-----PEQILQDEWF
|..  | |. ||.   .          .. ||. .|| ..|  |..   . .|  |..||.| |  . . |..      |.|.|..||
LMYEMLTGCPPFQGPND----------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 12851.AA Ciliate-E2a 1149-1349 31 2.2e-60 176.46 In-house 1-216 (275) Show / Hide 
Range on Protein: 1149-1349
Range on HMM: 1-216/275
Sequence Identity: 31% (67 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQKRKNVAREVKILSKIKHLNIIRLYDVIETNSQLHLLMEYPCSTPLNAHIKSKPHRKLCE
. | |..| |....|...|  .|....| |  .||  |. ...... .|..|.....| |||.||.| |..... | |||  .  |   || .   .  .
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

EEAKVIFSQLV-EAVKYCHRKSIVHRDIKLENVLYD---SNT---QTVKLIDFGFSIAL--APGTKLNIFCGTPSYMAPEIVNKKD------YTFPVDTW
.|.. |  ||  ... |.| . |.|||.|.||.|..   .|    . .|.||||..       . ..   |||| |.|||. | |.      |.  .| |
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

ALGILLFKALNGNFPF
 .|. ..  | |  ||
SCGVIFYILLCGKPPF
Kinase 12851.AA QIK 1149-1415 31 8.8e-59 201.6 In-house 1-272 (272) Show / Hide 
Range on Protein: 1149-1415
Range on HMM: 1-272/272
Sequence Identity: 31% (90 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEKKKLQDPQKRKNVAREVKILSKIKHLNIIRLYDVIETNSQLHLLMEYPCSTPLNAHIKSKPH-----
.  .. .| | .|||.. .  .||.| | |   | .| | .  . . |||.|.  ..| .||.||.|.|| . . ...||  .  .  .. .. .     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQL-DEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

-------------RKLCEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNTQTVKLIDFGFSIALAPGTKLNIFCGTPSYMAPEIVNKKDYTFP-
               . |.||. .|.|.. ||.|||.. |||||.| ||.| |.|   .|..|||||    .|  |. .||.| | |||.   |.|. | 
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMN-IKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPK

VDTWALGILLFKALNGNFPFREFQVINKYTKNLGQDDKELYRRINSCKLDFQPHVSSQARSLISKILRHNSNERYTPEQILQDEWF
|| | .|..|.    | .||             |. ...| .|. | |    . .|.   .|| . |  . . ||| .||.|  | 
VDIWSMGVVLYVLVCGALPFD------------GKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase 12851.AA TyrKc 1149-1414 21 4.2e-13 -10.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 1149-1414
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

FIFGKVLGLGSYAVVRVVQDQNTKEKYALKTYEK---KKLQDPQKRKNVAREVKILSKI--KHLNIIRLYDVIETN-------SQLHLLMEYPCSTPLNA
  .||.|| | . .|.  .             ..   |.|..   |.   || .|..|.  .| ||.||| |. .         .| ..||| .   |. 
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HIKSKPHRKLCEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNTQTVKLIDFGFSIALAPG-----------------TK--LNIFCGTPSYMA
..... .. || ..   .  |  .   | |.| ..|||.   |.|...|  |||  ||| | ..  .                 .|  | |       ||
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-----WMA

PEIVNKKDYTFPVDTWALGILLFKAL-NGNFPFRE-FQ--VINKYTKNLGQDDKELYRRIN----SCKLDFQPHVSSQARSLISKILRHNSNERYTPEQI
||  |.. .|.  | |. |....  . .|  |  .  |  . |.   .. .. . . .  |    |    | .. ..   .....  ... ..| | ..|
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI

LQDEW
  ...
-HECF
Kinase 12851.AA Pkinase_Tyr 1149-1340 27 2.2e-11 39.15 Pfam 1-205 (270) Show / Hide 
Range on Protein: 1149-1340
Range on HMM: 1-205/270
Sequence Identity: 27% (59 aa)

FIFGKVLGLGSYAVV---RVV-QDQNTKEKYALKTYEKKKLQDPQ-KRKNVAREVKILSKI-KHLNIIRLYDVIE-TNSQ--LHLLMEYPCSTPLNAHIK
 .|||.|| |.. .|   .   ...||| . | |.  | .  ..| .|.   ||.||.... .| ||.||| |.     .  . . ||| .   |  . .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SK--PHRKLCEEEAKVIFSQLVEAVKYCHRKSIVHRDIKLENVLYDSNTQTVKLIDFGFSIAL---------APGTKLNIFCGTPSYMAPEIVNKKDYTF
..  . ..|. ..   .  |  ..  | ..| ..|||.   |.| ..|  .||  ||| . ..         . |.|| |.      ||||  | . .| 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIK-----WMAPECINYGKFTT

PVDTWALGILLF
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KSDVWSFGVLMW
Kinase 12851.AA Ciliate-E2a 1384-1415 31 5.7e-09 22.58 In-house 244-275 (275) Show / Hide 
Range on Protein: 1384-1415
Range on HMM: 244-275/275
Sequence Identity: 31% (10 aa)

VSSQARSLISKILRHNSNERYTPEQILQDEWF
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CSKECKDLMKKMLEKDPKKRITAQQALNHPWF