Gene 13486 (Tetrahymena)

13486

Species: Tetrahymena
Alias: 259, PreTt13486, 38.m00321, TTHERM_00369640, 13486
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
13486.AA Protein None 440 None Fasta, JSON
13486.kin_dom Protein Kinase Domain None 305 None Fasta, JSON
13486.NA RNA None 1323 None Fasta, JSON

Protein domain

Protein domains of 13486.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13486.AA AGC 71-218 40 3.3e-105 272.4 In-house 1-203 (395) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-203/395
Sequence Identity: 40% (82 aa)

FITIKCLARGSFGKVLLVQNK------DTKQYYAMKTLKKAD---IINRNQIENALNE------------KKILQFSD----------HPFVVK-LKFCF
|  .|.. .|||||| ||. |      ||..||||| |||..   |...|..|....|            ..||.  .          |||.|| |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QNEFN--IYFIMEYMP---------GG-ELFHHIK---KRQRFQEQTCVYYSAQ-------VILALEYLHEKLNVIYRD-LKPENILMDEDGNVKLSDFG
|.. .  .||.|||||         || |||.|..   |..|| |... .| |.       ..|||||||.....|.|| |||||||.||||..||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAK
|.|
LCK
Kinase 13486.AA Ciliate-E2-Unclassified 71-375 30 3.5e-100 339.11 In-house 1-352 (352) Show / Hide 
Range on Protein: 71-375
Range on HMM: 1-352/352
Sequence Identity: 30% (117 aa)

FITIKCLARGSFGKVLLVQNKDTKQYYAMKTLKKADIINRNQIEN---------ALNEKK-------------ILQFSDHPFVVKLKFCFQNEFNIYFIM
.. ||.. .|.|||| ..|.|..|||||||..||. |....||.|         ..|.||             ||. ..|||.||. .|||...|||..|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYMPGGELFHHIKKR-----------------QRFQEQTCV-----YYSAQVILALEYLHEKLNVIYRDLKPENILMDEDG---NVKLSDFGLAKSSNYL
||..||.|. .||||                 ..|.|| ..     .| ||....|||||.|.|.|.||.||||||.|..|   ..|..|||..| ... 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

INYKHISQGDFFSHLFLFFNLYTYIKSYQINSCFHQKLQFLWYSRILSTRDHQMQESQSYLFIYQFIFLTKEEGHS----KPVDFWTLGCFIYEMLNGTP
.|..  .|                    |      ||.|.... .. ..    .  . .    |.   . ......    . .|.|.||. .|||| |..
NNCD-TNQ--------------------Q------QKMQIWKQQMMWTFCGTPNYMP-Q----YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY

PFRHPQRTI----------------LYNQIIQNKVTYPS--------HFSPEAKDLIS----NLLQSDPEKRLNFSQLKLHPFF
||  .....                ||..|.|... .|.        | ||||||.|.     .|. .|.||..|.|.. ||.|
PFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 13486.AA Ciliate-E2 71-375 27 1.5e-93 317.07 In-house 1-365 (365) Show / Hide 
Range on Protein: 71-375
Range on HMM: 1-365/365
Sequence Identity: 27% (113 aa)

FITIKCLARGSFG-----KVLLVQN------------------KDTKQYYAMKTLKKADIINRNQIENAL----------NEKKILQFSDHPFVVKLKFC
.. ||.. .|.||     || .||.                  |.....||||..|| .|.. .|... .          |||.||.. .||...|.. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--NEFNIYFIMEYMPGGELFHHIK-------------------KRQRFQEQTCV-------YYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNV
||  .. |||..|||  ||.||..||                   ..... .| .        .| |..||||||||.| |.|.||.||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLSDFGLAK----------------SSNYLINYKHISQGDFFSHLFLFFNLYTYIKSYQINSCFHQKLQFLWYSRILSTRDHQMQESQSYLFIY-QFIFL
|..||||.|                   .  |......|...                       |..|. .. .|. |   .. |  ..  .. |    
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-----------------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQ----

TKEEGHSKPVDFWTLGCFIYEMLNGTPPFRHPQRTILYNQIIQNKVTYP------------------SHFSPEAKDLISN----LLQSDPEKRLN-FSQL
.|..|... .|.| ||. .|||| | |||        ..||.|.|. .|                   . |.|.||||..    .|| |||||.. ..|.
QKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI

KLHPFF
. ||.|
LNHPWF
Kinase 13486.AA S_TKc 71-375 28 9.7e-87 295.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 71-375
Range on HMM: 1-231/231
Sequence Identity: 28% (94 aa)

FITIKCLARGSFGKVLLVQNKDTKQYYAMKTLKKADIINRNQIENALNEKKILQFSDHPFVVKLKFCFQNEFNIYFIMEYMPG--GELFHHIKKRQR---
.  .. . .|.|||| ....|.|....|.| .|          |....| .||.  .||..|||. .||.  ..|..|||..|  |.||..||||.|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FQEQTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAKSSNYLINYKHISQGDFFSHLFLFFNLYTYIKSYQINSCFHQKLQ
   | | .. .| .|...||||.|.. ..|.|||||||||.||  ..|..|||||.                                            
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

FLWYSRILSTRDHQMQESQSYLFIYQF----IFLTKEEGHSK-PVDFWTLGCFIYEMLNGTPPFRHPQRTILYNQIIQNKVTYPSHFSPEAKDLISNLLQ
                   ..     .    ..     |..| ..| | .|| .|||| | |||.  |   ....|           ||||||.|...||
------------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQ

SDPEKRLNFSQLKL-------HPFF
 |||||.   ..         ||.|
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13486.AA Akt 71-218 53 5.2e-84 268.42 In-house 1-149 (264) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-149/264
Sequence Identity: 53% (80 aa)

FITIKCLARGSFGKVLLVQNKDTKQYY-AMKTLKKADIINRNQIENALNEKKILQFSDHPFVVKLKFCFQNEFNIYFIMEYMPGGELFHHIKKRQRFQEQ
|  .|.| .||||||.||. |||...| ||| |||  ||..||.|... |..|||  .|||.|.|.. ||.. ..||.|.|..||||| |.....|| |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

TCVYYSAQVILALEYLHEKLNVIYRD-LKPENILMDEDGNVKLSDFGLAK
.  .| |..|||.|.||.  |.|||| |||||||||.||...| ||||.|
RARFYCAEIILAIEHLHS-KNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase 13486.AA AktR 71-218 56 1.6e-83 283.8 In-house 1-150 (268) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-150/268
Sequence Identity: 56% (85 aa)

FITIKCLARGSFGKVLLVQNK-DTKQYYAMKTLKKADIINRNQIENALNEKKILQ-FSDHPFVVKLKFCFQNEFNIYFIMEYMPGGELFHHIKKRQRFQE
|  .||| .| |||| ||| | |....|||| .|| .||.|||.. ...|..|..  ..||| |||..|||.. ...|||||.||||||.|.||...| |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAK
..   |.||..|||||||...|.|||||||||||.||||.||..||||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK
Kinase 13486.AA PKA 71-218 50 2.3e-73 250.05 In-house 1-149 (263) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-149/263
Sequence Identity: 50% (76 aa)

FITIKCLARGSFGKVLLVQNKDTKQYYAMKTLKKADIINRNQIENALNEKKILQFSDHPFVV-KLKFCFQNEFNIYFIMEYMPGGELFHHIKKRQRFQEQ
| .|. | .||||.| |...|....|||||.|||..|. ..|.|  .|||.|||  .|||.| |... ||.. ..|..||| ||||.|... |..|| ..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TCVYYSA-QVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAK
.   | | |..||||||| ..| |||||||||||.|..|..|. ||| ||
HAKFYAASQIVLALEYLH-SQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase 13486.AA SGK 71-218 38 2.4e-71 219.47 In-house 1-173 (283) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-173/283
Sequence Identity: 38% (67 aa)

FITIKCLARGSFGKVLLVQNKDT------------------KQYYAMKTLKKADII-------NRNQIENALNEK-KILQFSDHPFVVKLKFCFQNEFNI
|. .| .  ||||||..|. ||.                  .. |||| |.|. ||       ....  . . |. .||.   ||| |.|.. ||..   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFIMEYMPGGELFHHIKKRQRFQEQTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAK
|| |.|. |||.| |......| |     | |....|||||| ....||||||||||| | .|...| ||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLH-SQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase 13486.AA RSK-Unclassified 71-218 44 2.6e-68 213.51 In-house 1-149 (283) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-149/283
Sequence Identity: 44% (66 aa)

FITIKCLARGSFGKVLLVQNKDTKQYYAMKTLKKADIINRNQIENALNEKKILQFSDHPFVVKLKFCFQNEFNIYFIMEYMPGGELFHHIK--KRQRFQE
|| .. . .|.|||| ||. |||.| |||| |.|  .| .| |  .. |. |.  ..|||.|.| . || .   | .||| .||..| |    |  .| |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

QTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAK
    .| . |..|||||| |. .|||||||.||... .| |.|.||.| .
DDVRFYASEVTAALEYLH-KRDFIYRDLKPDNIVLHQEGHVMLTDFDLSI
Kinase 13486.AA RSK 74-218 44 3.8e-60 206.13 In-house 1-155 (278) Show / Hide 
Range on Protein: 74-218
Range on HMM: 1-155/278
Sequence Identity: 44% (70 aa)

IKCLARGSFGKVLLVQNK---DTKQYYAMKTLKKADIINRNQ-IENALNEKKILQFSD-HPFVVKLKFCFQNEFNIYFIMEYMPGGELFHHIKKRQR---
.| | .|..||| |.. .   ||.|.|||| |||| |..|.  .. .. | .||. .  |||.|.|.  || |  .| ||||..||||| |..|...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FQEQTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDE---DGNVKLSDFGLAK
| | .. .| |...||.|.||..  .|.||||||||| |.   .| .||.|||..|
FSEDEACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDESNEGHIKLTDFGFCK
Kinase 13486.AA MAST 71-218 41 8.3e-57 181.51 In-house 1-147 (334) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-147/334
Sequence Identity: 41% (62 aa)

FITIKCLARGSFGKVLLVQNKDTKQYYAMKTLKKADIINRNQIENALNEKKILQFSDHPFVVKLKFCFQNEFNIYFIMEYMPGGELFHHIKKRQRFQEQT
| .||.. .| .||| || .|.|.. .|||..||.| ||.|....   |. || ... |||||.  .|| . .....|||| || ......   .|.| .
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

CVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAK
   | |...|.|||||..   . |||||.|.| | .| .|| ||||.|
AKMYIAETVLCLEYLHSH-GIVHRDLKPDNMLIDSNGHIKLTDFGLSK
Kinase 13486.AA Pkinase 71-218 34 1.1e-52 186.12 Pfam 1-160 (293) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-160/293
Sequence Identity: 34% (56 aa)

FITIKCLARGSFGKVLLVQNKDTKQYYAMKTLKKADIINRNQIENAL-NEKKILQFSDHPFVVKLKFCFQNEFNIYFIMEYMPGG----ELFHHIK--KR
. ..... .||||.| . ..|.| . .|.|..|| ..    ...... .| .|..  .||..|.|. .|... .||..|||..||    .||..|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QRF--QEQTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNV----KLSDFGLAK
 .|  .|..|  |  |.. .|||.|.  ..|.|||||||||.|..|..    |..||||||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase 13486.AA AGC 298-375 33 6.7e-46 115.49 In-house 280-395 (395) Show / Hide 
Range on Protein: 298-375
Range on HMM: 280-395/395
Sequence Identity: 33% (39 aa)

HSKPVDFWT--LGCFIYEMLNGTPPFRHP----------QRTILYNQII------QNKVTYP----------SHFSPEAKDLISNLLQSDPEKRLN----
..|..| |.  |||..|||| | |||..           ..  ....|.      ..||..|          ..|||||||||. ||. ||||||     
YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGN

------FSQLKLHPFF
      ....| ||.|
DFGDKGAEEIKNHPWF
Kinase 13486.AA AktR 292-375 45 2.1e-34 120.62 In-house 176-268 (268) Show / Hide 
Range on Protein: 292-375
Range on HMM: 176-268/268
Sequence Identity: 45% (42 aa)

LTKEEGHSKPVDFWTLGCFIYEMLNGTPPFRH--PQRTILYNQIIQ-NKVTYPSHFSPEAKDLIS-NLLQSDPEKRL-----NFSQLKLHPFF
.||..|| |.||.|..|.|||||. | ||| |   .. ... .|.| ||..||| ||...||||   ||. .|.|||     .....| ||.|
ITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 13486.AA Akt 297-375 44 2.6e-33 103.79 In-house 178-264 (264) Show / Hide 
Range on Protein: 297-375
Range on HMM: 178-264/264
Sequence Identity: 44% (39 aa)

GHSKPVDFWT-LGCFIYEMLNGTPPFRHPQRTILYNQIIQNKVTYP--SHFSPEAKDLISNLLQSDPEKRL----N-FSQLKLHPFF
||.|.||.|. |||..|||. | ||| . ..  .. .| ...| .|  . .|||.||||| ||. ||.|||    |   ..| ||.|
GHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 13486.AA SGK 296-375 42 1.1e-31 94.81 In-house 200-283 (283) Show / Hide 
Range on Protein: 296-375
Range on HMM: 200-283/283
Sequence Identity: 42% (36 aa)

EGHSKPVDFWTLGCFIYEMLNGTPPFRHPQRTILYNQIIQNKVTYPSHFSPEAKDLISNLLQSDPEKRLNFS----QLKLHPFF
..|.. || | |||. |||. | ||| .  . ..| .||  .   |  .|..|.|||  ||| ||.|||.      . | ||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 13486.AA PKA 290-375 41 6.6e-29 102.36 In-house 169-263 (263) Show / Hide 
Range on Protein: 290-375
Range on HMM: 169-263/263
Sequence Identity: 41% (40 aa)

IFLTKEEGHSKPVDFWTLGCFIYEMLNGTPPFRHP--QRTILYNQIIQNKVTYPSHFSPEA---KDLISNLLQSDPEKRL-NFSQ----LKLHPFF
| ..|  || |.|| |.||. ||||| | |||.    .   .|. |.. |. .|.||.. |   ||||..||| |..||. |...     | |..|
IIQSKN-GHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 13486.AA MAST 294-375 37 3.1e-28 87.86 In-house 237-334 (334) Show / Hide 
Range on Protein: 294-375
Range on HMM: 237-334/334
Sequence Identity: 37% (37 aa)

KEEG-HSKPVDFWTLGCFIYEMLNGTPPFRHPQRTILYNQIIQNK---VTYP--------SHFSPEAKDLISNLLQSDPEKRLNFS----QLKLHPFF
. .| |.|||| | .|  .|| | |.|||    .......|.. .   . .|        . .||||.|||..||| ||.||| ..    . | ||||
LGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 13486.AA RSK 292-375 38 5.5e-27 95.85 In-house 180-278 (278) Show / Hide 
Range on Protein: 292-375
Range on HMM: 180-278/278
Sequence Identity: 38% (38 aa)

LT---KEEGHSKPVDFWTLGCFIYEMLNGTPPFRH---PQRTILYNQIIQNK--VTYP--SHFSPEAKDLISNLLQSDPEKRLN-----FSQLKLHPFF
|.   ...||.| .| |.||. .|||| | |||..    .|  . ..| ..|  .| |  .  |.||||||. .|. ||.|||.      ...| ||.|
LKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 13486.AA RSK-Unclassified 294-375 41 8.8e-23 67.93 In-house 195-283 (283) Show / Hide 
Range on Protein: 294-375
Range on HMM: 195-283/283
Sequence Identity: 41% (37 aa)

KEEGHSKPVDFWTLGCFIYEMLNGTPPFRHPQRTILYNQIIQNKVTYP--SHFSPEAKDLISNLLQSDPEKRLNFSQL-----KLHPFF
.  || | || ||||  .|||| | ||..   .  ... | .|.|  |  |  | ...|||  |||  | |||   .      | ||||
RRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 13486.AA Pkinase 294-375 24 5.7e-22 78.76 Pfam 185-293 (293) Show / Hide 
Range on Protein: 294-375
Range on HMM: 185-293/293
Sequence Identity: 24% (27 aa)

KEEGHSKPVDFWTLGCFIYEMLNGTPPFRHP------QRTILYNQIIQNKVTYPSHFS---------------------PEAKDLISNLLQSDPEKRLNF
. ......|| | .|| .||||.| |||..           ....| . .. ...  .                     .|.||.|...|. ||.||...
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

SQLKLHPFF
 |.. ||.|
EQILQHPWF
Kinase 13486.AA TyrKc 71-375 16 2.2e-12 -22.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-375
Range on HMM: 1-280/280
Sequence Identity: 16% (62 aa)

FITIKCLARGSFGKVLLVQNKDTKQYYAMKTLKKADIINRNQIENALNEKKILQFS--DHPFVVKLK-FCFQNE------FNIYFIMEYMPGGELFHHIK
   .| | .| ||.| . . |   .  | |.||.        .|  ..| .|.     .|| .|.|   | | .        .. .|||||.| | ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRQR-FQEQTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAKSSNYL-------INYK------HI------------------
|... .. .. .... |.    ||||.| |.| |||   |.| .|.. || |||||..              |.                          
KHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

-----------------SQGDFFSHL-----FLFFNLYTYIKSYQINSCFHQ----KLQFLWYSRILSTRDHQMQESQSYLFIYQFIFLTKEEGHSKPVD
                 . |.             . .. |.|.     . .                                                 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------------

FWTLGCFIYEMLNGTPPFRHPQRTILYNQIIQNKVTYPSHFSPEAKDLISNLLQSDPEKRLNFSQLKLHPFF
                                    .  . ..|  ....   . |||.| .||..  | .|
------------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 13486.AA Pkinase_Tyr 71-218 32 6.4e-11 37.61 Pfam 1-159 (270) Show / Hide 
Range on Protein: 71-218
Range on HMM: 1-159/270
Sequence Identity: 32% (53 aa)

FITIKCLARGSFGKVLLVQNK----DTKQYYAMKTLKKADIINRNQ--IENALNEKKILQFS-DHPFVVKLKFCFQ-NEFN--IYFIMEYMPGGELFHHI
 . .| | .|.||.| .   |    .||.  | |.||        |  .|  ..| ||.    .|| .|.|  .    .    || .|||||.| | .. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KK----RQRFQEQTCVYYSAQVILALEYLHEKLNVIYRDLKPENILMDEDGNVKLSDFGLAK
.|    .|..  .. . ...|.  ..|||..| | | |||   |.| .|.. || .|||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESK-NCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 13486.AA S_TK_X 376-435 16 3.9e-05 20.69 SMART 1-79 (79) Show / Hide 
Range on Protein: 376-435
Range on HMM: 1-79/79
Sequence Identity: 16% (13 aa)

KKINWEQMLQ--KKYQAPIKIDLQ----NVGLSNHVD---ANNQIQDTPQVRKIDEAMQDK----------FIGITYRG
..|.|.. ..  |....|.| ...    . .  .  |    .... .||. . . ..|. .          |.| ||. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF