Gene 22235 (Tetrahymena)

22235

Species: Tetrahymena
Alias: 22235, 18.m00261, PreTt22235, 3701.m00023, TTHERM_00216100, 516
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
22235.AA Protein None 492 None Fasta, JSON
22235.kin_dom Protein Kinase Domain None 265 None Fasta, JSON
22235.NA RNA None 1479 None Fasta, JSON

Protein domain

Protein domains of 22235.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22235.AA Ciliate-E2 141-407 25 9.6e-84 284.52 In-house 1-365 (365) Show / Hide 
Range on Protein: 141-407
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YVVGKKLGEGANAVVKACYQKDESGEP---------------EKCQSKLYAVKIFKTNSIEQILEIQRECQ-------------IMQQINHPSIIKFKEL
| . ||.|.|. ..|. | .. .  .                ||...|.||.||.| | ||||. ......             |..|.||| |||..| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IIEKSTNKAYLVQEFAQGKSLQSYLTENCQNR--------QMDEVTALSIVLQVLR---------------GLCSLHSRN-ICHFDIKPDNIIYNQNNGK
 .||..|. ||| |..||..|..|. .|...|        ...|  .. |  |.|.               .| .|||.| |.| ||||.||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

IKIIDFSSSRKSYPN---------QKLLTNIG------------------------TLNYKSPEYFGGSQ---------RNTKSDIWSVGVILYQLLTGF
||||||  |.|  ..         .|.... .                        |..|..|| ..| .          ..|.||||.|||||..|.| 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

LPFDDLSGNPCSITENIK-NMKFQQQ--------------YKEVISPKMLEILEL----MLVFDPSKRYS-ANQLLQKIPY
.||         . .... . .|...               .. .|...  ..      ||. ||.||.. ..|.|.    
PPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22235.AA Ciliate-E2-Unclassified 141-407 25 5.1e-82 278.8 In-house 1-352 (352) Show / Hide 
Range on Protein: 141-407
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

YVVGKKLGEGANAVVKACYQKDESGEP----EKCQSKLYAVKIFKTNSIEQILEIQRECQ-----------IMQQ--INHPSIIKFKELIIEKSTNKAYL
| ..|..|.|....|. |..|..  .     ...... |..|. ...  | ..|......           ||||  .|||.... |.. ....... |.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VQEFAQGKSLQSYLT-------------ENCQNRQ-MDEVTAL-----SIVLQVLRGLCSLHSRN-ICHFDIKPDNIIYNQNNG--KIKIIDFSSSRKSY
| |...|..|. |..             .|...|.  .|  |.      .  |.| ||..||. | |.| ||||.||....|..  .||||||..|.|. 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

PN----------------QKLLTNIGTLNYK----SPEYFGGSQRN----TKSDIWSVGVILYQLLTGFLPFD--DLSGNPCSITENIKN-----MKFQQ
 |                |.. |..||.||.    .||...| . .     |.||||.|||||..|.| .||.  .   . ..||..| |     . .|.
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQN

QYKE--------------VISPKMLEILE----LMLVFDPSKRYSANQLLQKIPY
...                .||.  ....     ||. .|.||....|.|.    
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22235.AA S_TKc 141-407 26 4.9e-69 236.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 141-407
Range on HMM: 1-231/231
Sequence Identity: 26% (75 aa)

YVVGKKLGEGANAVVKACYQKDESGEPEKCQSKLYAVKIFKTNSIEQILEIQRECQIMQQINHPSIIKFKELIIEKSTNKAYLVQEFAQG--KSLQSYLT
| ...|.|.|| ..|. |. |.          ...|.|| |         |.|| ||... .|| |.|... . .   .. |.| |.. |   .| .|. 
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIK

ENCQ---NRQMDEVTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQNNGKIKIIDFSSSRKSYPNQKLLTNIGTLNYKSPEYFGGSQRNT-KSDIWS
..     .....| .| ... |....|  .||..|.| |.||.||  ..    |||.|| ..|.        | .||..| .|| .   . .. |.|.||
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

VGVILYQLLTGFLPFDDLSGNPCSITENIKNMKFQQQYKEVISPKMLEILELMLVFDPSKRYSANQLLQ-------KIPY
.|.||| .|.|  ||.    ..  . ..|.            || ...... .|..||.||..| ..||           
CGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22235.AA CAMK 146-403 20 3.1e-65 208.9 In-house 1-421 (425) Show / Hide 
Range on Protein: 146-403
Range on HMM: 1-421/425
Sequence Identity: 20% (88 aa)

KLGEGANAVVKACYQKDESGEPEKCQS------KLYAVKIFKTNSIE----------------------------QILEIQRECQIMQQ-------INHP
.||.|. ..|| |..|   |. .   .      . .|.|| ... .                                ...|| .||..       ..||
TLGRGSFGKVKLCIHKNTTGKERV--HHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP

SIIKFKELIIEKS-----------------TNKAYLVQ---EFAQGK----SLQSYLTENCQN------------RQMDEVTALSIVLQVLRGLCSLHSR
 |||. | .  ..                 ... |.|    |...|      | .|..|. ..            . ..|  |  .. |.. ..  .||.
NIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NICHFDIKPDNIIYNQNN----------------GKIKIIDFSSSRKSYP------------------------NQKLLTNIGTLNYKS-PEYFGGSQ--
||.| |.||.|| ...||                ..||||||  ..|  |                        .||. |  ||. | . || . |..  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------RNTKSDIWSVGVILYQLLTGFLPFDDLSG-----------NPCSITENIKNMKFQ--QQYKEVIS--------------------PKM
             . |.|.||.||||| .|.|..||.. ..           |.  . |.|.. |..    |   ||                    .  
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

LEILELMLVFDPSKRYSANQLLQ
   .  ||. ||.||... | |.
KDLIRKMLQVDPEKRMTIEQCLN
Kinase 22235.AA Pkinase 141-405 26 1.6e-63 222.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 141-405
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

YVVGKKLGEGANAVVKACYQKDESGEPEKCQSKLYAVKIFKTNSIEQILEIQ----RECQIMQQINHPSIIKFKELIIEKSTNKAYLVQEFAQGK----S
|..|.|.|.|. ..|. |. |...         ..||||.|  ...   ...    .|.|||. .||| |.....   .   .. |.|.|...|     .
YHIGRKIGSGSFGCVYKCHHKGTGK--------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMD

LQSYLT--ENCQNRQMDEVTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQNNGKI----KIIDFSSSRK--SYPNQKLLTNIGTLNYKSPEYFG-G
| .|..  ...    ..| .. ....|.||||  .||..|.| |.||.|| .. ||| |    ||.|| ....    .|. . |  ||..| .||    |
LFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

SQRNTKSDIWSVGVILYQLLTGFLPFDDL----SGNPCSITENIKNMKFQQQYKEVIS-------------------PKMLEILELMLVFDPSKRYSANQ
.   .|.|.||.|.|||..|.| .||..     . ..  . ..|.  ..  .. . .|                   . ...... .| .||.||..| |
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLQK--I
.||   .
ILQHPWF
Kinase 22235.AA CAMKL 141-403 30 1.3e-58 185.58 In-house 1-293 (297) Show / Hide 
Range on Protein: 141-403
Range on HMM: 1-293/297
Sequence Identity: 30% (93 aa)

YVVGKKLGEGANAVVKACYQ-KDESGEPEKCQSKLYAVKIFK--TNSIEQILE-------------IQRECQIMQQIN---HPSIIKFKELIIEKST---
| .|| ||.|. ..|| .   .           . .|.|| .    . ... .             |.|| |||...|   || |||. | |  ...   
YRIGKTLGKGSFGKVKLATHIRTT--------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIE

-NKAYLVQEFAQGKS--LQSYLTENCQNR-QMDEVTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQNNG-KIKIIDFSSSRKSYP-----NQKLLT
 .| ||| | ..| .  |. |. ..   |  |.|  |  .  |.. ..  .||..|.| ||||.||   .|.  .||||||  | .  |     .||| |
TKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKT

NIGTLNYKSPEYFGG--SQRN-TKSDIWSVGVILYQLLTGFLPFDDLS----GNPCSITENIKNMKFQQQYKEV--ISPKMLEILELMLVFDPSKRYSAN
  |...| .|| | |   . .  | |||| ||||| ...| ||||| .    |. .  ..  |.|.   ..     .|     ..  ||. .|.||... 
FCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIH

QLLQ
|...
QIMN
Kinase 22235.AA CMGC 141-403 16 1.3e-49 160.71 In-house 1-509 (513) Show / Hide 
Range on Protein: 141-403
Range on HMM: 1-509/513
Sequence Identity: 16% (87 aa)

YVVGKKLGEGANAVVKACYQKDESGE-----PEKCQ-SKLYAVKIFKTNSIEQILEI------------QRECQIMQQIN-----------------HPS
| . ||.|||. .||  |. |.  ..      ....  ...|.|..| .  ... .             .||..|....|                 |. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKFKELIIEKSTN---------------KAYLVQEFAQG------KSLQS--------YLTENC-----------QNRQMDEVTALSIVLQVLRGLC--
|.| .. .  | ..               . ||| |. .       |. |         .|.|             . . .       .  |.||||   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

SLHSRN--ICHFDIKPDNIIYNQNN-------------------GKIKIIDFSSSRKSYPN---------------------QKLLT-NIGTLNYKSPEY
 .||..  |.| |.|| ||  |.|.                   |..||.|| ..|.  |.                     .. .| .. |. |..|| 
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

FGGSQRN----------TKSDIWSVGVILYQLLTG--------FLPFD-----------------------DLSGNP-------------CSITENIKNM
  |...           |. |.|||| |.. ..||           |                        .. |.|             |. .|.. ||
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

K----------------------------------FQQQYKEVIS------------------------------------------PKMLEILELMLVF
.                                  |.....  ..                                          |. .. |. ||..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPSKRYSANQLLQ
||.|| .| | ||
DPDKRITAEQALQ
Kinase 22235.AA STE 141-403 20 9e-44 151.74 In-house 1-353 (359) Show / Hide 
Range on Protein: 141-403
Range on HMM: 1-353/359
Sequence Identity: 20% (75 aa)

YVVGKKLGEGANAVVKACYQKD-----ESGEP--EKCQSKLYAVKIFKTNSI-----------------EQILEIQRECQIMQQIN--HPSIIKFKELII
.   .|.|.||  .|  .. ..     ..||   .. . ...|.|. . ..                  |.. .|..| .||.. |  || |.|.    .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----EKSTNKAYLVQEFAQGKSLQSYLTENC---QNRQ--------MDEVTALSIVLQVLRG-LCSLHSRNICHFDIKPDNIIYNQNNGKIKIIDFSSS
     .|. .. ... |.  | || . . ...   .. .        ..|     |. |.|.| |  ||| .| | ||||.||        .|..||  .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

RKSYPN-----------------QKLLTNIGTLNYKSPEYFGG------SQRNTKSDIWSVGVILYQLLTGFLPFDDLSGN--PCSITENIKNM------
 .  ..                 ||  | .||  . .||   .      .. .||.||||.|  .  ..||  |. |..       |. |.. .      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KFQQQYKE-------------------VISPKMLEILELMLVFDPSKRYSANQLLQ
    .   . ..                     ||.. . ... |. ||.|| .|.|||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase 22235.AA ULK 141-397 23 1.5e-43 149.9 In-house 1-319 (329) Show / Hide 
Range on Protein: 141-397
Range on HMM: 1-319/329
Sequence Identity: 23% (75 aa)

YVVGKKLGEGANAVVKACYQKDESGEPEKCQSKLYAVKIFKTNSIEQILE----------IQRECQIMQQIN--------HPSIIKFKELIIEKSTNKAY
|.. ..||.|. .  | .  ...  .    . ...|.|.   ... |..           ...|..||....        || |.|...   ..  |  |
YCLNHCLGKGSFG--KVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIY

LVQEFAQGKSLQSYLTENCQ-------NRQMDEVTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQNNGK-----------IKIIDFSSSRK-SYP-
...|. .|  |..|. .|         ..   |  |...  | | |.  ||..|| | ||||.||  . ...|           .|| ||  ... ... 
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

--NQKLLTNI------GTLNYKSPEYFG----GSQRN-TKSDIWSVGVILYQLLTGFLPFDDLSGNPCS---ITENIKNM--------KFQQQYK-----
  .| ..|        ||  | .|. .     . . .  |.||||.|.|.|..|.|  ||     |.     |...|.|         |.. |..     
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

EVISPKMLEILELMLVFDPSKRYS
 .|||.. ...  ||..|...| |
PQISPECKDLIRRMLQYDEKDRIS
Kinase 22235.AA ULK 141-397 24 2.9e-42 146.72 In-house 1-314 (324) Show / Hide 
Range on Protein: 141-397
Range on HMM: 1-314/324
Sequence Identity: 24% (79 aa)

YVVGKKLGEGANA-VVKACYQKDESGEPEKCQSKLYAV-KIFKTNSIEQILE---------IQRECQIMQQIN---HPS--IIKFKELIIEKSTNKAYLV
|.. ..||.|. . .|   . |.  .     | ...|. .| | . ... .|         ...| |||....   ||   |.|...   ..  |  |..
YCLNHCLGKGSFGVKVYKGRNKKTNT-----QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII

QEFAQGKSLQSYLTENCQ------NRQMDEVTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQNNGK-----------IKIIDFSSSRK-SYPN---
.|. .|  |..|. .|        ..   |  |...  | . |.  ||..|| | ||||.||  . ...|           .|| ||  ...  ..|   
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

QKLLTNI------GTLNYKSPEYFG----GSQRN-TKSDIWSVGVILYQLLTGFLPFDDLSGNP-C----SITEN-------IKNMKFQQQ---YKEVIS
|.. |        ||  | .|. .     . . .  |.||||.|.|.|..|.|  ||     |.      .  .|       ||| ..| .   .  .||
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

PKMLEILELMLVFDPSKRYS
|.. ...  ||..|...| |
PECKDLIRRMLQYDEKDRIS
Kinase 22235.AA MARK 141-403 30 5.2e-40 128.59 In-house 1-258 (262) Show / Hide 
Range on Protein: 141-403
Range on HMM: 1-258/262
Sequence Identity: 30% (83 aa)

YVVGKKLGEGANAVVKACYQKDESGEPEKCQSKLYAVKIFK--TNSI-EQILEIQRECQIMQQINHPSIIKFKELIIEKSTNKA--YLVQEFAQGKSLQS
| ..| .|.|. |.|| .          |.  . .|.|| .    .  ... ...|| .||....|| |||. . |  . |..   ||. | | |..| .
YKMLKTIGHGSYAKVKLAC--------HKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIE-QDTEQHQIYLIMEYASGGELYD

YLTENCQNRQMDEVTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQNN-GKIKIIDFSSSRKSYPNQKLLTNIGTLNYKSPEYFGGSQRN-TKSDIW
|. .   |. . |  |  |  |.. ... .||.||.| ||||.||   .|.  .||||||  |..  |.||| |  ||. | .|| | .   . .| |||
YIKAH-PNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIW

SVGVILYQLLTGFLPFDDLSGNPCSITENIKNMKFQQQYKEVISPKMLEILELMLVFDPSKRYSANQLLQ
| ||.|| ...| .|||. . .   . ..| . |..  ..  .|..   .. ..|...|..| .. ....
SLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMK
Kinase 22235.AA CAMK-Unique 173-403 20 9.6e-40 128.74 In-house 25-359 (363) Show / Hide 
Range on Protein: 173-403
Range on HMM: 25-359/363
Sequence Identity: 20% (70 aa)

KLYAVKIFKT---NSIEQIL-----------------EIQRECQIMQQINHPSIIKFKEL---IIEKSTN--------------KAYLVQEFAQGKSLQS
|..|.|..|     .. |..                 .  || ||..  .|| |||. .    | . ...              . |.|.|..||. |..
KKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFD

YLTENCQ-----------------NRQMDE--VTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQN---------------NGKIKIIDFSSSRKSY
.. ..                   .... |    ...|....|  .  .|| .| | |.|..|| .. .               | .||..||  ...  
WIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYN

PNQKLL---TNIGTLNYKSP--------------EYFGGSQRNTKS----DIWSVGVILYQLLTGFLPFDDLSGNP------CSITENIK--NM-KFQQQ
 |..     | .||. |..|              |  ...    ..    |||| |||.| .|.| .|||  . .        .| |.|.  .  .|  .
HNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWK

YKEV---ISPKMLEILELMLVFDPSKRYSANQLLQ
. ..   ||.    ...  .. ||..| ||..||.
MWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLE
Kinase 22235.AA TyrKc 141-405 22 1.1e-15 30.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 141-405
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

YVVGKKLGEGANAVVKACYQKDESGEPEKCQSKLYAVKIFKTNSIEQILEIQRECQIMQQI--NHPSIIKFKELIIEK-----STNKAYLVQEFAQGKSL
 . ||||||||  .|  .  |              |||  | ..   . .. || .|| ..  .|| |...   ....     .    ..| |.. . .|
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

QSYLTENCQNRQMDEVTALSIVLQVLRGLCSLHSRNICHFDIKPDNIIYNQNNGKIKIIDFSSSRKSYPN------QKLLTN----IGT--LNYK--SPE
..|| ..  .      . ||. .|. .|   |||.|. | |.   |. .. |.  .|| ||  ||. |        ..  .      |   | ..  .||
KDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

YFGGSQR--NTKSDIWSVGVILYQLLT-GFLPFDD-----LSGNPCSITENIKNMKFQQQYKEV-------ISPKMLEILELMLVFDPSKRYSANQLLQK
 .    .  .||||.|| || .. ..| |  |  .     .|     . |..|. .   | ...        ...| .| .    .||..| . ... ..
CI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ--EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
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F
Kinase 22235.AA Pkinase_Tyr 141-272 26 7.4e-09 30.63 Pfam 1-134 (270) Show / Hide 
Range on Protein: 141-272
Range on HMM: 1-134/270
Sequence Identity: 26% (37 aa)

YVVGKKLGEGANAVVKACYQK-DESGEPEKCQSKLYAVKIFKTNSIEQ---ILEIQRECQIMQQI-NHPSIIKFKELII-EKSTNKAYLVQEFAQGKSLQ
 . ||||||||  .|. .. | |....  ..     |||. | .. ..   . .  || .|| |. .|| |...   .. ..  |. |.| |.... .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-----AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SYLTEN-CQNRQMDEVTALSIVLQVLRGLCSLHSRNICH
.|| ..  .... .  . |.. .|. .|.  |.|.|. |
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH