19522

Species: Tetrahymena
Alias: 667, 19522, TTHERM_00485900, 3680.m00017, PreTt19522, 59.m00160
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2

Sequence

Name Sequence Type Origin Length Description Download
19522.AA Protein None 610 None Fasta, JSON
19522.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
19522.NA RNA None 1833 None Fasta, JSON

Protein domain

Protein domains of 19522.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19522.AA ULK 21-279 34 3.2e-90 306.06 In-house 1-324 (324) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-324/324
Sequence Identity: 34% (112 aa)

FVFVRPLDKGEFG-QIWIGRDIKN---NELVAIKQMS---LKKRS-----QYSLQLIRRELNIMKQLE--PNEN--VIRFIDQVRQD--DNLYIIMELCQ
..  . | || || .   ||..|.   |..||.|...   ..| .     || .||...| .|||.|    ..|  .....|  . .  .|.|||||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

Q-NLHQKISNIRK-----KKGTSVALTESEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVKNN-------------VLKIADFGLAINKE-------Y
. .| | | . .|     .|..   |.|.||....|||.|||. |.|.||||||||. |||..|.             ||||||||.|   .        
GGDLEQYIKKNKKLPETEEKKR---LSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQM

ASSQV------GTPYTKAPEVYD---GVSRYSDK-ADIWSLGIIFYQMLFDLNYPFP-AKDER----ELQNK-------IKQGNISYNI--QNIRISQQT
  ..|      |||.. ||..     .   |.|. .||||||.|||.||.   ..|  . |.     .|.|.       ||. .| ...  ... ||...
CQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

QALLNHMLQVNPDYRISWEELFNHPVF
. |.  |||.... ||||||.||||.|
KDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 19522.AA ULK 21-279 33 2.7e-88 299.65 In-house 1-329 (329) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-329/329
Sequence Identity: 33% (112 aa)

FVFVRPLDKGEFGQIWIGRDIKN----NELVAIKQMS---LKKRS-----QYSLQLIRRELNIMKQLE-------PNENVIRFIDQVRQD--DNLYIIME
..  . | || ||.   ||..|.    ||.||.|...   ... .     || .||...|  |||.|         ..|.....|  . .  .|.|||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCQQ-NLHQKISNIRK------KKGTSVALTESEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVKNN-------------VLKIADFGLAINKEY---
.|.. .| | |.. .|      .|..   |.|.||. ..|||||||. |.|.||||||||. |||..|.             ||||||||.|   ..   
YCNGGDLEQYIKKNKKLPEDTEEKKR---LSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

----ASSQV------GTPYTKAPEVYD---GVSRYSDK-ADIWSLGIIFYQMLFDLNYPFP-AKDER-----ELQNK-------IKQGNISYNI--QNIR
    . ..|      |||.. ||..     .   |.|. .||||||.|||.||.   ...  . |.      .| |.       ||. .. ..    .. 
EQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

ISQQTQALLNHMLQVNPDYRISWEELFNHPVF
||.... |.  |||.... |||||||||||.|
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 19522.AA Ciliate-E2-Unclassified 21-279 24 5.9e-87 295.18 In-house 1-352 (352) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

FVFVRPLDKGEFGQIWIGRDIKNNELVAIKQMSLKKRSQYSLQLIR-----RELNIMKQLE------------------PNENVIRFIDQVRQDDNLYII
. ... . .| ||...  ...|.. .......  |.... ..|  .     .|...|....                  |.......... ....|.||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MELCQQNLHQKISNIRKK-----------KGTSVALTESEAV-----GYMKQILNGFRSLRKQN-IIHRDIKLKNILVKNN----VLKIADFGLAI----
||.|... .... ..|||           . ..  .|| .|.      |..|||.|. .| ..| |||||||. |||..||     .||.|||...    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------NKEYASSQVGTPYTK----APEVYDGVSRYSD---KADIWSLGIIFYQMLFDLNYPFPAKDERE----------------LQNKI
                .. .....|||...    ||||..|   .     |.||||||.|.|.|||   |||..... .                |...|
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KQGNISYNIQNI-----RISQQTQALLN----HMLQVNPDYRISWEELFNHPVF
||.||... ..      ..|.. . ..|     ||..||..||..|...||| |
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 19522.AA Ciliate-E2 21-279 25 4.1e-82 279.1 In-house 1-365 (365) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-365/365
Sequence Identity: 25% (95 aa)

FVFVRPLDKGEFGQIWIGRDIKNNEL------------------VAIKQMSLKKRSQYSLQLIRRELNIMKQLEP---------------NENVIRFIDQ
. |.. . .| ||... ....|....                  |.||.  .|  ... .. | .|..||.....               . |.|.... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VR--QDDNLYIIMELCQQNLHQKISNIRKKKGTSV-----ALTESEAVGYMKQILN---------------GFRSLRKQN-IIHRDIKLKNILVKNNVLK
    .|.|.|..||.||..  ... ...||| ..       .|| |.  .|||||.               ....| ..| |||||||. |||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGLAI--------------NKEYASSQ----------------------VGTPYTKAPEVYDGVS--------RYSDKADIWSLGIIFYQMLFDLNY
|.||||.               .|.|   .                      .|||. .|||.. | .        .|. |.||||||.|.|.|||  ..
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-GKP

PFPAKDERELQNKIKQGNISYNIQN---------------IRISQQTQALLNH----MLQVNPDYRIS-WEELFNHPVF
||        |..|||..|... ..                 .||... |..     |||..|. ||. ||...||| |
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 19522.AA S_TKc 21-279 29 2.7e-71 244.1 SMART 1-231 (231) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

FVFVRPLDKGEFGQIWIGRDIKNNELVAIKQMSLKKRSQYSLQLIRRELNIMKQLEPNENVIRFIDQVRQDDNLYIIMELCQQ---NLHQKISNIRKKKG
. ..|.. || ||. . .|..| ...||||...         . ||||..|.|.    .|.....|  .  |.||..||.| .   .|.. | . .....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

TSVALTESEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVKNNVLKIADFGLAINKEYASSQVGTPYTKAPEVYDGVSRYSD-KADIWSLGIIFYQMLF
  . ..| .|  ||.||...   . ...|||||.|  |||. . ..||.|||||      ....|||.  ||||      |.  |.|.||.|.|.| || 
R-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC

DLNYPFPAKDERELQNKIKQGNISYNIQNIRISQQTQALLNHMLQVNPDYRISWEELFN-------HPVF
    |||  .. .. .||.             |..   .....||..|. |..  |...       || |
-GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 19522.AA Pkinase 21-279 27 3.8e-64 224.2 Pfam 1-293 (293) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

FVFVRPLDKGEFGQIWIGRDIKNNELVAIKQMSLKKRSQYSLQLIRR--ELNIMKQLEPNENVIRFIDQVRQDDNLYIIMELCQQ-----NLHQKISNIR
....|.. .| ||. ...........||.|........   .|  ||  |. ||| |   .|..|..| .. .|..|..||.|.       |.  ||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

KKKGTSVAL--TESEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVK-NNVL----KIADFGLA----INKEYASSQVGTPYTKAPEVYDGVSRYSDKA
     . ..  .| |.  ||.||| |   . ...|||||.|. |||.. |...    ||.|||||    .|.. ... .|||.  ||||  | . |. |.
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSLGIIFYQMLFDLNYPFPAK------DERELQNKIKQGNISYNIQNI------------------RISQQTQALLNHMLQVNPDYRISWEELFNHPV
|.||.|.|.|.||.    ||| .      |.... ..|... .......                   ..|.  . ... .|...|  |...|....|| 
DMWSCGCILYEMLCGR-PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F

Kinase 19522.AA CAMK 26-279 20 4.9e-63 201.68 In-house 1-425 (425) Show / Hide
Range on Protein: 26-279
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

PLDKGEFGQIWIGRDIKNN------------ELVAIKQMSLKKRS--------------------------QYSLQLIRRELNIMKQLEP------NENV
 | .| ||.   .......            . |||| .. || .                          ..... .|||..|||.|         .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRFIDQVRQ-------------------DDNLYIIM---ELCQQN-----LHQKISNIRKKKGTS--------VALTESEAVGYMKQILNGFRSLRKQNI
|....                       |...|..|   |.|.       | ..|   ...              .||.||  |..||. . . . ..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKLKNILVKNN------------------VLKIADFGLA--INK-------------------------EYASSQVGTPYTKA-PEVYDG------
.|||.|. |||. .|                   .||.|||.|  ...                         .  . ..|||.  | |||  |      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------VSRYSDKADIWSLGIIFYQMLFDLNYPFPAK-------------DERELQNKIKQGNISYN----------------------IQNIRISQQT
          |. |.|.||.|.| | ||    .|| ..             ...||  ||..|. ..                       ...  .||. 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGY-PPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

QALLNHMLQVNPDYRISWEELFNHPVF
. |...||||.|. |.. |.  ||| .
KDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 19522.AA CAMKL 21-279 26 9.7e-56 176.29 In-house 1-297 (297) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-297/297
Sequence Identity: 26% (82 aa)

FVFVRPLDKGEFGQIWIGRDIKN-NELVAIKQMS--LKKRSQYSLQL-----------IRRELNIMKQLE-P-NENVIRFIDQVRQDDN------LYIIM
. ... | || ||.   ...|.. .| |||| .    ..  .....            |||| .|||.|  .  .|.|.. . .  ...      .|..|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCQQN---LHQKISNIRKKKGTSVALTESEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVK-NN--VLKIADFGLA---IN-----KEYASSQVGTP
|.|.     |...| . ....     ..|.||  | .||. .   . ...|.|||||. |||.  |.  ..||.|||..   ..      .  . . |.|
EYCSGGEMDLFDYIVKHGHRR---GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

YTKAPEVYDG--VSRYSDKADIWSLGIIFYQMLFDLNYPFPAK--------DERELQNKIKQGNISYNIQNIRISQQTQALLNHMLQVNPDYRISWEELF
   |||.. |   . .  |.||||.|.| | |..  ..|| .         .  .| .||..|   ..|  ...| . . |. .||||||..|.. ... 
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCG-YLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIW-YHVS-DCRDLIRKMLQVNPEKRPTIHQIM

NHPVF
||| .
NHPWM

Kinase 19522.AA Ciliate-E2a 21-279 29 4.6e-54 157.54 In-house 1-275 (275) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-275/275
Sequence Identity: 29% (83 aa)

FVFVRPLDKGEFGQIWIGRDIKNNEL-VAIKQMSLKKRSQYSLQLIRRELNIMKQLEPNENVIRFIDQVRQDDNLYIIMELCQ-QNLHQKISNIR--KKK
. |.. . || ||.  . . .....  ...|       . .  . . .|.|||.||  . |.|....    ..|.|..||.|.   | .||..    ...
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQL-DHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

GTSVALTESEAVGYMKQIL-NGFRSLRKQNIIHRDIKLKNILVK----NN----VLKIADFGLA--I--N-KEYASSQVGTPYTKAPEVYDGVS-----R
       . |.  .|.|.|  |.  . ..||.|||.|. ||| |    |.     .||.|||||  |  . |.|  ...|||.  ||||.         .
-------IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQ

YSDKADIWSLGIIFYQMLFDLNYPFPAKDERELQNKIKQGNISYNIQN--IRISQQTQALLNHMLQVNPDYRISWEELFNHPVF
|. | |.||.|.||| .|.    ||..|...|   ..|. .|..|...    .|.... |.  ||...| .||. ... ||| |
YDTKCDMWSCGVIFYILLC-GKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase 19522.AA STE 21-279 20 1.6e-47 164.22 In-house 1-359 (359) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-359/359
Sequence Identity: 20% (75 aa)

FVFVRPLDKGEFGQIWIGRDI------KNNEL---------VAIKQMSLKKRSQ---------------YSLQLIRRELNIMKQLEP-NENVIRFIDQVR
. ... . || ||.   ....      |..|.         .|||||.|.. ..                 .| | .|..|||.. .  .|......   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QD-------DNLYIIMELCQ-QNLHQKISNIRKKKGTS-------VALTESEAVGYMKQILNG-FRSLRKQNIIHRDIKLKNILVKNNVLKIADFGLAIN
..       |.|.|.||..    | . | .  .....          . ||.   . .||| |    | ...|||||||  |||.     |..|||.. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

KE--------------------YASSQVGTPYTKAPEVYDG-----VSRYSDKADIWSLGIIFYQMLFDLNYPFPA-KDERELQNKIKQG----------
 .                       . ||||   |||| ..     .. |. |.||||||.    |. . ..|.   .. | . .... .          
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA-TGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NISYNIQN------------------IRISQQTQALLNHMLQVNPDYRISWEELFN--HPVF
   . .  ...                   . |.  .  .|. || .|. | . ..| .  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 19522.AA Ciliate-E2c 41-279 30 5.2e-45 155.71 In-house 31-310 (310) Show / Hide
Range on Protein: 41-279
Range on HMM: 31-310/310
Sequence Identity: 30% (87 aa)

IKNNELVAIKQMSLKKR--SQYSLQLIR----RELNIMKQLEPNENVIRFIDQVRQDDNLYIIMELCQQ-NLHQKISNI-RKKKGTSVALTESEAVGYMK
.. | | |||   ||    .....  |     ||.|.||..  . ..|.|.| .  | ..|.||| | . .| | |..  .        ..| . . | .
VQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMN-HPHIIKFYDAKQTDKHIYLIMEYCNGGTLEQYIYHKPK--------PNEKQCLYYFS

QILNGFRSLRKQ-NIIHRDIKLKNILVKNNVLKIADFGLA--INKEYAS-SQ-----VGTPYTKAPEVYDGVSRYSDKADIWSLGIIFYQMLFDLNYPFP
||...|  | |. ||.||||| .||| .| ..||||||..  .. .  .  |     .|||.  ||..  |   |  |.||||||.  |.||.  ..|. 
QIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKSDIWSLGVTLYYMLC-YKLPWE

----------------AKDE--RELQNKIK---------------QGNISYNIQ-NIRISQQTQALLNHMLQVNPDYRISWEELFNHPVF
                 ...   .|   |.               ..||. . .  . |||... |.. |||| .  ||.|.|.|||. .
SIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRIDWDEIFNHECI

Kinase 19522.AA CAMK-Unique 21-279 20 8.9e-45 145.63 In-house 1-363 (363) Show / Hide
Range on Protein: 21-279
Range on HMM: 1-363/363
Sequence Identity: 20% (74 aa)

FVFVRPLDKGEFGQIWIGRDIKNNELVAIKQMSLKKRSQYSLQL------------------IRRELNIMKQLEPNENVIRFIDQ----VRQDD------
  ..|.. .|.|| . .. |...  . |.|   ... .  .. .                   .||..|.| .  . | |.. |     .  ..      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHP-NIIKLYDWNNPIFCDRKYPLCDL

---------NLYIIMELCQQN-LHQKISNIRKKK-------------GTSVALTE--SEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVKNN------
         ..||.||.|| . | ..|    . .                  ..|  ...  .| ..|     . .|.|.|||.|| ||.|...      
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

-----------VLKIADFGLAINKEYASSQ------VGTPYTKAP--------------EVYDGVSRYSDKA----DIWSLGIIFYQMLFDLNYPFPAKD
            .|..||||.  ..   .       .|||. .||              || ... .|. .     |||||| | | ||.. . || . .
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQ-CYDQQCSPASDIWSLGVIMYYMLCG-CPPFDCEC

ER--------ELQNKIKQGNI-SYNIQNIRI----SQQTQALLNHMLQVNPDYRISWEELFNHPVF
|         |.  .|..|.. ..  .  ..    ||.   ..   ..| ||.|.| .||  |. .
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase 19522.AA Pkinase_Tyr 21-209 28 1.7e-19 66.65 Pfam 1-202 (270) Show / Hide
Range on Protein: 21-209
Range on HMM: 1-202/270
Sequence Identity: 28% (59 aa)

FVFVRPLDKGEFGQIWIGRDI----KNNELVAIKQMSLKKRSQY--SLQLIRRELNIMKQLEPNENVIRFIDQVR-QDDN--LYIIMELCQQ-NLHQKIS
 .| . | .|.||... |.      ...  ||.| .  .  ..   .  ..| |..|||||  ..|..|..  .  |..   .||.||...  .|.    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

NIRKKKGTSVALTESEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVK-NNVLKIADFGLAINK---EYASSQVGT------PYTKAPE-VYDGVSRYS
. |       .|| .. ...  || .|   |  .|.||||.  .|.||. ||| ||.|||||      .|  .....      . . |||   .|.  ..
KHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK--FT

DKADIWSLGI
 | |.|| |.
TKSDVWSFGV

Kinase 19522.AA TyrKc 21-285 21 4.8e-16 36.79 SMART 1-280 (280) Show / Hide
Range on Protein: 21-285
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FVFVRPLDKGEFGQIWIGRDIKNNELVAIKQMSLKKRSQYSLQLIRRELNIMKQL-EPNENVIRFIDQVRQD-------DNLYIIMELCQQ-NLHQKISN
 .. . |  |.||... |. .   . ||.| .   .     .. ..||..||..|   ..|..|..  ..|.       . |.|.||..   .|.. . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

IRKKKGTSVALTESEAVGYMKQILNGFRSLRKQNIIHRDIKLKNILVKNNV-LKIADFGLAINKEYA-----SSQVGTP----YTK--------APEVYD
 |.|      |. .. . .. || .| . | ..|.||||.   |.||..|   ||.||||. . .       |... ..     .|        |||.  
HRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

GVSR-YSDKADIWSLGIIFYQMLFDLNYPFPA-----KDERELQNKIKQGNISYNIQN------IRISQQTQALLNHMLQVNPDYRISWEELFNHPVFQQ
   . .. | |.|| |.  . .. .   | |      .. .|. ...|||.     .|       . ..    .     . .|. | . .|.        
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--------

QERL
 |..
HECF